Amino acid dipepetide frequency for Martelella mediterranea DSM 17316

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.256AlaAla: 16.256 ± 0.145	0.971AlaCys: 0.971 ± 0.024	7.048AlaAsp: 7.048 ± 0.077	8.08AlaGlu: 8.08 ± 0.087	4.921AlaPhe: 4.921 ± 0.067	10.863AlaGly: 10.863 ± 0.096	2.084AlaHis: 2.084 ± 0.036	7.211AlaIle: 7.211 ± 0.067	3.685AlaLys: 3.685 ± 0.052	13.585AlaLeu: 13.585 ± 0.119	3.752AlaMet: 3.752 ± 0.054	2.927AlaAsn: 2.927 ± 0.05	4.915AlaPro: 4.915 ± 0.062	3.09AlaGln: 3.09 ± 0.054	8.177AlaArg: 8.177 ± 0.101	6.264AlaSer: 6.264 ± 0.068	5.765AlaThr: 5.765 ± 0.065	8.652AlaVal: 8.652 ± 0.087	1.36AlaTrp: 1.36 ± 0.035	2.629AlaTyr: 2.629 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.876CysAla: 0.876 ± 0.023	0.115CysCys: 0.115 ± 0.009	0.517CysAsp: 0.517 ± 0.017	0.431CysGlu: 0.431 ± 0.015	0.329CysPhe: 0.329 ± 0.016	0.909CysGly: 0.909 ± 0.027	0.236CysHis: 0.236 ± 0.013	0.364CysIle: 0.364 ± 0.016	0.182CysLys: 0.182 ± 0.01	0.802CysLeu: 0.802 ± 0.023	0.175CysMet: 0.175 ± 0.011	0.217CysAsn: 0.217 ± 0.012	0.417CysPro: 0.417 ± 0.015	0.208CysGln: 0.208 ± 0.012	0.569CysArg: 0.569 ± 0.02	0.433CysSer: 0.433 ± 0.016	0.349CysThr: 0.349 ± 0.017	0.562CysVal: 0.562 ± 0.02	0.116CysTrp: 0.116 ± 0.008	0.205CysTyr: 0.205 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.762AspAla: 6.762 ± 0.068	0.502AspCys: 0.502 ± 0.017	3.612AspAsp: 3.612 ± 0.063	3.724AspGlu: 3.724 ± 0.05	2.497AspPhe: 2.497 ± 0.039	5.796AspGly: 5.796 ± 0.118	1.344AspHis: 1.344 ± 0.031	3.682AspIle: 3.682 ± 0.054	1.701AspLys: 1.701 ± 0.038	5.688AspLeu: 5.688 ± 0.062	1.623AspMet: 1.623 ± 0.03	1.672AspAsn: 1.672 ± 0.04	3.293AspPro: 3.293 ± 0.051	1.67AspGln: 1.67 ± 0.037	4.177AspArg: 4.177 ± 0.052	2.186AspSer: 2.186 ± 0.041	2.694AspThr: 2.694 ± 0.042	4.08AspVal: 4.08 ± 0.058	0.997AspTrp: 0.997 ± 0.026	1.649AspTyr: 1.649 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.016GluAla: 8.016 ± 0.088	0.362GluCys: 0.362 ± 0.015	3.282GluAsp: 3.282 ± 0.048	3.652GluGlu: 3.652 ± 0.057	1.717GluPhe: 1.717 ± 0.034	4.534GluGly: 4.534 ± 0.052	1.182GluHis: 1.182 ± 0.028	3.905GluIle: 3.905 ± 0.058	2.707GluLys: 2.707 ± 0.047	5.127GluLeu: 5.127 ± 0.062	1.674GluMet: 1.674 ± 0.033	2.19GluAsn: 2.19 ± 0.039	2.727GluPro: 2.727 ± 0.059	1.974GluGln: 1.974 ± 0.036	4.775GluArg: 4.775 ± 0.068	2.5GluSer: 2.5 ± 0.043	4.108GluThr: 4.108 ± 0.057	3.58GluVal: 3.58 ± 0.054	0.703GluTrp: 0.703 ± 0.025	1.065GluTyr: 1.065 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.804PheAla: 4.804 ± 0.068	0.392PheCys: 0.392 ± 0.013	2.827PheAsp: 2.827 ± 0.041	2.386PheGlu: 2.386 ± 0.041	1.627PhePhe: 1.627 ± 0.034	3.943PheGly: 3.943 ± 0.053	0.777PheHis: 0.777 ± 0.022	2.044PheIle: 2.044 ± 0.036	0.996PheLys: 0.996 ± 0.028	3.609PheLeu: 3.609 ± 0.057	0.935PheMet: 0.935 ± 0.023	1.158PheAsn: 1.158 ± 0.027	1.672PhePro: 1.672 ± 0.032	1.04PheGln: 1.04 ± 0.024	2.284PheArg: 2.284 ± 0.041	2.789PheSer: 2.789 ± 0.045	2.108PheThr: 2.108 ± 0.041	2.865PheVal: 2.865 ± 0.041	0.563PheTrp: 0.563 ± 0.022	1.002PheTyr: 1.002 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.215GlyAla: 9.215 ± 0.095	0.795GlyCys: 0.795 ± 0.023	4.783GlyAsp: 4.783 ± 0.085	5.091GlyGlu: 5.091 ± 0.06	3.888GlyPhe: 3.888 ± 0.053	7.657GlyGly: 7.657 ± 0.216	1.809GlyHis: 1.809 ± 0.038	5.227GlyIle: 5.227 ± 0.068	3.358GlyLys: 3.358 ± 0.052	8.996GlyLeu: 8.996 ± 0.09	2.579GlyMet: 2.579 ± 0.04	2.445GlyAsn: 2.445 ± 0.064	3.454GlyPro: 3.454 ± 0.055	2.619GlyGln: 2.619 ± 0.044	5.839GlyArg: 5.839 ± 0.063	4.67GlySer: 4.67 ± 0.103	4.525GlyThr: 4.525 ± 0.132	6.096GlyVal: 6.096 ± 0.067	1.252GlyTrp: 1.252 ± 0.03	2.472GlyTyr: 2.472 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.208HisAla: 2.208 ± 0.036	0.232HisCys: 0.232 ± 0.011	1.312HisAsp: 1.312 ± 0.028	1.055HisGlu: 1.055 ± 0.023	0.897HisPhe: 0.897 ± 0.025	1.869HisGly: 1.869 ± 0.033	0.54HisHis: 0.54 ± 0.018	1.016HisIle: 1.016 ± 0.026	0.504HisLys: 0.504 ± 0.018	1.933HisLeu: 1.933 ± 0.039	0.528HisMet: 0.528 ± 0.018	0.477HisAsn: 0.477 ± 0.017	1.259HisPro: 1.259 ± 0.031	0.561HisGln: 0.561 ± 0.02	1.311HisArg: 1.311 ± 0.032	0.84HisSer: 0.84 ± 0.024	0.796HisThr: 0.796 ± 0.024	1.404HisVal: 1.404 ± 0.027	0.296HisTrp: 0.296 ± 0.013	0.576HisTyr: 0.576 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	8.309IleAla: 8.309 ± 0.069	0.565IleCys: 0.565 ± 0.018	4.001IleAsp: 4.001 ± 0.048	3.727IleGlu: 3.727 ± 0.046	2.078IlePhe: 2.078 ± 0.035	5.57IleGly: 5.57 ± 0.066	0.954IleHis: 0.954 ± 0.027	2.841IleIle: 2.841 ± 0.047	1.383IleLys: 1.383 ± 0.03	4.868IleLeu: 4.868 ± 0.062	1.24IleMet: 1.24 ± 0.031	1.588IleAsn: 1.588 ± 0.03	2.479IlePro: 2.479 ± 0.047	1.106IleGln: 1.106 ± 0.027	3.341IleArg: 3.341 ± 0.057	3.319IleSer: 3.319 ± 0.054	2.947IleThr: 2.947 ± 0.044	4.566IleVal: 4.566 ± 0.058	0.668IleTrp: 0.668 ± 0.02	1.35IleTyr: 1.35 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.4LysAla: 4.4 ± 0.061	0.176LysCys: 0.176 ± 0.01	1.721LysAsp: 1.721 ± 0.033	1.623LysGlu: 1.623 ± 0.034	0.872LysPhe: 0.872 ± 0.025	2.616LysGly: 2.616 ± 0.041	0.586LysHis: 0.586 ± 0.018	1.77LysIle: 1.77 ± 0.039	1.285LysLys: 1.285 ± 0.034	3.216LysLeu: 3.216 ± 0.045	0.825LysMet: 0.825 ± 0.025	0.92LysAsn: 0.92 ± 0.023	2.098LysPro: 2.098 ± 0.037	0.942LysGln: 0.942 ± 0.021	2.404LysArg: 2.404 ± 0.038	1.917LysSer: 1.917 ± 0.037	2.125LysThr: 2.125 ± 0.03	2.36LysVal: 2.36 ± 0.05	0.392LysTrp: 0.392 ± 0.015	0.604LysTyr: 0.604 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.189LeuAla: 13.189 ± 0.113	0.856LeuCys: 0.856 ± 0.029	5.876LeuAsp: 5.876 ± 0.063	5.588LeuGlu: 5.588 ± 0.068	3.907LeuPhe: 3.907 ± 0.057	8.024LeuGly: 8.024 ± 0.089	1.658LeuHis: 1.658 ± 0.035	5.318LeuIle: 5.318 ± 0.065	3.842LeuLys: 3.842 ± 0.054	9.121LeuLeu: 9.121 ± 0.105	2.582LeuMet: 2.582 ± 0.038	2.671LeuAsn: 2.671 ± 0.04	5.215LeuPro: 5.215 ± 0.071	2.63LeuGln: 2.63 ± 0.039	5.728LeuArg: 5.728 ± 0.073	7.188LeuSer: 7.188 ± 0.073	5.723LeuThr: 5.723 ± 0.08	7.072LeuVal: 7.072 ± 0.074	1.049LeuTrp: 1.049 ± 0.027	2.217LeuTyr: 2.217 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.413MetAla: 3.413 ± 0.053	0.15MetCys: 0.15 ± 0.01	1.231MetAsp: 1.231 ± 0.027	1.301MetGlu: 1.301 ± 0.028	0.759MetPhe: 0.759 ± 0.019	1.87MetGly: 1.87 ± 0.038	0.487MetHis: 0.487 ± 0.018	1.691MetIle: 1.691 ± 0.031	1.122MetLys: 1.122 ± 0.026	2.774MetLeu: 2.774 ± 0.045	0.811MetMet: 0.811 ± 0.022	0.922MetAsn: 0.922 ± 0.027	1.571MetPro: 1.571 ± 0.031	0.846MetGln: 0.846 ± 0.022	1.901MetArg: 1.901 ± 0.032	1.771MetSer: 1.771 ± 0.032	2.088MetThr: 2.088 ± 0.037	1.842MetVal: 1.842 ± 0.036	0.207MetTrp: 0.207 ± 0.011	0.328MetTyr: 0.328 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.485AsnAla: 3.485 ± 0.05	0.226AsnCys: 0.226 ± 0.011	1.636AsnAsp: 1.636 ± 0.041	1.4AsnGlu: 1.4 ± 0.032	1.086AsnPhe: 1.086 ± 0.029	2.802AsnGly: 2.802 ± 0.06	0.559AsnHis: 0.559 ± 0.02	1.597AsnIle: 1.597 ± 0.034	0.668AsnLys: 0.668 ± 0.017	2.655AsnLeu: 2.655 ± 0.042	0.714AsnMet: 0.714 ± 0.021	0.787AsnAsn: 0.787 ± 0.03	1.905AsnPro: 1.905 ± 0.038	0.796AsnGln: 0.796 ± 0.025	1.871AsnArg: 1.871 ± 0.033	1.261AsnSer: 1.261 ± 0.033	1.356AsnThr: 1.356 ± 0.035	1.998AsnVal: 1.998 ± 0.038	0.492AsnTrp: 0.492 ± 0.017	0.754AsnTyr: 0.754 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.702ProAla: 5.702 ± 0.067	0.285ProCys: 0.285 ± 0.013	3.698ProAsp: 3.698 ± 0.054	4.091ProGlu: 4.091 ± 0.06	2.064ProPhe: 2.064 ± 0.038	4.257ProGly: 4.257 ± 0.05	1.033ProHis: 1.033 ± 0.025	2.249ProIle: 2.249 ± 0.042	1.586ProLys: 1.586 ± 0.038	4.595ProLeu: 4.595 ± 0.06	1.194ProMet: 1.194 ± 0.029	1.273ProAsn: 1.273 ± 0.03	2.172ProPro: 2.172 ± 0.048	1.487ProGln: 1.487 ± 0.03	2.475ProArg: 2.475 ± 0.043	2.564ProSer: 2.564 ± 0.042	2.238ProThr: 2.238 ± 0.04	4.208ProVal: 4.208 ± 0.055	0.631ProTrp: 0.631 ± 0.023	1.267ProTyr: 1.267 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.469GlnAla: 3.469 ± 0.044	0.186GlnCys: 0.186 ± 0.012	1.375GlnAsp: 1.375 ± 0.031	1.38GlnGlu: 1.38 ± 0.033	1.068GlnPhe: 1.068 ± 0.026	2.011GlnGly: 2.011 ± 0.034	0.528GlnHis: 0.528 ± 0.018	1.766GlnIle: 1.766 ± 0.036	1.149GlnLys: 1.149 ± 0.027	2.538GlnLeu: 2.538 ± 0.039	0.9GlnMet: 0.9 ± 0.023	0.893GlnAsn: 0.893 ± 0.024	1.511GlnPro: 1.511 ± 0.034	1.076GlnGln: 1.076 ± 0.03	2.037GlnArg: 2.037 ± 0.037	1.761GlnSer: 1.761 ± 0.041	1.736GlnThr: 1.736 ± 0.036	1.928GlnVal: 1.928 ± 0.037	0.357GlnTrp: 0.357 ± 0.016	0.638GlnTyr: 0.638 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.222ArgAla: 7.222 ± 0.076	0.419ArgCys: 0.419 ± 0.016	3.888ArgAsp: 3.888 ± 0.051	3.989ArgGlu: 3.989 ± 0.059	2.938ArgPhe: 2.938 ± 0.048	4.278ArgGly: 4.278 ± 0.062	1.63ArgHis: 1.63 ± 0.033	3.955ArgIle: 3.955 ± 0.047	2.424ArgLys: 2.424 ± 0.042	7.25ArgLeu: 7.25 ± 0.083	1.936ArgMet: 1.936 ± 0.032	1.89ArgAsn: 1.89 ± 0.037	3.192ArgPro: 3.192 ± 0.048	2.423ArgGln: 2.423 ± 0.038	4.87ArgArg: 4.87 ± 0.07	3.377ArgSer: 3.377 ± 0.054	3.027ArgThr: 3.027 ± 0.046	4.145ArgVal: 4.145 ± 0.051	0.818ArgTrp: 0.818 ± 0.021	1.746ArgTyr: 1.746 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.439SerAla: 6.439 ± 0.075	0.376SerCys: 0.376 ± 0.015	3.279SerAsp: 3.279 ± 0.046	3.159SerGlu: 3.159 ± 0.042	2.413SerPhe: 2.413 ± 0.036	5.933SerGly: 5.933 ± 0.114	1.131SerHis: 1.131 ± 0.025	2.895SerIle: 2.895 ± 0.046	1.523SerLys: 1.523 ± 0.036	5.608SerLeu: 5.608 ± 0.06	1.388SerMet: 1.388 ± 0.029	1.389SerAsn: 1.389 ± 0.032	2.669SerPro: 2.669 ± 0.043	1.505SerGln: 1.505 ± 0.033	3.447SerArg: 3.447 ± 0.044	2.996SerSer: 2.996 ± 0.068	2.689SerThr: 2.689 ± 0.055	4.22SerVal: 4.22 ± 0.057	0.734SerTrp: 0.734 ± 0.023	1.423SerTyr: 1.423 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.165ThrAla: 6.165 ± 0.071	0.41ThrCys: 0.41 ± 0.016	2.934ThrAsp: 2.934 ± 0.048	2.795ThrGlu: 2.795 ± 0.045	2.125ThrPhe: 2.125 ± 0.035	5.421ThrGly: 5.421 ± 0.095	0.987ThrHis: 0.987 ± 0.022	3.177ThrIle: 3.177 ± 0.056	1.377ThrLys: 1.377 ± 0.03	5.958ThrLeu: 5.958 ± 0.087	1.356ThrMet: 1.356 ± 0.031	1.32ThrAsn: 1.32 ± 0.044	3.202ThrPro: 3.202 ± 0.052	1.207ThrGln: 1.207 ± 0.031	3.139ThrArg: 3.139 ± 0.045	2.697ThrSer: 2.697 ± 0.054	2.816ThrThr: 2.816 ± 0.069	4.559ThrVal: 4.559 ± 0.085	0.629ThrTrp: 0.629 ± 0.018	1.252ThrTyr: 1.252 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.623ValAla: 8.623 ± 0.091	0.608ValCys: 0.608 ± 0.019	4.058ValAsp: 4.058 ± 0.053	4.451ValGlu: 4.451 ± 0.054	3.072ValPhe: 3.072 ± 0.043	5.317ValGly: 5.317 ± 0.075	1.257ValHis: 1.257 ± 0.03	4.428ValIle: 4.428 ± 0.052	2.236ValLys: 2.236 ± 0.042	7.196ValLeu: 7.196 ± 0.074	1.987ValMet: 1.987 ± 0.037	2.13ValAsn: 2.13 ± 0.034	3.43ValPro: 3.43 ± 0.049	1.749ValGln: 1.749 ± 0.03	4.274ValArg: 4.274 ± 0.047	4.661ValSer: 4.661 ± 0.06	4.537ValThr: 4.537 ± 0.068	5.525ValVal: 5.525 ± 0.07	0.866ValTrp: 0.866 ± 0.025	1.632ValTyr: 1.632 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.064TrpAla: 1.064 ± 0.029	0.124TrpCys: 0.124 ± 0.01	0.622TrpAsp: 0.622 ± 0.02	0.545TrpGlu: 0.545 ± 0.019	0.546TrpPhe: 0.546 ± 0.021	0.85TrpGly: 0.85 ± 0.023	0.309TrpHis: 0.309 ± 0.014	0.683TrpIle: 0.683 ± 0.023	0.506TrpLys: 0.506 ± 0.017	1.543TrpLeu: 1.543 ± 0.036	0.375TrpMet: 0.375 ± 0.017	0.465TrpAsn: 0.465 ± 0.016	0.644TrpPro: 0.644 ± 0.019	0.611TrpGln: 0.611 ± 0.02	0.986TrpArg: 0.986 ± 0.027	0.821TrpSer: 0.821 ± 0.024	0.739TrpThr: 0.739 ± 0.023	0.771TrpVal: 0.771 ± 0.023	0.227TrpTrp: 0.227 ± 0.014	0.3TrpTyr: 0.3 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.618TyrAla: 2.618 ± 0.042	0.263TyrCys: 0.263 ± 0.014	1.648TyrAsp: 1.648 ± 0.032	1.314TyrGlu: 1.314 ± 0.03	1.016TyrPhe: 1.016 ± 0.025	2.251TyrGly: 2.251 ± 0.043	0.523TyrHis: 0.523 ± 0.018	1.081TyrIle: 1.081 ± 0.03	0.62TyrLys: 0.62 ± 0.019	2.39TyrLeu: 2.39 ± 0.034	0.51TyrMet: 0.51 ± 0.021	0.713TyrAsn: 0.713 ± 0.021	1.242TyrPro: 1.242 ± 0.029	0.767TyrGln: 0.767 ± 0.02	1.81TyrArg: 1.81 ± 0.038	1.204TyrSer: 1.204 ± 0.032	1.158TyrThr: 1.158 ± 0.034	1.607TyrVal: 1.607 ± 0.028	0.372TyrTrp: 0.372 ± 0.016	0.674TyrTyr: 0.674 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5139 proteins (1671462 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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