Amino acid dipepetide frequency for Arsenophonus nasoniae (son-killer infecting Nasonia vitripennis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.344AlaAla: 6.344 ± 0.103	1.01AlaCys: 1.01 ± 0.028	3.965AlaAsp: 3.965 ± 0.069	5.025AlaGlu: 5.025 ± 0.076	2.794AlaPhe: 2.794 ± 0.048	4.971AlaGly: 4.971 ± 0.084	1.455AlaHis: 1.455 ± 0.035	6.297AlaIle: 6.297 ± 0.09	5.58AlaLys: 5.58 ± 0.071	8.237AlaLeu: 8.237 ± 0.098	2.168AlaMet: 2.168 ± 0.035	3.923AlaAsn: 3.923 ± 0.077	2.177AlaPro: 2.177 ± 0.045	3.434AlaGln: 3.434 ± 0.07	3.539AlaArg: 3.539 ± 0.062	4.291AlaSer: 4.291 ± 0.06	4.242AlaThr: 4.242 ± 0.088	4.637AlaVal: 4.637 ± 0.072	0.88AlaTrp: 0.88 ± 0.032	2.264AlaTyr: 2.264 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.864CysAla: 0.864 ± 0.029	0.262CysCys: 0.262 ± 0.017	0.662CysAsp: 0.662 ± 0.027	0.562CysGlu: 0.562 ± 0.025	0.549CysPhe: 0.549 ± 0.022	0.925CysGly: 0.925 ± 0.032	0.372CysHis: 0.372 ± 0.018	0.705CysIle: 0.705 ± 0.03	0.559CysLys: 0.559 ± 0.019	1.109CysLeu: 1.109 ± 0.031	0.236CysMet: 0.236 ± 0.013	0.427CysAsn: 0.427 ± 0.018	0.428CysPro: 0.428 ± 0.021	0.759CysGln: 0.759 ± 0.029	0.584CysArg: 0.584 ± 0.024	0.812CysSer: 0.812 ± 0.031	0.431CysThr: 0.431 ± 0.021	0.597CysVal: 0.597 ± 0.023	0.165CysTrp: 0.165 ± 0.012	0.458CysTyr: 0.458 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.448AspAla: 3.448 ± 0.055	0.673AspCys: 0.673 ± 0.027	2.646AspAsp: 2.646 ± 0.05	3.442AspGlu: 3.442 ± 0.055	2.402AspPhe: 2.402 ± 0.048	3.158AspGly: 3.158 ± 0.058	0.951AspHis: 0.951 ± 0.03	4.339AspIle: 4.339 ± 0.06	3.672AspLys: 3.672 ± 0.064	4.375AspLeu: 4.375 ± 0.067	1.209AspMet: 1.209 ± 0.034	3.095AspAsn: 3.095 ± 0.06	1.937AspPro: 1.937 ± 0.039	1.53AspGln: 1.53 ± 0.038	2.119AspArg: 2.119 ± 0.045	2.834AspSer: 2.834 ± 0.054	2.413AspThr: 2.413 ± 0.047	2.939AspVal: 2.939 ± 0.048	0.846AspTrp: 0.846 ± 0.028	2.091AspTyr: 2.091 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	4.108GluAla: 4.108 ± 0.073	0.47GluCys: 0.47 ± 0.018	2.043GluAsp: 2.043 ± 0.044	3.206GluGlu: 3.206 ± 0.064	2.063GluPhe: 2.063 ± 0.045	3.004GluGly: 3.004 ± 0.061	1.265GluHis: 1.265 ± 0.035	4.907GluIle: 4.907 ± 0.078	4.979GluLys: 4.979 ± 0.069	5.954GluLeu: 5.954 ± 0.086	1.666GluMet: 1.666 ± 0.036	3.324GluAsn: 3.324 ± 0.059	1.616GluPro: 1.616 ± 0.035	3.466GluGln: 3.466 ± 0.063	3.341GluArg: 3.341 ± 0.066	2.976GluSer: 2.976 ± 0.054	2.772GluThr: 2.772 ± 0.048	3.337GluVal: 3.337 ± 0.057	0.69GluTrp: 0.69 ± 0.024	1.73GluTyr: 1.73 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.096PheAla: 3.096 ± 0.047	0.693PheCys: 0.693 ± 0.025	2.562PheAsp: 2.562 ± 0.053	2.05PheGlu: 2.05 ± 0.042	2.161PhePhe: 2.161 ± 0.051	2.628PheGly: 2.628 ± 0.048	0.804PheHis: 0.804 ± 0.024	3.405PheIle: 3.405 ± 0.065	2.346PheLys: 2.346 ± 0.044	3.64PheLeu: 3.64 ± 0.061	1.025PheMet: 1.025 ± 0.027	2.484PheAsn: 2.484 ± 0.043	1.423PhePro: 1.423 ± 0.036	1.237PheGln: 1.237 ± 0.033	1.648PheArg: 1.648 ± 0.042	3.405PheSer: 3.405 ± 0.054	2.494PheThr: 2.494 ± 0.047	2.212PheVal: 2.212 ± 0.045	0.523PheTrp: 0.523 ± 0.023	1.577PheTyr: 1.577 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.275GlyAla: 4.275 ± 0.072	0.823GlyCys: 0.823 ± 0.027	2.956GlyAsp: 2.956 ± 0.054	3.6GlyGlu: 3.6 ± 0.057	3.0GlyPhe: 3.0 ± 0.063	4.09GlyGly: 4.09 ± 0.076	1.337GlyHis: 1.337 ± 0.034	5.118GlyIle: 5.118 ± 0.068	4.598GlyLys: 4.598 ± 0.089	6.078GlyLeu: 6.078 ± 0.073	1.67GlyMet: 1.67 ± 0.039	3.0GlyAsn: 3.0 ± 0.07	1.189GlyPro: 1.189 ± 0.037	2.676GlyGln: 2.676 ± 0.057	2.921GlyArg: 2.921 ± 0.058	3.464GlySer: 3.464 ± 0.06	2.878GlyThr: 2.878 ± 0.058	3.945GlyVal: 3.945 ± 0.065	0.904GlyTrp: 0.904 ± 0.03	2.497GlyTyr: 2.497 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.463HisAla: 1.463 ± 0.034	0.365HisCys: 0.365 ± 0.017	1.022HisAsp: 1.022 ± 0.03	1.068HisGlu: 1.068 ± 0.028	1.145HisPhe: 1.145 ± 0.032	1.308HisGly: 1.308 ± 0.039	0.864HisHis: 0.864 ± 0.025	1.779HisIle: 1.779 ± 0.047	1.076HisLys: 1.076 ± 0.027	2.348HisLeu: 2.348 ± 0.05	0.431HisMet: 0.431 ± 0.02	1.197HisAsn: 1.197 ± 0.033	1.033HisPro: 1.033 ± 0.031	1.264HisGln: 1.264 ± 0.036	1.123HisArg: 1.123 ± 0.033	1.432HisSer: 1.432 ± 0.038	1.063HisThr: 1.063 ± 0.03	1.249HisVal: 1.249 ± 0.033	0.378HisTrp: 0.378 ± 0.018	1.128HisTyr: 1.128 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.834IleAla: 6.834 ± 0.085	0.881IleCys: 0.881 ± 0.031	4.71IleAsp: 4.71 ± 0.064	5.009IleGlu: 5.009 ± 0.069	3.003IlePhe: 3.003 ± 0.061	4.978IleGly: 4.978 ± 0.064	1.555IleHis: 1.555 ± 0.037	5.715IleIle: 5.715 ± 0.091	4.896IleLys: 4.896 ± 0.069	6.554IleLeu: 6.554 ± 0.084	1.637IleMet: 1.637 ± 0.032	4.802IleAsn: 4.802 ± 0.076	3.19IlePro: 3.19 ± 0.057	2.729IleGln: 2.729 ± 0.046	3.46IleArg: 3.46 ± 0.061	5.289IleSer: 5.289 ± 0.07	4.777IleThr: 4.777 ± 0.074	4.081IleVal: 4.081 ± 0.059	0.8IleTrp: 0.8 ± 0.025	2.512IleTyr: 2.512 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	4.939LysAla: 4.939 ± 0.097	0.466LysCys: 0.466 ± 0.021	3.004LysAsp: 3.004 ± 0.053	3.832LysGlu: 3.832 ± 0.075	1.944LysPhe: 1.944 ± 0.043	3.63LysGly: 3.63 ± 0.056	1.429LysHis: 1.429 ± 0.036	4.992LysIle: 4.992 ± 0.073	5.21LysLys: 5.21 ± 0.095	6.581LysLeu: 6.581 ± 0.089	1.766LysMet: 1.766 ± 0.038	3.82LysAsn: 3.82 ± 0.076	2.78LysPro: 2.78 ± 0.058	3.543LysGln: 3.543 ± 0.059	3.409LysArg: 3.409 ± 0.055	3.852LysSer: 3.852 ± 0.063	3.852LysThr: 3.852 ± 0.076	3.7LysVal: 3.7 ± 0.059	0.643LysTrp: 0.643 ± 0.024	2.012LysTyr: 2.012 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	8.849LeuAla: 8.849 ± 0.106	1.268LeuCys: 1.268 ± 0.034	4.951LeuAsp: 4.951 ± 0.068	5.047LeuGlu: 5.047 ± 0.074	4.476LeuPhe: 4.476 ± 0.067	5.792LeuGly: 5.792 ± 0.087	2.059LeuHis: 2.059 ± 0.041	7.496LeuIle: 7.496 ± 0.096	6.401LeuLys: 6.401 ± 0.077	10.721LeuLeu: 10.721 ± 0.145	2.571LeuMet: 2.571 ± 0.046	5.418LeuAsn: 5.418 ± 0.078	5.301LeuPro: 5.301 ± 0.11	4.166LeuGln: 4.166 ± 0.062	4.85LeuArg: 4.85 ± 0.072	7.675LeuSer: 7.675 ± 0.1	6.489LeuThr: 6.489 ± 0.097	5.447LeuVal: 5.447 ± 0.072	1.038LeuTrp: 1.038 ± 0.032	2.731LeuTyr: 2.731 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.298MetAla: 2.298 ± 0.042	0.201MetCys: 0.201 ± 0.012	0.924MetAsp: 0.924 ± 0.026	1.125MetGlu: 1.125 ± 0.031	0.704MetPhe: 0.704 ± 0.026	1.512MetGly: 1.512 ± 0.038	0.379MetHis: 0.379 ± 0.018	1.81MetIle: 1.81 ± 0.039	1.729MetLys: 1.729 ± 0.041	2.834MetLeu: 2.834 ± 0.05	0.725MetMet: 0.725 ± 0.025	1.164MetAsn: 1.164 ± 0.034	1.18MetPro: 1.18 ± 0.03	1.206MetGln: 1.206 ± 0.033	1.204MetArg: 1.204 ± 0.032	1.672MetSer: 1.672 ± 0.039	1.561MetThr: 1.561 ± 0.037	1.49MetVal: 1.49 ± 0.031	0.228MetTrp: 0.228 ± 0.015	0.52MetTyr: 0.52 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.735AsnAla: 3.735 ± 0.06	0.511AsnCys: 0.511 ± 0.018	2.712AsnAsp: 2.712 ± 0.053	2.903AsnGlu: 2.903 ± 0.048	1.939AsnPhe: 1.939 ± 0.045	3.337AsnGly: 3.337 ± 0.071	1.244AsnHis: 1.244 ± 0.031	4.389AsnIle: 4.389 ± 0.072	3.647AsnLys: 3.647 ± 0.066	4.768AsnLeu: 4.768 ± 0.074	1.15AsnMet: 1.15 ± 0.031	3.662AsnAsn: 3.662 ± 0.096	2.109AsnPro: 2.109 ± 0.044	2.803AsnGln: 2.803 ± 0.062	2.493AsnArg: 2.493 ± 0.049	3.267AsnSer: 3.267 ± 0.057	2.694AsnThr: 2.694 ± 0.052	2.71AsnVal: 2.71 ± 0.049	0.799AsnTrp: 0.799 ± 0.025	2.018AsnTyr: 2.018 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	3.049ProAla: 3.049 ± 0.056	0.356ProCys: 0.356 ± 0.019	2.449ProAsp: 2.449 ± 0.048	2.674ProGlu: 2.674 ± 0.046	1.742ProPhe: 1.742 ± 0.037	1.97ProGly: 1.97 ± 0.05	0.934ProHis: 0.934 ± 0.027	2.871ProIle: 2.871 ± 0.055	2.239ProLys: 2.239 ± 0.049	3.881ProLeu: 3.881 ± 0.061	0.827ProMet: 0.827 ± 0.027	1.913ProAsn: 1.913 ± 0.042	1.373ProPro: 1.373 ± 0.037	1.75ProGln: 1.75 ± 0.042	1.381ProArg: 1.381 ± 0.035	2.256ProSer: 2.256 ± 0.04	2.275ProThr: 2.275 ± 0.055	2.653ProVal: 2.653 ± 0.049	0.503ProTrp: 0.503 ± 0.024	1.422ProTyr: 1.422 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.744GlnAla: 3.744 ± 0.069	0.423GlnCys: 0.423 ± 0.019	1.781GlnAsp: 1.781 ± 0.038	2.322GlnGlu: 2.322 ± 0.055	1.95GlnPhe: 1.95 ± 0.041	2.698GlnGly: 2.698 ± 0.049	1.39GlnHis: 1.39 ± 0.033	3.464GlnIle: 3.464 ± 0.055	2.854GlnLys: 2.854 ± 0.052	5.689GlnLeu: 5.689 ± 0.09	1.123GlnMet: 1.123 ± 0.031	1.984GlnAsn: 1.984 ± 0.046	1.901GlnPro: 1.901 ± 0.053	4.062GlnGln: 4.062 ± 0.07	2.627GlnArg: 2.627 ± 0.052	2.77GlnSer: 2.77 ± 0.049	2.419GlnThr: 2.419 ± 0.049	2.596GlnVal: 2.596 ± 0.051	0.646GlnTrp: 0.646 ± 0.025	1.669GlnTyr: 1.669 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	3.304ArgAla: 3.304 ± 0.059	0.504ArgCys: 0.504 ± 0.024	2.333ArgAsp: 2.333 ± 0.047	2.797ArgGlu: 2.797 ± 0.057	2.428ArgPhe: 2.428 ± 0.049	2.583ArgGly: 2.583 ± 0.05	1.342ArgHis: 1.342 ± 0.036	3.554ArgIle: 3.554 ± 0.061	3.171ArgLys: 3.171 ± 0.051	5.509ArgLeu: 5.509 ± 0.077	1.172ArgMet: 1.172 ± 0.028	2.211ArgAsn: 2.211 ± 0.043	1.723ArgPro: 1.723 ± 0.036	2.835ArgGln: 2.835 ± 0.049	2.874ArgArg: 2.874 ± 0.061	2.405ArgSer: 2.405 ± 0.042	2.079ArgThr: 2.079 ± 0.045	2.581ArgVal: 2.581 ± 0.053	0.738ArgTrp: 0.738 ± 0.03	2.258ArgTyr: 2.258 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	4.751SerAla: 4.751 ± 0.073	0.646SerCys: 0.646 ± 0.026	3.059SerAsp: 3.059 ± 0.049	3.443SerGlu: 3.443 ± 0.055	2.678SerPhe: 2.678 ± 0.052	4.304SerGly: 4.304 ± 0.07	1.625SerHis: 1.625 ± 0.037	4.49SerIle: 4.49 ± 0.069	3.381SerLys: 3.381 ± 0.06	6.984SerLeu: 6.984 ± 0.089	1.467SerMet: 1.467 ± 0.034	2.958SerAsn: 2.958 ± 0.063	2.533SerPro: 2.533 ± 0.053	2.996SerGln: 2.996 ± 0.06	2.897SerArg: 2.897 ± 0.05	3.926SerSer: 3.926 ± 0.075	3.14SerThr: 3.14 ± 0.052	4.062SerVal: 4.062 ± 0.06	0.854SerTrp: 0.854 ± 0.028	2.104SerTyr: 2.104 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.436ThrAla: 4.436 ± 0.1	0.505ThrCys: 0.505 ± 0.022	2.855ThrAsp: 2.855 ± 0.065	3.371ThrGlu: 3.371 ± 0.054	2.133ThrPhe: 2.133 ± 0.049	3.762ThrGly: 3.762 ± 0.059	1.193ThrHis: 1.193 ± 0.034	4.145ThrIle: 4.145 ± 0.074	3.017ThrLys: 3.017 ± 0.053	6.462ThrLeu: 6.462 ± 0.076	1.089ThrMet: 1.089 ± 0.03	2.393ThrAsn: 2.393 ± 0.054	2.532ThrPro: 2.532 ± 0.052	2.418ThrGln: 2.418 ± 0.054	2.275ThrArg: 2.275 ± 0.046	3.071ThrSer: 3.071 ± 0.057	3.158ThrThr: 3.158 ± 0.066	3.396ThrVal: 3.396 ± 0.076	0.554ThrTrp: 0.554 ± 0.022	1.688ThrTyr: 1.688 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	4.532ValAla: 4.532 ± 0.076	0.68ValCys: 0.68 ± 0.026	3.155ValAsp: 3.155 ± 0.055	3.456ValGlu: 3.456 ± 0.055	2.142ValPhe: 2.142 ± 0.049	3.436ValGly: 3.436 ± 0.063	1.101ValHis: 1.101 ± 0.035	4.853ValIle: 4.853 ± 0.071	3.917ValLys: 3.917 ± 0.07	5.134ValLeu: 5.134 ± 0.074	1.631ValMet: 1.631 ± 0.04	3.065ValAsn: 3.065 ± 0.052	2.128ValPro: 2.128 ± 0.046	1.767ValGln: 1.767 ± 0.038	2.748ValArg: 2.748 ± 0.051	3.998ValSer: 3.998 ± 0.076	3.718ValThr: 3.718 ± 0.096	3.792ValVal: 3.792 ± 0.069	0.718ValTrp: 0.718 ± 0.024	1.717ValTyr: 1.717 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.724TrpAla: 0.724 ± 0.024	0.193TrpCys: 0.193 ± 0.012	0.513TrpAsp: 0.513 ± 0.02	0.456TrpGlu: 0.456 ± 0.022	0.527TrpPhe: 0.527 ± 0.021	0.661TrpGly: 0.661 ± 0.023	0.428TrpHis: 0.428 ± 0.021	0.85TrpIle: 0.85 ± 0.023	0.597TrpLys: 0.597 ± 0.021	1.932TrpLeu: 1.932 ± 0.047	0.3TrpMet: 0.3 ± 0.016	0.533TrpAsn: 0.533 ± 0.021	0.549TrpPro: 0.549 ± 0.022	1.197TrpGln: 1.197 ± 0.034	0.844TrpArg: 0.844 ± 0.024	0.689TrpSer: 0.689 ± 0.023	0.405TrpThr: 0.405 ± 0.016	0.653TrpVal: 0.653 ± 0.025	0.155TrpTrp: 0.155 ± 0.011	0.36TrpTyr: 0.36 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.441TyrAla: 2.441 ± 0.05	0.538TyrCys: 0.538 ± 0.019	1.818TyrAsp: 1.818 ± 0.046	1.532TyrGlu: 1.532 ± 0.032	1.631TyrPhe: 1.631 ± 0.041	2.271TyrGly: 2.271 ± 0.043	1.009TyrHis: 1.009 ± 0.03	2.233TyrIle: 2.233 ± 0.047	1.534TyrLys: 1.534 ± 0.042	3.955TyrLeu: 3.955 ± 0.067	0.602TyrMet: 0.602 ± 0.021	1.516TyrAsn: 1.516 ± 0.039	1.415TyrPro: 1.415 ± 0.035	2.273TyrGln: 2.273 ± 0.048	2.063TyrArg: 2.063 ± 0.042	2.213TyrSer: 2.213 ± 0.047	1.594TyrThr: 1.594 ± 0.038	1.612TyrVal: 1.612 ± 0.035	0.504TyrTrp: 0.504 ± 0.022	1.387TyrTyr: 1.387 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4741 proteins (1228501 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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