Amino acid dipepetide frequency for Anaerostipes sp. CAG:276

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.319AlaAla: 7.319 ± 0.122	1.05AlaCys: 1.05 ± 0.033	4.297AlaAsp: 4.297 ± 0.075	5.308AlaGlu: 5.308 ± 0.091	3.03AlaPhe: 3.03 ± 0.057	6.578AlaGly: 6.578 ± 0.1	0.965AlaHis: 0.965 ± 0.032	4.187AlaIle: 4.187 ± 0.077	5.172AlaLys: 5.172 ± 0.09	6.361AlaLeu: 6.361 ± 0.097	2.337AlaMet: 2.337 ± 0.052	2.244AlaAsn: 2.244 ± 0.043	1.93AlaPro: 1.93 ± 0.05	1.986AlaGln: 1.986 ± 0.056	2.681AlaArg: 2.681 ± 0.056	3.925AlaSer: 3.925 ± 0.079	2.592AlaThr: 2.592 ± 0.06	7.189AlaVal: 7.189 ± 0.099	0.46AlaTrp: 0.46 ± 0.023	2.389AlaTyr: 2.389 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.965CysAla: 0.965 ± 0.036	0.291CysCys: 0.291 ± 0.016	0.752CysAsp: 0.752 ± 0.026	0.823CysGlu: 0.823 ± 0.029	0.733CysPhe: 0.733 ± 0.029	1.526CysGly: 1.526 ± 0.041	0.311CysHis: 0.311 ± 0.016	1.178CysIle: 1.178 ± 0.04	0.729CysLys: 0.729 ± 0.031	1.286CysLeu: 1.286 ± 0.04	0.492CysMet: 0.492 ± 0.023	0.455CysAsn: 0.455 ± 0.024	0.617CysPro: 0.617 ± 0.028	0.354CysGln: 0.354 ± 0.021	0.842CysArg: 0.842 ± 0.034	0.98CysSer: 0.98 ± 0.036	0.756CysThr: 0.756 ± 0.03	0.91CysVal: 0.91 ± 0.036	0.092CysTrp: 0.092 ± 0.011	0.524CysTyr: 0.524 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.727AspAla: 3.727 ± 0.07	0.856AspCys: 0.856 ± 0.03	2.796AspAsp: 2.796 ± 0.064	4.229AspGlu: 4.229 ± 0.07	2.701AspPhe: 2.701 ± 0.049	4.188AspGly: 4.188 ± 0.096	1.115AspHis: 1.115 ± 0.038	4.504AspIle: 4.504 ± 0.067	3.51AspLys: 3.51 ± 0.066	5.061AspLeu: 5.061 ± 0.073	1.882AspMet: 1.882 ± 0.041	1.704AspAsn: 1.704 ± 0.045	1.877AspPro: 1.877 ± 0.043	1.832AspGln: 1.832 ± 0.048	2.545AspArg: 2.545 ± 0.063	3.039AspSer: 3.039 ± 0.065	2.912AspThr: 2.912 ± 0.061	3.839AspVal: 3.839 ± 0.069	0.472AspTrp: 0.472 ± 0.023	2.623AspTyr: 2.623 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	5.505GluAla: 5.505 ± 0.087	0.81GluCys: 0.81 ± 0.03	4.565GluAsp: 4.565 ± 0.074	7.674GluGlu: 7.674 ± 0.127	2.807GluPhe: 2.807 ± 0.058	4.534GluGly: 4.534 ± 0.084	1.521GluHis: 1.521 ± 0.037	5.773GluIle: 5.773 ± 0.089	7.0GluLys: 7.0 ± 0.098	6.61GluLeu: 6.61 ± 0.1	2.438GluMet: 2.438 ± 0.053	3.667GluAsn: 3.667 ± 0.062	2.064GluPro: 2.064 ± 0.058	3.088GluGln: 3.088 ± 0.07	3.392GluArg: 3.392 ± 0.066	3.347GluSer: 3.347 ± 0.062	3.843GluThr: 3.843 ± 0.058	4.443GluVal: 4.443 ± 0.079	0.541GluTrp: 0.541 ± 0.023	2.825GluTyr: 2.825 ± 0.059	0.001GluXaa: 0.001 ± 0.001
Phe	2.958PheAla: 2.958 ± 0.055	0.789PheCys: 0.789 ± 0.029	2.459PheAsp: 2.459 ± 0.058	2.714PheGlu: 2.714 ± 0.054	2.054PhePhe: 2.054 ± 0.064	3.293PheGly: 3.293 ± 0.064	0.9PheHis: 0.9 ± 0.032	2.959PheIle: 2.959 ± 0.069	2.221PheLys: 2.221 ± 0.052	4.323PheLeu: 4.323 ± 0.093	1.245PheMet: 1.245 ± 0.034	1.334PheAsn: 1.334 ± 0.039	1.392PhePro: 1.392 ± 0.045	1.46PheGln: 1.46 ± 0.039	1.741PheArg: 1.741 ± 0.048	2.95PheSer: 2.95 ± 0.066	2.364PheThr: 2.364 ± 0.056	2.914PheVal: 2.914 ± 0.053	0.352PheTrp: 0.352 ± 0.019	1.72PheTyr: 1.72 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.378GlyAla: 5.378 ± 0.088	1.327GlyCys: 1.327 ± 0.041	3.682GlyAsp: 3.682 ± 0.056	4.734GlyGlu: 4.734 ± 0.077	3.35GlyPhe: 3.35 ± 0.062	5.436GlyGly: 5.436 ± 0.108	1.345GlyHis: 1.345 ± 0.043	6.817GlyIle: 6.817 ± 0.106	5.883GlyLys: 5.883 ± 0.09	6.133GlyLeu: 6.133 ± 0.096	2.564GlyMet: 2.564 ± 0.053	3.054GlyAsn: 3.054 ± 0.076	1.486GlyPro: 1.486 ± 0.043	2.265GlyGln: 2.265 ± 0.05	3.337GlyArg: 3.337 ± 0.065	4.38GlySer: 4.38 ± 0.075	4.546GlyThr: 4.546 ± 0.078	5.077GlyVal: 5.077 ± 0.083	0.6GlyTrp: 0.6 ± 0.023	3.274GlyTyr: 3.274 ± 0.061	0.002GlyXaa: 0.002 ± 0.001
His	1.053HisAla: 1.053 ± 0.033	0.337HisCys: 0.337 ± 0.021	0.854HisAsp: 0.854 ± 0.033	1.106HisGlu: 1.106 ± 0.035	0.805HisPhe: 0.805 ± 0.033	1.532HisGly: 1.532 ± 0.042	0.453HisHis: 0.453 ± 0.023	1.431HisIle: 1.431 ± 0.036	1.017HisLys: 1.017 ± 0.032	1.627HisLeu: 1.627 ± 0.047	0.616HisMet: 0.616 ± 0.028	0.67HisAsn: 0.67 ± 0.022	0.96HisPro: 0.96 ± 0.033	0.551HisGln: 0.551 ± 0.027	0.821HisArg: 0.821 ± 0.027	0.993HisSer: 0.993 ± 0.033	0.959HisThr: 0.959 ± 0.031	1.164HisVal: 1.164 ± 0.035	0.165HisTrp: 0.165 ± 0.013	0.74HisTyr: 0.74 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.368IleAla: 5.368 ± 0.085	1.323IleCys: 1.323 ± 0.043	3.858IleAsp: 3.858 ± 0.058	5.001IleGlu: 5.001 ± 0.083	3.071IlePhe: 3.071 ± 0.072	5.663IleGly: 5.663 ± 0.097	1.405IleHis: 1.405 ± 0.037	4.912IleIle: 4.912 ± 0.09	4.767IleLys: 4.767 ± 0.068	7.206IleLeu: 7.206 ± 0.123	1.944IleMet: 1.944 ± 0.053	2.684IleAsn: 2.684 ± 0.056	3.247IlePro: 3.247 ± 0.064	2.403IleGln: 2.403 ± 0.053	3.874IleArg: 3.874 ± 0.068	5.27IleSer: 5.27 ± 0.072	4.139IleThr: 4.139 ± 0.066	4.741IleVal: 4.741 ± 0.072	0.524IleTrp: 0.524 ± 0.026	2.711IleTyr: 2.711 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	5.371LysAla: 5.371 ± 0.081	0.649LysCys: 0.649 ± 0.028	4.776LysAsp: 4.776 ± 0.084	7.854LysGlu: 7.854 ± 0.108	2.136LysPhe: 2.136 ± 0.051	4.873LysGly: 4.873 ± 0.068	1.158LysHis: 1.158 ± 0.034	5.654LysIle: 5.654 ± 0.076	8.303LysLys: 8.303 ± 0.128	5.631LysLeu: 5.631 ± 0.071	2.315LysMet: 2.315 ± 0.046	3.795LysAsn: 3.795 ± 0.077	2.188LysPro: 2.188 ± 0.059	2.777LysGln: 2.777 ± 0.055	3.374LysArg: 3.374 ± 0.057	3.658LysSer: 3.658 ± 0.072	4.254LysThr: 4.254 ± 0.079	4.8LysVal: 4.8 ± 0.082	0.501LysTrp: 0.501 ± 0.029	2.84LysTyr: 2.84 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	6.221LeuAla: 6.221 ± 0.092	1.458LeuCys: 1.458 ± 0.048	4.98LeuAsp: 4.98 ± 0.066	6.183LeuGlu: 6.183 ± 0.106	3.816LeuPhe: 3.816 ± 0.079	6.35LeuGly: 6.35 ± 0.108	1.535LeuHis: 1.535 ± 0.044	6.155LeuIle: 6.155 ± 0.098	7.526LeuLys: 7.526 ± 0.092	8.32LeuLeu: 8.32 ± 0.126	2.784LeuMet: 2.784 ± 0.053	3.843LeuAsn: 3.843 ± 0.065	3.417LeuPro: 3.417 ± 0.061	2.275LeuGln: 2.275 ± 0.054	3.748LeuArg: 3.748 ± 0.062	6.747LeuSer: 6.747 ± 0.1	5.025LeuThr: 5.025 ± 0.077	5.145LeuVal: 5.145 ± 0.088	0.764LeuTrp: 0.764 ± 0.027	3.071LeuTyr: 3.071 ± 0.062	0.001LeuXaa: 0.001 ± 0.001
Met	2.38MetAla: 2.38 ± 0.049	0.312MetCys: 0.312 ± 0.017	1.957MetAsp: 1.957 ± 0.05	2.768MetGlu: 2.768 ± 0.053	1.192MetPhe: 1.192 ± 0.044	2.219MetGly: 2.219 ± 0.047	0.436MetHis: 0.436 ± 0.021	2.44MetIle: 2.44 ± 0.055	3.044MetLys: 3.044 ± 0.055	2.682MetLeu: 2.682 ± 0.057	1.021MetMet: 1.021 ± 0.037	1.561MetAsn: 1.561 ± 0.042	1.055MetPro: 1.055 ± 0.036	0.937MetGln: 0.937 ± 0.03	1.207MetArg: 1.207 ± 0.041	1.711MetSer: 1.711 ± 0.046	1.745MetThr: 1.745 ± 0.041	1.824MetVal: 1.824 ± 0.052	0.16MetTrp: 0.16 ± 0.014	0.88MetTyr: 0.88 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	2.616AsnAla: 2.616 ± 0.053	0.559AsnCys: 0.559 ± 0.027	1.966AsnAsp: 1.966 ± 0.054	2.652AsnGlu: 2.652 ± 0.057	1.569AsnPhe: 1.569 ± 0.045	3.198AsnGly: 3.198 ± 0.069	0.871AsnHis: 0.871 ± 0.033	3.287AsnIle: 3.287 ± 0.062	2.665AsnLys: 2.665 ± 0.063	3.518AsnLeu: 3.518 ± 0.061	1.234AsnMet: 1.234 ± 0.033	1.507AsnAsn: 1.507 ± 0.056	1.77AsnPro: 1.77 ± 0.047	1.524AsnGln: 1.524 ± 0.045	1.855AsnArg: 1.855 ± 0.047	2.157AsnSer: 2.157 ± 0.058	2.088AsnThr: 2.088 ± 0.053	2.713AsnVal: 2.713 ± 0.062	0.307AsnTrp: 0.307 ± 0.018	1.641AsnTyr: 1.641 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.451ProAla: 2.451 ± 0.051	0.465ProCys: 0.465 ± 0.023	2.193ProAsp: 2.193 ± 0.055	3.391ProGlu: 3.391 ± 0.062	1.555ProPhe: 1.555 ± 0.047	2.551ProGly: 2.551 ± 0.059	0.559ProHis: 0.559 ± 0.024	1.94ProIle: 1.94 ± 0.046	2.34ProLys: 2.34 ± 0.051	2.721ProLeu: 2.721 ± 0.051	0.98ProMet: 0.98 ± 0.03	1.166ProAsn: 1.166 ± 0.038	0.741ProPro: 0.741 ± 0.033	0.874ProGln: 0.874 ± 0.034	1.035ProArg: 1.035 ± 0.034	1.822ProSer: 1.822 ± 0.045	1.348ProThr: 1.348 ± 0.044	3.079ProVal: 3.079 ± 0.066	0.297ProTrp: 0.297 ± 0.02	1.391ProTyr: 1.391 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.304GlnAla: 2.304 ± 0.055	0.423GlnCys: 0.423 ± 0.022	1.444GlnAsp: 1.444 ± 0.038	2.42GlnGlu: 2.42 ± 0.058	1.155GlnPhe: 1.155 ± 0.039	2.17GlnGly: 2.17 ± 0.05	0.434GlnHis: 0.434 ± 0.02	2.693GlnIle: 2.693 ± 0.043	2.911GlnLys: 2.911 ± 0.065	2.658GlnLeu: 2.658 ± 0.047	1.234GlnMet: 1.234 ± 0.039	1.521GlnAsn: 1.521 ± 0.044	0.821GlnPro: 0.821 ± 0.026	1.008GlnGln: 1.008 ± 0.035	1.344GlnArg: 1.344 ± 0.044	1.668GlnSer: 1.668 ± 0.045	1.71GlnThr: 1.71 ± 0.041	2.104GlnVal: 2.104 ± 0.046	0.32GlnTrp: 0.32 ± 0.016	1.326GlnTyr: 1.326 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.664ArgAla: 2.664 ± 0.056	0.558ArgCys: 0.558 ± 0.024	2.334ArgAsp: 2.334 ± 0.053	4.071ArgGlu: 4.071 ± 0.08	1.855ArgPhe: 1.855 ± 0.049	2.595ArgGly: 2.595 ± 0.05	0.829ArgHis: 0.829 ± 0.032	3.564ArgIle: 3.564 ± 0.072	3.797ArgLys: 3.797 ± 0.059	4.104ArgLeu: 4.104 ± 0.074	1.57ArgMet: 1.57 ± 0.044	1.892ArgAsn: 1.892 ± 0.043	1.34ArgPro: 1.34 ± 0.041	1.75ArgGln: 1.75 ± 0.038	2.219ArgArg: 2.219 ± 0.06	2.13ArgSer: 2.13 ± 0.048	2.182ArgThr: 2.182 ± 0.049	2.597ArgVal: 2.597 ± 0.053	0.384ArgTrp: 0.384 ± 0.021	1.715ArgTyr: 1.715 ± 0.047	0.001ArgXaa: 0.001 ± 0.001
Ser	4.154SerAla: 4.154 ± 0.07	0.849SerCys: 0.849 ± 0.03	3.098SerAsp: 3.098 ± 0.058	3.99SerGlu: 3.99 ± 0.079	2.763SerPhe: 2.763 ± 0.059	5.377SerGly: 5.377 ± 0.086	1.065SerHis: 1.065 ± 0.031	4.085SerIle: 4.085 ± 0.074	3.801SerLys: 3.801 ± 0.071	5.443SerLeu: 5.443 ± 0.084	1.921SerMet: 1.921 ± 0.04	2.045SerAsn: 2.045 ± 0.047	1.85SerPro: 1.85 ± 0.05	1.739SerGln: 1.739 ± 0.046	2.886SerArg: 2.886 ± 0.059	3.687SerSer: 3.687 ± 0.076	2.625SerThr: 2.625 ± 0.057	4.585SerVal: 4.585 ± 0.073	0.504SerTrp: 0.504 ± 0.023	2.416SerTyr: 2.416 ± 0.055	0.001SerXaa: 0.001 ± 0.001
Thr	4.485ThrAla: 4.485 ± 0.074	0.623ThrCys: 0.623 ± 0.029	2.992ThrAsp: 2.992 ± 0.074	3.8ThrGlu: 3.8 ± 0.07	2.142ThrPhe: 2.142 ± 0.048	4.924ThrGly: 4.924 ± 0.082	0.79ThrHis: 0.79 ± 0.031	3.674ThrIle: 3.674 ± 0.073	3.764ThrLys: 3.764 ± 0.07	4.55ThrLeu: 4.55 ± 0.076	1.498ThrMet: 1.498 ± 0.039	1.812ThrAsn: 1.812 ± 0.045	1.943ThrPro: 1.943 ± 0.048	1.201ThrGln: 1.201 ± 0.038	1.85ThrArg: 1.85 ± 0.043	2.867ThrSer: 2.867 ± 0.053	2.53ThrThr: 2.53 ± 0.061	4.621ThrVal: 4.621 ± 0.086	0.363ThrTrp: 0.363 ± 0.019	1.894ThrTyr: 1.894 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	4.257ValAla: 4.257 ± 0.085	1.233ValCys: 1.233 ± 0.037	3.672ValAsp: 3.672 ± 0.062	4.27ValGlu: 4.27 ± 0.083	3.213ValPhe: 3.213 ± 0.066	4.277ValGly: 4.277 ± 0.088	1.187ValHis: 1.187 ± 0.034	5.466ValIle: 5.466 ± 0.075	5.348ValLys: 5.348 ± 0.085	6.863ValLeu: 6.863 ± 0.101	2.122ValMet: 2.122 ± 0.051	2.794ValAsn: 2.794 ± 0.058	2.597ValPro: 2.597 ± 0.055	1.899ValGln: 1.899 ± 0.044	3.103ValArg: 3.103 ± 0.07	4.942ValSer: 4.942 ± 0.08	4.284ValThr: 4.284 ± 0.077	4.501ValVal: 4.501 ± 0.078	0.526ValTrp: 0.526 ± 0.023	2.528ValTyr: 2.528 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.431TrpAla: 0.431 ± 0.023	0.103TrpCys: 0.103 ± 0.01	0.452TrpAsp: 0.452 ± 0.022	0.57TrpGlu: 0.57 ± 0.026	0.347TrpPhe: 0.347 ± 0.02	0.595TrpGly: 0.595 ± 0.022	0.142TrpHis: 0.142 ± 0.011	0.618TrpIle: 0.618 ± 0.027	0.676TrpLys: 0.676 ± 0.03	0.659TrpLeu: 0.659 ± 0.025	0.289TrpMet: 0.289 ± 0.021	0.466TrpAsn: 0.466 ± 0.023	0.189TrpPro: 0.189 ± 0.013	0.253TrpGln: 0.253 ± 0.017	0.305TrpArg: 0.305 ± 0.018	0.413TrpSer: 0.413 ± 0.024	0.36TrpThr: 0.36 ± 0.02	0.428TrpVal: 0.428 ± 0.021	0.084TrpTrp: 0.084 ± 0.01	0.315TrpTyr: 0.315 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.391TyrAla: 2.391 ± 0.047	0.602TyrCys: 0.602 ± 0.027	2.284TyrAsp: 2.284 ± 0.065	2.892TyrGlu: 2.892 ± 0.055	1.846TyrPhe: 1.846 ± 0.045	2.788TyrGly: 2.788 ± 0.057	0.833TyrHis: 0.833 ± 0.033	2.775TyrIle: 2.775 ± 0.051	2.435TyrLys: 2.435 ± 0.055	3.604TyrLeu: 3.604 ± 0.067	1.044TyrMet: 1.044 ± 0.034	1.483TyrAsn: 1.483 ± 0.039	1.416TyrPro: 1.416 ± 0.039	1.49TyrGln: 1.49 ± 0.042	1.992TyrArg: 1.992 ± 0.05	2.197TyrSer: 2.197 ± 0.056	2.062TyrThr: 2.062 ± 0.054	2.409TyrVal: 2.409 ± 0.048	0.277TyrTrp: 0.277 ± 0.018	1.705TyrTyr: 1.705 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.015XaaXaa: 0.015 ± 0.006

Statistics based on 3141 proteins (938375 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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