Amino acid dipepetide frequency for Leptospira ryugenii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.599AlaAla: 3.599 ± 0.074	0.624AlaCys: 0.624 ± 0.022	3.013AlaAsp: 3.013 ± 0.057	4.238AlaGlu: 4.238 ± 0.065	3.246AlaPhe: 3.246 ± 0.054	4.102AlaGly: 4.102 ± 0.068	1.028AlaHis: 1.028 ± 0.032	4.941AlaIle: 4.941 ± 0.074	5.436AlaLys: 5.436 ± 0.077	6.543AlaLeu: 6.543 ± 0.076	1.543AlaMet: 1.543 ± 0.034	3.113AlaAsn: 3.113 ± 0.059	1.81AlaPro: 1.81 ± 0.038	1.803AlaGln: 1.803 ± 0.045	2.519AlaArg: 2.519 ± 0.053	4.509AlaSer: 4.509 ± 0.068	2.807AlaThr: 2.807 ± 0.063	3.554AlaVal: 3.554 ± 0.062	0.631AlaTrp: 0.631 ± 0.024	2.314AlaTyr: 2.314 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.459CysAla: 0.459 ± 0.02	0.062CysCys: 0.062 ± 0.007	0.419CysAsp: 0.419 ± 0.022	0.423CysGlu: 0.423 ± 0.018	0.445CysPhe: 0.445 ± 0.018	0.583CysGly: 0.583 ± 0.025	0.198CysHis: 0.198 ± 0.014	0.606CysIle: 0.606 ± 0.021	0.543CysLys: 0.543 ± 0.024	0.91CysLeu: 0.91 ± 0.027	0.159CysMet: 0.159 ± 0.011	0.313CysAsn: 0.313 ± 0.016	0.359CysPro: 0.359 ± 0.018	0.271CysGln: 0.271 ± 0.014	0.283CysArg: 0.283 ± 0.015	0.538CysSer: 0.538 ± 0.022	0.379CysThr: 0.379 ± 0.018	0.43CysVal: 0.43 ± 0.021	0.046CysTrp: 0.046 ± 0.006	0.305CysTyr: 0.305 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.035AspAla: 3.035 ± 0.047	0.415AspCys: 0.415 ± 0.019	1.971AspAsp: 1.971 ± 0.057	3.315AspGlu: 3.315 ± 0.057	3.1AspPhe: 3.1 ± 0.049	3.037AspGly: 3.037 ± 0.064	0.968AspHis: 0.968 ± 0.028	3.523AspIle: 3.523 ± 0.052	2.973AspLys: 2.973 ± 0.056	6.068AspLeu: 6.068 ± 0.076	0.937AspMet: 0.937 ± 0.027	1.464AspAsn: 1.464 ± 0.039	2.602AspPro: 2.602 ± 0.051	1.856AspGln: 1.856 ± 0.039	2.571AspArg: 2.571 ± 0.047	3.437AspSer: 3.437 ± 0.054	2.408AspThr: 2.408 ± 0.041	2.575AspVal: 2.575 ± 0.045	0.763AspTrp: 0.763 ± 0.025	1.894AspTyr: 1.894 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.625GluAla: 4.625 ± 0.07	0.379GluCys: 0.379 ± 0.018	3.639GluAsp: 3.639 ± 0.067	6.418GluGlu: 6.418 ± 0.1	3.318GluPhe: 3.318 ± 0.056	3.913GluGly: 3.913 ± 0.054	1.09GluHis: 1.09 ± 0.032	6.406GluIle: 6.406 ± 0.079	6.499GluLys: 6.499 ± 0.093	6.525GluLeu: 6.525 ± 0.073	1.65GluMet: 1.65 ± 0.036	3.616GluAsn: 3.616 ± 0.067	1.963GluPro: 1.963 ± 0.041	1.991GluGln: 1.991 ± 0.039	3.678GluArg: 3.678 ± 0.057	5.429GluSer: 5.429 ± 0.07	3.911GluThr: 3.911 ± 0.059	4.052GluVal: 4.052 ± 0.058	0.829GluTrp: 0.829 ± 0.022	2.438GluTyr: 2.438 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.423PheAla: 3.423 ± 0.054	0.546PheCys: 0.546 ± 0.022	2.542PheAsp: 2.542 ± 0.047	3.181PheGlu: 3.181 ± 0.049	3.664PhePhe: 3.664 ± 0.076	3.741PheGly: 3.741 ± 0.058	1.21PheHis: 1.21 ± 0.034	3.283PheIle: 3.283 ± 0.058	2.665PheLys: 2.665 ± 0.057	6.973PheLeu: 6.973 ± 0.105	0.886PheMet: 0.886 ± 0.027	1.831PheAsn: 1.831 ± 0.051	2.652PhePro: 2.652 ± 0.053	2.768PheGln: 2.768 ± 0.052	2.586PheArg: 2.586 ± 0.052	4.66PheSer: 4.66 ± 0.065	2.732PheThr: 2.732 ± 0.051	3.198PheVal: 3.198 ± 0.051	0.678PheTrp: 0.678 ± 0.026	2.189PheTyr: 2.189 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	3.887GlyAla: 3.887 ± 0.077	0.415GlyCys: 0.415 ± 0.022	3.045GlyAsp: 3.045 ± 0.054	4.088GlyGlu: 4.088 ± 0.056	3.68GlyPhe: 3.68 ± 0.062	4.34GlyGly: 4.34 ± 0.084	1.177GlyHis: 1.177 ± 0.036	5.699GlyIle: 5.699 ± 0.075	5.747GlyLys: 5.747 ± 0.07	6.225GlyLeu: 6.225 ± 0.085	1.646GlyMet: 1.646 ± 0.044	3.105GlyAsn: 3.105 ± 0.078	1.618GlyPro: 1.618 ± 0.04	1.85GlyGln: 1.85 ± 0.045	2.552GlyArg: 2.552 ± 0.051	4.357GlySer: 4.357 ± 0.069	3.456GlyThr: 3.456 ± 0.071	3.69GlyVal: 3.69 ± 0.059	0.645GlyTrp: 0.645 ± 0.023	2.46GlyTyr: 2.46 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	0.962HisAla: 0.962 ± 0.031	0.234HisCys: 0.234 ± 0.014	0.651HisAsp: 0.651 ± 0.027	1.022HisGlu: 1.022 ± 0.033	1.299HisPhe: 1.299 ± 0.033	1.109HisGly: 1.109 ± 0.031	0.478HisHis: 0.478 ± 0.023	1.354HisIle: 1.354 ± 0.038	1.132HisLys: 1.132 ± 0.033	2.257HisLeu: 2.257 ± 0.046	0.355HisMet: 0.355 ± 0.017	0.666HisAsn: 0.666 ± 0.025	1.121HisPro: 1.121 ± 0.035	0.613HisGln: 0.613 ± 0.021	0.877HisArg: 0.877 ± 0.027	1.548HisSer: 1.548 ± 0.037	0.916HisThr: 0.916 ± 0.028	0.858HisVal: 0.858 ± 0.03	0.326HisTrp: 0.326 ± 0.018	0.752HisTyr: 0.752 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.944IleAla: 4.944 ± 0.068	0.662IleCys: 0.662 ± 0.028	3.793IleAsp: 3.793 ± 0.059	5.183IleGlu: 5.183 ± 0.069	3.81IlePhe: 3.81 ± 0.064	4.942IleGly: 4.942 ± 0.071	1.656IleHis: 1.656 ± 0.04	4.312IleIle: 4.312 ± 0.071	4.391IleLys: 4.391 ± 0.068	8.795IleLeu: 8.795 ± 0.104	1.108IleMet: 1.108 ± 0.03	2.866IleAsn: 2.866 ± 0.054	3.78IlePro: 3.78 ± 0.061	3.877IleGln: 3.877 ± 0.056	3.737IleArg: 3.737 ± 0.06	5.952IleSer: 5.952 ± 0.069	3.504IleThr: 3.504 ± 0.056	4.163IleVal: 4.163 ± 0.061	0.794IleTrp: 0.794 ± 0.028	2.569IleTyr: 2.569 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.519LysAla: 4.519 ± 0.068	0.32LysCys: 0.32 ± 0.017	4.311LysAsp: 4.311 ± 0.059	7.264LysGlu: 7.264 ± 0.08	2.831LysPhe: 2.831 ± 0.052	4.162LysGly: 4.162 ± 0.063	1.223LysHis: 1.223 ± 0.034	5.782LysIle: 5.782 ± 0.079	6.768LysLys: 6.768 ± 0.096	6.343LysLeu: 6.343 ± 0.087	1.726LysMet: 1.726 ± 0.041	3.938LysAsn: 3.938 ± 0.061	2.566LysPro: 2.566 ± 0.047	2.922LysGln: 2.922 ± 0.053	3.386LysArg: 3.386 ± 0.05	5.109LysSer: 5.109 ± 0.07	3.886LysThr: 3.886 ± 0.062	4.384LysVal: 4.384 ± 0.057	0.73LysTrp: 0.73 ± 0.026	2.287LysTyr: 2.287 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.942LeuAla: 6.942 ± 0.079	0.874LeuCys: 0.874 ± 0.029	5.21LeuAsp: 5.21 ± 0.07	7.31LeuGlu: 7.31 ± 0.088	6.141LeuPhe: 6.141 ± 0.088	7.199LeuGly: 7.199 ± 0.095	1.888LeuHis: 1.888 ± 0.051	6.687LeuIle: 6.687 ± 0.082	7.411LeuLys: 7.411 ± 0.09	10.939LeuLeu: 10.939 ± 0.141	1.851LeuMet: 1.851 ± 0.047	4.649LeuAsn: 4.649 ± 0.066	4.682LeuPro: 4.682 ± 0.07	3.812LeuGln: 3.812 ± 0.052	4.65LeuArg: 4.65 ± 0.059	9.311LeuSer: 9.311 ± 0.079	4.902LeuThr: 4.902 ± 0.056	6.591LeuVal: 6.591 ± 0.081	1.046LeuTrp: 1.046 ± 0.031	3.594LeuTyr: 3.594 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.55MetAla: 1.55 ± 0.037	0.116MetCys: 0.116 ± 0.011	1.17MetAsp: 1.17 ± 0.028	1.614MetGlu: 1.614 ± 0.04	0.812MetPhe: 0.812 ± 0.026	1.523MetGly: 1.523 ± 0.04	0.342MetHis: 0.342 ± 0.016	1.564MetIle: 1.564 ± 0.037	1.841MetLys: 1.841 ± 0.033	1.731MetLeu: 1.731 ± 0.033	0.465MetMet: 0.465 ± 0.021	1.097MetAsn: 1.097 ± 0.029	0.726MetPro: 0.726 ± 0.032	0.679MetGln: 0.679 ± 0.026	0.91MetArg: 0.91 ± 0.027	1.383MetSer: 1.383 ± 0.033	0.959MetThr: 0.959 ± 0.03	1.297MetVal: 1.297 ± 0.029	0.15MetTrp: 0.15 ± 0.013	0.532MetTyr: 0.532 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.963AsnAla: 2.963 ± 0.07	0.416AsnCys: 0.416 ± 0.022	1.943AsnAsp: 1.943 ± 0.042	2.942AsnGlu: 2.942 ± 0.051	2.435AsnPhe: 2.435 ± 0.048	2.858AsnGly: 2.858 ± 0.064	1.014AsnHis: 1.014 ± 0.029	3.071AsnIle: 3.071 ± 0.061	2.44AsnLys: 2.44 ± 0.047	5.399AsnLeu: 5.399 ± 0.072	0.79AsnMet: 0.79 ± 0.026	1.564AsnAsn: 1.564 ± 0.044	2.631AsnPro: 2.631 ± 0.048	2.598AsnGln: 2.598 ± 0.049	2.373AsnArg: 2.373 ± 0.044	3.044AsnSer: 3.044 ± 0.054	2.198AsnThr: 2.198 ± 0.054	2.567AsnVal: 2.567 ± 0.049	0.595AsnTrp: 0.595 ± 0.025	1.62AsnTyr: 1.62 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	1.925ProAla: 1.925 ± 0.039	0.221ProCys: 0.221 ± 0.014	2.099ProAsp: 2.099 ± 0.043	3.397ProGlu: 3.397 ± 0.054	2.283ProPhe: 2.283 ± 0.051	2.532ProGly: 2.532 ± 0.053	0.658ProHis: 0.658 ± 0.024	3.27ProIle: 3.27 ± 0.048	3.453ProLys: 3.453 ± 0.053	3.596ProLeu: 3.596 ± 0.062	0.822ProMet: 0.822 ± 0.028	2.449ProAsn: 2.449 ± 0.052	1.216ProPro: 1.216 ± 0.034	1.115ProGln: 1.115 ± 0.033	1.264ProArg: 1.264 ± 0.034	3.083ProSer: 3.083 ± 0.056	1.782ProThr: 1.782 ± 0.038	2.333ProVal: 2.333 ± 0.049	0.492ProTrp: 0.492 ± 0.023	1.376ProTyr: 1.376 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.367GlnAla: 2.367 ± 0.047	0.263GlnCys: 0.263 ± 0.014	1.64GlnAsp: 1.64 ± 0.039	2.643GlnGlu: 2.643 ± 0.051	1.961GlnPhe: 1.961 ± 0.042	2.024GlnGly: 2.024 ± 0.044	0.478GlnHis: 0.478 ± 0.021	3.497GlnIle: 3.497 ± 0.058	3.61GlnLys: 3.61 ± 0.061	3.119GlnLeu: 3.119 ± 0.048	0.918GlnMet: 0.918 ± 0.031	2.242GlnAsn: 2.242 ± 0.044	0.853GlnPro: 0.853 ± 0.026	0.819GlnGln: 0.819 ± 0.028	1.62GlnArg: 1.62 ± 0.039	3.004GlnSer: 3.004 ± 0.054	2.378GlnThr: 2.378 ± 0.049	2.158GlnVal: 2.158 ± 0.043	0.418GlnTrp: 0.418 ± 0.018	1.17GlnTyr: 1.17 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.513ArgAla: 2.513 ± 0.05	0.245ArgCys: 0.245 ± 0.015	2.272ArgAsp: 2.272 ± 0.043	3.611ArgGlu: 3.611 ± 0.069	2.537ArgPhe: 2.537 ± 0.043	2.31ArgGly: 2.31 ± 0.042	0.715ArgHis: 0.715 ± 0.022	3.883ArgIle: 3.883 ± 0.061	3.637ArgLys: 3.637 ± 0.057	4.52ArgLeu: 4.52 ± 0.068	1.191ArgMet: 1.191 ± 0.032	2.305ArgAsn: 2.305 ± 0.045	1.446ArgPro: 1.446 ± 0.035	1.326ArgGln: 1.326 ± 0.043	1.833ArgArg: 1.833 ± 0.044	3.038ArgSer: 3.038 ± 0.054	2.224ArgThr: 2.224 ± 0.047	2.532ArgVal: 2.532 ± 0.048	0.521ArgTrp: 0.521 ± 0.021	1.804ArgTyr: 1.804 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.372SerAla: 4.372 ± 0.06	0.617SerCys: 0.617 ± 0.026	3.532SerAsp: 3.532 ± 0.055	5.295SerGlu: 5.295 ± 0.065	4.823SerPhe: 4.823 ± 0.069	5.079SerGly: 5.079 ± 0.077	1.441SerHis: 1.441 ± 0.036	5.951SerIle: 5.951 ± 0.079	5.051SerLys: 5.051 ± 0.065	9.266SerLeu: 9.266 ± 0.098	1.449SerMet: 1.449 ± 0.036	3.097SerAsn: 3.097 ± 0.07	3.133SerPro: 3.133 ± 0.05	3.101SerGln: 3.101 ± 0.058	2.757SerArg: 2.757 ± 0.055	5.45SerSer: 5.45 ± 0.087	3.388SerThr: 3.388 ± 0.057	4.329SerVal: 4.329 ± 0.066	0.775SerTrp: 0.775 ± 0.026	2.779SerTyr: 2.779 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	3.082ThrAla: 3.082 ± 0.067	0.377ThrCys: 0.377 ± 0.02	2.381ThrAsp: 2.381 ± 0.051	3.413ThrGlu: 3.413 ± 0.059	2.605ThrPhe: 2.605 ± 0.045	3.677ThrGly: 3.677 ± 0.063	0.858ThrHis: 0.858 ± 0.026	4.001ThrIle: 4.001 ± 0.058	3.876ThrLys: 3.876 ± 0.058	5.027ThrLeu: 5.027 ± 0.071	0.956ThrMet: 0.956 ± 0.027	2.497ThrAsn: 2.497 ± 0.053	1.941ThrPro: 1.941 ± 0.04	1.643ThrGln: 1.643 ± 0.04	1.921ThrArg: 1.921 ± 0.041	3.479ThrSer: 3.479 ± 0.076	2.386ThrThr: 2.386 ± 0.057	3.019ThrVal: 3.019 ± 0.063	0.571ThrTrp: 0.571 ± 0.024	1.8ThrTyr: 1.8 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	3.502ValAla: 3.502 ± 0.054	0.575ValCys: 0.575 ± 0.021	2.861ValAsp: 2.861 ± 0.045	3.623ValGlu: 3.623 ± 0.057	3.343ValPhe: 3.343 ± 0.053	3.755ValGly: 3.755 ± 0.06	1.078ValHis: 1.078 ± 0.03	3.927ValIle: 3.927 ± 0.065	3.715ValLys: 3.715 ± 0.059	6.168ValLeu: 6.168 ± 0.077	1.146ValMet: 1.146 ± 0.033	2.579ValAsn: 2.579 ± 0.044	2.38ValPro: 2.38 ± 0.046	2.006ValGln: 2.006 ± 0.033	2.629ValArg: 2.629 ± 0.048	4.966ValSer: 4.966 ± 0.068	2.949ValThr: 2.949 ± 0.062	3.558ValVal: 3.558 ± 0.061	0.725ValTrp: 0.725 ± 0.025	2.202ValTyr: 2.202 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.548TrpAla: 0.548 ± 0.022	0.074TrpCys: 0.074 ± 0.008	0.642TrpAsp: 0.642 ± 0.021	1.091TrpGlu: 1.091 ± 0.036	0.533TrpPhe: 0.533 ± 0.023	0.662TrpGly: 0.662 ± 0.023	0.175TrpHis: 0.175 ± 0.013	0.957TrpIle: 0.957 ± 0.032	1.238TrpLys: 1.238 ± 0.036	0.947TrpLeu: 0.947 ± 0.034	0.283TrpMet: 0.283 ± 0.017	0.75TrpAsn: 0.75 ± 0.029	0.257TrpPro: 0.257 ± 0.015	0.429TrpGln: 0.429 ± 0.019	0.451TrpArg: 0.451 ± 0.022	0.703TrpSer: 0.703 ± 0.026	0.551TrpThr: 0.551 ± 0.024	0.556TrpVal: 0.556 ± 0.02	0.127TrpTrp: 0.127 ± 0.01	0.321TrpTyr: 0.321 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.156TyrAla: 2.156 ± 0.047	0.296TyrCys: 0.296 ± 0.017	1.778TyrAsp: 1.778 ± 0.04	2.3TyrGlu: 2.3 ± 0.045	2.541TyrPhe: 2.541 ± 0.057	2.135TyrGly: 2.135 ± 0.041	0.856TyrHis: 0.856 ± 0.025	2.126TyrIle: 2.126 ± 0.043	2.03TyrLys: 2.03 ± 0.042	4.336TyrLeu: 4.336 ± 0.076	0.579TyrMet: 0.579 ± 0.024	1.321TyrAsn: 1.321 ± 0.041	1.629TyrPro: 1.629 ± 0.035	1.701TyrGln: 1.701 ± 0.045	1.867TyrArg: 1.867 ± 0.041	2.684TyrSer: 2.684 ± 0.05	1.793TyrThr: 1.793 ± 0.042	1.84TyrVal: 1.84 ± 0.037	0.435TyrTrp: 0.435 ± 0.021	1.499TyrTyr: 1.499 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3659 proteins (1185067 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---