Amino acid dipepetide frequency for Paenibacillus crassostreae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.299AlaAla: 5.299 ± 0.08	0.585AlaCys: 0.585 ± 0.025	3.48AlaAsp: 3.48 ± 0.056	4.513AlaGlu: 4.513 ± 0.066	2.741AlaPhe: 2.741 ± 0.05	5.041AlaGly: 5.041 ± 0.081	1.237AlaHis: 1.237 ± 0.029	5.58AlaIle: 5.58 ± 0.062	3.851AlaLys: 3.851 ± 0.053	6.87AlaLeu: 6.87 ± 0.079	1.984AlaMet: 1.984 ± 0.041	2.698AlaAsn: 2.698 ± 0.044	2.017AlaPro: 2.017 ± 0.036	2.393AlaGln: 2.393 ± 0.05	2.718AlaArg: 2.718 ± 0.047	4.312AlaSer: 4.312 ± 0.064	3.743AlaThr: 3.743 ± 0.06	5.135AlaVal: 5.135 ± 0.076	0.707AlaTrp: 0.707 ± 0.029	2.307AlaTyr: 2.307 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.421CysAla: 0.421 ± 0.022	0.103CysCys: 0.103 ± 0.009	0.399CysAsp: 0.399 ± 0.019	0.45CysGlu: 0.45 ± 0.02	0.3CysPhe: 0.3 ± 0.014	0.744CysGly: 0.744 ± 0.025	0.208CysHis: 0.208 ± 0.014	0.601CysIle: 0.601 ± 0.021	0.389CysLys: 0.389 ± 0.017	0.708CysLeu: 0.708 ± 0.022	0.219CysMet: 0.219 ± 0.015	0.325CysAsn: 0.325 ± 0.018	0.319CysPro: 0.319 ± 0.016	0.245CysGln: 0.245 ± 0.013	0.376CysArg: 0.376 ± 0.018	0.578CysSer: 0.578 ± 0.024	0.43CysThr: 0.43 ± 0.019	0.477CysVal: 0.477 ± 0.02	0.083CysTrp: 0.083 ± 0.009	0.274CysTyr: 0.274 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.379AspAla: 3.379 ± 0.053	0.382AspCys: 0.382 ± 0.017	2.756AspAsp: 2.756 ± 0.051	4.101AspGlu: 4.101 ± 0.055	2.216AspPhe: 2.216 ± 0.045	3.667AspGly: 3.667 ± 0.063	1.339AspHis: 1.339 ± 0.033	4.35AspIle: 4.35 ± 0.063	2.99AspLys: 2.99 ± 0.05	5.215AspLeu: 5.215 ± 0.063	1.531AspMet: 1.531 ± 0.034	2.213AspAsn: 2.213 ± 0.045	2.198AspPro: 2.198 ± 0.04	2.214AspGln: 2.214 ± 0.043	2.465AspArg: 2.465 ± 0.049	3.01AspSer: 3.01 ± 0.054	2.728AspThr: 2.728 ± 0.05	3.773AspVal: 3.773 ± 0.063	0.797AspTrp: 0.797 ± 0.028	2.201AspTyr: 2.201 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.995GluAla: 4.995 ± 0.07	0.398GluCys: 0.398 ± 0.018	3.631GluAsp: 3.631 ± 0.057	5.455GluGlu: 5.455 ± 0.083	2.393GluPhe: 2.393 ± 0.052	4.31GluGly: 4.31 ± 0.063	1.545GluHis: 1.545 ± 0.046	5.239GluIle: 5.239 ± 0.062	4.312GluLys: 4.312 ± 0.061	7.248GluLeu: 7.248 ± 0.087	2.214GluMet: 2.214 ± 0.04	2.957GluAsn: 2.957 ± 0.049	1.971GluPro: 1.971 ± 0.038	3.624GluGln: 3.624 ± 0.057	3.409GluArg: 3.409 ± 0.057	3.98GluSer: 3.98 ± 0.057	3.135GluThr: 3.135 ± 0.06	4.934GluVal: 4.934 ± 0.075	0.95GluTrp: 0.95 ± 0.026	2.294GluTyr: 2.294 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	2.848PheAla: 2.848 ± 0.044	0.372PheCys: 0.372 ± 0.015	2.276PheAsp: 2.276 ± 0.044	2.525PheGlu: 2.525 ± 0.047	1.804PhePhe: 1.804 ± 0.045	3.048PheGly: 3.048 ± 0.051	0.91PheHis: 0.91 ± 0.031	3.509PheIle: 3.509 ± 0.063	2.113PheLys: 2.113 ± 0.041	3.751PheLeu: 3.751 ± 0.073	1.253PheMet: 1.253 ± 0.031	1.892PheAsn: 1.892 ± 0.042	1.536PhePro: 1.536 ± 0.034	1.48PheGln: 1.48 ± 0.034	1.75PheArg: 1.75 ± 0.039	2.919PheSer: 2.919 ± 0.053	2.558PheThr: 2.558 ± 0.046	2.807PheVal: 2.807 ± 0.05	0.545PheTrp: 0.545 ± 0.024	1.52PheTyr: 1.52 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.521GlyAla: 4.521 ± 0.084	0.659GlyCys: 0.659 ± 0.025	3.358GlyAsp: 3.358 ± 0.055	4.336GlyGlu: 4.336 ± 0.061	3.074GlyPhe: 3.074 ± 0.047	4.765GlyGly: 4.765 ± 0.076	1.44GlyHis: 1.44 ± 0.041	6.134GlyIle: 6.134 ± 0.08	4.346GlyLys: 4.346 ± 0.062	6.688GlyLeu: 6.688 ± 0.079	2.339GlyMet: 2.339 ± 0.043	2.96GlyAsn: 2.96 ± 0.051	1.698GlyPro: 1.698 ± 0.046	2.517GlyGln: 2.517 ± 0.046	2.936GlyArg: 2.936 ± 0.053	4.553GlySer: 4.553 ± 0.062	3.988GlyThr: 3.988 ± 0.063	5.033GlyVal: 5.033 ± 0.067	0.929GlyTrp: 0.929 ± 0.029	2.912GlyTyr: 2.912 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.384HisAla: 1.384 ± 0.037	0.192HisCys: 0.192 ± 0.012	1.078HisAsp: 1.078 ± 0.028	1.377HisGlu: 1.377 ± 0.033	1.026HisPhe: 1.026 ± 0.029	1.463HisGly: 1.463 ± 0.036	0.678HisHis: 0.678 ± 0.03	1.695HisIle: 1.695 ± 0.045	1.017HisLys: 1.017 ± 0.03	2.138HisLeu: 2.138 ± 0.053	0.607HisMet: 0.607 ± 0.023	0.871HisAsn: 0.871 ± 0.025	1.171HisPro: 1.171 ± 0.03	0.878HisGln: 0.878 ± 0.025	1.009HisArg: 1.009 ± 0.029	1.339HisSer: 1.339 ± 0.033	1.149HisThr: 1.149 ± 0.03	1.46HisVal: 1.46 ± 0.037	0.307HisTrp: 0.307 ± 0.015	0.945HisTyr: 0.945 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.006IleAla: 6.006 ± 0.073	0.677IleCys: 0.677 ± 0.025	4.299IleAsp: 4.299 ± 0.063	5.288IleGlu: 5.288 ± 0.07	2.976IlePhe: 2.976 ± 0.053	5.735IleGly: 5.735 ± 0.08	1.824IleHis: 1.824 ± 0.042	6.081IleIle: 6.081 ± 0.082	3.822IleLys: 3.822 ± 0.062	7.243IleLeu: 7.243 ± 0.093	2.03IleMet: 2.03 ± 0.037	3.293IleAsn: 3.293 ± 0.054	3.547IlePro: 3.547 ± 0.049	3.232IleGln: 3.232 ± 0.056	3.571IleArg: 3.571 ± 0.056	5.724IleSer: 5.724 ± 0.077	4.696IleThr: 4.696 ± 0.06	5.837IleVal: 5.837 ± 0.083	0.754IleTrp: 0.754 ± 0.022	2.478IleTyr: 2.478 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	3.756LysAla: 3.756 ± 0.052	0.321LysCys: 0.321 ± 0.017	3.37LysAsp: 3.37 ± 0.056	4.774LysGlu: 4.774 ± 0.062	1.785LysPhe: 1.785 ± 0.04	3.822LysGly: 3.822 ± 0.058	1.176LysHis: 1.176 ± 0.033	3.871LysIle: 3.871 ± 0.058	3.789LysLys: 3.789 ± 0.06	5.56LysLeu: 5.56 ± 0.066	1.833LysMet: 1.833 ± 0.036	2.61LysAsn: 2.61 ± 0.049	1.995LysPro: 1.995 ± 0.041	2.544LysGln: 2.544 ± 0.048	2.727LysArg: 2.727 ± 0.05	3.597LysSer: 3.597 ± 0.056	2.85LysThr: 2.85 ± 0.056	4.182LysVal: 4.182 ± 0.058	0.761LysTrp: 0.761 ± 0.026	2.077LysTyr: 2.077 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	6.81LeuAla: 6.81 ± 0.079	0.837LeuCys: 0.837 ± 0.026	5.388LeuAsp: 5.388 ± 0.067	6.348LeuGlu: 6.348 ± 0.071	4.434LeuPhe: 4.434 ± 0.079	6.474LeuGly: 6.474 ± 0.077	2.112LeuHis: 2.112 ± 0.041	7.439LeuIle: 7.439 ± 0.106	5.706LeuLys: 5.706 ± 0.069	10.217LeuLeu: 10.217 ± 0.117	2.796LeuMet: 2.796 ± 0.05	4.605LeuAsn: 4.605 ± 0.061	3.958LeuPro: 3.958 ± 0.058	4.067LeuGln: 4.067 ± 0.067	4.34LeuArg: 4.34 ± 0.067	7.445LeuSer: 7.445 ± 0.074	5.547LeuThr: 5.547 ± 0.069	6.187LeuVal: 6.187 ± 0.074	1.03LeuTrp: 1.03 ± 0.027	3.163LeuTyr: 3.163 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	1.997MetAla: 1.997 ± 0.041	0.167MetCys: 0.167 ± 0.011	1.722MetAsp: 1.722 ± 0.037	1.999MetGlu: 1.999 ± 0.043	1.083MetPhe: 1.083 ± 0.033	1.977MetGly: 1.977 ± 0.038	0.475MetHis: 0.475 ± 0.017	2.427MetIle: 2.427 ± 0.043	2.309MetLys: 2.309 ± 0.045	2.872MetLeu: 2.872 ± 0.056	1.004MetMet: 1.004 ± 0.034	1.813MetAsn: 1.813 ± 0.04	1.04MetPro: 1.04 ± 0.03	0.974MetGln: 0.974 ± 0.027	1.195MetArg: 1.195 ± 0.034	2.02MetSer: 2.02 ± 0.041	1.742MetThr: 1.742 ± 0.033	1.971MetVal: 1.971 ± 0.04	0.245MetTrp: 0.245 ± 0.013	0.797MetTyr: 0.797 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.705AsnAla: 2.705 ± 0.045	0.33AsnCys: 0.33 ± 0.016	2.387AsnAsp: 2.387 ± 0.043	3.194AsnGlu: 3.194 ± 0.049	1.566AsnPhe: 1.566 ± 0.033	3.385AsnGly: 3.385 ± 0.053	1.097AsnHis: 1.097 ± 0.028	3.504AsnIle: 3.504 ± 0.054	2.695AsnLys: 2.695 ± 0.05	3.979AsnLeu: 3.979 ± 0.057	1.288AsnMet: 1.288 ± 0.031	2.396AsnAsn: 2.396 ± 0.05	2.13AsnPro: 2.13 ± 0.041	1.906AsnGln: 1.906 ± 0.044	2.036AsnArg: 2.036 ± 0.036	2.732AsnSer: 2.732 ± 0.054	2.451AsnThr: 2.451 ± 0.046	3.032AsnVal: 3.032 ± 0.051	0.575AsnTrp: 0.575 ± 0.02	1.667AsnTyr: 1.667 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.218ProAla: 2.218 ± 0.047	0.229ProCys: 0.229 ± 0.012	2.197ProAsp: 2.197 ± 0.042	3.026ProGlu: 3.026 ± 0.047	1.776ProPhe: 1.776 ± 0.039	2.323ProGly: 2.323 ± 0.046	0.784ProHis: 0.784 ± 0.025	2.835ProIle: 2.835 ± 0.046	1.784ProLys: 1.784 ± 0.039	3.633ProLeu: 3.633 ± 0.057	0.983ProMet: 0.983 ± 0.032	1.705ProAsn: 1.705 ± 0.033	1.016ProPro: 1.016 ± 0.033	1.355ProGln: 1.355 ± 0.031	1.233ProArg: 1.233 ± 0.033	2.436ProSer: 2.436 ± 0.044	2.137ProThr: 2.137 ± 0.043	2.798ProVal: 2.798 ± 0.046	0.457ProTrp: 0.457 ± 0.018	1.433ProTyr: 1.433 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.778GlnAla: 2.778 ± 0.046	0.244GlnCys: 0.244 ± 0.016	1.925GlnAsp: 1.925 ± 0.044	2.872GlnGlu: 2.872 ± 0.052	1.648GlnPhe: 1.648 ± 0.033	2.544GlnGly: 2.544 ± 0.048	0.883GlnHis: 0.883 ± 0.026	2.96GlnIle: 2.96 ± 0.059	2.127GlnLys: 2.127 ± 0.042	4.466GlnLeu: 4.466 ± 0.062	1.286GlnMet: 1.286 ± 0.032	1.571GlnAsn: 1.571 ± 0.03	1.341GlnPro: 1.341 ± 0.033	2.098GlnGln: 2.098 ± 0.047	1.82GlnArg: 1.82 ± 0.033	2.568GlnSer: 2.568 ± 0.052	1.878GlnThr: 1.878 ± 0.041	2.698GlnVal: 2.698 ± 0.044	0.526GlnTrp: 0.526 ± 0.02	1.558GlnTyr: 1.558 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.457ArgAla: 2.457 ± 0.044	0.316ArgCys: 0.316 ± 0.015	2.299ArgAsp: 2.299 ± 0.049	3.194ArgGlu: 3.194 ± 0.056	1.861ArgPhe: 1.861 ± 0.038	2.626ArgGly: 2.626 ± 0.055	0.893ArgHis: 0.893 ± 0.028	3.671ArgIle: 3.671 ± 0.057	2.952ArgLys: 2.952 ± 0.046	4.379ArgLeu: 4.379 ± 0.064	1.486ArgMet: 1.486 ± 0.037	2.176ArgAsn: 2.176 ± 0.044	1.345ArgPro: 1.345 ± 0.037	1.705ArgGln: 1.705 ± 0.036	2.226ArgArg: 2.226 ± 0.046	2.803ArgSer: 2.803 ± 0.045	2.416ArgThr: 2.416 ± 0.043	2.897ArgVal: 2.897 ± 0.049	0.536ArgTrp: 0.536 ± 0.021	1.728ArgTyr: 1.728 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.998SerAla: 3.998 ± 0.057	0.454SerCys: 0.454 ± 0.017	3.468SerAsp: 3.468 ± 0.06	4.215SerGlu: 4.215 ± 0.069	3.198SerPhe: 3.198 ± 0.05	5.018SerGly: 5.018 ± 0.068	1.433SerHis: 1.433 ± 0.036	5.514SerIle: 5.514 ± 0.077	3.749SerLys: 3.749 ± 0.055	6.673SerLeu: 6.673 ± 0.071	1.995SerMet: 1.995 ± 0.036	3.058SerAsn: 3.058 ± 0.051	2.331SerPro: 2.331 ± 0.047	2.373SerGln: 2.373 ± 0.046	2.741SerArg: 2.741 ± 0.051	4.792SerSer: 4.792 ± 0.079	3.64SerThr: 3.64 ± 0.056	4.531SerVal: 4.531 ± 0.063	0.788SerTrp: 0.788 ± 0.025	2.495SerTyr: 2.495 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	3.887ThrAla: 3.887 ± 0.062	0.373ThrCys: 0.373 ± 0.017	2.891ThrAsp: 2.891 ± 0.053	3.457ThrGlu: 3.457 ± 0.058	2.482ThrPhe: 2.482 ± 0.047	4.157ThrGly: 4.157 ± 0.062	1.155ThrHis: 1.155 ± 0.034	4.452ThrIle: 4.452 ± 0.066	2.773ThrLys: 2.773 ± 0.049	5.726ThrLeu: 5.726 ± 0.077	1.456ThrMet: 1.456 ± 0.038	2.377ThrAsn: 2.377 ± 0.046	2.372ThrPro: 2.372 ± 0.046	1.79ThrGln: 1.79 ± 0.034	2.139ThrArg: 2.139 ± 0.045	3.692ThrSer: 3.692 ± 0.054	3.248ThrThr: 3.248 ± 0.057	4.247ThrVal: 4.247 ± 0.065	0.636ThrTrp: 0.636 ± 0.021	1.935ThrTyr: 1.935 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	4.867ValAla: 4.867 ± 0.073	0.578ValCys: 0.578 ± 0.02	3.896ValAsp: 3.896 ± 0.064	4.732ValGlu: 4.732 ± 0.078	2.822ValPhe: 2.822 ± 0.052	4.667ValGly: 4.667 ± 0.07	1.472ValHis: 1.472 ± 0.036	5.658ValIle: 5.658 ± 0.073	4.023ValLys: 4.023 ± 0.056	6.856ValLeu: 6.856 ± 0.077	2.076ValMet: 2.076 ± 0.043	3.252ValAsn: 3.252 ± 0.048	2.613ValPro: 2.613 ± 0.039	2.564ValGln: 2.564 ± 0.044	2.872ValArg: 2.872 ± 0.055	4.788ValSer: 4.788 ± 0.057	4.367ValThr: 4.367 ± 0.066	5.106ValVal: 5.106 ± 0.074	0.716ValTrp: 0.716 ± 0.022	2.294ValTyr: 2.294 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.683TrpAla: 0.683 ± 0.025	0.103TrpCys: 0.103 ± 0.008	0.696TrpAsp: 0.696 ± 0.023	0.745TrpGlu: 0.745 ± 0.025	0.532TrpPhe: 0.532 ± 0.022	0.816TrpGly: 0.816 ± 0.025	0.256TrpHis: 0.256 ± 0.017	1.049TrpIle: 1.049 ± 0.027	0.714TrpLys: 0.714 ± 0.023	1.24TrpLeu: 1.24 ± 0.028	0.457TrpMet: 0.457 ± 0.02	0.692TrpAsn: 0.692 ± 0.024	0.295TrpPro: 0.295 ± 0.015	0.425TrpGln: 0.425 ± 0.019	0.526TrpArg: 0.526 ± 0.021	0.784TrpSer: 0.784 ± 0.026	0.601TrpThr: 0.601 ± 0.021	0.78TrpVal: 0.78 ± 0.028	0.193TrpTrp: 0.193 ± 0.013	0.396TrpTyr: 0.396 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.201TyrAla: 2.201 ± 0.04	0.33TyrCys: 0.33 ± 0.018	2.013TyrAsp: 2.013 ± 0.04	2.392TyrGlu: 2.392 ± 0.04	1.702TyrPhe: 1.702 ± 0.038	2.604TyrGly: 2.604 ± 0.048	0.868TyrHis: 0.868 ± 0.025	2.546TyrIle: 2.546 ± 0.048	1.936TyrLys: 1.936 ± 0.037	3.442TyrLeu: 3.442 ± 0.053	0.994TyrMet: 0.994 ± 0.028	1.589TyrAsn: 1.589 ± 0.041	1.464TyrPro: 1.464 ± 0.031	1.404TyrGln: 1.404 ± 0.032	1.882TyrArg: 1.882 ± 0.043	2.39TyrSer: 2.39 ± 0.042	1.938TyrThr: 1.938 ± 0.039	2.334TyrVal: 2.334 ± 0.039	0.445TyrTrp: 0.445 ± 0.017	1.437TyrTyr: 1.437 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4133 proteins (1305229 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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