Amino acid dipepetide frequency for Enterococcus saccharolyticus subsp. saccharolyticus ATCC 43076

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.672AlaAla: 5.672 ± 0.11
0.614AlaCys: 0.614 ± 0.029
3.799AlaAsp: 3.799 ± 0.075
5.101AlaGlu: 5.101 ± 0.099
3.439AlaPhe: 3.439 ± 0.067
4.951AlaGly: 4.951 ± 0.086
1.357AlaHis: 1.357 ± 0.042
6.155AlaIle: 6.155 ± 0.095
4.977AlaLys: 4.977 ± 0.094
7.648AlaLeu: 7.648 ± 0.116
2.136AlaMet: 2.136 ± 0.062
3.133AlaAsn: 3.133 ± 0.068
2.13AlaPro: 2.13 ± 0.053
3.167AlaGln: 3.167 ± 0.08
2.617AlaArg: 2.617 ± 0.07
4.251AlaSer: 4.251 ± 0.07
4.688AlaThr: 4.688 ± 0.082
5.225AlaVal: 5.225 ± 0.093
0.581AlaTrp: 0.581 ± 0.027
2.603AlaTyr: 2.603 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.417CysAla: 0.417 ± 0.022
0.079CysCys: 0.079 ± 0.012
0.339CysAsp: 0.339 ± 0.023
0.364CysGlu: 0.364 ± 0.022
0.324CysPhe: 0.324 ± 0.022
0.631CysGly: 0.631 ± 0.031
0.197CysHis: 0.197 ± 0.02
0.406CysIle: 0.406 ± 0.024
0.231CysLys: 0.231 ± 0.016
0.668CysLeu: 0.668 ± 0.035
0.148CysMet: 0.148 ± 0.014
0.214CysAsn: 0.214 ± 0.016
0.293CysPro: 0.293 ± 0.023
0.302CysGln: 0.302 ± 0.02
0.251CysArg: 0.251 ± 0.02
0.445CysSer: 0.445 ± 0.026
0.332CysThr: 0.332 ± 0.02
0.403CysVal: 0.403 ± 0.022
0.063CysTrp: 0.063 ± 0.009
0.269CysTyr: 0.269 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.791AspAla: 3.791 ± 0.08
0.307AspCys: 0.307 ± 0.021
2.5AspAsp: 2.5 ± 0.072
4.439AspGlu: 4.439 ± 0.085
2.893AspPhe: 2.893 ± 0.065
3.431AspGly: 3.431 ± 0.078
1.019AspHis: 1.019 ± 0.036
3.946AspIle: 3.946 ± 0.085
3.024AspLys: 3.024 ± 0.072
4.904AspLeu: 4.904 ± 0.083
1.289AspMet: 1.289 ± 0.046
2.084AspAsn: 2.084 ± 0.057
1.773AspPro: 1.773 ± 0.048
1.903AspGln: 1.903 ± 0.047
1.923AspArg: 1.923 ± 0.049
2.574AspSer: 2.574 ± 0.062
2.863AspThr: 2.863 ± 0.064
3.959AspVal: 3.959 ± 0.077
0.669AspTrp: 0.669 ± 0.035
2.367AspTyr: 2.367 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
5.71GluAla: 5.71 ± 0.1
0.357GluCys: 0.357 ± 0.024
3.549GluAsp: 3.549 ± 0.075
6.937GluGlu: 6.937 ± 0.115
2.731GluPhe: 2.731 ± 0.054
3.913GluGly: 3.913 ± 0.086
1.268GluHis: 1.268 ± 0.047
5.666GluIle: 5.666 ± 0.094
6.453GluLys: 6.453 ± 0.104
7.541GluLeu: 7.541 ± 0.104
2.321GluMet: 2.321 ± 0.054
3.843GluAsn: 3.843 ± 0.066
1.886GluPro: 1.886 ± 0.06
3.712GluGln: 3.712 ± 0.087
3.035GluArg: 3.035 ± 0.072
3.218GluSer: 3.218 ± 0.066
4.696GluThr: 4.696 ± 0.081
4.981GluVal: 4.981 ± 0.09
0.686GluTrp: 0.686 ± 0.029
2.201GluTyr: 2.201 ± 0.061
0.0GluXaa: 0.0 ± 0.0
Phe
3.382PheAla: 3.382 ± 0.068
0.366PheCys: 0.366 ± 0.024
2.767PheAsp: 2.767 ± 0.062
2.947PheGlu: 2.947 ± 0.064
2.565PhePhe: 2.565 ± 0.071
3.312PheGly: 3.312 ± 0.068
0.92PheHis: 0.92 ± 0.038
3.405PheIle: 3.405 ± 0.079
2.179PheLys: 2.179 ± 0.058
4.877PheLeu: 4.877 ± 0.117
1.108PheMet: 1.108 ± 0.038
1.952PheAsn: 1.952 ± 0.041
1.773PhePro: 1.773 ± 0.043
1.953PheGln: 1.953 ± 0.052
1.53PheArg: 1.53 ± 0.052
3.337PheSer: 3.337 ± 0.085
2.674PheThr: 2.674 ± 0.061
3.47PheVal: 3.47 ± 0.076
0.457PheTrp: 0.457 ± 0.027
1.94PheTyr: 1.94 ± 0.062
0.0PheXaa: 0.0 ± 0.0
Gly
4.499GlyAla: 4.499 ± 0.094
0.463GlyCys: 0.463 ± 0.028
3.046GlyAsp: 3.046 ± 0.068
4.175GlyGlu: 4.175 ± 0.081
3.234GlyPhe: 3.234 ± 0.074
4.398GlyGly: 4.398 ± 0.092
1.218GlyHis: 1.218 ± 0.041
5.85GlyIle: 5.85 ± 0.096
4.646GlyLys: 4.646 ± 0.083
6.269GlyLeu: 6.269 ± 0.104
2.057GlyMet: 2.057 ± 0.058
2.721GlyAsn: 2.721 ± 0.064
1.445GlyPro: 1.445 ± 0.045
2.347GlyGln: 2.347 ± 0.059
2.391GlyArg: 2.391 ± 0.062
3.532GlySer: 3.532 ± 0.068
4.129GlyThr: 4.129 ± 0.074
4.892GlyVal: 4.892 ± 0.095
0.652GlyTrp: 0.652 ± 0.033
2.663GlyTyr: 2.663 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
1.322HisAla: 1.322 ± 0.047
0.158HisCys: 0.158 ± 0.013
1.0HisAsp: 1.0 ± 0.037
1.323HisGlu: 1.323 ± 0.048
1.175HisPhe: 1.175 ± 0.038
1.252HisGly: 1.252 ± 0.044
0.588HisHis: 0.588 ± 0.03
1.235HisIle: 1.235 ± 0.047
0.828HisLys: 0.828 ± 0.036
2.12HisLeu: 2.12 ± 0.055
0.441HisMet: 0.441 ± 0.029
0.65HisAsn: 0.65 ± 0.03
1.079HisPro: 1.079 ± 0.038
1.106HisGln: 1.106 ± 0.04
0.925HisArg: 0.925 ± 0.039
1.163HisSer: 1.163 ± 0.04
1.1HisThr: 1.1 ± 0.039
1.323HisVal: 1.323 ± 0.049
0.232HisTrp: 0.232 ± 0.017
0.936HisTyr: 0.936 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.228IleAla: 6.228 ± 0.1
0.634IleCys: 0.634 ± 0.029
4.51IleAsp: 4.51 ± 0.09
5.295IleGlu: 5.295 ± 0.09
3.491IlePhe: 3.491 ± 0.086
5.572IleGly: 5.572 ± 0.1
1.604IleHis: 1.604 ± 0.05
5.305IleIle: 5.305 ± 0.112
3.703IleLys: 3.703 ± 0.065
7.13IleLeu: 7.13 ± 0.115
1.576IleMet: 1.576 ± 0.043
3.112IleAsn: 3.112 ± 0.063
3.132IlePro: 3.132 ± 0.059
3.599IleGln: 3.599 ± 0.084
3.065IleArg: 3.065 ± 0.066
4.514IleSer: 4.514 ± 0.088
4.207IleThr: 4.207 ± 0.078
5.439IleVal: 5.439 ± 0.086
0.563IleTrp: 0.563 ± 0.027
2.537IleTyr: 2.537 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
4.478LysAla: 4.478 ± 0.094
0.24LysCys: 0.24 ± 0.02
3.306LysAsp: 3.306 ± 0.063
6.682LysGlu: 6.682 ± 0.105
1.877LysPhe: 1.877 ± 0.057
3.57LysGly: 3.57 ± 0.071
1.063LysHis: 1.063 ± 0.037
4.792LysIle: 4.792 ± 0.079
5.518LysLys: 5.518 ± 0.1
5.061LysLeu: 5.061 ± 0.076
2.188LysMet: 2.188 ± 0.053
3.49LysAsn: 3.49 ± 0.083
1.697LysPro: 1.697 ± 0.053
3.339LysGln: 3.339 ± 0.08
2.974LysArg: 2.974 ± 0.068
2.745LysSer: 2.745 ± 0.064
3.48LysThr: 3.48 ± 0.068
4.141LysVal: 4.141 ± 0.067
0.566LysTrp: 0.566 ± 0.028
2.084LysTyr: 2.084 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
8.672LeuAla: 8.672 ± 0.119
0.654LeuCys: 0.654 ± 0.032
5.089LeuAsp: 5.089 ± 0.095
6.606LeuGlu: 6.606 ± 0.097
4.971LeuPhe: 4.971 ± 0.115
6.384LeuGly: 6.384 ± 0.101
1.839LeuHis: 1.839 ± 0.049
6.913LeuIle: 6.913 ± 0.127
5.771LeuLys: 5.771 ± 0.09
10.41LeuLeu: 10.41 ± 0.173
2.519LeuMet: 2.519 ± 0.05
4.103LeuAsn: 4.103 ± 0.084
4.292LeuPro: 4.292 ± 0.089
4.03LeuGln: 4.03 ± 0.085
3.707LeuArg: 3.707 ± 0.073
6.474LeuSer: 6.474 ± 0.11
6.467LeuThr: 6.467 ± 0.101
6.844LeuVal: 6.844 ± 0.108
0.706LeuTrp: 0.706 ± 0.03
3.092LeuTyr: 3.092 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
1.915MetAla: 1.915 ± 0.055
0.137MetCys: 0.137 ± 0.012
1.444MetAsp: 1.444 ± 0.048
1.709MetGlu: 1.709 ± 0.05
0.973MetPhe: 0.973 ± 0.036
1.695MetGly: 1.695 ± 0.06
0.457MetHis: 0.457 ± 0.023
2.191MetIle: 2.191 ± 0.066
2.188MetLys: 2.188 ± 0.056
2.322MetLeu: 2.322 ± 0.056
0.907MetMet: 0.907 ± 0.046
1.614MetAsn: 1.614 ± 0.043
0.854MetPro: 0.854 ± 0.036
1.072MetGln: 1.072 ± 0.037
1.02MetArg: 1.02 ± 0.035
1.614MetSer: 1.614 ± 0.046
1.991MetThr: 1.991 ± 0.054
1.784MetVal: 1.784 ± 0.048
0.163MetTrp: 0.163 ± 0.015
0.875MetTyr: 0.875 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.763AsnAla: 2.763 ± 0.062
0.272AsnCys: 0.272 ± 0.018
2.37AsnAsp: 2.37 ± 0.067
3.296AsnGlu: 3.296 ± 0.068
1.897AsnPhe: 1.897 ± 0.052
3.188AsnGly: 3.188 ± 0.072
1.109AsnHis: 1.109 ± 0.042
3.052AsnIle: 3.052 ± 0.055
2.428AsnLys: 2.428 ± 0.067
3.949AsnLeu: 3.949 ± 0.07
1.068AsnMet: 1.068 ± 0.035
1.94AsnAsn: 1.94 ± 0.062
1.982AsnPro: 1.982 ± 0.057
2.664AsnGln: 2.664 ± 0.066
1.922AsnArg: 1.922 ± 0.051
2.057AsnSer: 2.057 ± 0.056
2.146AsnThr: 2.146 ± 0.052
2.944AsnVal: 2.944 ± 0.06
0.501AsnTrp: 0.501 ± 0.027
2.011AsnTyr: 2.011 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
2.34ProAla: 2.34 ± 0.064
0.163ProCys: 0.163 ± 0.015
1.907ProAsp: 1.907 ± 0.053
3.301ProGlu: 3.301 ± 0.081
1.792ProPhe: 1.792 ± 0.053
1.84ProGly: 1.84 ± 0.051
0.698ProHis: 0.698 ± 0.03
2.637ProIle: 2.637 ± 0.057
2.296ProLys: 2.296 ± 0.055
3.348ProLeu: 3.348 ± 0.076
0.865ProMet: 0.865 ± 0.034
1.659ProAsn: 1.659 ± 0.044
0.698ProPro: 0.698 ± 0.036
1.47ProGln: 1.47 ± 0.043
1.07ProArg: 1.07 ± 0.037
1.968ProSer: 1.968 ± 0.061
2.401ProThr: 2.401 ± 0.057
2.619ProVal: 2.619 ± 0.062
0.305ProTrp: 0.305 ± 0.021
1.421ProTyr: 1.421 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
4.064GlnAla: 4.064 ± 0.083
0.168GlnCys: 0.168 ± 0.014
1.824GlnAsp: 1.824 ± 0.049
3.712GlnGlu: 3.712 ± 0.09
1.813GlnPhe: 1.813 ± 0.05
2.416GlnGly: 2.416 ± 0.058
0.925GlnHis: 0.925 ± 0.036
2.939GlnIle: 2.939 ± 0.058
3.322GlnLys: 3.322 ± 0.079
5.292GlnLeu: 5.292 ± 0.1
1.218GlnMet: 1.218 ± 0.046
1.748GlnAsn: 1.748 ± 0.054
1.559GlnPro: 1.559 ± 0.047
2.953GlnGln: 2.953 ± 0.107
2.055GlnArg: 2.055 ± 0.058
2.105GlnSer: 2.105 ± 0.062
3.039GlnThr: 3.039 ± 0.076
2.991GlnVal: 2.991 ± 0.064
0.474GlnTrp: 0.474 ± 0.025
1.355GlnTyr: 1.355 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
2.365ArgAla: 2.365 ± 0.057
0.248ArgCys: 0.248 ± 0.02
1.803ArgAsp: 1.803 ± 0.055
3.092ArgGlu: 3.092 ± 0.069
1.966ArgPhe: 1.966 ± 0.054
2.136ArgGly: 2.136 ± 0.054
0.777ArgHis: 0.777 ± 0.032
2.861ArgIle: 2.861 ± 0.063
2.93ArgLys: 2.93 ± 0.07
4.073ArgLeu: 4.073 ± 0.083
1.156ArgMet: 1.156 ± 0.042
1.708ArgAsn: 1.708 ± 0.05
1.313ArgPro: 1.313 ± 0.042
2.105ArgGln: 2.105 ± 0.047
1.889ArgArg: 1.889 ± 0.051
1.949ArgSer: 1.949 ± 0.054
2.065ArgThr: 2.065 ± 0.052
2.717ArgVal: 2.717 ± 0.062
0.382ArgTrp: 0.382 ± 0.021
1.8ArgTyr: 1.8 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
3.591SerAla: 3.591 ± 0.083
0.368SerCys: 0.368 ± 0.024
2.726SerAsp: 2.726 ± 0.058
3.914SerGlu: 3.914 ± 0.072
3.077SerPhe: 3.077 ± 0.069
4.154SerGly: 4.154 ± 0.077
1.183SerHis: 1.183 ± 0.039
4.301SerIle: 4.301 ± 0.073
3.238SerLys: 3.238 ± 0.064
5.842SerLeu: 5.842 ± 0.108
1.495SerMet: 1.495 ± 0.048
2.247SerAsn: 2.247 ± 0.059
1.794SerPro: 1.794 ± 0.048
2.327SerGln: 2.327 ± 0.057
2.175SerArg: 2.175 ± 0.056
3.401SerSer: 3.401 ± 0.086
3.193SerThr: 3.193 ± 0.071
3.956SerVal: 3.956 ± 0.086
0.626SerTrp: 0.626 ± 0.029
2.23SerTyr: 2.23 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
4.275ThrAla: 4.275 ± 0.072
0.328ThrCys: 0.328 ± 0.019
3.197ThrAsp: 3.197 ± 0.078
4.028ThrGlu: 4.028 ± 0.07
2.877ThrPhe: 2.877 ± 0.067
4.141ThrGly: 4.141 ± 0.075
1.292ThrHis: 1.292 ± 0.041
5.278ThrIle: 5.278 ± 0.092
3.621ThrLys: 3.621 ± 0.071
5.879ThrLeu: 5.879 ± 0.081
1.517ThrMet: 1.517 ± 0.045
2.704ThrAsn: 2.704 ± 0.061
2.594ThrPro: 2.594 ± 0.068
2.204ThrGln: 2.204 ± 0.068
2.054ThrArg: 2.054 ± 0.052
3.443ThrSer: 3.443 ± 0.064
3.944ThrThr: 3.944 ± 0.085
4.364ThrVal: 4.364 ± 0.084
0.518ThrTrp: 0.518 ± 0.026
2.28ThrTyr: 2.28 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
5.846ValAla: 5.846 ± 0.094
0.484ValCys: 0.484 ± 0.029
3.792ValAsp: 3.792 ± 0.072
4.723ValGlu: 4.723 ± 0.089
3.247ValPhe: 3.247 ± 0.073
4.673ValGly: 4.673 ± 0.081
1.281ValHis: 1.281 ± 0.043
5.517ValIle: 5.517 ± 0.085
3.847ValLys: 3.847 ± 0.079
6.88ValLeu: 6.88 ± 0.11
1.865ValMet: 1.865 ± 0.056
2.735ValAsn: 2.735 ± 0.057
2.787ValPro: 2.787 ± 0.063
2.529ValGln: 2.529 ± 0.062
2.567ValArg: 2.567 ± 0.068
4.509ValSer: 4.509 ± 0.069
4.65ValThr: 4.65 ± 0.087
5.383ValVal: 5.383 ± 0.098
0.581ValTrp: 0.581 ± 0.037
2.407ValTyr: 2.407 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.55TrpAla: 0.55 ± 0.027
0.075TrpCys: 0.075 ± 0.012
0.515TrpAsp: 0.515 ± 0.028
0.604TrpGlu: 0.604 ± 0.029
0.488TrpPhe: 0.488 ± 0.029
0.572TrpGly: 0.572 ± 0.031
0.23TrpHis: 0.23 ± 0.02
0.644TrpIle: 0.644 ± 0.029
0.505TrpLys: 0.505 ± 0.025
1.148TrpLeu: 1.148 ± 0.044
0.293TrpMet: 0.293 ± 0.022
0.445TrpAsn: 0.445 ± 0.027
0.189TrpPro: 0.189 ± 0.017
0.711TrpGln: 0.711 ± 0.034
0.404TrpArg: 0.404 ± 0.021
0.491TrpSer: 0.491 ± 0.024
0.503TrpThr: 0.503 ± 0.022
0.497TrpVal: 0.497 ± 0.025
0.125TrpTrp: 0.125 ± 0.013
0.293TrpTyr: 0.293 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.364TyrAla: 2.364 ± 0.055
0.261TyrCys: 0.261 ± 0.018
2.172TyrAsp: 2.172 ± 0.068
2.457TyrGlu: 2.457 ± 0.067
2.086TyrPhe: 2.086 ± 0.064
2.401TyrGly: 2.401 ± 0.064
0.932TyrHis: 0.932 ± 0.034
2.124TyrIle: 2.124 ± 0.059
1.587TyrLys: 1.587 ± 0.046
4.179TyrLeu: 4.179 ± 0.069
0.756TyrMet: 0.756 ± 0.033
1.457TyrAsn: 1.457 ± 0.046
1.527TyrPro: 1.527 ± 0.045
2.478TyrGln: 2.478 ± 0.07
1.76TyrArg: 1.76 ± 0.05
2.05TyrSer: 2.05 ± 0.049
1.971TyrThr: 1.971 ± 0.059
2.372TyrVal: 2.372 ± 0.054
0.431TyrTrp: 0.431 ± 0.024
1.551TyrTyr: 1.551 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2573 proteins (761874 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski