Amino acid dipepetide frequency for Feline coronavirus UU15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.264AlaAla: 4.264 ± 0.844
2.426AlaCys: 2.426 ± 0.473
2.426AlaAsp: 2.426 ± 0.543
2.867AlaGlu: 2.867 ± 0.345
4.191AlaPhe: 4.191 ± 0.584
3.088AlaGly: 3.088 ± 0.424
0.809AlaHis: 0.809 ± 0.138
5.441AlaIle: 5.441 ± 0.814
4.632AlaLys: 4.632 ± 0.892
5.147AlaLeu: 5.147 ± 0.65
1.25AlaMet: 1.25 ± 0.215
3.676AlaAsn: 3.676 ± 0.44
1.544AlaPro: 1.544 ± 0.227
1.397AlaGln: 1.397 ± 0.37
2.573AlaArg: 2.573 ± 0.327
4.411AlaSer: 4.411 ± 0.637
2.867AlaThr: 2.867 ± 0.404
4.853AlaVal: 4.853 ± 1.358
0.588AlaTrp: 0.588 ± 0.21
3.75AlaTyr: 3.75 ± 0.834
0.221AlaXaa: 0.221 ± 0.09
Cys
1.544CysAla: 1.544 ± 0.435
0.809CysCys: 0.809 ± 0.233
2.279CysAsp: 2.279 ± 0.664
0.735CysGlu: 0.735 ± 0.219
1.397CysPhe: 1.397 ± 0.239
3.014CysGly: 3.014 ± 0.87
0.515CysHis: 0.515 ± 0.18
1.618CysIle: 1.618 ± 0.478
1.397CysLys: 1.397 ± 0.42
2.206CysLeu: 2.206 ± 0.537
0.735CysMet: 0.735 ± 0.373
1.691CysAsn: 1.691 ± 0.394
1.25CysPro: 1.25 ± 0.186
0.662CysGln: 0.662 ± 0.196
0.735CysArg: 0.735 ± 0.26
1.838CysSer: 1.838 ± 0.417
1.912CysThr: 1.912 ± 0.555
3.162CysVal: 3.162 ± 0.494
0.515CysTrp: 0.515 ± 0.182
2.353CysTyr: 2.353 ± 0.535
0.0CysXaa: 0.0 ± 0.0
Asp
4.117AspAla: 4.117 ± 0.563
1.691AspCys: 1.691 ± 0.355
2.72AspAsp: 2.72 ± 0.399
2.72AspGlu: 2.72 ± 0.342
3.676AspPhe: 3.676 ± 0.533
4.191AspGly: 4.191 ± 0.638
1.25AspHis: 1.25 ± 0.284
2.059AspIle: 2.059 ± 0.462
2.72AspLys: 2.72 ± 0.627
5.588AspLeu: 5.588 ± 0.469
1.323AspMet: 1.323 ± 0.35
2.867AspAsn: 2.867 ± 0.697
1.47AspPro: 1.47 ± 0.393
1.029AspGln: 1.029 ± 0.555
2.059AspArg: 2.059 ± 0.242
3.456AspSer: 3.456 ± 0.838
2.573AspThr: 2.573 ± 0.667
6.25AspVal: 6.25 ± 1.139
0.882AspTrp: 0.882 ± 0.324
3.603AspTyr: 3.603 ± 0.584
0.0AspXaa: 0.0 ± 0.0
Glu
2.426GluAla: 2.426 ± 0.526
1.765GluCys: 1.765 ± 0.295
2.867GluAsp: 2.867 ± 0.66
3.235GluGlu: 3.235 ± 0.722
2.794GluPhe: 2.794 ± 0.493
3.014GluGly: 3.014 ± 0.775
1.397GluHis: 1.397 ± 0.391
2.279GluIle: 2.279 ± 0.633
3.088GluLys: 3.088 ± 0.497
3.603GluLeu: 3.603 ± 0.373
0.515GluMet: 0.515 ± 0.2
2.206GluAsn: 2.206 ± 0.646
1.544GluPro: 1.544 ± 0.294
2.059GluGln: 2.059 ± 0.378
1.985GluArg: 1.985 ± 0.481
2.794GluSer: 2.794 ± 0.517
1.985GluThr: 1.985 ± 0.386
3.75GluVal: 3.75 ± 0.79
0.368GluTrp: 0.368 ± 0.175
1.618GluTyr: 1.618 ± 0.368
0.147GluXaa: 0.147 ± 0.054
Phe
3.088PheAla: 3.088 ± 0.568
1.691PheCys: 1.691 ± 0.507
4.117PheAsp: 4.117 ± 0.694
2.794PheGlu: 2.794 ± 0.349
2.647PhePhe: 2.647 ± 0.585
3.456PheGly: 3.456 ± 0.435
0.294PheHis: 0.294 ± 0.292
3.235PheIle: 3.235 ± 0.638
4.411PheLys: 4.411 ± 0.837
3.603PheLeu: 3.603 ± 0.361
1.397PheMet: 1.397 ± 0.373
3.97PheAsn: 3.97 ± 1.241
0.515PhePro: 0.515 ± 0.182
1.029PheGln: 1.029 ± 0.635
0.735PheArg: 0.735 ± 0.26
3.897PheSer: 3.897 ± 1.285
3.088PheThr: 3.088 ± 0.585
7.646PheVal: 7.646 ± 0.856
1.029PheTrp: 1.029 ± 0.523
3.603PheTyr: 3.603 ± 0.575
0.074PheXaa: 0.074 ± 0.258
Gly
3.823GlyAla: 3.823 ± 0.373
1.618GlyCys: 1.618 ± 0.33
5.073GlyAsp: 5.073 ± 0.698
3.75GlyGlu: 3.75 ± 0.775
4.632GlyPhe: 4.632 ± 0.463
3.382GlyGly: 3.382 ± 0.363
0.441GlyHis: 0.441 ± 0.138
3.309GlyIle: 3.309 ± 0.602
4.411GlyLys: 4.411 ± 0.516
4.338GlyLeu: 4.338 ± 0.607
1.323GlyMet: 1.323 ± 0.313
3.456GlyAsn: 3.456 ± 0.486
1.618GlyPro: 1.618 ± 0.325
0.809GlyGln: 0.809 ± 0.395
1.618GlyArg: 1.618 ± 1.162
4.853GlySer: 4.853 ± 0.767
4.117GlyThr: 4.117 ± 0.663
5.882GlyVal: 5.882 ± 0.605
0.294GlyTrp: 0.294 ± 0.224
2.941GlyTyr: 2.941 ± 0.328
0.221GlyXaa: 0.221 ± 0.201
His
1.25HisAla: 1.25 ± 0.303
0.441HisCys: 0.441 ± 0.139
1.25HisAsp: 1.25 ± 0.304
0.735HisGlu: 0.735 ± 0.295
1.47HisPhe: 1.47 ± 0.187
0.662HisGly: 0.662 ± 0.557
0.294HisHis: 0.294 ± 0.133
0.956HisIle: 0.956 ± 0.425
1.912HisLys: 1.912 ± 0.336
1.912HisLeu: 1.912 ± 0.585
0.441HisMet: 0.441 ± 0.187
1.47HisAsn: 1.47 ± 0.273
0.588HisPro: 0.588 ± 0.267
0.147HisGln: 0.147 ± 0.15
0.368HisArg: 0.368 ± 0.122
0.588HisSer: 0.588 ± 0.262
1.103HisThr: 1.103 ± 0.33
1.912HisVal: 1.912 ± 0.383
0.147HisTrp: 0.147 ± 0.094
0.662HisTyr: 0.662 ± 0.19
0.0HisXaa: 0.0 ± 0.0
Ile
4.558IleAla: 4.558 ± 0.775
0.956IleCys: 0.956 ± 0.296
2.72IleAsp: 2.72 ± 0.994
2.426IleGlu: 2.426 ± 0.366
2.426IlePhe: 2.426 ± 0.288
3.456IleGly: 3.456 ± 0.76
0.588IleHis: 0.588 ± 0.206
2.5IleIle: 2.5 ± 2.18
3.676IleLys: 3.676 ± 0.721
5.808IleLeu: 5.808 ± 1.026
1.176IleMet: 1.176 ± 0.268
3.529IleAsn: 3.529 ± 0.79
1.985IlePro: 1.985 ± 0.395
1.397IleGln: 1.397 ± 0.382
1.691IleArg: 1.691 ± 0.423
2.867IleSer: 2.867 ± 0.669
4.117IleThr: 4.117 ± 0.836
6.617IleVal: 6.617 ± 1.0
0.515IleTrp: 0.515 ± 0.278
2.132IleTyr: 2.132 ± 0.321
0.147IleXaa: 0.147 ± 0.054
Lys
4.117LysAla: 4.117 ± 0.706
2.573LysCys: 2.573 ± 0.639
3.823LysAsp: 3.823 ± 0.913
2.353LysGlu: 2.353 ± 0.553
2.794LysPhe: 2.794 ± 0.559
2.794LysGly: 2.794 ± 0.625
2.132LysHis: 2.132 ± 0.598
4.485LysIle: 4.485 ± 0.691
2.353LysLys: 2.353 ± 0.434
6.176LysLeu: 6.176 ± 1.132
2.132LysMet: 2.132 ± 0.54
3.162LysAsn: 3.162 ± 0.399
3.603LysPro: 3.603 ± 0.53
2.279LysGln: 2.279 ± 0.494
1.544LysArg: 1.544 ± 0.496
4.706LysSer: 4.706 ± 0.722
4.117LysThr: 4.117 ± 0.718
5.073LysVal: 5.073 ± 0.843
0.588LysTrp: 0.588 ± 0.477
3.456LysTyr: 3.456 ± 0.483
0.147LysXaa: 0.147 ± 0.054
Leu
4.926LeuAla: 4.926 ± 0.723
2.941LeuCys: 2.941 ± 0.563
4.044LeuAsp: 4.044 ± 0.735
5.514LeuGlu: 5.514 ± 0.81
4.558LeuPhe: 4.558 ± 0.659
5.514LeuGly: 5.514 ± 0.568
1.323LeuHis: 1.323 ± 0.616
3.823LeuIle: 3.823 ± 1.367
6.47LeuLys: 6.47 ± 1.124
8.235LeuLeu: 8.235 ± 2.937
1.838LeuMet: 1.838 ± 0.252
5.367LeuAsn: 5.367 ± 1.182
3.382LeuPro: 3.382 ± 0.83
3.823LeuGln: 3.823 ± 0.679
2.206LeuArg: 2.206 ± 0.847
5.808LeuSer: 5.808 ± 0.428
4.926LeuThr: 4.926 ± 0.66
5.514LeuVal: 5.514 ± 1.03
1.47LeuTrp: 1.47 ± 0.421
3.529LeuTyr: 3.529 ± 0.591
0.368LeuXaa: 0.368 ± 0.273
Met
2.206MetAla: 2.206 ± 0.3
1.103MetCys: 1.103 ± 0.405
0.882MetAsp: 0.882 ± 0.222
0.147MetGlu: 0.147 ± 0.094
0.662MetPhe: 0.662 ± 0.713
1.47MetGly: 1.47 ± 0.532
0.735MetHis: 0.735 ± 0.26
1.618MetIle: 1.618 ± 0.41
0.735MetLys: 0.735 ± 0.212
3.014MetLeu: 3.014 ± 0.304
0.662MetMet: 0.662 ± 0.375
0.588MetAsn: 0.588 ± 0.195
1.397MetPro: 1.397 ± 0.34
0.956MetGln: 0.956 ± 0.348
1.029MetArg: 1.029 ± 0.308
1.323MetSer: 1.323 ± 0.394
1.47MetThr: 1.47 ± 0.393
1.985MetVal: 1.985 ± 0.587
0.074MetTrp: 0.074 ± 0.237
1.25MetTyr: 1.25 ± 0.197
0.147MetXaa: 0.147 ± 0.054
Asn
3.823AsnAla: 3.823 ± 0.691
1.765AsnCys: 1.765 ± 0.302
2.279AsnAsp: 2.279 ± 0.302
2.059AsnGlu: 2.059 ± 0.324
3.162AsnPhe: 3.162 ± 0.825
5.882AsnGly: 5.882 ± 1.066
0.956AsnHis: 0.956 ± 0.29
2.867AsnIle: 2.867 ± 0.516
2.941AsnLys: 2.941 ± 0.649
4.558AsnLeu: 4.558 ± 0.64
1.544AsnMet: 1.544 ± 0.362
4.779AsnAsn: 4.779 ± 0.919
1.618AsnPro: 1.618 ± 0.549
1.25AsnGln: 1.25 ± 0.622
1.47AsnArg: 1.47 ± 0.734
4.706AsnSer: 4.706 ± 0.552
3.529AsnThr: 3.529 ± 0.975
6.764AsnVal: 6.764 ± 1.193
0.588AsnTrp: 0.588 ± 1.098
1.985AsnTyr: 1.985 ± 0.401
0.368AsnXaa: 0.368 ± 0.288
Pro
2.353ProAla: 2.353 ± 0.479
0.588ProCys: 0.588 ± 0.153
1.912ProAsp: 1.912 ± 0.466
1.397ProGlu: 1.397 ± 0.164
1.838ProPhe: 1.838 ± 0.771
2.5ProGly: 2.5 ± 0.627
1.029ProHis: 1.029 ± 0.405
1.691ProIle: 1.691 ± 0.243
2.426ProLys: 2.426 ± 0.502
2.426ProLeu: 2.426 ± 0.44
0.441ProMet: 0.441 ± 0.381
1.25ProAsn: 1.25 ± 0.351
1.103ProPro: 1.103 ± 0.258
1.47ProGln: 1.47 ± 0.426
0.882ProArg: 0.882 ± 0.415
2.867ProSer: 2.867 ± 0.814
2.132ProThr: 2.132 ± 0.289
3.088ProVal: 3.088 ± 0.66
0.735ProTrp: 0.735 ± 0.2
0.882ProTyr: 0.882 ± 0.279
0.221ProXaa: 0.221 ± 0.202
Gln
2.132GlnAla: 2.132 ± 0.315
0.441GlnCys: 0.441 ± 0.174
1.25GlnAsp: 1.25 ± 0.324
1.323GlnGlu: 1.323 ± 0.175
1.176GlnPhe: 1.176 ± 0.787
2.059GlnGly: 2.059 ± 0.525
0.515GlnHis: 0.515 ± 0.814
1.544GlnIle: 1.544 ± 0.735
1.691GlnLys: 1.691 ± 0.258
3.382GlnLeu: 3.382 ± 0.71
0.515GlnMet: 0.515 ± 0.178
0.882GlnAsn: 0.882 ± 0.22
1.765GlnPro: 1.765 ± 0.543
1.176GlnGln: 1.176 ± 0.713
1.323GlnArg: 1.323 ± 1.032
2.132GlnSer: 2.132 ± 0.475
2.132GlnThr: 2.132 ± 0.515
2.426GlnVal: 2.426 ± 0.448
0.294GlnTrp: 0.294 ± 0.216
1.544GlnTyr: 1.544 ± 0.357
0.074GlnXaa: 0.074 ± 0.104
Arg
1.691ArgAla: 1.691 ± 0.551
1.176ArgCys: 1.176 ± 0.423
1.765ArgAsp: 1.765 ± 0.342
0.588ArgGlu: 0.588 ± 0.176
2.353ArgPhe: 2.353 ± 0.381
1.618ArgGly: 1.618 ± 1.065
0.441ArgHis: 0.441 ± 0.387
1.765ArgIle: 1.765 ± 0.952
2.794ArgLys: 2.794 ± 0.553
2.573ArgLeu: 2.573 ± 1.599
0.515ArgMet: 0.515 ± 0.199
2.279ArgAsn: 2.279 ± 0.46
0.662ArgPro: 0.662 ± 0.302
1.691ArgGln: 1.691 ± 0.555
1.323ArgArg: 1.323 ± 1.388
2.5ArgSer: 2.5 ± 2.478
2.059ArgThr: 2.059 ± 0.78
2.206ArgVal: 2.206 ± 0.542
0.368ArgTrp: 0.368 ± 0.188
0.809ArgTyr: 0.809 ± 0.376
0.0ArgXaa: 0.0 ± 0.0
Ser
4.558SerAla: 4.558 ± 0.736
0.809SerCys: 0.809 ± 0.254
4.264SerAsp: 4.264 ± 0.796
2.353SerGlu: 2.353 ± 0.422
3.382SerPhe: 3.382 ± 0.594
3.75SerGly: 3.75 ± 0.532
1.103SerHis: 1.103 ± 0.531
4.264SerIle: 4.264 ± 1.016
3.897SerLys: 3.897 ± 1.083
5.588SerLeu: 5.588 ± 1.218
1.838SerMet: 1.838 ± 0.301
3.529SerAsn: 3.529 ± 0.495
1.544SerPro: 1.544 ± 0.418
2.353SerGln: 2.353 ± 1.107
2.5SerArg: 2.5 ± 2.541
4.411SerSer: 4.411 ± 0.569
3.382SerThr: 3.382 ± 0.319
8.161SerVal: 8.161 ± 1.255
1.103SerTrp: 1.103 ± 0.673
4.117SerTyr: 4.117 ± 0.664
0.221SerXaa: 0.221 ± 0.09
Thr
3.676ThrAla: 3.676 ± 0.445
2.206ThrCys: 2.206 ± 0.583
2.794ThrAsp: 2.794 ± 0.63
2.059ThrGlu: 2.059 ± 0.344
3.309ThrPhe: 3.309 ± 0.497
3.529ThrGly: 3.529 ± 0.554
1.029ThrHis: 1.029 ± 0.537
4.411ThrIle: 4.411 ± 0.716
2.647ThrLys: 2.647 ± 0.494
5.294ThrLeu: 5.294 ± 1.225
1.544ThrMet: 1.544 ± 0.476
3.603ThrAsn: 3.603 ± 0.35
3.088ThrPro: 3.088 ± 0.49
2.279ThrGln: 2.279 ± 0.373
1.765ThrArg: 1.765 ± 0.285
4.338ThrSer: 4.338 ± 1.077
5.661ThrThr: 5.661 ± 0.933
5.514ThrVal: 5.514 ± 0.875
0.882ThrTrp: 0.882 ± 0.149
2.059ThrTyr: 2.059 ± 0.769
0.0ThrXaa: 0.0 ± 0.0
Val
4.044ValAla: 4.044 ± 0.555
3.235ValCys: 3.235 ± 0.441
4.853ValAsp: 4.853 ± 0.684
5.808ValGlu: 5.808 ± 0.847
5.367ValPhe: 5.367 ± 0.576
4.264ValGly: 4.264 ± 0.682
2.279ValHis: 2.279 ± 0.424
4.338ValIle: 4.338 ± 0.474
8.161ValLys: 8.161 ± 1.692
8.308ValLeu: 8.308 ± 1.316
2.353ValMet: 2.353 ± 0.614
7.205ValAsn: 7.205 ± 0.499
2.72ValPro: 2.72 ± 0.319
2.647ValGln: 2.647 ± 0.503
3.309ValArg: 3.309 ± 0.535
5.808ValSer: 5.808 ± 0.654
6.691ValThr: 6.691 ± 0.598
10.367ValVal: 10.367 ± 1.654
0.882ValTrp: 0.882 ± 0.271
3.382ValTyr: 3.382 ± 0.739
0.221ValXaa: 0.221 ± 0.189
Trp
0.441TrpAla: 0.441 ± 0.19
0.294TrpCys: 0.294 ± 0.12
1.029TrpAsp: 1.029 ± 0.267
0.515TrpGlu: 0.515 ± 0.104
1.323TrpPhe: 1.323 ± 0.297
0.294TrpGly: 0.294 ± 0.189
0.147TrpHis: 0.147 ± 0.225
0.515TrpIle: 0.515 ± 0.389
0.515TrpLys: 0.515 ± 0.2
1.397TrpLeu: 1.397 ± 0.49
0.221TrpMet: 0.221 ± 0.236
0.956TrpAsn: 0.956 ± 0.424
0.515TrpPro: 0.515 ± 0.302
0.147TrpGln: 0.147 ± 0.094
0.441TrpArg: 0.441 ± 0.139
1.103TrpSer: 1.103 ± 0.512
0.588TrpThr: 0.588 ± 0.176
0.588TrpVal: 0.588 ± 0.17
0.074TrpTrp: 0.074 ± 0.237
0.662TrpTyr: 0.662 ± 0.552
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.235TyrAla: 3.235 ± 0.619
1.691TyrCys: 1.691 ± 0.291
3.75TyrAsp: 3.75 ± 0.853
1.912TyrGlu: 1.912 ± 0.608
2.941TyrPhe: 2.941 ± 0.311
3.676TyrGly: 3.676 ± 0.371
1.029TyrHis: 1.029 ± 0.202
2.573TyrIle: 2.573 ± 0.509
3.235TyrLys: 3.235 ± 0.469
2.353TyrLeu: 2.353 ± 0.352
1.544TyrMet: 1.544 ± 0.328
2.353TyrAsn: 2.353 ± 0.812
1.176TyrPro: 1.176 ± 0.417
1.176TyrGln: 1.176 ± 0.232
1.47TyrArg: 1.47 ± 0.534
2.5TyrSer: 2.5 ± 0.439
3.162TyrThr: 3.162 ± 0.658
4.411TyrVal: 4.411 ± 0.658
0.294TyrTrp: 0.294 ± 0.189
3.014TyrTyr: 3.014 ± 0.307
0.147TyrXaa: 0.147 ± 0.282
Xaa
0.147XaaAla: 0.147 ± 0.054
0.147XaaCys: 0.147 ± 0.054
0.147XaaAsp: 0.147 ± 0.054
0.147XaaGlu: 0.147 ± 0.054
0.221XaaPhe: 0.221 ± 0.09
0.294XaaGly: 0.294 ± 0.187
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.294XaaLys: 0.294 ± 0.109
0.147XaaLeu: 0.147 ± 0.208
0.074XaaMet: 0.074 ± 0.214
0.074XaaAsn: 0.074 ± 0.258
0.147XaaPro: 0.147 ± 0.208
0.0XaaGln: 0.0 ± 0.0
0.147XaaArg: 0.147 ± 0.358
0.221XaaSer: 0.221 ± 0.09
0.074XaaThr: 0.074 ± 0.104
0.074XaaVal: 0.074 ± 0.104
0.074XaaTrp: 0.074 ± 0.104
0.294XaaTyr: 0.294 ± 0.174
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (13602 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski