Amino acid dipepetide frequency for Pseudomonas putida S11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.317AlaAla: 13.317 ± 0.177
1.597AlaCys: 1.597 ± 0.05
5.734AlaAsp: 5.734 ± 0.083
6.641AlaGlu: 6.641 ± 0.131
3.908AlaPhe: 3.908 ± 0.079
10.425AlaGly: 10.425 ± 0.15
2.442AlaHis: 2.442 ± 0.057
4.993AlaIle: 4.993 ± 0.083
3.715AlaLys: 3.715 ± 0.103
13.06AlaLeu: 13.06 ± 0.153
3.149AlaMet: 3.149 ± 0.061
2.724AlaAsn: 2.724 ± 0.071
4.98AlaPro: 4.98 ± 0.111
5.237AlaGln: 5.237 ± 0.109
7.712AlaArg: 7.712 ± 0.13
6.133AlaSer: 6.133 ± 0.102
5.036AlaThr: 5.036 ± 0.104
8.078AlaVal: 8.078 ± 0.113
1.721AlaTrp: 1.721 ± 0.054
2.444AlaTyr: 2.444 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
1.341CysAla: 1.341 ± 0.045
0.301CysCys: 0.301 ± 0.02
0.604CysAsp: 0.604 ± 0.031
0.546CysGlu: 0.546 ± 0.028
0.408CysPhe: 0.408 ± 0.024
1.188CysGly: 1.188 ± 0.04
0.36CysHis: 0.36 ± 0.022
0.481CysIle: 0.481 ± 0.031
0.334CysLys: 0.334 ± 0.021
1.404CysLeu: 1.404 ± 0.049
0.343CysMet: 0.343 ± 0.022
0.298CysAsn: 0.298 ± 0.019
0.737CysPro: 0.737 ± 0.03
0.62CysGln: 0.62 ± 0.028
1.273CysArg: 1.273 ± 0.053
0.915CysSer: 0.915 ± 0.038
0.654CysThr: 0.654 ± 0.03
0.788CysVal: 0.788 ± 0.037
0.28CysTrp: 0.28 ± 0.02
0.296CysTyr: 0.296 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
5.356AspAla: 5.356 ± 0.085
0.647AspCys: 0.647 ± 0.033
2.949AspAsp: 2.949 ± 0.07
3.225AspGlu: 3.225 ± 0.069
1.854AspPhe: 1.854 ± 0.049
4.32AspGly: 4.32 ± 0.078
1.451AspHis: 1.451 ± 0.051
2.397AspIle: 2.397 ± 0.063
1.804AspLys: 1.804 ± 0.048
5.476AspLeu: 5.476 ± 0.083
1.113AspMet: 1.113 ± 0.04
1.557AspAsn: 1.557 ± 0.051
2.708AspPro: 2.708 ± 0.065
2.354AspGln: 2.354 ± 0.057
3.472AspArg: 3.472 ± 0.075
2.741AspSer: 2.741 ± 0.062
2.218AspThr: 2.218 ± 0.063
3.353AspVal: 3.353 ± 0.068
0.874AspTrp: 0.874 ± 0.036
1.535AspTyr: 1.535 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
6.328GluAla: 6.328 ± 0.119
0.533GluCys: 0.533 ± 0.026
2.411GluAsp: 2.411 ± 0.066
2.909GluGlu: 2.909 ± 0.081
1.591GluPhe: 1.591 ± 0.049
3.893GluGly: 3.893 ± 0.08
1.705GluHis: 1.705 ± 0.054
2.552GluIle: 2.552 ± 0.07
1.827GluLys: 1.827 ± 0.059
6.483GluLeu: 6.483 ± 0.111
1.275GluMet: 1.275 ± 0.046
1.35GluAsn: 1.35 ± 0.049
2.564GluPro: 2.564 ± 0.067
3.722GluGln: 3.722 ± 0.086
4.68GluArg: 4.68 ± 0.084
2.407GluSer: 2.407 ± 0.059
2.184GluThr: 2.184 ± 0.053
4.168GluVal: 4.168 ± 0.071
0.658GluTrp: 0.658 ± 0.034
1.13GluTyr: 1.13 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.956PheAla: 3.956 ± 0.069
0.531PheCys: 0.531 ± 0.031
2.188PheAsp: 2.188 ± 0.054
2.075PheGlu: 2.075 ± 0.058
1.46PhePhe: 1.46 ± 0.051
3.122PheGly: 3.122 ± 0.073
0.744PheHis: 0.744 ± 0.033
1.771PheIle: 1.771 ± 0.055
1.215PheLys: 1.215 ± 0.045
3.149PheLeu: 3.149 ± 0.065
0.813PheMet: 0.813 ± 0.032
1.234PheAsn: 1.234 ± 0.041
1.307PhePro: 1.307 ± 0.038
1.315PheGln: 1.315 ± 0.047
1.904PheArg: 1.904 ± 0.053
2.204PheSer: 2.204 ± 0.06
1.804PheThr: 1.804 ± 0.047
2.525PheVal: 2.525 ± 0.062
0.516PheTrp: 0.516 ± 0.027
0.92PheTyr: 0.92 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
7.957GlyAla: 7.957 ± 0.13
1.353GlyCys: 1.353 ± 0.042
4.199GlyAsp: 4.199 ± 0.084
4.537GlyGlu: 4.537 ± 0.087
3.391GlyPhe: 3.391 ± 0.066
6.923GlyGly: 6.923 ± 0.131
2.405GlyHis: 2.405 ± 0.063
3.855GlyIle: 3.855 ± 0.08
3.435GlyLys: 3.435 ± 0.074
9.396GlyLeu: 9.396 ± 0.145
2.402GlyMet: 2.402 ± 0.064
2.464GlyAsn: 2.464 ± 0.061
2.974GlyPro: 2.974 ± 0.075
4.432GlyGln: 4.432 ± 0.081
6.087GlyArg: 6.087 ± 0.098
4.699GlySer: 4.699 ± 0.095
3.882GlyThr: 3.882 ± 0.08
6.29GlyVal: 6.29 ± 0.106
1.447GlyTrp: 1.447 ± 0.045
2.277GlyTyr: 2.277 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.718HisAla: 2.718 ± 0.066
0.388HisCys: 0.388 ± 0.024
1.4HisAsp: 1.4 ± 0.043
1.231HisGlu: 1.231 ± 0.044
0.98HisPhe: 0.98 ± 0.036
2.477HisGly: 2.477 ± 0.07
0.881HisHis: 0.881 ± 0.046
0.973HisIle: 0.973 ± 0.037
0.653HisLys: 0.653 ± 0.032
2.819HisLeu: 2.819 ± 0.065
0.577HisMet: 0.577 ± 0.028
0.577HisAsn: 0.577 ± 0.03
1.66HisPro: 1.66 ± 0.055
1.215HisGln: 1.215 ± 0.046
2.018HisArg: 2.018 ± 0.06
1.317HisSer: 1.317 ± 0.045
0.961HisThr: 0.961 ± 0.036
1.578HisVal: 1.578 ± 0.055
0.461HisTrp: 0.461 ± 0.028
0.697HisTyr: 0.697 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.464IleAla: 5.464 ± 0.091
0.517IleCys: 0.517 ± 0.028
3.015IleAsp: 3.015 ± 0.065
3.145IleGlu: 3.145 ± 0.057
1.355IlePhe: 1.355 ± 0.046
4.286IleGly: 4.286 ± 0.083
0.92IleHis: 0.92 ± 0.036
1.975IleIle: 1.975 ± 0.067
1.66IleLys: 1.66 ± 0.049
3.779IleLeu: 3.779 ± 0.079
0.817IleMet: 0.817 ± 0.036
1.557IleAsn: 1.557 ± 0.052
2.082IlePro: 2.082 ± 0.055
1.544IleGln: 1.544 ± 0.047
2.704IleArg: 2.704 ± 0.062
2.699IleSer: 2.699 ± 0.069
2.387IleThr: 2.387 ± 0.069
2.859IleVal: 2.859 ± 0.066
0.464IleTrp: 0.464 ± 0.025
0.965IleTyr: 0.965 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.266LysAla: 4.266 ± 0.089
0.214LysCys: 0.214 ± 0.017
1.675LysAsp: 1.675 ± 0.053
1.594LysGlu: 1.594 ± 0.047
0.834LysPhe: 0.834 ± 0.032
2.555LysGly: 2.555 ± 0.064
0.794LysHis: 0.794 ± 0.034
1.398LysIle: 1.398 ± 0.053
1.283LysLys: 1.283 ± 0.046
3.473LysLeu: 3.473 ± 0.077
0.734LysMet: 0.734 ± 0.03
0.83LysAsn: 0.83 ± 0.041
2.082LysPro: 2.082 ± 0.077
1.46LysGln: 1.46 ± 0.05
2.439LysArg: 2.439 ± 0.059
1.602LysSer: 1.602 ± 0.049
1.665LysThr: 1.665 ± 0.052
2.801LysVal: 2.801 ± 0.066
0.341LysTrp: 0.341 ± 0.023
0.711LysTyr: 0.711 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
14.074LeuAla: 14.074 ± 0.156
1.471LeuCys: 1.471 ± 0.052
6.386LeuAsp: 6.386 ± 0.105
6.167LeuGlu: 6.167 ± 0.107
3.94LeuPhe: 3.94 ± 0.083
9.125LeuGly: 9.125 ± 0.127
2.688LeuHis: 2.688 ± 0.063
4.952LeuIle: 4.952 ± 0.096
3.835LeuLys: 3.835 ± 0.075
13.091LeuLeu: 13.091 ± 0.187
2.592LeuMet: 2.592 ± 0.069
2.986LeuAsn: 2.986 ± 0.067
6.234LeuPro: 6.234 ± 0.099
4.883LeuGln: 4.883 ± 0.095
7.551LeuArg: 7.551 ± 0.116
6.384LeuSer: 6.384 ± 0.099
5.139LeuThr: 5.139 ± 0.092
8.075LeuVal: 8.075 ± 0.118
1.283LeuTrp: 1.283 ± 0.051
2.362LeuTyr: 2.362 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.799MetAla: 2.799 ± 0.071
0.223MetCys: 0.223 ± 0.02
1.04MetAsp: 1.04 ± 0.043
1.03MetGlu: 1.03 ± 0.038
0.733MetPhe: 0.733 ± 0.036
1.731MetGly: 1.731 ± 0.05
0.568MetHis: 0.568 ± 0.029
1.247MetIle: 1.247 ± 0.042
0.944MetLys: 0.944 ± 0.037
2.835MetLeu: 2.835 ± 0.068
0.536MetMet: 0.536 ± 0.029
0.841MetAsn: 0.841 ± 0.036
1.522MetPro: 1.522 ± 0.046
1.133MetGln: 1.133 ± 0.046
1.728MetArg: 1.728 ± 0.047
1.69MetSer: 1.69 ± 0.047
1.387MetThr: 1.387 ± 0.048
1.61MetVal: 1.61 ± 0.05
0.214MetTrp: 0.214 ± 0.015
0.396MetTyr: 0.396 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.869AsnAla: 2.869 ± 0.065
0.333AsnCys: 0.333 ± 0.025
1.454AsnAsp: 1.454 ± 0.053
1.278AsnGlu: 1.278 ± 0.037
0.975AsnPhe: 0.975 ± 0.039
2.388AsnGly: 2.388 ± 0.064
0.651AsnHis: 0.651 ± 0.03
1.213AsnIle: 1.213 ± 0.047
0.837AsnLys: 0.837 ± 0.036
3.079AsnLeu: 3.079 ± 0.067
0.551AsnMet: 0.551 ± 0.03
0.82AsnAsn: 0.82 ± 0.041
1.811AsnPro: 1.811 ± 0.054
1.164AsnGln: 1.164 ± 0.045
1.812AsnArg: 1.812 ± 0.047
1.405AsnSer: 1.405 ± 0.051
1.318AsnThr: 1.318 ± 0.051
1.855AsnVal: 1.855 ± 0.052
0.477AsnTrp: 0.477 ± 0.025
0.71AsnTyr: 0.71 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
6.558ProAla: 6.558 ± 0.122
0.648ProCys: 0.648 ± 0.029
2.658ProAsp: 2.658 ± 0.061
2.955ProGlu: 2.955 ± 0.061
1.69ProPhe: 1.69 ± 0.052
5.232ProGly: 5.232 ± 0.106
1.165ProHis: 1.165 ± 0.04
1.812ProIle: 1.812 ± 0.054
1.42ProLys: 1.42 ± 0.039
5.434ProLeu: 5.434 ± 0.101
1.238ProMet: 1.238 ± 0.044
1.214ProAsn: 1.214 ± 0.044
2.155ProPro: 2.155 ± 0.062
2.359ProGln: 2.359 ± 0.06
3.212ProArg: 3.212 ± 0.081
2.701ProSer: 2.701 ± 0.067
2.334ProThr: 2.334 ± 0.064
4.119ProVal: 4.119 ± 0.081
0.834ProTrp: 0.834 ± 0.035
1.037ProTyr: 1.037 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
6.521GlnAla: 6.521 ± 0.099
0.516GlnCys: 0.516 ± 0.033
1.764GlnAsp: 1.764 ± 0.048
1.864GlnGlu: 1.864 ± 0.058
1.311GlnPhe: 1.311 ± 0.044
4.022GlnGly: 4.022 ± 0.086
1.451GlnHis: 1.451 ± 0.045
1.777GlnIle: 1.777 ± 0.054
1.204GlnLys: 1.204 ± 0.044
5.597GlnLeu: 5.597 ± 0.093
1.087GlnMet: 1.087 ± 0.038
0.93GlnAsn: 0.93 ± 0.038
2.931GlnPro: 2.931 ± 0.066
2.961GlnGln: 2.961 ± 0.074
4.355GlnArg: 4.355 ± 0.096
2.005GlnSer: 2.005 ± 0.05
1.804GlnThr: 1.804 ± 0.056
3.898GlnVal: 3.898 ± 0.09
0.693GlnTrp: 0.693 ± 0.029
1.005GlnTyr: 1.005 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
6.98ArgAla: 6.98 ± 0.117
1.145ArgCys: 1.145 ± 0.045
3.393ArgAsp: 3.393 ± 0.082
4.04ArgGlu: 4.04 ± 0.077
2.661ArgPhe: 2.661 ± 0.053
4.84ArgGly: 4.84 ± 0.096
2.275ArgHis: 2.275 ± 0.069
3.136ArgIle: 3.136 ± 0.067
2.325ArgLys: 2.325 ± 0.059
8.578ArgLeu: 8.578 ± 0.125
1.987ArgMet: 1.987 ± 0.05
1.93ArgAsn: 1.93 ± 0.051
3.818ArgPro: 3.818 ± 0.083
4.155ArgGln: 4.155 ± 0.088
6.161ArgArg: 6.161 ± 0.12
3.99ArgSer: 3.99 ± 0.08
2.906ArgThr: 2.906 ± 0.076
4.547ArgVal: 4.547 ± 0.071
1.208ArgTrp: 1.208 ± 0.037
2.012ArgTyr: 2.012 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
5.794SerAla: 5.794 ± 0.087
0.67SerCys: 0.67 ± 0.034
2.645SerAsp: 2.645 ± 0.062
2.802SerGlu: 2.802 ± 0.073
2.031SerPhe: 2.031 ± 0.058
5.024SerGly: 5.024 ± 0.086
1.354SerHis: 1.354 ± 0.046
2.591SerIle: 2.591 ± 0.062
1.791SerLys: 1.791 ± 0.057
6.278SerLeu: 6.278 ± 0.107
1.455SerMet: 1.455 ± 0.044
1.632SerAsn: 1.632 ± 0.059
2.769SerPro: 2.769 ± 0.072
2.282SerGln: 2.282 ± 0.061
3.888SerArg: 3.888 ± 0.079
3.458SerSer: 3.458 ± 0.088
2.874SerThr: 2.874 ± 0.063
3.726SerVal: 3.726 ± 0.085
0.777SerTrp: 0.777 ± 0.034
1.257SerTyr: 1.257 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
5.124ThrAla: 5.124 ± 0.084
0.628ThrCys: 0.628 ± 0.032
2.244ThrAsp: 2.244 ± 0.065
2.194ThrGlu: 2.194 ± 0.05
1.638ThrPhe: 1.638 ± 0.052
4.199ThrGly: 4.199 ± 0.079
1.045ThrHis: 1.045 ± 0.037
1.927ThrIle: 1.927 ± 0.064
1.117ThrLys: 1.117 ± 0.044
6.023ThrLeu: 6.023 ± 0.117
0.863ThrMet: 0.863 ± 0.036
1.08ThrAsn: 1.08 ± 0.038
2.964ThrPro: 2.964 ± 0.073
1.8ThrGln: 1.8 ± 0.053
2.958ThrArg: 2.958 ± 0.069
2.648ThrSer: 2.648 ± 0.06
2.485ThrThr: 2.485 ± 0.08
3.581ThrVal: 3.581 ± 0.09
0.721ThrTrp: 0.721 ± 0.032
1.131ThrTyr: 1.131 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
8.174ValAla: 8.174 ± 0.119
0.887ValCys: 0.887 ± 0.034
3.892ValAsp: 3.892 ± 0.08
4.442ValGlu: 4.442 ± 0.08
2.579ValPhe: 2.579 ± 0.065
5.906ValGly: 5.906 ± 0.129
1.637ValHis: 1.637 ± 0.049
3.592ValIle: 3.592 ± 0.075
2.201ValLys: 2.201 ± 0.057
8.121ValLeu: 8.121 ± 0.134
1.788ValMet: 1.788 ± 0.042
1.911ValAsn: 1.911 ± 0.061
3.463ValPro: 3.463 ± 0.086
2.881ValGln: 2.881 ± 0.064
4.726ValArg: 4.726 ± 0.091
3.993ValSer: 3.993 ± 0.075
3.705ValThr: 3.705 ± 0.093
5.779ValVal: 5.779 ± 0.108
0.871ValTrp: 0.871 ± 0.037
1.472ValTyr: 1.472 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
1.25TrpAla: 1.25 ± 0.042
0.246TrpCys: 0.246 ± 0.019
0.517TrpAsp: 0.517 ± 0.032
0.57TrpGlu: 0.57 ± 0.03
0.481TrpPhe: 0.481 ± 0.029
0.93TrpGly: 0.93 ± 0.043
0.467TrpHis: 0.467 ± 0.028
0.634TrpIle: 0.634 ± 0.028
0.457TrpLys: 0.457 ± 0.026
2.215TrpLeu: 2.215 ± 0.061
0.401TrpMet: 0.401 ± 0.025
0.388TrpAsn: 0.388 ± 0.023
0.887TrpPro: 0.887 ± 0.042
0.927TrpGln: 0.927 ± 0.032
1.323TrpArg: 1.323 ± 0.051
0.784TrpSer: 0.784 ± 0.031
0.484TrpThr: 0.484 ± 0.026
0.95TrpVal: 0.95 ± 0.038
0.256TrpTrp: 0.256 ± 0.022
0.328TrpTyr: 0.328 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.198TyrAla: 2.198 ± 0.047
0.324TyrCys: 0.324 ± 0.02
1.235TyrAsp: 1.235 ± 0.054
1.124TyrGlu: 1.124 ± 0.043
0.933TyrPhe: 0.933 ± 0.036
1.817TyrGly: 1.817 ± 0.056
0.576TyrHis: 0.576 ± 0.029
0.92TyrIle: 0.92 ± 0.037
0.698TyrLys: 0.698 ± 0.032
2.926TyrLeu: 2.926 ± 0.063
0.483TyrMet: 0.483 ± 0.028
0.68TyrAsn: 0.68 ± 0.034
1.13TyrPro: 1.13 ± 0.04
1.251TyrGln: 1.251 ± 0.042
2.087TyrArg: 2.087 ± 0.058
1.324TyrSer: 1.324 ± 0.048
1.143TyrThr: 1.143 ± 0.043
1.44TyrVal: 1.44 ± 0.047
0.398TyrTrp: 0.398 ± 0.024
0.677TyrTyr: 0.677 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3597 proteins (700176 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski