Amino acid dipepetide frequency for Lachnospiraceae bacterium 10-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.976AlaAla: 6.976 ± 0.105	1.064AlaCys: 1.064 ± 0.026	4.376AlaAsp: 4.376 ± 0.055	5.413AlaGlu: 5.413 ± 0.071	2.981AlaPhe: 2.981 ± 0.053	6.256AlaGly: 6.256 ± 0.076	1.004AlaHis: 1.004 ± 0.025	4.463AlaIle: 4.463 ± 0.072	4.29AlaLys: 4.29 ± 0.07	6.55AlaLeu: 6.55 ± 0.068	2.154AlaMet: 2.154 ± 0.043	2.353AlaAsn: 2.353 ± 0.051	1.814AlaPro: 1.814 ± 0.045	2.353AlaGln: 2.353 ± 0.047	2.788AlaArg: 2.788 ± 0.046	3.809AlaSer: 3.809 ± 0.069	2.696AlaThr: 2.696 ± 0.058	6.097AlaVal: 6.097 ± 0.079	0.638AlaTrp: 0.638 ± 0.024	2.955AlaTyr: 2.955 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.945CysAla: 0.945 ± 0.025	0.314CysCys: 0.314 ± 0.016	0.814CysAsp: 0.814 ± 0.025	0.905CysGlu: 0.905 ± 0.03	0.716CysPhe: 0.716 ± 0.023	1.487CysGly: 1.487 ± 0.039	0.3CysHis: 0.3 ± 0.016	1.235CysIle: 1.235 ± 0.033	0.874CysLys: 0.874 ± 0.026	1.225CysLeu: 1.225 ± 0.032	0.502CysMet: 0.502 ± 0.019	0.624CysAsn: 0.624 ± 0.027	0.585CysPro: 0.585 ± 0.023	0.427CysGln: 0.427 ± 0.019	0.841CysArg: 0.841 ± 0.026	0.945CysSer: 0.945 ± 0.029	0.731CysThr: 0.731 ± 0.029	0.971CysVal: 0.971 ± 0.026	0.129CysTrp: 0.129 ± 0.01	0.66CysTyr: 0.66 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	3.817AspAla: 3.817 ± 0.068	0.783AspCys: 0.783 ± 0.027	2.63AspAsp: 2.63 ± 0.061	4.478AspGlu: 4.478 ± 0.072	2.744AspPhe: 2.744 ± 0.049	4.139AspGly: 4.139 ± 0.064	0.8AspHis: 0.8 ± 0.025	4.463AspIle: 4.463 ± 0.068	3.821AspLys: 3.821 ± 0.058	4.443AspLeu: 4.443 ± 0.058	1.957AspMet: 1.957 ± 0.04	2.33AspAsn: 2.33 ± 0.05	1.444AspPro: 1.444 ± 0.039	1.418AspGln: 1.418 ± 0.031	2.473AspArg: 2.473 ± 0.047	2.975AspSer: 2.975 ± 0.048	2.811AspThr: 2.811 ± 0.042	3.536AspVal: 3.536 ± 0.054	0.614AspTrp: 0.614 ± 0.022	2.808AspTyr: 2.808 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	5.625GluAla: 5.625 ± 0.071	0.897GluCys: 0.897 ± 0.029	4.244GluAsp: 4.244 ± 0.067	8.07GluGlu: 8.07 ± 0.114	2.812GluPhe: 2.812 ± 0.05	4.871GluGly: 4.871 ± 0.068	1.181GluHis: 1.181 ± 0.031	6.223GluIle: 6.223 ± 0.096	7.659GluLys: 7.659 ± 0.084	6.804GluLeu: 6.804 ± 0.084	2.576GluMet: 2.576 ± 0.047	4.724GluAsn: 4.724 ± 0.063	1.764GluPro: 1.764 ± 0.035	3.183GluGln: 3.183 ± 0.049	3.514GluArg: 3.514 ± 0.056	3.612GluSer: 3.612 ± 0.056	3.701GluThr: 3.701 ± 0.054	4.344GluVal: 4.344 ± 0.067	0.75GluTrp: 0.75 ± 0.022	3.43GluTyr: 3.43 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	2.876PheAla: 2.876 ± 0.054	0.829PheCys: 0.829 ± 0.024	2.587PheAsp: 2.587 ± 0.045	2.811PheGlu: 2.811 ± 0.049	2.168PhePhe: 2.168 ± 0.049	2.926PheGly: 2.926 ± 0.049	0.889PheHis: 0.889 ± 0.028	3.133PheIle: 3.133 ± 0.06	2.363PheLys: 2.363 ± 0.05	4.391PheLeu: 4.391 ± 0.082	1.349PheMet: 1.349 ± 0.033	1.586PheAsn: 1.586 ± 0.033	1.44PhePro: 1.44 ± 0.034	1.413PheGln: 1.413 ± 0.033	1.619PheArg: 1.619 ± 0.038	3.136PheSer: 3.136 ± 0.048	2.302PheThr: 2.302 ± 0.048	2.737PheVal: 2.737 ± 0.046	0.469PheTrp: 0.469 ± 0.017	2.066PheTyr: 2.066 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.586GlyAla: 4.586 ± 0.081	1.247GlyCys: 1.247 ± 0.03	3.222GlyAsp: 3.222 ± 0.05	5.07GlyGlu: 5.07 ± 0.075	3.136GlyPhe: 3.136 ± 0.055	4.695GlyGly: 4.695 ± 0.099	1.094GlyHis: 1.094 ± 0.029	6.427GlyIle: 6.427 ± 0.075	5.627GlyLys: 5.627 ± 0.063	5.492GlyLeu: 5.492 ± 0.076	2.536GlyMet: 2.536 ± 0.053	3.496GlyAsn: 3.496 ± 0.065	1.002GlyPro: 1.002 ± 0.03	2.177GlyGln: 2.177 ± 0.04	3.433GlyArg: 3.433 ± 0.056	4.053GlySer: 4.053 ± 0.067	3.871GlyThr: 3.871 ± 0.074	4.292GlyVal: 4.292 ± 0.065	0.737GlyTrp: 0.737 ± 0.026	3.354GlyTyr: 3.354 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	0.951HisAla: 0.951 ± 0.025	0.287HisCys: 0.287 ± 0.014	0.838HisAsp: 0.838 ± 0.025	1.04HisGlu: 1.04 ± 0.029	0.877HisPhe: 0.877 ± 0.027	1.137HisGly: 1.137 ± 0.03	0.361HisHis: 0.361 ± 0.02	1.363HisIle: 1.363 ± 0.032	1.024HisLys: 1.024 ± 0.032	1.48HisLeu: 1.48 ± 0.04	0.582HisMet: 0.582 ± 0.022	0.737HisAsn: 0.737 ± 0.025	0.778HisPro: 0.778 ± 0.023	0.534HisGln: 0.534 ± 0.021	0.71HisArg: 0.71 ± 0.025	0.907HisSer: 0.907 ± 0.029	0.913HisThr: 0.913 ± 0.03	0.989HisVal: 0.989 ± 0.032	0.145HisTrp: 0.145 ± 0.01	0.795HisTyr: 0.795 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.357IleAla: 5.357 ± 0.07	1.411IleCys: 1.411 ± 0.035	4.206IleAsp: 4.206 ± 0.057	5.151IleGlu: 5.151 ± 0.065	3.311IlePhe: 3.311 ± 0.063	4.83IleGly: 4.83 ± 0.075	1.349IleHis: 1.349 ± 0.034	5.587IleIle: 5.587 ± 0.074	4.836IleLys: 4.836 ± 0.073	7.404IleLeu: 7.404 ± 0.092	2.176IleMet: 2.176 ± 0.045	3.286IleAsn: 3.286 ± 0.054	3.139IlePro: 3.139 ± 0.055	2.21IleGln: 2.21 ± 0.038	3.592IleArg: 3.592 ± 0.061	5.422IleSer: 5.422 ± 0.066	4.246IleThr: 4.246 ± 0.057	4.715IleVal: 4.715 ± 0.062	0.752IleTrp: 0.752 ± 0.023	3.272IleTyr: 3.272 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	5.065LysAla: 5.065 ± 0.07	0.855LysCys: 0.855 ± 0.029	4.047LysAsp: 4.047 ± 0.055	7.74LysGlu: 7.74 ± 0.086	2.028LysPhe: 2.028 ± 0.043	4.511LysGly: 4.511 ± 0.061	1.001LysHis: 1.001 ± 0.029	5.353LysIle: 5.353 ± 0.067	6.383LysLys: 6.383 ± 0.083	5.596LysLeu: 5.596 ± 0.076	2.186LysMet: 2.186 ± 0.041	3.895LysAsn: 3.895 ± 0.056	1.955LysPro: 1.955 ± 0.046	2.53LysGln: 2.53 ± 0.044	3.374LysArg: 3.374 ± 0.054	3.636LysSer: 3.636 ± 0.058	3.627LysThr: 3.627 ± 0.055	4.285LysVal: 4.285 ± 0.055	0.734LysTrp: 0.734 ± 0.027	3.053LysTyr: 3.053 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	6.315LeuAla: 6.315 ± 0.076	1.57LeuCys: 1.57 ± 0.039	4.722LeuAsp: 4.722 ± 0.059	6.419LeuGlu: 6.419 ± 0.074	4.178LeuPhe: 4.178 ± 0.072	5.496LeuGly: 5.496 ± 0.07	1.514LeuHis: 1.514 ± 0.034	6.208LeuIle: 6.208 ± 0.087	6.684LeuLys: 6.684 ± 0.075	9.096LeuLeu: 9.096 ± 0.123	2.644LeuMet: 2.644 ± 0.05	4.133LeuAsn: 4.133 ± 0.054	3.355LeuPro: 3.355 ± 0.06	2.75LeuGln: 2.75 ± 0.04	3.49LeuArg: 3.49 ± 0.057	6.526LeuSer: 6.526 ± 0.081	4.916LeuThr: 4.916 ± 0.069	4.996LeuVal: 4.996 ± 0.069	0.859LeuTrp: 0.859 ± 0.028	3.65LeuTyr: 3.65 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.41MetAla: 2.41 ± 0.049	0.373MetCys: 0.373 ± 0.015	1.81MetAsp: 1.81 ± 0.041	3.053MetGlu: 3.053 ± 0.054	1.016MetPhe: 1.016 ± 0.031	2.154MetGly: 2.154 ± 0.049	0.454MetHis: 0.454 ± 0.018	2.266MetIle: 2.266 ± 0.051	2.56MetLys: 2.56 ± 0.049	2.762MetLeu: 2.762 ± 0.042	0.954MetMet: 0.954 ± 0.028	1.556MetAsn: 1.556 ± 0.033	1.147MetPro: 1.147 ± 0.032	1.218MetGln: 1.218 ± 0.033	1.307MetArg: 1.307 ± 0.028	1.708MetSer: 1.708 ± 0.034	1.576MetThr: 1.576 ± 0.036	1.918MetVal: 1.918 ± 0.042	0.253MetTrp: 0.253 ± 0.015	0.933MetTyr: 0.933 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.266AsnAla: 3.266 ± 0.058	0.656AsnCys: 0.656 ± 0.021	2.208AsnAsp: 2.208 ± 0.044	3.178AsnGlu: 3.178 ± 0.048	1.795AsnPhe: 1.795 ± 0.038	3.624AsnGly: 3.624 ± 0.06	0.869AsnHis: 0.869 ± 0.027	3.712AsnIle: 3.712 ± 0.064	2.951AsnLys: 2.951 ± 0.056	3.921AsnLeu: 3.921 ± 0.055	1.463AsnMet: 1.463 ± 0.034	2.082AsnAsn: 2.082 ± 0.05	1.853AsnPro: 1.853 ± 0.036	1.583AsnGln: 1.583 ± 0.036	2.097AsnArg: 2.097 ± 0.037	2.6AsnSer: 2.6 ± 0.055	2.377AsnThr: 2.377 ± 0.05	2.876AsnVal: 2.876 ± 0.051	0.455AsnTrp: 0.455 ± 0.019	2.136AsnTyr: 2.136 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.368ProAla: 2.368 ± 0.048	0.424ProCys: 0.424 ± 0.02	2.261ProAsp: 2.261 ± 0.044	3.2ProGlu: 3.2 ± 0.046	1.521ProPhe: 1.521 ± 0.034	2.009ProGly: 2.009 ± 0.042	0.506ProHis: 0.506 ± 0.02	1.928ProIle: 1.928 ± 0.036	1.805ProLys: 1.805 ± 0.036	2.57ProLeu: 2.57 ± 0.041	0.798ProMet: 0.798 ± 0.025	1.112ProAsn: 1.112 ± 0.029	0.734ProPro: 0.734 ± 0.026	0.959ProGln: 0.959 ± 0.027	0.945ProArg: 0.945 ± 0.029	1.677ProSer: 1.677 ± 0.04	1.327ProThr: 1.327 ± 0.044	2.923ProVal: 2.923 ± 0.051	0.304ProTrp: 0.304 ± 0.015	1.47ProTyr: 1.47 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.508GlnAla: 2.508 ± 0.04	0.364GlnCys: 0.364 ± 0.015	1.567GlnAsp: 1.567 ± 0.034	3.007GlnGlu: 3.007 ± 0.054	1.245GlnPhe: 1.245 ± 0.034	2.137GlnGly: 2.137 ± 0.041	0.452GlnHis: 0.452 ± 0.019	2.891GlnIle: 2.891 ± 0.051	2.779GlnLys: 2.779 ± 0.046	2.755GlnLeu: 2.755 ± 0.047	1.276GlnMet: 1.276 ± 0.033	1.751GlnAsn: 1.751 ± 0.035	0.878GlnPro: 0.878 ± 0.027	1.238GlnGln: 1.238 ± 0.036	1.374GlnArg: 1.374 ± 0.032	1.621GlnSer: 1.621 ± 0.037	1.603GlnThr: 1.603 ± 0.037	2.194GlnVal: 2.194 ± 0.047	0.331GlnTrp: 0.331 ± 0.018	1.374GlnTyr: 1.374 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.515ArgAla: 2.515 ± 0.049	0.61ArgCys: 0.61 ± 0.024	2.077ArgAsp: 2.077 ± 0.045	3.869ArgGlu: 3.869 ± 0.061	1.849ArgPhe: 1.849 ± 0.041	2.37ArgGly: 2.37 ± 0.043	0.748ArgHis: 0.748 ± 0.024	3.645ArgIle: 3.645 ± 0.056	3.936ArgLys: 3.936 ± 0.057	3.91ArgLeu: 3.91 ± 0.057	1.584ArgMet: 1.584 ± 0.035	2.088ArgAsn: 2.088 ± 0.044	1.224ArgPro: 1.224 ± 0.031	1.919ArgGln: 1.919 ± 0.042	2.244ArgArg: 2.244 ± 0.046	2.162ArgSer: 2.162 ± 0.043	2.091ArgThr: 2.091 ± 0.04	2.386ArgVal: 2.386 ± 0.044	0.418ArgTrp: 0.418 ± 0.018	1.936ArgTyr: 1.936 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.142SerAla: 4.142 ± 0.071	0.805SerCys: 0.805 ± 0.025	3.219SerAsp: 3.219 ± 0.049	3.956SerGlu: 3.956 ± 0.054	2.966SerPhe: 2.966 ± 0.055	5.033SerGly: 5.033 ± 0.073	1.025SerHis: 1.025 ± 0.027	4.521SerIle: 4.521 ± 0.058	3.496SerLys: 3.496 ± 0.051	5.261SerLeu: 5.261 ± 0.078	1.787SerMet: 1.787 ± 0.041	2.383SerAsn: 2.383 ± 0.048	1.773SerPro: 1.773 ± 0.039	1.907SerGln: 1.907 ± 0.04	2.768SerArg: 2.768 ± 0.054	3.597SerSer: 3.597 ± 0.068	2.728SerThr: 2.728 ± 0.047	4.151SerVal: 4.151 ± 0.061	0.566SerTrp: 0.566 ± 0.021	2.642SerTyr: 2.642 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	3.907ThrAla: 3.907 ± 0.068	0.663ThrCys: 0.663 ± 0.022	3.047ThrAsp: 3.047 ± 0.056	3.686ThrGlu: 3.686 ± 0.06	2.109ThrPhe: 2.109 ± 0.046	4.36ThrGly: 4.36 ± 0.062	0.805ThrHis: 0.805 ± 0.024	3.872ThrIle: 3.872 ± 0.058	2.898ThrLys: 2.898 ± 0.046	4.509ThrLeu: 4.509 ± 0.06	1.331ThrMet: 1.331 ± 0.035	2.01ThrAsn: 2.01 ± 0.043	1.957ThrPro: 1.957 ± 0.045	1.472ThrGln: 1.472 ± 0.032	1.786ThrArg: 1.786 ± 0.033	2.8ThrSer: 2.8 ± 0.051	2.478ThrThr: 2.478 ± 0.056	3.934ThrVal: 3.934 ± 0.063	0.502ThrTrp: 0.502 ± 0.022	2.148ThrTyr: 2.148 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	4.017ValAla: 4.017 ± 0.059	1.193ValCys: 1.193 ± 0.033	3.477ValAsp: 3.477 ± 0.052	4.651ValGlu: 4.651 ± 0.063	3.122ValPhe: 3.122 ± 0.053	3.68ValGly: 3.68 ± 0.059	1.015ValHis: 1.015 ± 0.028	5.205ValIle: 5.205 ± 0.064	4.52ValLys: 4.52 ± 0.06	6.279ValLeu: 6.279 ± 0.081	1.996ValMet: 1.996 ± 0.043	2.952ValAsn: 2.952 ± 0.047	2.25ValPro: 2.25 ± 0.046	1.863ValGln: 1.863 ± 0.04	2.762ValArg: 2.762 ± 0.044	4.566ValSer: 4.566 ± 0.056	3.609ValThr: 3.609 ± 0.067	4.285ValVal: 4.285 ± 0.07	0.637ValTrp: 0.637 ± 0.025	2.737ValTyr: 2.737 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.522TrpAla: 0.522 ± 0.021	0.164TrpCys: 0.164 ± 0.011	0.564TrpAsp: 0.564 ± 0.02	0.824TrpGlu: 0.824 ± 0.025	0.418TrpPhe: 0.418 ± 0.02	0.758TrpGly: 0.758 ± 0.027	0.202TrpHis: 0.202 ± 0.014	0.758TrpIle: 0.758 ± 0.027	0.769TrpLys: 0.769 ± 0.024	0.901TrpLeu: 0.901 ± 0.032	0.336TrpMet: 0.336 ± 0.018	0.634TrpAsn: 0.634 ± 0.025	0.211TrpPro: 0.211 ± 0.013	0.436TrpGln: 0.436 ± 0.018	0.398TrpArg: 0.398 ± 0.016	0.471TrpSer: 0.471 ± 0.019	0.374TrpThr: 0.374 ± 0.015	0.517TrpVal: 0.517 ± 0.022	0.125TrpTrp: 0.125 ± 0.01	0.433TrpTyr: 0.433 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.863TyrAla: 2.863 ± 0.05	0.719TyrCys: 0.719 ± 0.023	2.569TyrAsp: 2.569 ± 0.057	3.465TyrGlu: 3.465 ± 0.055	2.098TyrPhe: 2.098 ± 0.043	3.072TyrGly: 3.072 ± 0.055	0.878TyrHis: 0.878 ± 0.027	2.998TyrIle: 2.998 ± 0.052	2.577TyrLys: 2.577 ± 0.048	4.171TyrLeu: 4.171 ± 0.055	1.242TyrMet: 1.242 ± 0.031	1.97TyrAsn: 1.97 ± 0.043	1.537TyrPro: 1.537 ± 0.033	1.755TyrGln: 1.755 ± 0.037	2.064TyrArg: 2.064 ± 0.041	2.508TyrSer: 2.508 ± 0.051	2.299TyrThr: 2.299 ± 0.053	2.67TyrVal: 2.67 ± 0.048	0.399TyrTrp: 0.399 ± 0.019	2.185TyrTyr: 2.185 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4280 proteins (1335959 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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