Amino acid dipepetide frequency for Escherichia phage 933W (Bacteriophage 933W)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.914AlaAla: 8.914 ± 0.779
1.148AlaCys: 1.148 ± 0.312
4.758AlaAsp: 4.758 ± 0.655
8.039AlaGlu: 8.039 ± 0.819
3.555AlaPhe: 3.555 ± 0.514
7.93AlaGly: 7.93 ± 1.283
1.531AlaHis: 1.531 ± 0.335
4.43AlaIle: 4.43 ± 0.504
5.141AlaLys: 5.141 ± 0.537
7.438AlaLeu: 7.438 ± 0.714
2.953AlaMet: 2.953 ± 0.475
3.008AlaAsn: 3.008 ± 0.392
3.281AlaPro: 3.281 ± 0.413
5.524AlaGln: 5.524 ± 0.71
5.524AlaArg: 5.524 ± 0.658
5.414AlaSer: 5.414 ± 0.518
5.633AlaThr: 5.633 ± 0.836
6.508AlaVal: 6.508 ± 0.581
1.695AlaTrp: 1.695 ± 0.316
2.188AlaTyr: 2.188 ± 0.32
0.0AlaXaa: 0.0 ± 0.0
Cys
1.258CysAla: 1.258 ± 0.334
0.438CysCys: 0.438 ± 0.163
0.547CysAsp: 0.547 ± 0.199
0.711CysGlu: 0.711 ± 0.234
0.438CysPhe: 0.438 ± 0.165
0.875CysGly: 0.875 ± 0.276
0.438CysHis: 0.438 ± 0.169
0.602CysIle: 0.602 ± 0.206
0.328CysLys: 0.328 ± 0.17
0.93CysLeu: 0.93 ± 0.26
0.273CysMet: 0.273 ± 0.103
0.219CysAsn: 0.219 ± 0.117
0.438CysPro: 0.438 ± 0.151
0.328CysGln: 0.328 ± 0.136
1.313CysArg: 1.313 ± 0.381
1.039CysSer: 1.039 ± 0.307
0.492CysThr: 0.492 ± 0.172
1.094CysVal: 1.094 ± 0.339
0.164CysTrp: 0.164 ± 0.096
0.273CysTyr: 0.273 ± 0.121
0.0CysXaa: 0.0 ± 0.0
Asp
6.289AspAla: 6.289 ± 0.608
0.602AspCys: 0.602 ± 0.209
3.938AspAsp: 3.938 ± 0.423
4.266AspGlu: 4.266 ± 0.457
1.477AspPhe: 1.477 ± 0.243
4.813AspGly: 4.813 ± 0.526
0.82AspHis: 0.82 ± 0.273
3.555AspIle: 3.555 ± 0.378
3.938AspLys: 3.938 ± 0.386
4.32AspLeu: 4.32 ± 0.556
1.969AspMet: 1.969 ± 0.246
2.734AspAsn: 2.734 ± 0.412
2.352AspPro: 2.352 ± 0.396
1.586AspGln: 1.586 ± 0.354
3.281AspArg: 3.281 ± 0.406
3.008AspSer: 3.008 ± 0.348
2.516AspThr: 2.516 ± 0.466
4.102AspVal: 4.102 ± 0.406
1.094AspTrp: 1.094 ± 0.341
1.531AspTyr: 1.531 ± 0.256
0.0AspXaa: 0.0 ± 0.0
Glu
6.836GluAla: 6.836 ± 0.59
1.148GluCys: 1.148 ± 0.321
2.242GluAsp: 2.242 ± 0.352
3.883GluGlu: 3.883 ± 0.418
2.461GluPhe: 2.461 ± 0.379
3.883GluGly: 3.883 ± 0.494
1.148GluHis: 1.148 ± 0.201
4.102GluIle: 4.102 ± 0.49
4.649GluLys: 4.649 ± 0.6
5.36GluLeu: 5.36 ± 0.706
2.078GluMet: 2.078 ± 0.307
3.227GluAsn: 3.227 ± 0.469
1.75GluPro: 1.75 ± 0.437
4.32GluGln: 4.32 ± 0.572
5.469GluArg: 5.469 ± 0.638
3.992GluSer: 3.992 ± 0.408
3.828GluThr: 3.828 ± 0.713
4.156GluVal: 4.156 ± 0.567
1.203GluTrp: 1.203 ± 0.257
2.406GluTyr: 2.406 ± 0.368
0.0GluXaa: 0.0 ± 0.0
Phe
2.899PheAla: 2.899 ± 0.451
0.328PheCys: 0.328 ± 0.134
1.859PheAsp: 1.859 ± 0.323
1.203PheGlu: 1.203 ± 0.286
0.984PhePhe: 0.984 ± 0.244
2.57PheGly: 2.57 ± 0.253
0.656PheHis: 0.656 ± 0.155
1.914PheIle: 1.914 ± 0.254
1.531PheLys: 1.531 ± 0.248
1.75PheLeu: 1.75 ± 0.362
1.094PheMet: 1.094 ± 0.274
1.367PheAsn: 1.367 ± 0.286
1.258PhePro: 1.258 ± 0.249
0.984PheGln: 0.984 ± 0.24
2.188PheArg: 2.188 ± 0.391
2.899PheSer: 2.899 ± 0.397
2.516PheThr: 2.516 ± 0.308
2.352PheVal: 2.352 ± 0.403
0.766PheTrp: 0.766 ± 0.207
0.93PheTyr: 0.93 ± 0.175
0.0PheXaa: 0.0 ± 0.0
Gly
5.906GlyAla: 5.906 ± 1.092
1.094GlyCys: 1.094 ± 0.362
4.485GlyAsp: 4.485 ± 0.817
6.125GlyGlu: 6.125 ± 1.568
2.352GlyPhe: 2.352 ± 0.364
5.031GlyGly: 5.031 ± 0.676
1.094GlyHis: 1.094 ± 0.246
3.883GlyIle: 3.883 ± 0.578
4.867GlyLys: 4.867 ± 0.868
4.758GlyLeu: 4.758 ± 0.509
2.57GlyMet: 2.57 ± 0.313
3.063GlyAsn: 3.063 ± 0.366
3.938GlyPro: 3.938 ± 2.428
2.57GlyGln: 2.57 ± 0.436
4.102GlyArg: 4.102 ± 0.439
3.719GlySer: 3.719 ± 0.456
3.938GlyThr: 3.938 ± 0.504
5.578GlyVal: 5.578 ± 0.53
1.313GlyTrp: 1.313 ± 0.244
2.516GlyTyr: 2.516 ± 0.364
0.0GlyXaa: 0.0 ± 0.0
His
1.367HisAla: 1.367 ± 0.254
0.164HisCys: 0.164 ± 0.083
1.094HisAsp: 1.094 ± 0.308
0.711HisGlu: 0.711 ± 0.204
0.875HisPhe: 0.875 ± 0.266
1.75HisGly: 1.75 ± 0.419
0.273HisHis: 0.273 ± 0.113
0.766HisIle: 0.766 ± 0.214
0.93HisLys: 0.93 ± 0.273
1.641HisLeu: 1.641 ± 0.367
0.219HisMet: 0.219 ± 0.099
0.984HisAsn: 0.984 ± 0.201
0.875HisPro: 0.875 ± 0.225
0.656HisGln: 0.656 ± 0.238
0.82HisArg: 0.82 ± 0.222
0.766HisSer: 0.766 ± 0.223
1.094HisThr: 1.094 ± 0.271
0.984HisVal: 0.984 ± 0.222
0.383HisTrp: 0.383 ± 0.178
0.656HisTyr: 0.656 ± 0.183
0.0HisXaa: 0.0 ± 0.0
Ile
4.922IleAla: 4.922 ± 0.527
0.93IleCys: 0.93 ± 0.261
3.828IleAsp: 3.828 ± 0.533
3.555IleGlu: 3.555 ± 0.588
0.93IlePhe: 0.93 ± 0.241
2.953IleGly: 2.953 ± 0.565
0.984IleHis: 0.984 ± 0.225
2.242IleIle: 2.242 ± 0.379
3.391IleLys: 3.391 ± 0.433
3.5IleLeu: 3.5 ± 0.588
1.094IleMet: 1.094 ± 0.226
3.117IleAsn: 3.117 ± 0.412
2.406IlePro: 2.406 ± 0.35
1.859IleGln: 1.859 ± 0.288
4.649IleArg: 4.649 ± 0.474
4.102IleSer: 4.102 ± 0.576
3.828IleThr: 3.828 ± 0.628
2.406IleVal: 2.406 ± 0.423
0.383IleTrp: 0.383 ± 0.181
1.531IleTyr: 1.531 ± 0.28
0.0IleXaa: 0.0 ± 0.0
Lys
6.344LysAla: 6.344 ± 0.615
0.492LysCys: 0.492 ± 0.185
3.5LysAsp: 3.5 ± 0.479
3.883LysGlu: 3.883 ± 0.468
1.039LysPhe: 1.039 ± 0.185
5.633LysGly: 5.633 ± 1.243
0.875LysHis: 0.875 ± 0.229
3.336LysIle: 3.336 ± 0.425
3.61LysLys: 3.61 ± 0.587
5.086LysLeu: 5.086 ± 0.51
1.969LysMet: 1.969 ± 0.287
3.5LysAsn: 3.5 ± 0.458
2.297LysPro: 2.297 ± 0.362
3.117LysGln: 3.117 ± 0.559
3.063LysArg: 3.063 ± 0.441
3.281LysSer: 3.281 ± 0.424
3.5LysThr: 3.5 ± 0.439
3.172LysVal: 3.172 ± 0.504
0.93LysTrp: 0.93 ± 0.263
1.859LysTyr: 1.859 ± 0.375
0.0LysXaa: 0.0 ± 0.0
Leu
8.368LeuAla: 8.368 ± 0.764
1.148LeuCys: 1.148 ± 0.306
4.047LeuAsp: 4.047 ± 0.512
4.102LeuGlu: 4.102 ± 0.589
2.516LeuPhe: 2.516 ± 0.382
3.883LeuGly: 3.883 ± 0.558
1.258LeuHis: 1.258 ± 0.235
3.61LeuIle: 3.61 ± 0.534
4.867LeuLys: 4.867 ± 0.469
5.688LeuLeu: 5.688 ± 0.426
2.297LeuMet: 2.297 ± 0.39
4.102LeuAsn: 4.102 ± 0.537
3.938LeuPro: 3.938 ± 0.423
3.117LeuGln: 3.117 ± 0.628
5.141LeuArg: 5.141 ± 0.541
5.196LeuSer: 5.196 ± 0.494
5.141LeuThr: 5.141 ± 0.477
4.703LeuVal: 4.703 ± 0.368
0.547LeuTrp: 0.547 ± 0.187
2.242LeuTyr: 2.242 ± 0.345
0.0LeuXaa: 0.0 ± 0.0
Met
3.172MetAla: 3.172 ± 0.362
0.219MetCys: 0.219 ± 0.127
1.313MetAsp: 1.313 ± 0.256
1.313MetGlu: 1.313 ± 0.233
0.711MetPhe: 0.711 ± 0.196
1.367MetGly: 1.367 ± 0.372
0.438MetHis: 0.438 ± 0.152
0.93MetIle: 0.93 ± 0.186
2.461MetLys: 2.461 ± 0.342
2.352MetLeu: 2.352 ± 0.361
0.766MetMet: 0.766 ± 0.223
1.531MetAsn: 1.531 ± 0.318
1.859MetPro: 1.859 ± 0.379
1.586MetGln: 1.586 ± 0.248
1.75MetArg: 1.75 ± 0.318
1.914MetSer: 1.914 ± 0.365
2.57MetThr: 2.57 ± 0.288
1.531MetVal: 1.531 ± 0.31
0.273MetTrp: 0.273 ± 0.134
0.547MetTyr: 0.547 ± 0.239
0.0MetXaa: 0.0 ± 0.0
Asn
4.813AsnAla: 4.813 ± 0.631
0.383AsnCys: 0.383 ± 0.159
2.57AsnAsp: 2.57 ± 0.41
3.5AsnGlu: 3.5 ± 0.44
1.422AsnPhe: 1.422 ± 0.357
3.445AsnGly: 3.445 ± 0.495
1.203AsnHis: 1.203 ± 0.315
2.789AsnIle: 2.789 ± 0.438
2.078AsnLys: 2.078 ± 0.344
3.336AsnLeu: 3.336 ± 0.477
1.422AsnMet: 1.422 ± 0.26
1.914AsnAsn: 1.914 ± 0.323
1.969AsnPro: 1.969 ± 0.32
2.188AsnGln: 2.188 ± 0.399
2.625AsnArg: 2.625 ± 0.506
2.789AsnSer: 2.789 ± 0.366
2.242AsnThr: 2.242 ± 0.376
2.242AsnVal: 2.242 ± 0.316
0.438AsnTrp: 0.438 ± 0.137
1.203AsnTyr: 1.203 ± 0.307
0.0AsnXaa: 0.0 ± 0.0
Pro
3.336ProAla: 3.336 ± 0.67
0.383ProCys: 0.383 ± 0.15
4.266ProAsp: 4.266 ± 0.504
5.196ProGlu: 5.196 ± 0.809
1.367ProPhe: 1.367 ± 0.236
3.172ProGly: 3.172 ± 0.519
0.602ProHis: 0.602 ± 0.184
0.984ProIle: 0.984 ± 0.248
2.953ProLys: 2.953 ± 0.778
2.789ProLeu: 2.789 ± 0.364
0.766ProMet: 0.766 ± 0.185
1.313ProAsn: 1.313 ± 0.343
1.313ProPro: 1.313 ± 0.273
2.516ProGln: 2.516 ± 0.605
2.024ProArg: 2.024 ± 0.386
2.242ProSer: 2.242 ± 0.354
1.75ProThr: 1.75 ± 0.352
4.375ProVal: 4.375 ± 0.468
0.656ProTrp: 0.656 ± 0.179
1.586ProTyr: 1.586 ± 0.294
0.0ProXaa: 0.0 ± 0.0
Gln
4.922GlnAla: 4.922 ± 0.611
0.656GlnCys: 0.656 ± 0.213
2.352GlnAsp: 2.352 ± 0.398
3.227GlnGlu: 3.227 ± 0.461
1.75GlnPhe: 1.75 ± 0.289
3.281GlnGly: 3.281 ± 0.758
0.875GlnHis: 0.875 ± 0.253
2.078GlnIle: 2.078 ± 0.375
3.227GlnLys: 3.227 ± 0.445
3.391GlnLeu: 3.391 ± 0.456
1.039GlnMet: 1.039 ± 0.287
2.024GlnAsn: 2.024 ± 0.376
1.969GlnPro: 1.969 ± 0.416
3.828GlnGln: 3.828 ± 0.761
3.391GlnArg: 3.391 ± 0.567
2.461GlnSer: 2.461 ± 0.337
2.133GlnThr: 2.133 ± 0.343
2.352GlnVal: 2.352 ± 0.43
0.656GlnTrp: 0.656 ± 0.208
1.367GlnTyr: 1.367 ± 0.222
0.0GlnXaa: 0.0 ± 0.0
Arg
4.539ArgAla: 4.539 ± 0.449
0.219ArgCys: 0.219 ± 0.128
4.266ArgAsp: 4.266 ± 0.551
5.36ArgGlu: 5.36 ± 0.647
2.188ArgPhe: 2.188 ± 0.35
4.922ArgGly: 4.922 ± 1.004
1.641ArgHis: 1.641 ± 0.355
3.883ArgIle: 3.883 ± 0.521
4.43ArgLys: 4.43 ± 0.542
5.36ArgLeu: 5.36 ± 0.524
1.805ArgMet: 1.805 ± 0.262
3.172ArgAsn: 3.172 ± 0.473
2.133ArgPro: 2.133 ± 0.371
2.953ArgGln: 2.953 ± 0.382
5.305ArgArg: 5.305 ± 0.578
3.445ArgSer: 3.445 ± 0.435
3.555ArgThr: 3.555 ± 0.581
3.828ArgVal: 3.828 ± 0.504
0.984ArgTrp: 0.984 ± 0.205
1.969ArgTyr: 1.969 ± 0.438
0.0ArgXaa: 0.0 ± 0.0
Ser
5.414SerAla: 5.414 ± 0.643
0.656SerCys: 0.656 ± 0.244
3.774SerAsp: 3.774 ± 0.41
4.32SerGlu: 4.32 ± 0.477
1.75SerPhe: 1.75 ± 0.242
5.688SerGly: 5.688 ± 0.554
0.656SerHis: 0.656 ± 0.152
2.844SerIle: 2.844 ± 0.329
3.063SerLys: 3.063 ± 0.564
5.196SerLeu: 5.196 ± 0.721
1.695SerMet: 1.695 ± 0.366
2.297SerAsn: 2.297 ± 0.354
3.281SerPro: 3.281 ± 0.489
2.953SerGln: 2.953 ± 0.404
3.992SerArg: 3.992 ± 0.65
3.063SerSer: 3.063 ± 0.608
3.336SerThr: 3.336 ± 0.463
3.938SerVal: 3.938 ± 0.49
1.094SerTrp: 1.094 ± 0.266
1.586SerTyr: 1.586 ± 0.346
0.0SerXaa: 0.0 ± 0.0
Thr
5.305ThrAla: 5.305 ± 0.414
0.602ThrCys: 0.602 ± 0.22
3.172ThrAsp: 3.172 ± 0.396
3.664ThrGlu: 3.664 ± 0.392
2.078ThrPhe: 2.078 ± 0.395
5.688ThrGly: 5.688 ± 0.829
0.93ThrHis: 0.93 ± 0.221
3.883ThrIle: 3.883 ± 0.399
3.172ThrLys: 3.172 ± 0.478
4.703ThrLeu: 4.703 ± 0.45
0.875ThrMet: 0.875 ± 0.199
1.969ThrAsn: 1.969 ± 0.359
3.61ThrPro: 3.61 ± 0.398
1.641ThrGln: 1.641 ± 0.319
2.789ThrArg: 2.789 ± 0.391
3.938ThrSer: 3.938 ± 0.564
3.008ThrThr: 3.008 ± 0.448
4.32ThrVal: 4.32 ± 0.534
0.766ThrTrp: 0.766 ± 0.173
1.094ThrTyr: 1.094 ± 0.278
0.0ThrXaa: 0.0 ± 0.0
Val
6.235ValAla: 6.235 ± 0.484
1.039ValCys: 1.039 ± 0.215
4.047ValAsp: 4.047 ± 0.441
3.336ValGlu: 3.336 ± 0.324
2.188ValPhe: 2.188 ± 0.286
3.227ValGly: 3.227 ± 0.445
0.602ValHis: 0.602 ± 0.17
3.938ValIle: 3.938 ± 0.583
3.5ValLys: 3.5 ± 0.377
5.524ValLeu: 5.524 ± 0.574
1.805ValMet: 1.805 ± 0.271
3.227ValAsn: 3.227 ± 0.367
2.899ValPro: 2.899 ± 0.387
2.297ValGln: 2.297 ± 0.343
4.977ValArg: 4.977 ± 1.062
4.703ValSer: 4.703 ± 0.553
4.102ValThr: 4.102 ± 0.389
3.992ValVal: 3.992 ± 0.452
0.766ValTrp: 0.766 ± 0.221
2.024ValTyr: 2.024 ± 0.306
0.0ValXaa: 0.0 ± 0.0
Trp
0.93TrpAla: 0.93 ± 0.288
0.328TrpCys: 0.328 ± 0.162
0.438TrpAsp: 0.438 ± 0.156
0.492TrpGlu: 0.492 ± 0.133
0.711TrpPhe: 0.711 ± 0.172
0.602TrpGly: 0.602 ± 0.171
0.328TrpHis: 0.328 ± 0.128
1.094TrpIle: 1.094 ± 0.248
1.094TrpLys: 1.094 ± 0.2
1.531TrpLeu: 1.531 ± 0.36
0.984TrpMet: 0.984 ± 0.253
0.602TrpAsn: 0.602 ± 0.177
0.656TrpPro: 0.656 ± 0.241
1.203TrpGln: 1.203 ± 0.201
1.148TrpArg: 1.148 ± 0.283
0.93TrpSer: 0.93 ± 0.189
0.492TrpThr: 0.492 ± 0.169
0.984TrpVal: 0.984 ± 0.247
0.273TrpTrp: 0.273 ± 0.147
0.273TrpTyr: 0.273 ± 0.088
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.844TyrAla: 2.844 ± 0.432
0.219TyrCys: 0.219 ± 0.105
1.75TyrAsp: 1.75 ± 0.228
1.258TyrGlu: 1.258 ± 0.287
1.258TyrPhe: 1.258 ± 0.201
2.188TyrGly: 2.188 ± 0.408
0.656TyrHis: 0.656 ± 0.258
1.75TyrIle: 1.75 ± 0.331
1.258TyrLys: 1.258 ± 0.292
1.258TyrLeu: 1.258 ± 0.247
0.875TyrMet: 0.875 ± 0.204
1.203TyrAsn: 1.203 ± 0.207
1.367TyrPro: 1.367 ± 0.232
1.75TyrGln: 1.75 ± 0.257
2.406TyrArg: 2.406 ± 0.437
1.695TyrSer: 1.695 ± 0.271
1.531TyrThr: 1.531 ± 0.388
1.805TyrVal: 1.805 ± 0.267
0.711TyrTrp: 0.711 ± 0.149
1.094TyrTyr: 1.094 ± 0.229
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 80 proteins (18286 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski