Amino acid dipepetide frequency for Escherichia phage BZ13 (Bacteriophage BZ13)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.386AlaAla: 5.386 ± 0.732
1.795AlaCys: 1.795 ± 1.164
3.591AlaAsp: 3.591 ± 0.893
2.693AlaGlu: 2.693 ± 2.857
0.898AlaPhe: 0.898 ± 0.729
3.591AlaGly: 3.591 ± 0.893
0.898AlaHis: 0.898 ± 0.582
2.693AlaIle: 2.693 ± 2.623
7.181AlaLys: 7.181 ± 2.794
5.386AlaLeu: 5.386 ± 1.767
1.795AlaMet: 1.795 ± 1.308
2.693AlaAsn: 2.693 ± 1.065
4.488AlaPro: 4.488 ± 1.949
0.898AlaGln: 0.898 ± 0.582
3.591AlaArg: 3.591 ± 2.328
8.079AlaSer: 8.079 ± 3.668
4.488AlaThr: 4.488 ± 2.277
3.591AlaVal: 3.591 ± 2.328
1.795AlaTrp: 1.795 ± 1.465
8.977AlaTyr: 8.977 ± 1.711
0.0AlaXaa: 0.0 ± 0.0
Cys
2.693CysAla: 2.693 ± 1.746
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.898CysGly: 0.898 ± 0.582
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
3.591CysLys: 3.591 ± 2.328
0.898CysLeu: 0.898 ± 0.582
0.898CysMet: 0.898 ± 0.582
2.693CysAsn: 2.693 ± 1.746
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.795CysSer: 1.795 ± 1.94
0.0CysThr: 0.0 ± 0.0
0.898CysVal: 0.898 ± 0.582
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.795AspAla: 1.795 ± 1.164
1.795AspCys: 1.795 ± 1.164
2.693AspAsp: 2.693 ± 1.065
2.693AspGlu: 2.693 ± 0.9
2.693AspPhe: 2.693 ± 1.711
3.591AspGly: 3.591 ± 1.402
0.898AspHis: 0.898 ± 0.729
1.795AspIle: 1.795 ± 0.576
1.795AspLys: 1.795 ± 1.313
6.284AspLeu: 6.284 ± 1.514
4.488AspMet: 4.488 ± 1.949
1.795AspAsn: 1.795 ± 1.465
2.693AspPro: 2.693 ± 0.9
1.795AspGln: 1.795 ± 1.164
6.284AspArg: 6.284 ± 1.934
3.591AspSer: 3.591 ± 1.64
1.795AspThr: 1.795 ± 0.576
1.795AspVal: 1.795 ± 1.313
0.898AspTrp: 0.898 ± 0.729
1.795AspTyr: 1.795 ± 0.576
0.0AspXaa: 0.0 ± 0.0
Glu
3.591GluAla: 3.591 ± 1.267
1.795GluCys: 1.795 ± 1.164
0.0GluAsp: 0.0 ± 0.0
0.0GluGlu: 0.0 ± 0.0
0.898GluPhe: 0.898 ± 0.582
0.0GluGly: 0.0 ± 0.0
0.898GluHis: 0.898 ± 0.729
1.795GluIle: 1.795 ± 0.576
2.693GluLys: 2.693 ± 1.178
5.386GluLeu: 5.386 ± 1.47
0.0GluMet: 0.0 ± 0.0
2.693GluAsn: 2.693 ± 1.711
0.898GluPro: 0.898 ± 0.582
0.898GluGln: 0.898 ± 0.729
0.0GluArg: 0.0 ± 0.0
5.386GluSer: 5.386 ± 1.799
3.591GluThr: 3.591 ± 2.328
3.591GluVal: 3.591 ± 1.267
1.795GluTrp: 1.795 ± 1.313
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
1.795PheAla: 1.795 ± 1.313
0.0PheCys: 0.0 ± 0.0
0.898PheAsp: 0.898 ± 0.582
2.693PheGlu: 2.693 ± 0.9
0.898PhePhe: 0.898 ± 0.582
0.0PheGly: 0.0 ± 0.0
0.898PheHis: 0.898 ± 0.582
1.795PheIle: 1.795 ± 0.576
4.488PheLys: 4.488 ± 2.089
2.693PheLeu: 2.693 ± 0.9
0.898PheMet: 0.898 ± 0.729
1.795PheAsn: 1.795 ± 0.576
4.488PhePro: 4.488 ± 1.394
0.898PheGln: 0.898 ± 0.729
6.284PheArg: 6.284 ± 1.934
4.488PheSer: 4.488 ± 1.769
6.284PheThr: 6.284 ± 1.69
2.693PheVal: 2.693 ± 2.623
1.795PheTrp: 1.795 ± 0.576
2.693PheTyr: 2.693 ± 1.065
0.0PheXaa: 0.0 ± 0.0
Gly
4.488GlyAla: 4.488 ± 2.089
0.898GlyCys: 0.898 ± 0.582
3.591GlyAsp: 3.591 ± 1.152
0.898GlyGlu: 0.898 ± 0.582
5.386GlyPhe: 5.386 ± 1.47
5.386GlyGly: 5.386 ± 1.315
0.898GlyHis: 0.898 ± 0.582
3.591GlyIle: 3.591 ± 1.402
1.795GlyLys: 1.795 ± 1.458
8.079GlyLeu: 8.079 ± 3.335
0.898GlyMet: 0.898 ± 0.582
6.284GlyAsn: 6.284 ± 1.878
0.898GlyPro: 0.898 ± 0.729
0.898GlyGln: 0.898 ± 0.582
3.591GlyArg: 3.591 ± 1.152
5.386GlySer: 5.386 ± 3.492
4.488GlyThr: 4.488 ± 2.892
4.488GlyVal: 4.488 ± 2.277
2.693GlyTrp: 2.693 ± 1.178
2.693GlyTyr: 2.693 ± 0.9
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.898HisGlu: 0.898 ± 0.582
1.795HisPhe: 1.795 ± 1.164
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.898HisIle: 0.898 ± 0.582
1.795HisLys: 1.795 ± 1.94
1.795HisLeu: 1.795 ± 1.458
0.898HisMet: 0.898 ± 0.582
0.898HisAsn: 0.898 ± 0.729
0.898HisPro: 0.898 ± 0.582
0.0HisGln: 0.0 ± 0.0
1.795HisArg: 1.795 ± 1.458
1.795HisSer: 1.795 ± 1.164
0.0HisThr: 0.0 ± 0.0
1.795HisVal: 1.795 ± 1.164
1.795HisTrp: 1.795 ± 1.94
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.386IleAla: 5.386 ± 1.79
0.0IleCys: 0.0 ± 0.0
7.181IleAsp: 7.181 ± 1.475
2.693IleGlu: 2.693 ± 0.9
2.693IlePhe: 2.693 ± 2.564
0.898IleGly: 0.898 ± 0.729
0.0IleHis: 0.0 ± 0.0
1.795IleIle: 1.795 ± 0.576
0.898IleLys: 0.898 ± 1.483
2.693IleLeu: 2.693 ± 3.934
0.0IleMet: 0.0 ± 0.0
1.795IleAsn: 1.795 ± 1.458
2.693IlePro: 2.693 ± 1.388
0.898IleGln: 0.898 ± 0.582
4.488IleArg: 4.488 ± 1.394
6.284IleSer: 6.284 ± 3.031
0.0IleThr: 0.0 ± 0.0
3.591IleVal: 3.591 ± 2.27
2.693IleTrp: 2.693 ± 1.711
2.693IleTyr: 2.693 ± 1.178
0.0IleXaa: 0.0 ± 0.0
Lys
3.591LysAla: 3.591 ± 2.657
0.0LysCys: 0.0 ± 0.0
0.898LysAsp: 0.898 ± 0.729
3.591LysGlu: 3.591 ± 2.246
1.795LysPhe: 1.795 ± 0.576
3.591LysGly: 3.591 ± 1.402
1.795LysHis: 1.795 ± 1.94
3.591LysIle: 3.591 ± 1.676
2.693LysLys: 2.693 ± 1.746
8.079LysLeu: 8.079 ± 3.331
0.898LysMet: 0.898 ± 0.729
0.898LysAsn: 0.898 ± 0.582
3.591LysPro: 3.591 ± 1.402
0.898LysGln: 0.898 ± 0.729
5.386LysArg: 5.386 ± 1.79
3.591LysSer: 3.591 ± 1.267
5.386LysThr: 5.386 ± 1.799
4.488LysVal: 4.488 ± 0.855
1.795LysTrp: 1.795 ± 0.576
0.898LysTyr: 0.898 ± 1.483
0.0LysXaa: 0.0 ± 0.0
Leu
9.874LeuAla: 9.874 ± 0.814
2.693LeuCys: 2.693 ± 2.017
2.693LeuAsp: 2.693 ± 0.9
6.284LeuGlu: 6.284 ± 0.997
5.386LeuPhe: 5.386 ± 1.47
6.284LeuGly: 6.284 ± 2.256
2.693LeuHis: 2.693 ± 0.9
6.284LeuIle: 6.284 ± 4.64
3.591LeuLys: 3.591 ± 1.64
8.079LeuLeu: 8.079 ± 1.806
2.693LeuMet: 2.693 ± 1.711
5.386LeuAsn: 5.386 ± 2.356
7.181LeuPro: 7.181 ± 1.385
3.591LeuGln: 3.591 ± 1.64
4.488LeuArg: 4.488 ± 1.068
12.567LeuSer: 12.567 ± 1.429
4.488LeuThr: 4.488 ± 0.855
5.386LeuVal: 5.386 ± 1.47
0.0LeuTrp: 0.0 ± 0.0
0.898LeuTyr: 0.898 ± 2.035
0.0LeuXaa: 0.0 ± 0.0
Met
0.898MetAla: 0.898 ± 1.483
0.0MetCys: 0.0 ± 0.0
2.693MetAsp: 2.693 ± 2.017
0.898MetGlu: 0.898 ± 0.582
1.795MetPhe: 1.795 ± 0.576
4.488MetGly: 4.488 ± 2.589
0.0MetHis: 0.0 ± 0.0
2.693MetIle: 2.693 ± 1.746
1.795MetLys: 1.795 ± 0.576
1.795MetLeu: 1.795 ± 1.164
0.0MetMet: 0.0 ± 0.0
0.898MetAsn: 0.898 ± 0.582
1.795MetPro: 1.795 ± 1.458
0.898MetGln: 0.898 ± 0.582
0.0MetArg: 0.0 ± 0.0
3.591MetSer: 3.591 ± 1.775
0.898MetThr: 0.898 ± 0.729
0.898MetVal: 0.898 ± 0.729
0.0MetTrp: 0.0 ± 0.0
0.898MetTyr: 0.898 ± 0.582
0.0MetXaa: 0.0 ± 0.0
Asn
2.693AsnAla: 2.693 ± 1.777
0.0AsnCys: 0.0 ± 0.0
1.795AsnAsp: 1.795 ± 1.164
0.0AsnGlu: 0.0 ± 0.0
1.795AsnPhe: 1.795 ± 0.576
8.079AsnGly: 8.079 ± 3.486
0.898AsnHis: 0.898 ± 0.582
3.591AsnIle: 3.591 ± 1.873
3.591AsnLys: 3.591 ± 1.152
4.488AsnLeu: 4.488 ± 1.541
1.795AsnMet: 1.795 ± 0.576
1.795AsnAsn: 1.795 ± 1.313
3.591AsnPro: 3.591 ± 2.287
2.693AsnGln: 2.693 ± 1.178
1.795AsnArg: 1.795 ± 0.576
5.386AsnSer: 5.386 ± 1.47
0.898AsnThr: 0.898 ± 0.729
1.795AsnVal: 1.795 ± 1.465
0.0AsnTrp: 0.0 ± 0.0
3.591AsnTyr: 3.591 ± 2.916
0.0AsnXaa: 0.0 ± 0.0
Pro
1.795ProAla: 1.795 ± 0.576
0.0ProCys: 0.0 ± 0.0
3.591ProAsp: 3.591 ± 2.328
0.0ProGlu: 0.0 ± 0.0
2.693ProPhe: 2.693 ± 0.9
2.693ProGly: 2.693 ± 1.178
1.795ProHis: 1.795 ± 1.164
2.693ProIle: 2.693 ± 2.74
3.591ProLys: 3.591 ± 0.893
5.386ProLeu: 5.386 ± 3.307
1.795ProMet: 1.795 ± 0.576
2.693ProAsn: 2.693 ± 0.9
1.795ProPro: 1.795 ± 1.164
0.898ProGln: 0.898 ± 0.582
1.795ProArg: 1.795 ± 0.576
0.898ProSer: 0.898 ± 0.582
3.591ProThr: 3.591 ± 1.775
5.386ProVal: 5.386 ± 2.678
1.795ProTrp: 1.795 ± 0.576
1.795ProTyr: 1.795 ± 0.576
0.0ProXaa: 0.0 ± 0.0
Gln
2.693GlnAla: 2.693 ± 1.388
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
2.693GlnGlu: 2.693 ± 1.746
0.0GlnPhe: 0.0 ± 0.0
0.898GlnGly: 0.898 ± 0.582
0.898GlnHis: 0.898 ± 0.729
0.898GlnIle: 0.898 ± 0.582
0.898GlnLys: 0.898 ± 0.582
1.795GlnLeu: 1.795 ± 1.458
0.0GlnMet: 0.0 ± 0.0
1.795GlnAsn: 1.795 ± 0.576
0.898GlnPro: 0.898 ± 0.729
0.0GlnGln: 0.0 ± 0.0
2.693GlnArg: 2.693 ± 1.711
3.591GlnSer: 3.591 ± 1.267
3.591GlnThr: 3.591 ± 1.64
2.693GlnVal: 2.693 ± 1.777
0.0GlnTrp: 0.0 ± 0.0
0.898GlnTyr: 0.898 ± 0.729
0.0GlnXaa: 0.0 ± 0.0
Arg
4.488ArgAla: 4.488 ± 1.772
1.795ArgCys: 1.795 ± 1.164
4.488ArgAsp: 4.488 ± 1.949
1.795ArgGlu: 1.795 ± 0.576
3.591ArgPhe: 3.591 ± 1.402
1.795ArgGly: 1.795 ± 0.576
0.0ArgHis: 0.0 ± 0.0
2.693ArgIle: 2.693 ± 0.9
3.591ArgLys: 3.591 ± 0.893
8.079ArgLeu: 8.079 ± 1.801
0.898ArgMet: 0.898 ± 0.64
1.795ArgAsn: 1.795 ± 1.458
1.795ArgPro: 1.795 ± 0.576
0.898ArgGln: 0.898 ± 0.729
3.591ArgArg: 3.591 ± 1.152
7.181ArgSer: 7.181 ± 2.589
2.693ArgThr: 2.693 ± 0.9
3.591ArgVal: 3.591 ± 0.893
1.795ArgTrp: 1.795 ± 0.576
1.795ArgTyr: 1.795 ± 0.576
0.0ArgXaa: 0.0 ± 0.0
Ser
5.386SerAla: 5.386 ± 0.732
0.898SerCys: 0.898 ± 0.582
11.67SerAsp: 11.67 ± 2.999
1.795SerGlu: 1.795 ± 0.576
7.181SerPhe: 7.181 ± 0.968
8.079SerGly: 8.079 ± 2.082
2.693SerHis: 2.693 ± 2.017
4.488SerIle: 4.488 ± 2.189
3.591SerLys: 3.591 ± 2.27
6.284SerLeu: 6.284 ± 1.008
1.795SerMet: 1.795 ± 1.643
8.079SerAsn: 8.079 ± 2.082
2.693SerPro: 2.693 ± 0.9
6.284SerGln: 6.284 ± 3.309
0.898SerArg: 0.898 ± 1.483
6.284SerSer: 6.284 ± 1.964
1.795SerThr: 1.795 ± 0.576
7.181SerVal: 7.181 ± 2.028
0.0SerTrp: 0.0 ± 0.0
3.591SerTyr: 3.591 ± 1.267
0.0SerXaa: 0.0 ± 0.0
Thr
6.284ThrAla: 6.284 ± 1.946
1.795ThrCys: 1.795 ± 1.164
0.898ThrAsp: 0.898 ± 1.483
0.898ThrGlu: 0.898 ± 0.582
4.488ThrPhe: 4.488 ± 1.541
4.488ThrGly: 4.488 ± 1.068
0.898ThrHis: 0.898 ± 0.729
3.591ThrIle: 3.591 ± 2.626
2.693ThrLys: 2.693 ± 1.178
7.181ThrLeu: 7.181 ± 1.434
1.795ThrMet: 1.795 ± 1.164
0.898ThrAsn: 0.898 ± 0.729
1.795ThrPro: 1.795 ± 1.458
2.693ThrGln: 2.693 ± 1.065
3.591ThrArg: 3.591 ± 1.152
0.898ThrSer: 0.898 ± 2.035
0.898ThrThr: 0.898 ± 0.582
4.488ThrVal: 4.488 ± 2.277
1.795ThrTrp: 1.795 ± 1.458
2.693ThrTyr: 2.693 ± 0.9
0.0ThrXaa: 0.0 ± 0.0
Val
5.386ValAla: 5.386 ± 0.732
0.0ValCys: 0.0 ± 0.0
1.795ValAsp: 1.795 ± 1.465
4.488ValGlu: 4.488 ± 1.772
0.0ValPhe: 0.0 ± 0.0
5.386ValGly: 5.386 ± 1.315
0.898ValHis: 0.898 ± 0.582
1.795ValIle: 1.795 ± 1.465
2.693ValLys: 2.693 ± 1.178
7.181ValLeu: 7.181 ± 1.434
3.591ValMet: 3.591 ± 3.405
3.591ValAsn: 3.591 ± 1.267
3.591ValPro: 3.591 ± 2.626
0.0ValGln: 0.0 ± 0.0
3.591ValArg: 3.591 ± 1.402
4.488ValSer: 4.488 ± 2.277
8.079ValThr: 8.079 ± 4.764
2.693ValVal: 2.693 ± 2.857
1.795ValTrp: 1.795 ± 1.94
2.693ValTyr: 2.693 ± 1.746
0.0ValXaa: 0.0 ± 0.0
Trp
1.795TrpAla: 1.795 ± 0.576
0.0TrpCys: 0.0 ± 0.0
0.898TrpAsp: 0.898 ± 0.582
0.898TrpGlu: 0.898 ± 0.729
1.795TrpPhe: 1.795 ± 0.576
1.795TrpGly: 1.795 ± 1.94
0.0TrpHis: 0.0 ± 0.0
1.795TrpIle: 1.795 ± 4.07
1.795TrpLys: 1.795 ± 1.313
3.591TrpLeu: 3.591 ± 1.267
0.0TrpMet: 0.0 ± 0.0
0.898TrpAsn: 0.898 ± 0.729
0.0TrpPro: 0.0 ± 0.0
1.795TrpGln: 1.795 ± 0.576
1.795TrpArg: 1.795 ± 0.576
2.693TrpSer: 2.693 ± 2.187
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
1.795TrpTyr: 1.795 ± 0.576
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.488TyrAla: 4.488 ± 2.277
0.898TyrCys: 0.898 ± 0.582
3.591TyrAsp: 3.591 ± 1.873
0.0TyrGlu: 0.0 ± 0.0
2.693TyrPhe: 2.693 ± 1.178
5.386TyrGly: 5.386 ± 1.799
0.0TyrHis: 0.0 ± 0.0
0.898TyrIle: 0.898 ± 0.729
2.693TyrLys: 2.693 ± 2.187
5.386TyrLeu: 5.386 ± 2.511
0.898TyrMet: 0.898 ± 0.582
0.898TyrAsn: 0.898 ± 0.582
0.898TyrPro: 0.898 ± 0.729
0.0TyrGln: 0.0 ± 0.0
2.693TyrArg: 2.693 ± 2.857
3.591TyrSer: 3.591 ± 1.152
1.795TyrThr: 1.795 ± 1.465
2.693TyrVal: 2.693 ± 1.711
0.898TyrTrp: 0.898 ± 0.729
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1115 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski