Amino acid dipepetide frequency for Thermus virus P23-45 (Thermus thermophilus phage P23-45)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.91AlaAla: 8.91 ± 0.817
0.148AlaCys: 0.148 ± 0.078
4.474AlaAsp: 4.474 ± 0.431
7.321AlaGlu: 7.321 ± 0.898
4.215AlaPhe: 4.215 ± 0.355
5.139AlaGly: 5.139 ± 0.804
1.553AlaHis: 1.553 ± 0.259
4.511AlaIle: 4.511 ± 0.367
6.581AlaLys: 6.581 ± 0.891
12.534AlaLeu: 12.534 ± 1.231
2.329AlaMet: 2.329 ± 0.27
2.884AlaAsn: 2.884 ± 0.302
3.549AlaPro: 3.549 ± 0.305
3.882AlaGln: 3.882 ± 0.447
5.99AlaArg: 5.99 ± 0.605
5.546AlaSer: 5.546 ± 0.537
4.363AlaThr: 4.363 ± 0.391
6.877AlaVal: 6.877 ± 0.6
1.294AlaTrp: 1.294 ± 0.313
4.326AlaTyr: 4.326 ± 0.349
0.0AlaXaa: 0.0 ± 0.0
Cys
0.555CysAla: 0.555 ± 0.234
0.074CysCys: 0.074 ± 0.053
0.111CysAsp: 0.111 ± 0.075
0.222CysGlu: 0.222 ± 0.101
0.148CysPhe: 0.148 ± 0.083
0.37CysGly: 0.37 ± 0.141
0.074CysHis: 0.074 ± 0.048
0.111CysIle: 0.111 ± 0.065
0.111CysLys: 0.111 ± 0.073
0.333CysLeu: 0.333 ± 0.136
0.185CysMet: 0.185 ± 0.087
0.111CysAsn: 0.111 ± 0.075
0.37CysPro: 0.37 ± 0.162
0.111CysGln: 0.111 ± 0.067
0.222CysArg: 0.222 ± 0.089
0.185CysSer: 0.185 ± 0.091
0.185CysThr: 0.185 ± 0.086
0.259CysVal: 0.259 ± 0.125
0.148CysTrp: 0.148 ± 0.072
0.148CysTyr: 0.148 ± 0.082
0.0CysXaa: 0.0 ± 0.0
Asp
4.474AspAla: 4.474 ± 0.507
0.185AspCys: 0.185 ± 0.107
2.514AspAsp: 2.514 ± 0.427
4.104AspGlu: 4.104 ± 0.344
2.921AspPhe: 2.921 ± 0.411
4.733AspGly: 4.733 ± 0.626
0.481AspHis: 0.481 ± 0.138
1.997AspIle: 1.997 ± 0.335
2.181AspLys: 2.181 ± 0.24
7.838AspLeu: 7.838 ± 0.486
0.629AspMet: 0.629 ± 0.132
1.368AspAsn: 1.368 ± 0.213
3.438AspPro: 3.438 ± 0.409
1.442AspGln: 1.442 ± 0.201
2.995AspArg: 2.995 ± 0.335
1.96AspSer: 1.96 ± 0.397
2.773AspThr: 2.773 ± 0.296
2.884AspVal: 2.884 ± 0.409
1.072AspTrp: 1.072 ± 0.26
2.329AspTyr: 2.329 ± 0.419
0.0AspXaa: 0.0 ± 0.0
Glu
8.726GluAla: 8.726 ± 0.955
0.185GluCys: 0.185 ± 0.09
3.697GluAsp: 3.697 ± 0.331
7.616GluGlu: 7.616 ± 0.792
2.588GluPhe: 2.588 ± 0.323
5.176GluGly: 5.176 ± 0.566
1.257GluHis: 1.257 ± 0.259
2.773GluIle: 2.773 ± 0.305
2.625GluLys: 2.625 ± 0.511
10.315GluLeu: 10.315 ± 1.305
1.294GluMet: 1.294 ± 0.215
1.59GluAsn: 1.59 ± 0.199
3.18GluPro: 3.18 ± 0.471
2.255GluGln: 2.255 ± 0.344
5.694GluArg: 5.694 ± 0.8
3.143GluSer: 3.143 ± 0.345
2.625GluThr: 2.625 ± 0.283
7.579GluVal: 7.579 ± 0.538
0.813GluTrp: 0.813 ± 0.169
2.292GluTyr: 2.292 ± 0.281
0.0GluXaa: 0.0 ± 0.0
Phe
3.808PheAla: 3.808 ± 0.378
0.222PheCys: 0.222 ± 0.109
1.923PheAsp: 1.923 ± 0.324
1.553PheGlu: 1.553 ± 0.298
1.923PhePhe: 1.923 ± 0.374
3.254PheGly: 3.254 ± 0.294
0.813PheHis: 0.813 ± 0.189
1.405PheIle: 1.405 ± 0.359
2.181PheLys: 2.181 ± 0.289
4.252PheLeu: 4.252 ± 0.365
1.146PheMet: 1.146 ± 0.234
1.442PheAsn: 1.442 ± 0.289
2.292PhePro: 2.292 ± 0.428
1.442PheGln: 1.442 ± 0.257
2.366PheArg: 2.366 ± 0.226
2.81PheSer: 2.81 ± 0.393
2.699PheThr: 2.699 ± 0.387
3.438PheVal: 3.438 ± 0.49
0.444PheTrp: 0.444 ± 0.118
1.701PheTyr: 1.701 ± 0.377
0.0PheXaa: 0.0 ± 0.0
Gly
4.991GlyAla: 4.991 ± 0.537
0.185GlyCys: 0.185 ± 0.091
3.475GlyAsp: 3.475 ± 0.323
4.363GlyGlu: 4.363 ± 0.421
3.217GlyPhe: 3.217 ± 0.329
4.843GlyGly: 4.843 ± 0.625
1.109GlyHis: 1.109 ± 0.198
2.736GlyIle: 2.736 ± 0.359
3.845GlyLys: 3.845 ± 0.479
8.06GlyLeu: 8.06 ± 0.846
1.553GlyMet: 1.553 ± 0.268
2.403GlyAsn: 2.403 ± 0.279
2.551GlyPro: 2.551 ± 0.257
2.551GlyGln: 2.551 ± 0.308
3.993GlyArg: 3.993 ± 0.353
4.104GlySer: 4.104 ± 0.375
4.4GlyThr: 4.4 ± 0.389
6.027GlyVal: 6.027 ± 0.55
1.405GlyTrp: 1.405 ± 0.331
3.365GlyTyr: 3.365 ± 0.361
0.0GlyXaa: 0.0 ± 0.0
His
1.849HisAla: 1.849 ± 0.327
0.185HisCys: 0.185 ± 0.088
0.961HisAsp: 0.961 ± 0.254
0.739HisGlu: 0.739 ± 0.2
0.739HisPhe: 0.739 ± 0.244
1.146HisGly: 1.146 ± 0.22
0.333HisHis: 0.333 ± 0.149
0.518HisIle: 0.518 ± 0.128
0.444HisLys: 0.444 ± 0.095
2.144HisLeu: 2.144 ± 0.3
0.222HisMet: 0.222 ± 0.087
0.518HisAsn: 0.518 ± 0.152
1.183HisPro: 1.183 ± 0.254
0.592HisGln: 0.592 ± 0.126
1.368HisArg: 1.368 ± 0.244
0.444HisSer: 0.444 ± 0.167
0.592HisThr: 0.592 ± 0.118
1.775HisVal: 1.775 ± 0.331
0.222HisTrp: 0.222 ± 0.096
0.739HisTyr: 0.739 ± 0.168
0.0HisXaa: 0.0 ± 0.0
Ile
3.586IleAla: 3.586 ± 0.352
0.111IleCys: 0.111 ± 0.071
1.479IleAsp: 1.479 ± 0.295
2.662IleGlu: 2.662 ± 0.405
1.516IlePhe: 1.516 ± 0.293
2.551IleGly: 2.551 ± 0.228
0.739IleHis: 0.739 ± 0.169
1.257IleIle: 1.257 ± 0.228
2.255IleLys: 2.255 ± 0.318
4.215IleLeu: 4.215 ± 0.351
0.592IleMet: 0.592 ± 0.176
1.183IleAsn: 1.183 ± 0.3
2.144IlePro: 2.144 ± 0.458
1.516IleGln: 1.516 ± 0.291
2.181IleArg: 2.181 ± 0.226
2.07IleSer: 2.07 ± 0.362
1.812IleThr: 1.812 ± 0.234
2.292IleVal: 2.292 ± 0.289
0.333IleTrp: 0.333 ± 0.141
1.59IleTyr: 1.59 ± 0.282
0.0IleXaa: 0.0 ± 0.0
Lys
5.25LysAla: 5.25 ± 0.67
0.074LysCys: 0.074 ± 0.053
2.625LysAsp: 2.625 ± 0.437
5.028LysGlu: 5.028 ± 0.755
1.257LysPhe: 1.257 ± 0.203
3.734LysGly: 3.734 ± 0.427
0.776LysHis: 0.776 ± 0.161
0.998LysIle: 0.998 ± 0.199
1.664LysLys: 1.664 ± 0.279
5.916LysLeu: 5.916 ± 0.593
0.629LysMet: 0.629 ± 0.143
1.516LysAsn: 1.516 ± 0.222
3.069LysPro: 3.069 ± 0.356
1.553LysGln: 1.553 ± 0.268
4.437LysArg: 4.437 ± 0.474
2.181LysSer: 2.181 ± 0.289
2.625LysThr: 2.625 ± 0.244
5.213LysVal: 5.213 ± 0.472
0.444LysTrp: 0.444 ± 0.112
1.738LysTyr: 1.738 ± 0.293
0.0LysXaa: 0.0 ± 0.0
Leu
12.275LeuAla: 12.275 ± 0.976
0.333LeuCys: 0.333 ± 0.128
7.099LeuAsp: 7.099 ± 0.514
9.354LeuGlu: 9.354 ± 0.904
3.365LeuPhe: 3.365 ± 0.329
7.616LeuGly: 7.616 ± 0.85
1.997LeuHis: 1.997 ± 0.409
3.586LeuIle: 3.586 ± 0.459
7.542LeuLys: 7.542 ± 0.781
9.354LeuLeu: 9.354 ± 0.653
2.514LeuMet: 2.514 ± 0.268
4.178LeuAsn: 4.178 ± 0.439
6.322LeuPro: 6.322 ± 0.424
4.585LeuGln: 4.585 ± 0.46
6.433LeuArg: 6.433 ± 0.654
6.951LeuSer: 6.951 ± 0.557
6.174LeuThr: 6.174 ± 0.453
9.724LeuVal: 9.724 ± 0.637
1.257LeuTrp: 1.257 ± 0.249
4.141LeuTyr: 4.141 ± 0.463
0.0LeuXaa: 0.0 ± 0.0
Met
2.255MetAla: 2.255 ± 0.316
0.0MetCys: 0.0 ± 0.0
1.331MetAsp: 1.331 ± 0.255
1.812MetGlu: 1.812 ± 0.226
0.518MetPhe: 0.518 ± 0.129
1.442MetGly: 1.442 ± 0.197
0.407MetHis: 0.407 ± 0.145
0.407MetIle: 0.407 ± 0.123
0.592MetLys: 0.592 ± 0.174
1.59MetLeu: 1.59 ± 0.214
0.481MetMet: 0.481 ± 0.108
0.702MetAsn: 0.702 ± 0.131
1.035MetPro: 1.035 ± 0.188
0.592MetGln: 0.592 ± 0.106
1.59MetArg: 1.59 ± 0.305
1.072MetSer: 1.072 ± 0.229
1.22MetThr: 1.22 ± 0.231
1.442MetVal: 1.442 ± 0.257
0.259MetTrp: 0.259 ± 0.111
0.481MetTyr: 0.481 ± 0.145
0.0MetXaa: 0.0 ± 0.0
Asn
3.291AsnAla: 3.291 ± 0.359
0.148AsnCys: 0.148 ± 0.083
1.479AsnAsp: 1.479 ± 0.236
1.405AsnGlu: 1.405 ± 0.188
1.479AsnPhe: 1.479 ± 0.3
2.588AsnGly: 2.588 ± 0.487
0.666AsnHis: 0.666 ± 0.184
1.072AsnIle: 1.072 ± 0.182
1.442AsnLys: 1.442 ± 0.224
3.919AsnLeu: 3.919 ± 0.603
0.518AsnMet: 0.518 ± 0.161
0.961AsnAsn: 0.961 ± 0.198
2.736AsnPro: 2.736 ± 0.284
1.257AsnGln: 1.257 ± 0.215
2.551AsnArg: 2.551 ± 0.344
1.294AsnSer: 1.294 ± 0.257
1.812AsnThr: 1.812 ± 0.303
1.997AsnVal: 1.997 ± 0.434
0.592AsnTrp: 0.592 ± 0.147
0.998AsnTyr: 0.998 ± 0.248
0.0AsnXaa: 0.0 ± 0.0
Pro
3.328ProAla: 3.328 ± 0.416
0.259ProCys: 0.259 ± 0.102
3.734ProAsp: 3.734 ± 0.418
4.917ProGlu: 4.917 ± 0.522
2.736ProPhe: 2.736 ± 0.294
3.217ProGly: 3.217 ± 0.399
1.22ProHis: 1.22 ± 0.238
2.403ProIle: 2.403 ± 0.336
3.069ProLys: 3.069 ± 0.432
5.028ProLeu: 5.028 ± 0.592
0.776ProMet: 0.776 ± 0.213
2.366ProAsn: 2.366 ± 0.39
2.847ProPro: 2.847 ± 0.414
1.257ProGln: 1.257 ± 0.232
2.181ProArg: 2.181 ± 0.365
3.106ProSer: 3.106 ± 0.373
2.514ProThr: 2.514 ± 0.346
4.363ProVal: 4.363 ± 0.37
0.592ProTrp: 0.592 ± 0.174
2.07ProTyr: 2.07 ± 0.351
0.0ProXaa: 0.0 ± 0.0
Gln
5.324GlnAla: 5.324 ± 0.805
0.074GlnCys: 0.074 ± 0.062
1.96GlnAsp: 1.96 ± 0.238
2.551GlnGlu: 2.551 ± 0.512
1.146GlnPhe: 1.146 ± 0.193
2.995GlnGly: 2.995 ± 0.312
0.37GlnHis: 0.37 ± 0.111
1.405GlnIle: 1.405 ± 0.221
1.627GlnLys: 1.627 ± 0.25
2.921GlnLeu: 2.921 ± 0.353
0.481GlnMet: 0.481 ± 0.118
1.405GlnAsn: 1.405 ± 0.178
1.146GlnPro: 1.146 ± 0.324
1.072GlnGln: 1.072 ± 0.2
2.181GlnArg: 2.181 ± 0.391
1.96GlnSer: 1.96 ± 0.286
1.627GlnThr: 1.627 ± 0.248
3.291GlnVal: 3.291 ± 0.374
0.37GlnTrp: 0.37 ± 0.109
0.924GlnTyr: 0.924 ± 0.156
0.0GlnXaa: 0.0 ± 0.0
Arg
5.435ArgAla: 5.435 ± 0.629
0.259ArgCys: 0.259 ± 0.112
2.773ArgAsp: 2.773 ± 0.281
5.546ArgGlu: 5.546 ± 0.786
3.143ArgPhe: 3.143 ± 0.352
3.438ArgGly: 3.438 ± 0.435
1.257ArgHis: 1.257 ± 0.215
2.588ArgIle: 2.588 ± 0.32
3.328ArgLys: 3.328 ± 0.348
8.282ArgLeu: 8.282 ± 0.629
1.664ArgMet: 1.664 ± 0.269
1.664ArgAsn: 1.664 ± 0.218
2.81ArgPro: 2.81 ± 0.352
2.884ArgGln: 2.884 ± 0.419
4.954ArgArg: 4.954 ± 0.539
2.884ArgSer: 2.884 ± 0.348
3.069ArgThr: 3.069 ± 0.38
5.62ArgVal: 5.62 ± 0.413
0.813ArgTrp: 0.813 ± 0.21
3.032ArgTyr: 3.032 ± 0.302
0.0ArgXaa: 0.0 ± 0.0
Ser
5.102SerAla: 5.102 ± 0.517
0.37SerCys: 0.37 ± 0.165
2.218SerAsp: 2.218 ± 0.299
3.069SerGlu: 3.069 ± 0.317
2.514SerPhe: 2.514 ± 0.32
4.622SerGly: 4.622 ± 0.495
0.666SerHis: 0.666 ± 0.133
1.738SerIle: 1.738 ± 0.373
2.292SerLys: 2.292 ± 0.299
6.47SerLeu: 6.47 ± 0.499
0.961SerMet: 0.961 ± 0.159
1.294SerAsn: 1.294 ± 0.253
3.328SerPro: 3.328 ± 0.304
1.59SerGln: 1.59 ± 0.252
3.032SerArg: 3.032 ± 0.399
3.069SerSer: 3.069 ± 0.484
2.921SerThr: 2.921 ± 0.309
4.326SerVal: 4.326 ± 0.486
0.813SerTrp: 0.813 ± 0.203
2.403SerTyr: 2.403 ± 0.384
0.0SerXaa: 0.0 ± 0.0
Thr
4.178ThrAla: 4.178 ± 0.378
0.222ThrCys: 0.222 ± 0.112
2.403ThrAsp: 2.403 ± 0.261
2.662ThrGlu: 2.662 ± 0.271
2.477ThrPhe: 2.477 ± 0.368
3.919ThrGly: 3.919 ± 0.387
0.629ThrHis: 0.629 ± 0.143
2.44ThrIle: 2.44 ± 0.393
1.886ThrLys: 1.886 ± 0.235
6.064ThrLeu: 6.064 ± 0.425
0.739ThrMet: 0.739 ± 0.188
1.479ThrAsn: 1.479 ± 0.229
3.401ThrPro: 3.401 ± 0.511
1.331ThrGln: 1.331 ± 0.233
3.18ThrArg: 3.18 ± 0.36
2.736ThrSer: 2.736 ± 0.389
2.366ThrThr: 2.366 ± 0.335
3.808ThrVal: 3.808 ± 0.407
1.035ThrTrp: 1.035 ± 0.248
2.255ThrTyr: 2.255 ± 0.286
0.0ThrXaa: 0.0 ± 0.0
Val
7.542ValAla: 7.542 ± 0.837
0.555ValCys: 0.555 ± 0.168
4.252ValAsp: 4.252 ± 0.404
6.84ValGlu: 6.84 ± 0.437
3.217ValPhe: 3.217 ± 0.444
4.622ValGly: 4.622 ± 0.429
1.257ValHis: 1.257 ± 0.299
2.329ValIle: 2.329 ± 0.308
5.213ValLys: 5.213 ± 0.62
9.391ValLeu: 9.391 ± 0.6
1.664ValMet: 1.664 ± 0.234
3.069ValAsn: 3.069 ± 0.492
3.882ValPro: 3.882 ± 0.498
3.365ValGln: 3.365 ± 0.485
5.361ValArg: 5.361 ± 0.384
4.659ValSer: 4.659 ± 0.587
2.477ValThr: 2.477 ± 0.376
6.507ValVal: 6.507 ± 0.641
1.553ValTrp: 1.553 ± 0.394
4.03ValTyr: 4.03 ± 0.435
0.0ValXaa: 0.0 ± 0.0
Trp
1.183TrpAla: 1.183 ± 0.283
0.111TrpCys: 0.111 ± 0.069
0.887TrpAsp: 0.887 ± 0.226
1.257TrpGlu: 1.257 ± 0.235
0.592TrpPhe: 0.592 ± 0.162
0.666TrpGly: 0.666 ± 0.178
0.481TrpHis: 0.481 ± 0.205
0.407TrpIle: 0.407 ± 0.125
0.592TrpLys: 0.592 ± 0.161
1.516TrpLeu: 1.516 ± 0.317
0.333TrpMet: 0.333 ± 0.136
0.702TrpAsn: 0.702 ± 0.168
0.592TrpPro: 0.592 ± 0.152
0.333TrpGln: 0.333 ± 0.119
1.035TrpArg: 1.035 ± 0.244
0.813TrpSer: 0.813 ± 0.215
0.629TrpThr: 0.629 ± 0.188
1.257TrpVal: 1.257 ± 0.259
0.481TrpTrp: 0.481 ± 0.149
0.813TrpTyr: 0.813 ± 0.214
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.4TyrAla: 4.4 ± 0.446
0.333TyrCys: 0.333 ± 0.122
2.921TyrAsp: 2.921 ± 0.341
2.403TyrGlu: 2.403 ± 0.282
1.405TyrPhe: 1.405 ± 0.268
3.106TyrGly: 3.106 ± 0.368
0.629TyrHis: 0.629 ± 0.194
1.405TyrIle: 1.405 ± 0.285
1.257TyrLys: 1.257 ± 0.212
4.659TyrLeu: 4.659 ± 0.543
0.481TyrMet: 0.481 ± 0.118
1.368TyrAsn: 1.368 ± 0.215
2.107TyrPro: 2.107 ± 0.402
1.22TyrGln: 1.22 ± 0.194
3.697TyrArg: 3.697 ± 0.318
1.812TyrSer: 1.812 ± 0.307
2.329TyrThr: 2.329 ± 0.348
3.106TyrVal: 3.106 ± 0.371
0.739TyrTrp: 0.739 ± 0.171
1.664TyrTyr: 1.664 ± 0.26
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 117 proteins (27048 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski