Amino acid dipepetide frequency for Chitinophaga caeni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.675AlaAla: 6.675 ± 0.09	0.824AlaCys: 0.824 ± 0.04	3.864AlaAsp: 3.864 ± 0.055	4.007AlaGlu: 4.007 ± 0.066	3.388AlaPhe: 3.388 ± 0.05	5.451AlaGly: 5.451 ± 0.076	1.233AlaHis: 1.233 ± 0.028	5.485AlaIle: 5.485 ± 0.066	4.684AlaLys: 4.684 ± 0.066	6.77AlaLeu: 6.77 ± 0.076	1.886AlaMet: 1.886 ± 0.036	3.722AlaAsn: 3.722 ± 0.064	2.651AlaPro: 2.651 ± 0.066	2.938AlaGln: 2.938 ± 0.047	2.785AlaArg: 2.785 ± 0.04	4.658AlaSer: 4.658 ± 0.075	4.437AlaThr: 4.437 ± 0.081	4.696AlaVal: 4.696 ± 0.063	0.919AlaTrp: 0.919 ± 0.026	3.061AlaTyr: 3.061 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.486CysAla: 0.486 ± 0.026	0.177CysCys: 0.177 ± 0.011	0.427CysAsp: 0.427 ± 0.043	0.409CysGlu: 0.409 ± 0.019	0.4CysPhe: 0.4 ± 0.017	0.671CysGly: 0.671 ± 0.056	0.198CysHis: 0.198 ± 0.013	0.686CysIle: 0.686 ± 0.022	0.504CysLys: 0.504 ± 0.019	0.842CysLeu: 0.842 ± 0.027	0.229CysMet: 0.229 ± 0.011	0.432CysAsn: 0.432 ± 0.019	0.346CysPro: 0.346 ± 0.017	0.273CysGln: 0.273 ± 0.016	0.344CysArg: 0.344 ± 0.017	0.612CysSer: 0.612 ± 0.029	0.434CysThr: 0.434 ± 0.02	0.422CysVal: 0.422 ± 0.015	0.121CysTrp: 0.121 ± 0.009	0.344CysTyr: 0.344 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.2AspAla: 4.2 ± 0.066	0.381AspCys: 0.381 ± 0.023	2.673AspAsp: 2.673 ± 0.051	3.416AspGlu: 3.416 ± 0.052	2.875AspPhe: 2.875 ± 0.041	3.903AspGly: 3.903 ± 0.053	1.111AspHis: 1.111 ± 0.031	4.202AspIle: 4.202 ± 0.059	3.55AspLys: 3.55 ± 0.048	4.736AspLeu: 4.736 ± 0.055	1.212AspMet: 1.212 ± 0.025	2.734AspAsn: 2.734 ± 0.067	2.452AspPro: 2.452 ± 0.046	2.028AspGln: 2.028 ± 0.04	2.181AspArg: 2.181 ± 0.039	3.058AspSer: 3.058 ± 0.055	2.706AspThr: 2.706 ± 0.059	3.371AspVal: 3.371 ± 0.051	0.83AspTrp: 0.83 ± 0.024	2.647AspTyr: 2.647 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.364GluAla: 4.364 ± 0.072	0.325GluCys: 0.325 ± 0.023	2.907GluAsp: 2.907 ± 0.045	3.604GluGlu: 3.604 ± 0.061	2.386GluPhe: 2.386 ± 0.037	3.501GluGly: 3.501 ± 0.055	1.264GluHis: 1.264 ± 0.03	4.288GluIle: 4.288 ± 0.062	4.517GluLys: 4.517 ± 0.066	5.626GluLeu: 5.626 ± 0.066	1.601GluMet: 1.601 ± 0.035	3.292GluAsn: 3.292 ± 0.046	1.766GluPro: 1.766 ± 0.037	2.711GluGln: 2.711 ± 0.049	2.564GluArg: 2.564 ± 0.048	2.912GluSer: 2.912 ± 0.046	2.691GluThr: 2.691 ± 0.044	3.71GluVal: 3.71 ± 0.051	0.7GluTrp: 0.7 ± 0.021	2.141GluTyr: 2.141 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.133PheAla: 3.133 ± 0.049	0.425PheCys: 0.425 ± 0.02	3.001PheAsp: 3.001 ± 0.047	2.857PheGlu: 2.857 ± 0.054	2.277PhePhe: 2.277 ± 0.05	3.212PheGly: 3.212 ± 0.058	0.917PheHis: 0.917 ± 0.024	3.52PheIle: 3.52 ± 0.056	3.118PheLys: 3.118 ± 0.044	4.307PheLeu: 4.307 ± 0.062	1.18PheMet: 1.18 ± 0.029	2.905PheAsn: 2.905 ± 0.049	1.856PhePro: 1.856 ± 0.034	1.582PheGln: 1.582 ± 0.029	1.937PheArg: 1.937 ± 0.04	3.455PheSer: 3.455 ± 0.05	2.943PheThr: 2.943 ± 0.047	2.764PheVal: 2.764 ± 0.044	0.571PheTrp: 0.571 ± 0.023	2.119PheTyr: 2.119 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.791GlyAla: 4.791 ± 0.071	0.637GlyCys: 0.637 ± 0.03	3.527GlyAsp: 3.527 ± 0.053	3.564GlyGlu: 3.564 ± 0.051	3.495GlyPhe: 3.495 ± 0.052	4.91GlyGly: 4.91 ± 0.075	1.243GlyHis: 1.243 ± 0.029	5.593GlyIle: 5.593 ± 0.074	5.529GlyLys: 5.529 ± 0.067	6.095GlyLeu: 6.095 ± 0.08	1.949GlyMet: 1.949 ± 0.041	4.177GlyAsn: 4.177 ± 0.064	1.524GlyPro: 1.524 ± 0.034	2.499GlyGln: 2.499 ± 0.04	2.561GlyArg: 2.561 ± 0.047	4.436GlySer: 4.436 ± 0.075	4.192GlyThr: 4.192 ± 0.072	4.198GlyVal: 4.198 ± 0.058	0.982GlyTrp: 0.982 ± 0.028	3.207GlyTyr: 3.207 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.271HisAla: 1.271 ± 0.03	0.206HisCys: 0.206 ± 0.011	0.928HisAsp: 0.928 ± 0.024	1.05HisGlu: 1.05 ± 0.028	1.234HisPhe: 1.234 ± 0.034	1.185HisGly: 1.185 ± 0.031	0.608HisHis: 0.608 ± 0.021	1.341HisIle: 1.341 ± 0.032	1.045HisLys: 1.045 ± 0.028	2.045HisLeu: 2.045 ± 0.044	0.374HisMet: 0.374 ± 0.016	0.878HisAsn: 0.878 ± 0.026	1.122HisPro: 1.122 ± 0.032	0.855HisGln: 0.855 ± 0.021	0.888HisArg: 0.888 ± 0.024	1.051HisSer: 1.051 ± 0.029	1.033HisThr: 1.033 ± 0.027	1.026HisVal: 1.026 ± 0.026	0.298HisTrp: 0.298 ± 0.017	0.988HisTyr: 0.988 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.593IleAla: 5.593 ± 0.075	0.748IleCys: 0.748 ± 0.026	4.2IleAsp: 4.2 ± 0.051	4.069IleGlu: 4.069 ± 0.059	3.191IlePhe: 3.191 ± 0.055	4.629IleGly: 4.629 ± 0.072	1.495IleHis: 1.495 ± 0.031	5.129IleIle: 5.129 ± 0.073	4.338IleLys: 4.338 ± 0.055	6.528IleLeu: 6.528 ± 0.079	1.527IleMet: 1.527 ± 0.038	3.785IleAsn: 3.785 ± 0.052	3.432IlePro: 3.432 ± 0.059	2.738IleGln: 2.738 ± 0.048	3.095IleArg: 3.095 ± 0.047	4.974IleSer: 4.974 ± 0.07	4.379IleThr: 4.379 ± 0.078	4.384IleVal: 4.384 ± 0.064	0.707IleTrp: 0.707 ± 0.021	2.813IleTyr: 2.813 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.863LysAla: 4.863 ± 0.076	0.337LysCys: 0.337 ± 0.016	4.266LysAsp: 4.266 ± 0.057	4.659LysGlu: 4.659 ± 0.069	2.625LysPhe: 2.625 ± 0.042	4.373LysGly: 4.373 ± 0.058	1.271LysHis: 1.271 ± 0.031	4.894LysIle: 4.894 ± 0.058	4.963LysLys: 4.963 ± 0.067	5.808LysLeu: 5.808 ± 0.065	1.932LysMet: 1.932 ± 0.043	3.775LysAsn: 3.775 ± 0.058	2.515LysPro: 2.515 ± 0.043	2.798LysGln: 2.798 ± 0.043	2.68LysArg: 2.68 ± 0.044	3.897LysSer: 3.897 ± 0.056	3.466LysThr: 3.466 ± 0.051	4.419LysVal: 4.419 ± 0.055	0.807LysTrp: 0.807 ± 0.024	2.88LysTyr: 2.88 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	6.86LeuAla: 6.86 ± 0.081	0.831LeuCys: 0.831 ± 0.023	5.17LeuAsp: 5.17 ± 0.068	5.412LeuGlu: 5.412 ± 0.074	4.39LeuPhe: 4.39 ± 0.067	5.972LeuGly: 5.972 ± 0.07	1.892LeuHis: 1.892 ± 0.041	5.626LeuIle: 5.626 ± 0.067	6.563LeuLys: 6.563 ± 0.066	9.347LeuLeu: 9.347 ± 0.096	2.249LeuMet: 2.249 ± 0.041	4.971LeuAsn: 4.971 ± 0.075	4.399LeuPro: 4.399 ± 0.057	4.482LeuGln: 4.482 ± 0.063	3.73LeuArg: 3.73 ± 0.056	6.74LeuSer: 6.74 ± 0.066	4.705LeuThr: 4.705 ± 0.059	5.964LeuVal: 5.964 ± 0.073	0.893LeuTrp: 0.893 ± 0.026	3.563LeuTyr: 3.563 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.958MetAla: 1.958 ± 0.04	0.161MetCys: 0.161 ± 0.011	1.411MetAsp: 1.411 ± 0.03	1.605MetGlu: 1.605 ± 0.034	0.924MetPhe: 0.924 ± 0.026	1.613MetGly: 1.613 ± 0.039	0.545MetHis: 0.545 ± 0.021	1.63MetIle: 1.63 ± 0.034	2.158MetLys: 2.158 ± 0.042	2.327MetLeu: 2.327 ± 0.039	0.74MetMet: 0.74 ± 0.022	1.429MetAsn: 1.429 ± 0.029	1.205MetPro: 1.205 ± 0.026	1.25MetGln: 1.25 ± 0.028	1.068MetArg: 1.068 ± 0.027	1.337MetSer: 1.337 ± 0.031	1.127MetThr: 1.127 ± 0.028	1.436MetVal: 1.436 ± 0.033	0.193MetTrp: 0.193 ± 0.012	0.801MetTyr: 0.801 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.867AsnAla: 3.867 ± 0.064	0.409AsnCys: 0.409 ± 0.037	2.777AsnAsp: 2.777 ± 0.044	2.881AsnGlu: 2.881 ± 0.042	2.645AsnPhe: 2.645 ± 0.05	4.064AsnGly: 4.064 ± 0.066	0.94AsnHis: 0.94 ± 0.026	4.397AsnIle: 4.397 ± 0.053	3.401AsnLys: 3.401 ± 0.061	4.799AsnLeu: 4.799 ± 0.068	1.304AsnMet: 1.304 ± 0.026	3.172AsnAsn: 3.172 ± 0.062	2.682AsnPro: 2.682 ± 0.045	1.911AsnGln: 1.911 ± 0.037	2.434AsnArg: 2.434 ± 0.044	3.235AsnSer: 3.235 ± 0.059	3.256AsnThr: 3.256 ± 0.06	3.191AsnVal: 3.191 ± 0.053	0.754AsnTrp: 0.754 ± 0.026	2.569AsnTyr: 2.569 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	3.506ProAla: 3.506 ± 0.081	0.233ProCys: 0.233 ± 0.013	2.273ProAsp: 2.273 ± 0.04	2.366ProGlu: 2.366 ± 0.039	1.953ProPhe: 1.953 ± 0.038	3.97ProGly: 3.97 ± 0.056	0.635ProHis: 0.635 ± 0.023	2.435ProIle: 2.435 ± 0.04	2.237ProLys: 2.237 ± 0.041	3.439ProLeu: 3.439 ± 0.049	0.875ProMet: 0.875 ± 0.021	2.042ProAsn: 2.042 ± 0.038	1.237ProPro: 1.237 ± 0.037	1.332ProGln: 1.332 ± 0.028	1.359ProArg: 1.359 ± 0.032	2.523ProSer: 2.523 ± 0.048	2.104ProThr: 2.104 ± 0.046	3.387ProVal: 3.387 ± 0.068	0.477ProTrp: 0.477 ± 0.017	1.689ProTyr: 1.689 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.83GlnAla: 2.83 ± 0.047	0.252GlnCys: 0.252 ± 0.014	2.047GlnAsp: 2.047 ± 0.045	2.426GlnGlu: 2.426 ± 0.046	1.981GlnPhe: 1.981 ± 0.039	2.235GlnGly: 2.235 ± 0.041	1.029GlnHis: 1.029 ± 0.027	2.315GlnIle: 2.315 ± 0.038	2.536GlnLys: 2.536 ± 0.052	4.416GlnLeu: 4.416 ± 0.058	1.012GlnMet: 1.012 ± 0.03	1.88GlnAsn: 1.88 ± 0.036	1.683GlnPro: 1.683 ± 0.039	2.6GlnGln: 2.6 ± 0.049	1.62GlnArg: 1.62 ± 0.035	2.284GlnSer: 2.284 ± 0.041	1.881GlnThr: 1.881 ± 0.033	2.897GlnVal: 2.897 ± 0.049	0.499GlnTrp: 0.499 ± 0.018	1.78GlnTyr: 1.78 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.492ArgAla: 2.492 ± 0.043	0.241ArgCys: 0.241 ± 0.014	2.126ArgAsp: 2.126 ± 0.036	2.582ArgGlu: 2.582 ± 0.046	2.169ArgPhe: 2.169 ± 0.037	2.323ArgGly: 2.323 ± 0.051	0.74ArgHis: 0.74 ± 0.021	3.01ArgIle: 3.01 ± 0.049	3.1ArgLys: 3.1 ± 0.049	3.975ArgLeu: 3.975 ± 0.051	1.185ArgMet: 1.185 ± 0.028	2.342ArgAsn: 2.342 ± 0.045	1.377ArgPro: 1.377 ± 0.036	1.649ArgGln: 1.649 ± 0.031	1.738ArgArg: 1.738 ± 0.039	2.368ArgSer: 2.368 ± 0.038	2.028ArgThr: 2.028 ± 0.045	2.463ArgVal: 2.463 ± 0.04	0.682ArgTrp: 0.682 ± 0.023	2.004ArgTyr: 2.004 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.27SerAla: 4.27 ± 0.084	0.617SerCys: 0.617 ± 0.028	2.942SerAsp: 2.942 ± 0.046	2.991SerGlu: 2.991 ± 0.046	3.474SerPhe: 3.474 ± 0.05	4.963SerGly: 4.963 ± 0.081	1.074SerHis: 1.074 ± 0.03	4.895SerIle: 4.895 ± 0.066	3.841SerLys: 3.841 ± 0.056	6.398SerLeu: 6.398 ± 0.074	1.601SerMet: 1.601 ± 0.038	3.343SerAsn: 3.343 ± 0.052	2.482SerPro: 2.482 ± 0.044	2.094SerGln: 2.094 ± 0.037	2.598SerArg: 2.598 ± 0.046	4.214SerSer: 4.214 ± 0.088	3.525SerThr: 3.525 ± 0.067	3.739SerVal: 3.739 ± 0.056	0.881SerTrp: 0.881 ± 0.03	2.763SerTyr: 2.763 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.59ThrAla: 4.59 ± 0.087	0.431ThrCys: 0.431 ± 0.021	2.971ThrAsp: 2.971 ± 0.061	2.601ThrGlu: 2.601 ± 0.042	2.632ThrPhe: 2.632 ± 0.043	4.662ThrGly: 4.662 ± 0.067	0.931ThrHis: 0.931 ± 0.026	4.045ThrIle: 4.045 ± 0.082	2.955ThrLys: 2.955 ± 0.047	5.088ThrLeu: 5.088 ± 0.061	1.138ThrMet: 1.138 ± 0.027	2.688ThrAsn: 2.688 ± 0.052	2.423ThrPro: 2.423 ± 0.048	1.72ThrGln: 1.72 ± 0.039	2.145ThrArg: 2.145 ± 0.045	3.278ThrSer: 3.278 ± 0.058	3.207ThrThr: 3.207 ± 0.06	4.175ThrVal: 4.175 ± 0.097	0.797ThrTrp: 0.797 ± 0.034	2.433ThrTyr: 2.433 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.799ValAla: 4.799 ± 0.064	0.606ValCys: 0.606 ± 0.022	3.602ValAsp: 3.602 ± 0.062	3.464ValGlu: 3.464 ± 0.058	2.992ValPhe: 2.992 ± 0.046	3.782ValGly: 3.782 ± 0.06	1.14ValHis: 1.14 ± 0.029	4.61ValIle: 4.61 ± 0.056	4.448ValLys: 4.448 ± 0.061	5.872ValLeu: 5.872 ± 0.066	1.618ValMet: 1.618 ± 0.034	3.714ValAsn: 3.714 ± 0.056	2.758ValPro: 2.758 ± 0.048	2.327ValGln: 2.327 ± 0.046	2.379ValArg: 2.379 ± 0.047	4.177ValSer: 4.177 ± 0.054	3.651ValThr: 3.651 ± 0.077	4.069ValVal: 4.069 ± 0.066	0.655ValTrp: 0.655 ± 0.025	2.584ValTyr: 2.584 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.774TrpAla: 0.774 ± 0.023	0.128TrpCys: 0.128 ± 0.009	0.647TrpAsp: 0.647 ± 0.023	0.75TrpGlu: 0.75 ± 0.024	0.572TrpPhe: 0.572 ± 0.021	0.826TrpGly: 0.826 ± 0.024	0.266TrpHis: 0.266 ± 0.013	0.875TrpIle: 0.875 ± 0.026	0.942TrpLys: 0.942 ± 0.03	1.258TrpLeu: 1.258 ± 0.031	0.423TrpMet: 0.423 ± 0.016	0.754TrpAsn: 0.754 ± 0.023	0.335TrpPro: 0.335 ± 0.016	0.626TrpGln: 0.626 ± 0.019	0.54TrpArg: 0.54 ± 0.019	0.699TrpSer: 0.699 ± 0.023	0.66TrpThr: 0.66 ± 0.03	0.733TrpVal: 0.733 ± 0.023	0.242TrpTrp: 0.242 ± 0.015	0.538TrpTyr: 0.538 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.813TyrAla: 2.813 ± 0.054	0.391TyrCys: 0.391 ± 0.017	2.508TyrAsp: 2.508 ± 0.049	2.157TyrGlu: 2.157 ± 0.044	2.475TyrPhe: 2.475 ± 0.042	2.861TyrGly: 2.861 ± 0.049	0.896TyrHis: 0.896 ± 0.025	2.778TyrIle: 2.778 ± 0.045	2.801TyrLys: 2.801 ± 0.041	4.081TyrLeu: 4.081 ± 0.057	0.882TyrMet: 0.882 ± 0.026	2.651TyrAsn: 2.651 ± 0.056	1.828TyrPro: 1.828 ± 0.038	1.792TyrGln: 1.792 ± 0.04	1.948TyrArg: 1.948 ± 0.039	2.795TyrSer: 2.795 ± 0.046	2.485TyrThr: 2.485 ± 0.053	2.204TyrVal: 2.204 ± 0.038	0.58TyrTrp: 0.58 ± 0.018	2.171TyrTyr: 2.171 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4319 proteins (1512512 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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