Amino acid dipepetide frequency for Prune dwarf virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.525AlaAla: 5.525 ± 1.074
2.125AlaCys: 2.125 ± 0.603
2.55AlaAsp: 2.55 ± 0.813
5.1AlaGlu: 5.1 ± 0.558
3.825AlaPhe: 3.825 ± 1.224
5.1AlaGly: 5.1 ± 1.842
0.85AlaHis: 0.85 ± 0.57
5.1AlaIle: 5.1 ± 0.833
4.25AlaLys: 4.25 ± 1.454
6.8AlaLeu: 6.8 ± 0.901
1.275AlaMet: 1.275 ± 0.595
1.275AlaAsn: 1.275 ± 0.347
2.55AlaPro: 2.55 ± 2.038
1.275AlaGln: 1.275 ± 0.398
1.275AlaArg: 1.275 ± 0.841
4.675AlaSer: 4.675 ± 1.432
3.825AlaThr: 3.825 ± 1.193
3.825AlaVal: 3.825 ± 1.224
0.85AlaTrp: 0.85 ± 0.57
0.0AlaTyr: 0.0 ± 0.0
0.0AlaXaa: 0.0 ± 0.0
Cys
1.7CysAla: 1.7 ± 1.139
0.85CysCys: 0.85 ± 0.57
0.85CysAsp: 0.85 ± 0.57
1.7CysGlu: 1.7 ± 0.644
1.275CysPhe: 1.275 ± 0.601
0.425CysGly: 0.425 ± 0.285
0.425CysHis: 0.425 ± 0.285
0.425CysIle: 0.425 ± 0.285
1.275CysLys: 1.275 ± 0.559
2.55CysLeu: 2.55 ± 0.482
0.0CysMet: 0.0 ± 0.0
0.85CysAsn: 0.85 ± 0.253
0.425CysPro: 0.425 ± 0.285
0.425CysGln: 0.425 ± 0.285
0.85CysArg: 0.85 ± 0.253
2.975CysSer: 2.975 ± 1.028
1.275CysThr: 1.275 ± 0.595
1.275CysVal: 1.275 ± 0.398
0.0CysTrp: 0.0 ± 0.0
0.425CysTyr: 0.425 ± 0.364
0.0CysXaa: 0.0 ± 0.0
Asp
7.225AspAla: 7.225 ± 1.237
2.125AspCys: 2.125 ± 0.603
8.925AspAsp: 8.925 ± 1.604
5.1AspGlu: 5.1 ± 1.16
5.1AspPhe: 5.1 ± 0.746
3.4AspGly: 3.4 ± 1.118
1.275AspHis: 1.275 ± 0.855
4.25AspIle: 4.25 ± 0.72
5.525AspLys: 5.525 ± 2.021
5.1AspLeu: 5.1 ± 1.111
0.425AspMet: 0.425 ± 0.285
1.275AspAsn: 1.275 ± 0.595
1.7AspPro: 1.7 ± 0.507
0.0AspGln: 0.0 ± 0.0
2.975AspArg: 2.975 ± 1.028
5.1AspSer: 5.1 ± 1.33
4.25AspThr: 4.25 ± 1.075
6.375AspVal: 6.375 ± 2.644
1.7AspTrp: 1.7 ± 0.559
3.825AspTyr: 3.825 ± 1.274
0.0AspXaa: 0.0 ± 0.0
Glu
4.25GluAla: 4.25 ± 1.932
0.85GluCys: 0.85 ± 0.253
2.975GluAsp: 2.975 ± 2.15
1.7GluGlu: 1.7 ± 0.372
1.7GluPhe: 1.7 ± 0.909
0.85GluGly: 0.85 ± 0.57
0.85GluHis: 0.85 ± 0.253
2.975GluIle: 2.975 ± 0.609
5.525GluLys: 5.525 ± 2.117
6.375GluLeu: 6.375 ± 2.116
0.85GluMet: 0.85 ± 0.57
2.55GluAsn: 2.55 ± 0.669
1.275GluPro: 1.275 ± 0.855
2.55GluGln: 2.55 ± 1.189
3.825GluArg: 3.825 ± 1.034
3.4GluSer: 3.4 ± 1.512
2.975GluThr: 2.975 ± 0.637
6.375GluVal: 6.375 ± 0.62
0.425GluTrp: 0.425 ± 0.77
1.275GluTyr: 1.275 ± 0.855
0.0GluXaa: 0.0 ± 0.0
Phe
2.975PheAla: 2.975 ± 1.423
0.85PheCys: 0.85 ± 0.728
5.1PheAsp: 5.1 ± 1.584
2.55PheGlu: 2.55 ± 1.221
2.975PhePhe: 2.975 ± 1.464
2.125PheGly: 2.125 ± 0.565
0.85PheHis: 0.85 ± 0.253
2.975PheIle: 2.975 ± 1.032
2.125PheLys: 2.125 ± 1.099
5.525PheLeu: 5.525 ± 2.579
0.425PheMet: 0.425 ± 0.285
1.275PheAsn: 1.275 ± 0.347
3.825PhePro: 3.825 ± 1.813
2.125PheGln: 2.125 ± 0.892
1.7PheArg: 1.7 ± 0.552
7.225PheSer: 7.225 ± 1.326
1.7PheThr: 1.7 ± 0.665
3.825PheVal: 3.825 ± 1.026
0.85PheTrp: 0.85 ± 0.514
0.85PheTyr: 0.85 ± 0.439
0.0PheXaa: 0.0 ± 0.0
Gly
0.425GlyAla: 0.425 ± 0.285
0.425GlyCys: 0.425 ± 0.285
5.525GlyAsp: 5.525 ± 0.449
2.975GlyGlu: 2.975 ± 0.609
2.975GlyPhe: 2.975 ± 1.111
2.975GlyGly: 2.975 ± 0.835
0.85GlyHis: 0.85 ± 0.439
2.125GlyIle: 2.125 ± 0.591
7.225GlyLys: 7.225 ± 1.506
2.55GlyLeu: 2.55 ± 0.455
2.125GlyMet: 2.125 ± 2.007
2.125GlyAsn: 2.125 ± 0.913
1.275GlyPro: 1.275 ± 0.794
0.85GlyGln: 0.85 ± 0.514
1.275GlyArg: 1.275 ± 0.601
2.975GlySer: 2.975 ± 0.765
0.85GlyThr: 0.85 ± 0.439
7.65GlyVal: 7.65 ± 1.756
0.0GlyTrp: 0.0 ± 0.0
2.125GlyTyr: 2.125 ± 1.424
0.0GlyXaa: 0.0 ± 0.0
His
1.275HisAla: 1.275 ± 0.825
1.7HisCys: 1.7 ± 0.644
0.85HisAsp: 0.85 ± 0.728
1.7HisGlu: 1.7 ± 0.644
1.7HisPhe: 1.7 ± 0.507
1.275HisGly: 1.275 ± 0.794
1.275HisHis: 1.275 ± 0.347
1.7HisIle: 1.7 ± 0.644
1.275HisLys: 1.275 ± 0.601
2.125HisLeu: 2.125 ± 0.788
0.85HisMet: 0.85 ± 0.253
0.85HisAsn: 0.85 ± 0.728
1.275HisPro: 1.275 ± 0.855
0.425HisGln: 0.425 ± 0.364
0.425HisArg: 0.425 ± 0.285
1.7HisSer: 1.7 ± 0.855
0.85HisThr: 0.85 ± 0.57
1.7HisVal: 1.7 ± 0.831
0.0HisTrp: 0.0 ± 0.0
1.275HisTyr: 1.275 ± 0.398
0.0HisXaa: 0.0 ± 0.0
Ile
2.55IleAla: 2.55 ± 1.189
2.125IleCys: 2.125 ± 0.426
3.825IleAsp: 3.825 ± 0.913
2.975IleGlu: 2.975 ± 0.66
2.55IlePhe: 2.55 ± 0.461
1.7IleGly: 1.7 ± 1.028
0.85IleHis: 0.85 ± 0.253
1.7IleIle: 1.7 ± 0.831
5.525IleLys: 5.525 ± 1.891
4.25IleLeu: 4.25 ± 0.986
0.85IleMet: 0.85 ± 0.57
2.55IleAsn: 2.55 ± 0.461
4.25IlePro: 4.25 ± 0.365
1.7IleGln: 1.7 ± 0.372
1.7IleArg: 1.7 ± 0.909
5.95IleSer: 5.95 ± 1.022
3.4IleThr: 3.4 ± 0.872
4.25IleVal: 4.25 ± 1.075
0.0IleTrp: 0.0 ± 0.0
3.825IleTyr: 3.825 ± 1.632
0.0IleXaa: 0.0 ± 0.0
Lys
5.95LysAla: 5.95 ± 2.236
0.85LysCys: 0.85 ± 0.514
2.975LysAsp: 2.975 ± 0.511
3.825LysGlu: 3.825 ± 1.418
5.1LysPhe: 5.1 ± 2.257
5.1LysGly: 5.1 ± 0.267
1.7LysHis: 1.7 ± 0.831
5.1LysIle: 5.1 ± 0.746
7.65LysLys: 7.65 ± 0.947
4.25LysLeu: 4.25 ± 0.851
2.125LysMet: 2.125 ± 0.565
2.125LysAsn: 2.125 ± 1.511
3.4LysPro: 3.4 ± 0.344
3.825LysGln: 3.825 ± 1.577
2.125LysArg: 2.125 ± 0.493
8.5LysSer: 8.5 ± 1.898
2.975LysThr: 2.975 ± 1.994
5.95LysVal: 5.95 ± 1.208
0.0LysTrp: 0.0 ± 0.0
2.55LysTyr: 2.55 ± 0.455
0.0LysXaa: 0.0 ± 0.0
Leu
5.525LeuAla: 5.525 ± 1.507
1.275LeuCys: 1.275 ± 0.559
5.525LeuAsp: 5.525 ± 1.933
4.675LeuGlu: 4.675 ± 0.84
5.1LeuPhe: 5.1 ± 1.662
4.25LeuGly: 4.25 ± 1.206
2.125LeuHis: 2.125 ± 0.591
3.825LeuIle: 3.825 ± 1.813
7.65LeuLys: 7.65 ± 1.969
8.5LeuLeu: 8.5 ± 1.762
3.4LeuMet: 3.4 ± 0.487
2.975LeuAsn: 2.975 ± 0.609
3.825LeuPro: 3.825 ± 1.733
3.825LeuGln: 3.825 ± 1.645
5.1LeuArg: 5.1 ± 1.097
6.8LeuSer: 6.8 ± 1.41
4.675LeuThr: 4.675 ± 0.403
6.375LeuVal: 6.375 ± 1.427
0.425LeuTrp: 0.425 ± 0.77
2.125LeuTyr: 2.125 ± 0.591
0.0LeuXaa: 0.0 ± 0.0
Met
1.275MetAla: 1.275 ± 0.601
0.0MetCys: 0.0 ± 0.0
2.125MetAsp: 2.125 ± 1.326
0.85MetGlu: 0.85 ± 0.57
0.85MetPhe: 0.85 ± 0.253
0.425MetGly: 0.425 ± 0.285
0.0MetHis: 0.0 ± 0.0
2.975MetIle: 2.975 ± 0.576
2.55MetLys: 2.55 ± 0.878
1.7MetLeu: 1.7 ± 0.945
0.425MetMet: 0.425 ± 0.433
0.85MetAsn: 0.85 ± 0.253
1.275MetPro: 1.275 ± 0.595
0.85MetGln: 0.85 ± 0.57
0.85MetArg: 0.85 ± 0.253
0.85MetSer: 0.85 ± 0.752
2.975MetThr: 2.975 ± 0.957
0.85MetVal: 0.85 ± 0.253
0.0MetTrp: 0.0 ± 0.0
0.85MetTyr: 0.85 ± 0.439
0.0MetXaa: 0.0 ± 0.0
Asn
2.975AsnAla: 2.975 ± 1.592
0.425AsnCys: 0.425 ± 0.285
2.55AsnAsp: 2.55 ± 0.76
1.275AsnGlu: 1.275 ± 0.778
1.275AsnPhe: 1.275 ± 0.398
1.7AsnGly: 1.7 ± 0.855
0.85AsnHis: 0.85 ± 0.57
0.425AsnIle: 0.425 ± 0.364
1.7AsnLys: 1.7 ± 0.559
2.975AsnLeu: 2.975 ± 0.346
0.425AsnMet: 0.425 ± 0.364
1.7AsnAsn: 1.7 ± 1.457
2.55AsnPro: 2.55 ± 0.482
0.425AsnGln: 0.425 ± 0.364
1.7AsnArg: 1.7 ± 0.507
2.55AsnSer: 2.55 ± 0.669
2.975AsnThr: 2.975 ± 0.617
5.525AsnVal: 5.525 ± 1.045
0.0AsnTrp: 0.0 ± 0.0
1.275AsnTyr: 1.275 ± 0.559
0.0AsnXaa: 0.0 ± 0.0
Pro
1.7ProAla: 1.7 ± 0.665
0.425ProCys: 0.425 ± 0.285
5.1ProAsp: 5.1 ± 0.972
0.425ProGlu: 0.425 ± 0.285
1.7ProPhe: 1.7 ± 0.559
1.7ProGly: 1.7 ± 0.507
0.425ProHis: 0.425 ± 0.364
4.25ProIle: 4.25 ± 1.593
2.55ProLys: 2.55 ± 0.832
4.675ProLeu: 4.675 ± 0.904
0.425ProMet: 0.425 ± 0.433
2.975ProAsn: 2.975 ± 1.943
0.425ProPro: 0.425 ± 0.77
1.7ProGln: 1.7 ± 0.909
1.275ProArg: 1.275 ± 0.825
4.675ProSer: 4.675 ± 1.769
4.25ProThr: 4.25 ± 1.607
2.975ProVal: 2.975 ± 1.943
0.0ProTrp: 0.0 ± 0.0
1.275ProTyr: 1.275 ± 0.347
0.0ProXaa: 0.0 ± 0.0
Gln
0.85GlnAla: 0.85 ± 0.728
1.275GlnCys: 1.275 ± 0.855
0.425GlnAsp: 0.425 ± 0.285
1.7GlnGlu: 1.7 ± 1.456
1.7GlnPhe: 1.7 ± 0.665
0.85GlnGly: 0.85 ± 0.57
0.85GlnHis: 0.85 ± 0.728
2.125GlnIle: 2.125 ± 0.493
0.85GlnLys: 0.85 ± 0.253
3.4GlnLeu: 3.4 ± 0.644
0.0GlnMet: 0.0 ± 0.0
0.0GlnAsn: 0.0 ± 0.0
1.275GlnPro: 1.275 ± 0.873
2.125GlnGln: 2.125 ± 0.788
2.125GlnArg: 2.125 ± 0.493
2.975GlnSer: 2.975 ± 0.346
2.55GlnThr: 2.55 ± 1.107
1.7GlnVal: 1.7 ± 0.507
0.0GlnTrp: 0.0 ± 0.0
2.125GlnTyr: 2.125 ± 1.148
0.0GlnXaa: 0.0 ± 0.0
Arg
1.7ArgAla: 1.7 ± 0.372
0.425ArgCys: 0.425 ± 0.285
2.55ArgAsp: 2.55 ± 0.669
2.55ArgGlu: 2.55 ± 0.832
2.975ArgPhe: 2.975 ± 1.574
1.275ArgGly: 1.275 ± 0.398
2.55ArgHis: 2.55 ± 1.189
0.85ArgIle: 0.85 ± 0.57
2.975ArgLys: 2.975 ± 1.318
4.675ArgLeu: 4.675 ± 1.066
0.425ArgMet: 0.425 ± 0.364
1.7ArgAsn: 1.7 ± 0.507
1.7ArgPro: 1.7 ± 0.909
1.275ArgGln: 1.275 ± 0.398
2.975ArgArg: 2.975 ± 0.576
5.525ArgSer: 5.525 ± 0.599
2.55ArgThr: 2.55 ± 0.622
2.55ArgVal: 2.55 ± 0.832
1.7ArgTrp: 1.7 ± 0.831
1.275ArgTyr: 1.275 ± 0.595
0.0ArgXaa: 0.0 ± 0.0
Ser
4.25SerAla: 4.25 ± 1.932
1.7SerCys: 1.7 ± 0.644
5.95SerAsp: 5.95 ± 1.09
5.525SerGlu: 5.525 ± 0.687
4.25SerPhe: 4.25 ± 0.979
8.075SerGly: 8.075 ± 4.848
2.975SerHis: 2.975 ± 1.464
5.1SerIle: 5.1 ± 0.787
4.25SerLys: 4.25 ± 0.419
8.925SerLeu: 8.925 ± 2.164
2.55SerMet: 2.55 ± 1.189
2.975SerAsn: 2.975 ± 0.511
1.7SerPro: 1.7 ± 1.101
2.975SerGln: 2.975 ± 0.617
5.95SerArg: 5.95 ± 2.042
6.375SerSer: 6.375 ± 1.151
4.675SerThr: 4.675 ± 0.74
5.525SerVal: 5.525 ± 0.266
1.275SerTrp: 1.275 ± 0.559
2.125SerTyr: 2.125 ± 0.788
0.0SerXaa: 0.0 ± 0.0
Thr
2.975ThrAla: 2.975 ± 2.216
0.425ThrCys: 0.425 ± 0.285
2.55ThrAsp: 2.55 ± 0.813
1.275ThrGlu: 1.275 ± 0.794
2.55ThrPhe: 2.55 ± 0.699
2.975ThrGly: 2.975 ± 0.773
1.7ThrHis: 1.7 ± 0.507
4.25ThrIle: 4.25 ± 1.132
3.825ThrLys: 3.825 ± 1.213
4.675ThrLeu: 4.675 ± 1.099
2.125ThrMet: 2.125 ± 0.591
1.275ThrAsn: 1.275 ± 0.398
2.55ThrPro: 2.55 ± 0.832
0.85ThrGln: 0.85 ± 0.728
2.975ThrArg: 2.975 ± 0.576
6.375ThrSer: 6.375 ± 1.22
4.675ThrThr: 4.675 ± 1.684
5.95ThrVal: 5.95 ± 1.233
0.85ThrTrp: 0.85 ± 0.253
2.125ThrTyr: 2.125 ± 0.913
0.0ThrXaa: 0.0 ± 0.0
Val
4.675ValAla: 4.675 ± 1.242
1.275ValCys: 1.275 ± 0.559
11.475ValAsp: 11.475 ± 2.634
5.525ValGlu: 5.525 ± 0.921
0.85ValPhe: 0.85 ± 0.728
3.825ValGly: 3.825 ± 1.068
2.55ValHis: 2.55 ± 1.201
4.675ValIle: 4.675 ± 0.553
7.225ValLys: 7.225 ± 0.841
4.675ValLeu: 4.675 ± 0.215
2.55ValMet: 2.55 ± 1.135
4.25ValAsn: 4.25 ± 1.493
6.375ValPro: 6.375 ± 1.835
0.85ValGln: 0.85 ± 0.728
2.55ValArg: 2.55 ± 0.455
6.375ValSer: 6.375 ± 1.397
2.55ValThr: 2.55 ± 0.461
5.1ValVal: 5.1 ± 2.726
0.85ValTrp: 0.85 ± 0.728
3.4ValTyr: 3.4 ± 2.209
0.0ValXaa: 0.0 ± 0.0
Trp
0.425TrpAla: 0.425 ± 0.285
0.0TrpCys: 0.0 ± 0.0
1.275TrpAsp: 1.275 ± 0.347
0.0TrpGlu: 0.0 ± 0.0
2.125TrpPhe: 2.125 ± 1.614
0.425TrpGly: 0.425 ± 0.285
0.425TrpHis: 0.425 ± 0.285
0.0TrpIle: 0.0 ± 0.0
0.85TrpLys: 0.85 ± 0.253
0.85TrpLeu: 0.85 ± 0.253
0.425TrpMet: 0.425 ± 0.77
0.85TrpAsn: 0.85 ± 0.439
0.425TrpPro: 0.425 ± 0.433
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.425TrpThr: 0.425 ± 0.285
0.425TrpVal: 0.425 ± 0.285
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.825TyrAla: 3.825 ± 1.034
0.85TyrCys: 0.85 ± 0.728
2.55TyrAsp: 2.55 ± 0.669
2.125TyrGlu: 2.125 ± 1.087
1.275TyrPhe: 1.275 ± 0.559
1.275TyrGly: 1.275 ± 1.472
0.85TyrHis: 0.85 ± 0.728
1.7TyrIle: 1.7 ± 0.372
1.275TyrLys: 1.275 ± 0.855
3.4TyrLeu: 3.4 ± 0.344
0.425TyrMet: 0.425 ± 0.285
0.85TyrAsn: 0.85 ± 0.57
0.85TyrPro: 0.85 ± 0.867
0.85TyrGln: 0.85 ± 0.253
2.55TyrArg: 2.55 ± 0.76
2.125TyrSer: 2.125 ± 0.565
2.55TyrThr: 2.55 ± 1.38
3.4TyrVal: 3.4 ± 0.872
0.0TyrTrp: 0.0 ± 0.0
1.7TyrTyr: 1.7 ± 0.552
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (2354 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski