Amino acid dipepetide frequency for Serratia ficaria

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.34AlaAla: 13.34 ± 0.148	1.151AlaCys: 1.151 ± 0.032	5.64AlaAsp: 5.64 ± 0.067	6.445AlaGlu: 6.445 ± 0.079	3.854AlaPhe: 3.854 ± 0.059	9.073AlaGly: 9.073 ± 0.096	1.874AlaHis: 1.874 ± 0.041	5.932AlaIle: 5.932 ± 0.074	3.529AlaLys: 3.529 ± 0.056	13.985AlaLeu: 13.985 ± 0.128	3.058AlaMet: 3.058 ± 0.048	3.112AlaAsn: 3.112 ± 0.048	4.458AlaPro: 4.458 ± 0.075	5.225AlaGln: 5.225 ± 0.069	6.359AlaArg: 6.359 ± 0.061	5.356AlaSer: 5.356 ± 0.06	4.737AlaThr: 4.737 ± 0.063	7.468AlaVal: 7.468 ± 0.086	1.501AlaTrp: 1.501 ± 0.035	2.49AlaTyr: 2.49 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.035CysAla: 1.035 ± 0.031	0.163CysCys: 0.163 ± 0.011	0.541CysAsp: 0.541 ± 0.018	0.512CysGlu: 0.512 ± 0.018	0.407CysPhe: 0.407 ± 0.016	1.108CysGly: 1.108 ± 0.033	0.292CysHis: 0.292 ± 0.015	0.502CysIle: 0.502 ± 0.02	0.254CysLys: 0.254 ± 0.013	1.044CysLeu: 1.044 ± 0.024	0.234CysMet: 0.234 ± 0.013	0.293CysAsn: 0.293 ± 0.013	0.46CysPro: 0.46 ± 0.019	0.4CysGln: 0.4 ± 0.019	0.717CysArg: 0.717 ± 0.023	0.642CysSer: 0.642 ± 0.024	0.432CysThr: 0.432 ± 0.016	0.709CysVal: 0.709 ± 0.026	0.175CysTrp: 0.175 ± 0.011	0.308CysTyr: 0.308 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.589AspAla: 5.589 ± 0.065	0.506AspCys: 0.506 ± 0.017	2.831AspAsp: 2.831 ± 0.046	3.182AspGlu: 3.182 ± 0.057	2.092AspPhe: 2.092 ± 0.045	4.19AspGly: 4.19 ± 0.065	0.998AspHis: 0.998 ± 0.027	3.13AspIle: 3.13 ± 0.051	2.137AspLys: 2.137 ± 0.044	4.8AspLeu: 4.8 ± 0.065	1.29AspMet: 1.29 ± 0.03	1.928AspAsn: 1.928 ± 0.043	2.306AspPro: 2.306 ± 0.042	1.649AspGln: 1.649 ± 0.034	3.267AspArg: 3.267 ± 0.046	2.766AspSer: 2.766 ± 0.045	2.205AspThr: 2.205 ± 0.04	3.463AspVal: 3.463 ± 0.056	0.907AspTrp: 0.907 ± 0.026	1.844AspTyr: 1.844 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.221GluAla: 5.221 ± 0.072	0.392GluCys: 0.392 ± 0.016	2.249GluAsp: 2.249 ± 0.047	2.89GluGlu: 2.89 ± 0.059	1.72GluPhe: 1.72 ± 0.036	3.38GluGly: 3.38 ± 0.047	1.349GluHis: 1.349 ± 0.034	2.867GluIle: 2.867 ± 0.053	2.49GluLys: 2.49 ± 0.051	5.916GluLeu: 5.916 ± 0.083	1.609GluMet: 1.609 ± 0.036	1.962GluAsn: 1.962 ± 0.039	2.187GluPro: 2.187 ± 0.043	3.627GluGln: 3.627 ± 0.051	4.193GluArg: 4.193 ± 0.059	2.586GluSer: 2.586 ± 0.042	2.477GluThr: 2.477 ± 0.043	3.661GluVal: 3.661 ± 0.051	0.721GluTrp: 0.721 ± 0.024	1.293GluTyr: 1.293 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.823PheAla: 3.823 ± 0.053	0.51PheCys: 0.51 ± 0.02	2.395PheAsp: 2.395 ± 0.051	1.739PheGlu: 1.739 ± 0.035	1.638PhePhe: 1.638 ± 0.041	3.469PheGly: 3.469 ± 0.051	0.791PheHis: 0.791 ± 0.02	2.39PheIle: 2.39 ± 0.044	1.181PheLys: 1.181 ± 0.03	3.279PheLeu: 3.279 ± 0.06	0.958PheMet: 0.958 ± 0.024	1.704PheAsn: 1.704 ± 0.031	1.517PhePro: 1.517 ± 0.036	1.142PheGln: 1.142 ± 0.027	1.953PheArg: 1.953 ± 0.035	3.072PheSer: 3.072 ± 0.043	2.12PheThr: 2.12 ± 0.037	2.473PheVal: 2.473 ± 0.048	0.575PheTrp: 0.575 ± 0.021	1.239PheTyr: 1.239 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	7.506GlyAla: 7.506 ± 0.091	1.012GlyCys: 1.012 ± 0.027	3.924GlyAsp: 3.924 ± 0.064	4.799GlyGlu: 4.799 ± 0.062	3.334GlyPhe: 3.334 ± 0.053	6.255GlyGly: 6.255 ± 0.079	1.7GlyHis: 1.7 ± 0.039	4.852GlyIle: 4.852 ± 0.068	3.823GlyLys: 3.823 ± 0.054	8.352GlyLeu: 8.352 ± 0.095	2.481GlyMet: 2.481 ± 0.047	2.629GlyAsn: 2.629 ± 0.046	2.321GlyPro: 2.321 ± 0.037	3.29GlyGln: 3.29 ± 0.052	4.364GlyArg: 4.364 ± 0.057	4.468GlySer: 4.468 ± 0.058	3.567GlyThr: 3.567 ± 0.052	6.199GlyVal: 6.199 ± 0.07	1.424GlyTrp: 1.424 ± 0.035	2.828GlyTyr: 2.828 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.081HisAla: 2.081 ± 0.037	0.318HisCys: 0.318 ± 0.015	1.093HisAsp: 1.093 ± 0.028	0.984HisGlu: 0.984 ± 0.026	1.034HisPhe: 1.034 ± 0.026	1.826HisGly: 1.826 ± 0.039	0.692HisHis: 0.692 ± 0.023	1.18HisIle: 1.18 ± 0.028	0.587HisLys: 0.587 ± 0.021	2.261HisLeu: 2.261 ± 0.043	0.488HisMet: 0.488 ± 0.018	0.763HisAsn: 0.763 ± 0.024	1.358HisPro: 1.358 ± 0.03	1.25HisGln: 1.25 ± 0.025	1.487HisArg: 1.487 ± 0.036	1.226HisSer: 1.226 ± 0.027	0.963HisThr: 0.963 ± 0.026	1.152HisVal: 1.152 ± 0.03	0.422HisTrp: 0.422 ± 0.017	0.868HisTyr: 0.868 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.684IleAla: 6.684 ± 0.078	0.583IleCys: 0.583 ± 0.02	3.384IleAsp: 3.384 ± 0.05	3.114IleGlu: 3.114 ± 0.049	1.856IlePhe: 1.856 ± 0.043	5.035IleGly: 5.035 ± 0.066	1.01IleHis: 1.01 ± 0.028	2.701IleIle: 2.701 ± 0.058	2.001IleLys: 2.001 ± 0.043	4.64IleLeu: 4.64 ± 0.072	1.099IleMet: 1.099 ± 0.033	2.213IleAsn: 2.213 ± 0.043	2.462IlePro: 2.462 ± 0.04	1.664IleGln: 1.664 ± 0.037	2.833IleArg: 2.833 ± 0.044	3.302IleSer: 3.302 ± 0.048	2.923IleThr: 2.923 ± 0.045	3.746IleVal: 3.746 ± 0.055	0.585IleTrp: 0.585 ± 0.026	1.445IleTyr: 1.445 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.748LysAla: 3.748 ± 0.067	0.208LysCys: 0.208 ± 0.013	1.79LysAsp: 1.79 ± 0.044	1.838LysGlu: 1.838 ± 0.044	0.94LysPhe: 0.94 ± 0.026	2.551LysGly: 2.551 ± 0.051	0.77LysHis: 0.77 ± 0.023	2.003LysIle: 2.003 ± 0.038	1.757LysLys: 1.757 ± 0.041	3.849LysLeu: 3.849 ± 0.049	1.058LysMet: 1.058 ± 0.031	1.419LysAsn: 1.419 ± 0.033	2.001LysPro: 2.001 ± 0.041	1.853LysGln: 1.853 ± 0.035	2.429LysArg: 2.429 ± 0.044	1.949LysSer: 1.949 ± 0.039	2.117LysThr: 2.117 ± 0.042	2.684LysVal: 2.684 ± 0.04	0.363LysTrp: 0.363 ± 0.018	0.946LysTyr: 0.946 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	13.824LeuAla: 13.824 ± 0.131	1.271LeuCys: 1.271 ± 0.027	5.609LeuAsp: 5.609 ± 0.073	5.41LeuGlu: 5.41 ± 0.065	4.407LeuPhe: 4.407 ± 0.062	8.352LeuGly: 8.352 ± 0.094	2.352LeuHis: 2.352 ± 0.045	5.703LeuIle: 5.703 ± 0.073	4.075LeuLys: 4.075 ± 0.061	13.433LeuLeu: 13.433 ± 0.151	3.056LeuMet: 3.056 ± 0.054	3.946LeuAsn: 3.946 ± 0.053	6.217LeuPro: 6.217 ± 0.071	5.033LeuGln: 5.033 ± 0.061	6.785LeuArg: 6.785 ± 0.071	7.512LeuSer: 7.512 ± 0.08	6.164LeuThr: 6.164 ± 0.063	7.4LeuVal: 7.4 ± 0.078	1.433LeuTrp: 1.433 ± 0.032	2.667LeuTyr: 2.667 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.052MetAla: 3.052 ± 0.045	0.189MetCys: 0.189 ± 0.011	1.089MetAsp: 1.089 ± 0.027	1.038MetGlu: 1.038 ± 0.027	0.89MetPhe: 0.89 ± 0.024	1.798MetGly: 1.798 ± 0.042	0.49MetHis: 0.49 ± 0.019	1.377MetIle: 1.377 ± 0.035	1.195MetLys: 1.195 ± 0.032	3.256MetLeu: 3.256 ± 0.048	0.783MetMet: 0.783 ± 0.026	0.96MetAsn: 0.96 ± 0.028	1.375MetPro: 1.375 ± 0.03	1.155MetGln: 1.155 ± 0.028	1.523MetArg: 1.523 ± 0.033	1.797MetSer: 1.797 ± 0.034	1.599MetThr: 1.599 ± 0.03	1.78MetVal: 1.78 ± 0.038	0.224MetTrp: 0.224 ± 0.012	0.494MetTyr: 0.494 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.524AsnAla: 3.524 ± 0.047	0.306AsnCys: 0.306 ± 0.016	1.878AsnAsp: 1.878 ± 0.042	1.523AsnGlu: 1.523 ± 0.033	1.22AsnPhe: 1.22 ± 0.03	2.97AsnGly: 2.97 ± 0.053	0.751AsnHis: 0.751 ± 0.023	1.918AsnIle: 1.918 ± 0.039	1.216AsnLys: 1.216 ± 0.028	3.38AsnLeu: 3.38 ± 0.052	0.783AsnMet: 0.783 ± 0.025	1.305AsnAsn: 1.305 ± 0.027	2.063AsnPro: 2.063 ± 0.038	1.511AsnGln: 1.511 ± 0.035	2.094AsnArg: 2.094 ± 0.04	1.722AsnSer: 1.722 ± 0.037	1.6AsnThr: 1.6 ± 0.036	2.294AsnVal: 2.294 ± 0.044	0.482AsnTrp: 0.482 ± 0.021	1.074AsnTyr: 1.074 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.567ProAla: 5.567 ± 0.071	0.383ProCys: 0.383 ± 0.013	2.586ProAsp: 2.586 ± 0.043	3.194ProGlu: 3.194 ± 0.052	1.862ProPhe: 1.862 ± 0.038	3.622ProGly: 3.622 ± 0.05	1.108ProHis: 1.108 ± 0.029	2.054ProIle: 2.054 ± 0.04	1.439ProLys: 1.439 ± 0.032	5.787ProLeu: 5.787 ± 0.065	1.12ProMet: 1.12 ± 0.027	1.383ProAsn: 1.383 ± 0.034	2.036ProPro: 2.036 ± 0.038	2.926ProGln: 2.926 ± 0.051	2.22ProArg: 2.22 ± 0.037	2.226ProSer: 2.226 ± 0.04	2.131ProThr: 2.131 ± 0.045	3.54ProVal: 3.54 ± 0.054	0.706ProTrp: 0.706 ± 0.02	1.327ProTyr: 1.327 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	5.635GlnAla: 5.635 ± 0.068	0.361GlnCys: 0.361 ± 0.016	2.019GlnAsp: 2.019 ± 0.04	2.055GlnGlu: 2.055 ± 0.038	1.446GlnPhe: 1.446 ± 0.035	3.665GlnGly: 3.665 ± 0.045	1.274GlnHis: 1.274 ± 0.029	2.151GlnIle: 2.151 ± 0.039	1.547GlnLys: 1.547 ± 0.037	5.544GlnLeu: 5.544 ± 0.077	1.177GlnMet: 1.177 ± 0.029	1.295GlnAsn: 1.295 ± 0.031	2.69GlnPro: 2.69 ± 0.041	3.737GlnGln: 3.737 ± 0.08	4.042GlnArg: 4.042 ± 0.059	2.249GlnSer: 2.249 ± 0.042	2.082GlnThr: 2.082 ± 0.037	3.321GlnVal: 3.321 ± 0.051	0.715GlnTrp: 0.715 ± 0.026	1.133GlnTyr: 1.133 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	5.631ArgAla: 5.631 ± 0.067	0.643ArgCys: 0.643 ± 0.023	3.125ArgAsp: 3.125 ± 0.048	3.648ArgGlu: 3.648 ± 0.052	2.73ArgPhe: 2.73 ± 0.037	3.924ArgGly: 3.924 ± 0.054	1.803ArgHis: 1.803 ± 0.038	3.42ArgIle: 3.42 ± 0.05	2.075ArgLys: 2.075 ± 0.039	7.901ArgLeu: 7.901 ± 0.098	1.618ArgMet: 1.618 ± 0.036	1.909ArgAsn: 1.909 ± 0.038	2.697ArgPro: 2.697 ± 0.044	3.85ArgGln: 3.85 ± 0.063	4.534ArgArg: 4.534 ± 0.068	3.069ArgSer: 3.069 ± 0.048	2.412ArgThr: 2.412 ± 0.039	4.216ArgVal: 4.216 ± 0.049	1.052ArgTrp: 1.052 ± 0.029	2.297ArgTyr: 2.297 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.022SerAla: 6.022 ± 0.066	0.557SerCys: 0.557 ± 0.018	2.803SerAsp: 2.803 ± 0.047	2.833SerGlu: 2.833 ± 0.041	2.336SerPhe: 2.336 ± 0.036	5.327SerGly: 5.327 ± 0.069	1.349SerHis: 1.349 ± 0.033	2.796SerIle: 2.796 ± 0.051	1.77SerLys: 1.77 ± 0.036	6.723SerLeu: 6.723 ± 0.064	1.371SerMet: 1.371 ± 0.033	1.693SerAsn: 1.693 ± 0.039	2.602SerPro: 2.602 ± 0.045	2.451SerGln: 2.451 ± 0.046	3.462SerArg: 3.462 ± 0.047	3.176SerSer: 3.176 ± 0.053	2.594SerThr: 2.594 ± 0.044	3.956SerVal: 3.956 ± 0.056	0.898SerTrp: 0.898 ± 0.029	1.69SerTyr: 1.69 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.979ThrAla: 4.979 ± 0.06	0.398ThrCys: 0.398 ± 0.018	2.342ThrAsp: 2.342 ± 0.043	2.267ThrGlu: 2.267 ± 0.043	1.811ThrPhe: 1.811 ± 0.036	4.06ThrGly: 4.06 ± 0.06	1.089ThrHis: 1.089 ± 0.026	2.281ThrIle: 2.281 ± 0.042	1.198ThrLys: 1.198 ± 0.033	7.405ThrLeu: 7.405 ± 0.071	0.897ThrMet: 0.897 ± 0.026	1.234ThrAsn: 1.234 ± 0.032	3.225ThrPro: 3.225 ± 0.053	1.995ThrGln: 1.995 ± 0.038	2.957ThrArg: 2.957 ± 0.047	2.424ThrSer: 2.424 ± 0.04	2.34ThrThr: 2.34 ± 0.048	3.43ThrVal: 3.43 ± 0.048	0.592ThrTrp: 0.592 ± 0.021	1.169ThrTyr: 1.169 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	7.624ValAla: 7.624 ± 0.079	0.752ValCys: 0.752 ± 0.025	3.651ValAsp: 3.651 ± 0.052	3.766ValGlu: 3.766 ± 0.055	2.576ValPhe: 2.576 ± 0.046	5.202ValGly: 5.202 ± 0.065	1.215ValHis: 1.215 ± 0.032	4.199ValIle: 4.199 ± 0.059	2.806ValLys: 2.806 ± 0.045	7.313ValLeu: 7.313 ± 0.073	2.049ValMet: 2.049 ± 0.039	2.538ValAsn: 2.538 ± 0.04	3.089ValPro: 3.089 ± 0.049	2.447ValGln: 2.447 ± 0.039	3.833ValArg: 3.833 ± 0.053	4.478ValSer: 4.478 ± 0.062	3.883ValThr: 3.883 ± 0.047	5.368ValVal: 5.368 ± 0.069	0.887ValTrp: 0.887 ± 0.025	1.742ValTyr: 1.742 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.075TrpAla: 1.075 ± 0.028	0.165TrpCys: 0.165 ± 0.012	0.594TrpAsp: 0.594 ± 0.021	0.522TrpGlu: 0.522 ± 0.019	0.625TrpPhe: 0.625 ± 0.024	0.95TrpGly: 0.95 ± 0.026	0.391TrpHis: 0.391 ± 0.018	0.615TrpIle: 0.615 ± 0.02	0.415TrpLys: 0.415 ± 0.017	2.35TrpLeu: 2.35 ± 0.052	0.38TrpMet: 0.38 ± 0.015	0.428TrpAsn: 0.428 ± 0.019	0.663TrpPro: 0.663 ± 0.02	1.173TrpGln: 1.173 ± 0.031	1.256TrpArg: 1.256 ± 0.037	0.764TrpSer: 0.764 ± 0.028	0.48TrpThr: 0.48 ± 0.019	0.903TrpVal: 0.903 ± 0.027	0.232TrpTrp: 0.232 ± 0.014	0.361TrpTyr: 0.361 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.625TyrAla: 2.625 ± 0.042	0.359TyrCys: 0.359 ± 0.015	1.536TyrAsp: 1.536 ± 0.043	1.028TyrGlu: 1.028 ± 0.028	1.187TyrPhe: 1.187 ± 0.026	2.372TyrGly: 2.372 ± 0.047	0.736TyrHis: 0.736 ± 0.023	1.208TyrIle: 1.208 ± 0.027	0.781TyrLys: 0.781 ± 0.028	3.434TyrLeu: 3.434 ± 0.046	0.552TyrMet: 0.552 ± 0.016	0.9TyrAsn: 0.9 ± 0.031	1.491TyrPro: 1.491 ± 0.031	1.76TyrGln: 1.76 ± 0.035	2.248TyrArg: 2.248 ± 0.045	1.626TyrSer: 1.626 ± 0.037	1.267TyrThr: 1.267 ± 0.03	1.656TyrVal: 1.656 ± 0.029	0.45TyrTrp: 0.45 ± 0.017	0.921TyrTyr: 0.921 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4652 proteins (1501398 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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