Amino acid dipepetide frequency for Faecalibacterium sp. CAG:1138

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.538AlaAla: 8.538 ± 0.223	1.052AlaCys: 1.052 ± 0.058	5.128AlaAsp: 5.128 ± 0.108	7.171AlaGlu: 7.171 ± 0.151	3.665AlaPhe: 3.665 ± 0.128	6.022AlaGly: 6.022 ± 0.133	0.953AlaHis: 0.953 ± 0.052	5.004AlaIle: 5.004 ± 0.121	6.693AlaLys: 6.693 ± 0.137	7.703AlaLeu: 7.703 ± 0.16	1.965AlaMet: 1.965 ± 0.071	2.96AlaAsn: 2.96 ± 0.09	2.293AlaPro: 2.293 ± 0.081	1.642AlaGln: 1.642 ± 0.056	2.663AlaArg: 2.663 ± 0.084	4.452AlaSer: 4.452 ± 0.128	4.166AlaThr: 4.166 ± 0.131	7.73AlaVal: 7.73 ± 0.184	0.453AlaTrp: 0.453 ± 0.042	3.017AlaTyr: 3.017 ± 0.084	0.0AlaXaa: 0.0 ± 0.0
Cys	1.023CysAla: 1.023 ± 0.049	0.279CysCys: 0.279 ± 0.039	0.854CysAsp: 0.854 ± 0.046	0.694CysGlu: 0.694 ± 0.039	0.732CysPhe: 0.732 ± 0.039	1.6CysGly: 1.6 ± 0.07	0.237CysHis: 0.237 ± 0.024	0.755CysIle: 0.755 ± 0.043	0.881CysLys: 0.881 ± 0.044	1.077CysLeu: 1.077 ± 0.054	0.279CysMet: 0.279 ± 0.024	0.527CysAsn: 0.527 ± 0.037	0.613CysPro: 0.613 ± 0.044	0.293CysGln: 0.293 ± 0.025	0.55CysArg: 0.55 ± 0.039	0.761CysSer: 0.761 ± 0.048	0.694CysThr: 0.694 ± 0.048	0.964CysVal: 0.964 ± 0.05	0.11CysTrp: 0.11 ± 0.016	0.656CysTyr: 0.656 ± 0.039	0.0CysXaa: 0.0 ± 0.0
Asp	4.359AspAla: 4.359 ± 0.117	0.804AspCys: 0.804 ± 0.047	3.6AspAsp: 3.6 ± 0.11	5.062AspGlu: 5.062 ± 0.107	3.458AspPhe: 3.458 ± 0.099	5.357AspGly: 5.357 ± 0.153	0.59AspHis: 0.59 ± 0.041	3.501AspIle: 3.501 ± 0.097	4.846AspLys: 4.846 ± 0.11	4.609AspLeu: 4.609 ± 0.157	1.473AspMet: 1.473 ± 0.059	2.449AspAsn: 2.449 ± 0.074	1.552AspPro: 1.552 ± 0.06	0.8AspGln: 0.8 ± 0.043	2.363AspArg: 2.363 ± 0.078	3.012AspSer: 3.012 ± 0.087	2.638AspThr: 2.638 ± 0.077	5.587AspVal: 5.587 ± 0.125	0.421AspTrp: 0.421 ± 0.035	2.681AspTyr: 2.681 ± 0.091	0.0AspXaa: 0.0 ± 0.0
Glu	5.452GluAla: 5.452 ± 0.122	0.741GluCys: 0.741 ± 0.041	3.647GluAsp: 3.647 ± 0.095	5.326GluGlu: 5.326 ± 0.168	2.879GluPhe: 2.879 ± 0.09	4.494GluGly: 4.494 ± 0.101	0.957GluHis: 0.957 ± 0.053	5.716GluIle: 5.716 ± 0.114	7.482GluLys: 7.482 ± 0.153	5.905GluLeu: 5.905 ± 0.123	1.793GluMet: 1.793 ± 0.062	4.616GluAsn: 4.616 ± 0.121	1.654GluPro: 1.654 ± 0.075	1.935GluGln: 1.935 ± 0.082	2.902GluArg: 2.902 ± 0.099	3.145GluSer: 3.145 ± 0.089	4.08GluThr: 4.08 ± 0.095	4.704GluVal: 4.704 ± 0.108	0.586GluTrp: 0.586 ± 0.033	2.814GluTyr: 2.814 ± 0.087	0.0GluXaa: 0.0 ± 0.0
Phe	3.69PheAla: 3.69 ± 0.107	0.845PheCys: 0.845 ± 0.043	3.551PheAsp: 3.551 ± 0.1	3.188PheGlu: 3.188 ± 0.095	1.944PhePhe: 1.944 ± 0.077	3.947PheGly: 3.947 ± 0.114	0.455PheHis: 0.455 ± 0.034	2.158PheIle: 2.158 ± 0.072	2.969PheLys: 2.969 ± 0.079	3.584PheLeu: 3.584 ± 0.105	1.122PheMet: 1.122 ± 0.057	1.807PheAsn: 1.807 ± 0.077	1.291PhePro: 1.291 ± 0.056	0.831PheGln: 0.831 ± 0.046	1.859PheArg: 1.859 ± 0.063	3.801PheSer: 3.801 ± 0.112	2.566PheThr: 2.566 ± 0.085	3.895PheVal: 3.895 ± 0.102	0.39PheTrp: 0.39 ± 0.029	1.78PheTyr: 1.78 ± 0.066	0.0PheXaa: 0.0 ± 0.0
Gly	5.698GlyAla: 5.698 ± 0.13	0.962GlyCys: 0.962 ± 0.056	4.121GlyAsp: 4.121 ± 0.102	5.308GlyGlu: 5.308 ± 0.106	3.501GlyPhe: 3.501 ± 0.095	6.072GlyGly: 6.072 ± 0.131	1.124GlyHis: 1.124 ± 0.046	5.195GlyIle: 5.195 ± 0.124	6.682GlyLys: 6.682 ± 0.125	6.385GlyLeu: 6.385 ± 0.167	1.73GlyMet: 1.73 ± 0.068	3.082GlyAsn: 3.082 ± 0.099	1.183GlyPro: 1.183 ± 0.081	1.674GlyGln: 1.674 ± 0.055	3.073GlyArg: 3.073 ± 0.09	4.134GlySer: 4.134 ± 0.118	4.075GlyThr: 4.075 ± 0.11	6.34GlyVal: 6.34 ± 0.11	0.635GlyTrp: 0.635 ± 0.048	3.296GlyTyr: 3.296 ± 0.085	0.0GlyXaa: 0.0 ± 0.0
His	0.903HisAla: 0.903 ± 0.046	0.178HisCys: 0.178 ± 0.023	0.68HisAsp: 0.68 ± 0.035	0.737HisGlu: 0.737 ± 0.048	0.737HisPhe: 0.737 ± 0.041	1.072HisGly: 1.072 ± 0.057	0.309HisHis: 0.309 ± 0.048	0.915HisIle: 0.915 ± 0.047	0.919HisLys: 0.919 ± 0.044	1.147HisLeu: 1.147 ± 0.057	0.216HisMet: 0.216 ± 0.025	0.662HisAsn: 0.662 ± 0.043	0.617HisPro: 0.617 ± 0.049	0.295HisGln: 0.295 ± 0.029	0.561HisArg: 0.561 ± 0.038	0.737HisSer: 0.737 ± 0.044	0.741HisThr: 0.741 ± 0.046	1.009HisVal: 1.009 ± 0.057	0.106HisTrp: 0.106 ± 0.015	0.525HisTyr: 0.525 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.556IleAla: 5.556 ± 0.147	0.975IleCys: 0.975 ± 0.058	3.765IleAsp: 3.765 ± 0.115	4.202IleGlu: 4.202 ± 0.104	2.649IlePhe: 2.649 ± 0.072	4.476IleGly: 4.476 ± 0.132	0.723IleHis: 0.723 ± 0.044	3.785IleIle: 3.785 ± 0.099	4.648IleLys: 4.648 ± 0.122	5.486IleLeu: 5.486 ± 0.11	1.595IleMet: 1.595 ± 0.067	2.638IleAsn: 2.638 ± 0.072	2.372IlePro: 2.372 ± 0.07	1.174IleGln: 1.174 ± 0.06	2.399IleArg: 2.399 ± 0.072	4.44IleSer: 4.44 ± 0.116	3.803IleThr: 3.803 ± 0.095	5.441IleVal: 5.441 ± 0.126	0.439IleTrp: 0.439 ± 0.032	2.131IleTyr: 2.131 ± 0.076	0.0IleXaa: 0.0 ± 0.0
Lys	6.389LysAla: 6.389 ± 0.137	1.012LysCys: 1.012 ± 0.053	4.03LysAsp: 4.03 ± 0.095	5.752LysGlu: 5.752 ± 0.159	3.014LysPhe: 3.014 ± 0.086	4.553LysGly: 4.553 ± 0.105	1.167LysHis: 1.167 ± 0.052	5.923LysIle: 5.923 ± 0.123	7.146LysLys: 7.146 ± 0.16	6.696LysLeu: 6.696 ± 0.137	2.257LysMet: 2.257 ± 0.08	4.745LysAsn: 4.745 ± 0.099	2.6LysPro: 2.6 ± 0.095	2.226LysGln: 2.226 ± 0.069	3.487LysArg: 3.487 ± 0.097	4.353LysSer: 4.353 ± 0.115	5.317LysThr: 5.317 ± 0.113	5.387LysVal: 5.387 ± 0.131	0.701LysTrp: 0.701 ± 0.044	3.174LysTyr: 3.174 ± 0.087	0.0LysXaa: 0.0 ± 0.0
Leu	7.333LeuAla: 7.333 ± 0.134	1.273LeuCys: 1.273 ± 0.059	5.11LeuAsp: 5.11 ± 0.161	5.398LeuGlu: 5.398 ± 0.135	3.936LeuPhe: 3.936 ± 0.114	6.058LeuGly: 6.058 ± 0.162	1.102LeuHis: 1.102 ± 0.055	4.947LeuIle: 4.947 ± 0.123	7.338LeuLys: 7.338 ± 0.159	7.633LeuLeu: 7.633 ± 0.193	2.106LeuMet: 2.106 ± 0.089	3.519LeuAsn: 3.519 ± 0.1	3.451LeuPro: 3.451 ± 0.092	1.98LeuGln: 1.98 ± 0.077	3.352LeuArg: 3.352 ± 0.092	7.252LeuSer: 7.252 ± 0.154	5.979LeuThr: 5.979 ± 0.125	6.164LeuVal: 6.164 ± 0.123	0.586LeuTrp: 0.586 ± 0.035	3.055LeuTyr: 3.055 ± 0.093	0.002LeuXaa: 0.002 ± 0.002
Met	2.142MetAla: 2.142 ± 0.08	0.356MetCys: 0.356 ± 0.029	1.365MetAsp: 1.365 ± 0.053	1.446MetGlu: 1.446 ± 0.063	0.994MetPhe: 0.994 ± 0.048	1.622MetGly: 1.622 ± 0.064	0.356MetHis: 0.356 ± 0.033	1.467MetIle: 1.467 ± 0.058	2.075MetLys: 2.075 ± 0.068	2.438MetLeu: 2.438 ± 0.088	0.631MetMet: 0.631 ± 0.045	1.016MetAsn: 1.016 ± 0.05	1.162MetPro: 1.162 ± 0.052	0.8MetGln: 0.8 ± 0.046	0.982MetArg: 0.982 ± 0.057	1.5MetSer: 1.5 ± 0.059	1.433MetThr: 1.433 ± 0.054	1.561MetVal: 1.561 ± 0.06	0.189MetTrp: 0.189 ± 0.024	0.734MetTyr: 0.734 ± 0.042	0.0MetXaa: 0.0 ± 0.0
Asn	3.638AsnAla: 3.638 ± 0.094	0.565AsnCys: 0.565 ± 0.037	2.318AsnAsp: 2.318 ± 0.077	2.598AsnGlu: 2.598 ± 0.077	2.21AsnPhe: 2.21 ± 0.079	3.807AsnGly: 3.807 ± 0.12	0.626AsnHis: 0.626 ± 0.039	2.514AsnIle: 2.514 ± 0.084	2.852AsnLys: 2.852 ± 0.088	4.308AsnLeu: 4.308 ± 0.124	1.217AsnMet: 1.217 ± 0.054	1.793AsnAsn: 1.793 ± 0.073	2.086AsnPro: 2.086 ± 0.066	0.933AsnGln: 0.933 ± 0.041	1.755AsnArg: 1.755 ± 0.062	2.359AsnSer: 2.359 ± 0.098	1.96AsnThr: 1.96 ± 0.067	4.15AsnVal: 4.15 ± 0.109	0.374AsnTrp: 0.374 ± 0.03	1.922AsnTyr: 1.922 ± 0.075	0.0AsnXaa: 0.0 ± 0.0
Pro	2.429ProAla: 2.429 ± 0.082	0.401ProCys: 0.401 ± 0.03	2.307ProAsp: 2.307 ± 0.077	3.066ProGlu: 3.066 ± 0.08	1.536ProPhe: 1.536 ± 0.069	1.588ProGly: 1.588 ± 0.06	0.493ProHis: 0.493 ± 0.036	1.928ProIle: 1.928 ± 0.066	2.546ProLys: 2.546 ± 0.092	2.69ProLeu: 2.69 ± 0.092	0.77ProMet: 0.77 ± 0.042	1.379ProAsn: 1.379 ± 0.061	0.829ProPro: 0.829 ± 0.047	1.072ProGln: 1.072 ± 0.068	0.942ProArg: 0.942 ± 0.047	1.987ProSer: 1.987 ± 0.068	2.046ProThr: 2.046 ± 0.063	2.645ProVal: 2.645 ± 0.087	0.255ProTrp: 0.255 ± 0.027	1.39ProTyr: 1.39 ± 0.057	0.0ProXaa: 0.0 ± 0.0
Gln	1.796GlnAla: 1.796 ± 0.062	0.221GlnCys: 0.221 ± 0.022	0.906GlnAsp: 0.906 ± 0.045	1.138GlnGlu: 1.138 ± 0.057	0.829GlnPhe: 0.829 ± 0.044	1.467GlnGly: 1.467 ± 0.073	0.279GlnHis: 0.279 ± 0.025	1.94GlnIle: 1.94 ± 0.072	2.685GlnLys: 2.685 ± 0.084	1.766GlnLeu: 1.766 ± 0.078	0.565GlnMet: 0.565 ± 0.035	1.516GlnAsn: 1.516 ± 0.06	0.748GlnPro: 0.748 ± 0.044	0.725GlnGln: 0.725 ± 0.048	1.113GlnArg: 1.113 ± 0.052	1.329GlnSer: 1.329 ± 0.053	1.521GlnThr: 1.521 ± 0.054	1.349GlnVal: 1.349 ± 0.054	0.162GlnTrp: 0.162 ± 0.019	0.782GlnTyr: 0.782 ± 0.049	0.002GlnXaa: 0.002 ± 0.002
Arg	2.936ArgAla: 2.936 ± 0.09	0.554ArgCys: 0.554 ± 0.037	1.906ArgAsp: 1.906 ± 0.085	2.609ArgGlu: 2.609 ± 0.093	1.949ArgPhe: 1.949 ± 0.076	2.397ArgGly: 2.397 ± 0.081	0.633ArgHis: 0.633 ± 0.039	2.983ArgIle: 2.983 ± 0.097	3.152ArgLys: 3.152 ± 0.105	3.92ArgLeu: 3.92 ± 0.092	1.059ArgMet: 1.059 ± 0.052	1.881ArgAsn: 1.881 ± 0.074	1.392ArgPro: 1.392 ± 0.059	1.147ArgGln: 1.147 ± 0.064	1.944ArgArg: 1.944 ± 0.09	1.908ArgSer: 1.908 ± 0.062	2.084ArgThr: 2.084 ± 0.07	2.6ArgVal: 2.6 ± 0.077	0.306ArgTrp: 0.306 ± 0.028	1.773ArgTyr: 1.773 ± 0.062	0.0ArgXaa: 0.0 ± 0.0
Ser	5.713SerAla: 5.713 ± 0.147	0.714SerCys: 0.714 ± 0.051	4.569SerAsp: 4.569 ± 0.108	4.652SerGlu: 4.652 ± 0.11	2.861SerPhe: 2.861 ± 0.077	5.932SerGly: 5.932 ± 0.143	0.77SerHis: 0.77 ± 0.045	3.113SerIle: 3.113 ± 0.097	3.742SerLys: 3.742 ± 0.092	5.186SerLeu: 5.186 ± 0.141	1.316SerMet: 1.316 ± 0.05	1.998SerAsn: 1.998 ± 0.076	1.951SerPro: 1.951 ± 0.068	1.304SerGln: 1.304 ± 0.057	2.01SerArg: 2.01 ± 0.07	3.641SerSer: 3.641 ± 0.123	2.724SerThr: 2.724 ± 0.095	6.108SerVal: 6.108 ± 0.136	0.457SerTrp: 0.457 ± 0.033	2.44SerTyr: 2.44 ± 0.084	0.002SerXaa: 0.002 ± 0.002
Thr	5.315ThrAla: 5.315 ± 0.113	0.59ThrCys: 0.59 ± 0.045	3.587ThrAsp: 3.587 ± 0.098	4.233ThrGlu: 4.233 ± 0.109	2.618ThrPhe: 2.618 ± 0.087	4.346ThrGly: 4.346 ± 0.118	0.779ThrHis: 0.779 ± 0.038	3.138ThrIle: 3.138 ± 0.103	3.474ThrLys: 3.474 ± 0.081	5.085ThrLeu: 5.085 ± 0.126	1.108ThrMet: 1.108 ± 0.047	1.818ThrAsn: 1.818 ± 0.072	2.188ThrPro: 2.188 ± 0.077	1.05ThrGln: 1.05 ± 0.048	1.791ThrArg: 1.791 ± 0.061	3.195ThrSer: 3.195 ± 0.096	2.787ThrThr: 2.787 ± 0.098	6.225ThrVal: 6.225 ± 0.191	0.342ThrTrp: 0.342 ± 0.029	2.28ThrTyr: 2.28 ± 0.099	0.0ThrXaa: 0.0 ± 0.0
Val	6.743ValAla: 6.743 ± 0.149	1.392ValCys: 1.392 ± 0.067	4.474ValAsp: 4.474 ± 0.106	5.436ValGlu: 5.436 ± 0.113	3.884ValPhe: 3.884 ± 0.106	5.756ValGly: 5.756 ± 0.146	0.849ValHis: 0.849 ± 0.056	5.013ValIle: 5.013 ± 0.111	6.47ValLys: 6.47 ± 0.123	7.779ValLeu: 7.779 ± 0.151	1.958ValMet: 1.958 ± 0.068	3.305ValAsn: 3.305 ± 0.11	2.8ValPro: 2.8 ± 0.079	1.685ValGln: 1.685 ± 0.064	3.42ValArg: 3.42 ± 0.094	6.189ValSer: 6.189 ± 0.144	4.763ValThr: 4.763 ± 0.149	7.101ValVal: 7.101 ± 0.153	0.653ValTrp: 0.653 ± 0.043	3.298ValTyr: 3.298 ± 0.098	0.0ValXaa: 0.0 ± 0.0
Trp	0.556TrpAla: 0.556 ± 0.036	0.101TrpCys: 0.101 ± 0.015	0.435TrpAsp: 0.435 ± 0.034	0.48TrpGlu: 0.48 ± 0.031	0.363TrpPhe: 0.363 ± 0.029	0.556TrpGly: 0.556 ± 0.036	0.162TrpHis: 0.162 ± 0.021	0.491TrpIle: 0.491 ± 0.035	0.514TrpLys: 0.514 ± 0.035	0.809TrpLeu: 0.809 ± 0.051	0.201TrpMet: 0.201 ± 0.021	0.365TrpAsn: 0.365 ± 0.032	0.167TrpPro: 0.167 ± 0.019	0.309TrpGln: 0.309 ± 0.028	0.309TrpArg: 0.309 ± 0.025	0.43TrpSer: 0.43 ± 0.036	0.444TrpThr: 0.444 ± 0.039	0.408TrpVal: 0.408 ± 0.032	0.108TrpTrp: 0.108 ± 0.017	0.34TrpTyr: 0.34 ± 0.031	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.059TyrAla: 3.059 ± 0.083	0.561TyrCys: 0.561 ± 0.038	2.814TyrAsp: 2.814 ± 0.101	2.334TyrGlu: 2.334 ± 0.078	1.915TyrPhe: 1.915 ± 0.07	3.145TyrGly: 3.145 ± 0.084	0.5TyrHis: 0.5 ± 0.036	2.212TyrIle: 2.212 ± 0.073	2.812TyrLys: 2.812 ± 0.089	3.37TyrLeu: 3.37 ± 0.09	0.906TyrMet: 0.906 ± 0.04	1.908TyrAsn: 1.908 ± 0.073	1.347TyrPro: 1.347 ± 0.057	0.964TyrGln: 0.964 ± 0.049	1.658TyrArg: 1.658 ± 0.066	2.577TyrSer: 2.577 ± 0.099	2.129TyrThr: 2.129 ± 0.087	3.602TyrVal: 3.602 ± 0.127	0.273TyrTrp: 0.273 ± 0.025	1.656TyrTyr: 1.656 ± 0.067	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.002	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.002XaaSer: 0.002 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.007XaaXaa: 0.007 ± 0.004

Statistics based on 1284 proteins (443877 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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