Amino acid dipepetide frequency for Methylosinus sp. R-45379

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.173AlaAla: 20.173 ± 0.219
1.108AlaCys: 1.108 ± 0.032
6.811AlaAsp: 6.811 ± 0.079
8.518AlaGlu: 8.518 ± 0.101
4.999AlaPhe: 4.999 ± 0.073
10.427AlaGly: 10.427 ± 0.115
2.674AlaHis: 2.674 ± 0.044
6.614AlaIle: 6.614 ± 0.077
4.58AlaLys: 4.58 ± 0.073
15.787AlaLeu: 15.787 ± 0.153
2.913AlaMet: 2.913 ± 0.052
2.958AlaAsn: 2.958 ± 0.056
7.764AlaPro: 7.764 ± 0.111
4.536AlaGln: 4.536 ± 0.065
10.998AlaArg: 10.998 ± 0.119
7.42AlaSer: 7.42 ± 0.094
6.53AlaThr: 6.53 ± 0.078
7.858AlaVal: 7.858 ± 0.082
1.375AlaTrp: 1.375 ± 0.034
2.859AlaTyr: 2.859 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.19CysAla: 1.19 ± 0.03
0.146CysCys: 0.146 ± 0.012
0.537CysAsp: 0.537 ± 0.02
0.517CysGlu: 0.517 ± 0.023
0.318CysPhe: 0.318 ± 0.015
0.883CysGly: 0.883 ± 0.025
0.205CysHis: 0.205 ± 0.012
0.312CysIle: 0.312 ± 0.016
0.216CysLys: 0.216 ± 0.013
0.833CysLeu: 0.833 ± 0.027
0.147CysMet: 0.147 ± 0.011
0.193CysAsn: 0.193 ± 0.012
0.411CysPro: 0.411 ± 0.018
0.173CysGln: 0.173 ± 0.01
0.649CysArg: 0.649 ± 0.02
0.445CysSer: 0.445 ± 0.018
0.298CysThr: 0.298 ± 0.017
0.726CysVal: 0.726 ± 0.023
0.098CysTrp: 0.098 ± 0.01
0.201CysTyr: 0.201 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.434AspAla: 7.434 ± 0.086
0.54AspCys: 0.54 ± 0.021
3.042AspAsp: 3.042 ± 0.051
3.675AspGlu: 3.675 ± 0.063
2.372AspPhe: 2.372 ± 0.039
4.783AspGly: 4.783 ± 0.068
1.218AspHis: 1.218 ± 0.035
2.925AspIle: 2.925 ± 0.045
1.802AspLys: 1.802 ± 0.041
5.829AspLeu: 5.829 ± 0.074
1.103AspMet: 1.103 ± 0.029
1.235AspAsn: 1.235 ± 0.033
3.298AspPro: 3.298 ± 0.051
1.389AspGln: 1.389 ± 0.033
4.236AspArg: 4.236 ± 0.057
2.325AspSer: 2.325 ± 0.04
2.01AspThr: 2.01 ± 0.042
3.877AspVal: 3.877 ± 0.05
0.928AspTrp: 0.928 ± 0.024
1.527AspTyr: 1.527 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
8.725GluAla: 8.725 ± 0.108
0.367GluCys: 0.367 ± 0.018
2.66GluAsp: 2.66 ± 0.047
3.744GluGlu: 3.744 ± 0.064
1.949GluPhe: 1.949 ± 0.044
4.31GluGly: 4.31 ± 0.067
1.23GluHis: 1.23 ± 0.037
3.906GluIle: 3.906 ± 0.065
2.671GluLys: 2.671 ± 0.056
5.67GluLeu: 5.67 ± 0.058
1.301GluMet: 1.301 ± 0.031
1.606GluAsn: 1.606 ± 0.033
3.073GluPro: 3.073 ± 0.067
2.094GluGln: 2.094 ± 0.048
5.952GluArg: 5.952 ± 0.084
2.878GluSer: 2.878 ± 0.047
3.993GluThr: 3.993 ± 0.054
3.306GluVal: 3.306 ± 0.052
0.736GluTrp: 0.736 ± 0.024
0.907GluTyr: 0.907 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
5.22PheAla: 5.22 ± 0.068
0.429PheCys: 0.429 ± 0.019
3.048PheAsp: 3.048 ± 0.051
2.396PheGlu: 2.396 ± 0.048
1.655PhePhe: 1.655 ± 0.043
3.802PheGly: 3.802 ± 0.069
0.783PheHis: 0.783 ± 0.023
1.557PheIle: 1.557 ± 0.029
0.922PheLys: 0.922 ± 0.029
3.714PheLeu: 3.714 ± 0.064
0.717PheMet: 0.717 ± 0.021
0.896PheAsn: 0.896 ± 0.026
1.727PhePro: 1.727 ± 0.039
0.96PheGln: 0.96 ± 0.028
2.54PheArg: 2.54 ± 0.046
2.523PheSer: 2.523 ± 0.046
1.88PheThr: 1.88 ± 0.036
3.142PheVal: 3.142 ± 0.058
0.535PheTrp: 0.535 ± 0.022
0.946PheTyr: 0.946 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
11.579GlyAla: 11.579 ± 0.117
0.76GlyCys: 0.76 ± 0.024
4.267GlyAsp: 4.267 ± 0.058
5.144GlyGlu: 5.144 ± 0.074
3.675GlyPhe: 3.675 ± 0.043
7.46GlyGly: 7.46 ± 0.142
1.671GlyHis: 1.671 ± 0.034
2.706GlyIle: 2.706 ± 0.046
3.05GlyLys: 3.05 ± 0.051
8.602GlyLeu: 8.602 ± 0.093
1.627GlyMet: 1.627 ± 0.039
1.757GlyAsn: 1.757 ± 0.054
3.331GlyPro: 3.331 ± 0.053
2.254GlyGln: 2.254 ± 0.041
6.433GlyArg: 6.433 ± 0.073
4.325GlySer: 4.325 ± 0.091
3.08GlyThr: 3.08 ± 0.076
7.102GlyVal: 7.102 ± 0.085
1.161GlyTrp: 1.161 ± 0.033
2.137GlyTyr: 2.137 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.372HisAla: 2.372 ± 0.045
0.231HisCys: 0.231 ± 0.011
1.139HisAsp: 1.139 ± 0.04
1.157HisGlu: 1.157 ± 0.031
0.911HisPhe: 0.911 ± 0.027
1.852HisGly: 1.852 ± 0.04
0.559HisHis: 0.559 ± 0.033
0.99HisIle: 0.99 ± 0.03
0.492HisLys: 0.492 ± 0.018
1.824HisLeu: 1.824 ± 0.04
0.412HisMet: 0.412 ± 0.017
0.434HisAsn: 0.434 ± 0.017
1.162HisPro: 1.162 ± 0.032
0.434HisGln: 0.434 ± 0.018
1.382HisArg: 1.382 ± 0.037
1.05HisSer: 1.05 ± 0.031
0.7HisThr: 0.7 ± 0.024
1.522HisVal: 1.522 ± 0.036
0.317HisTrp: 0.317 ± 0.014
0.563HisTyr: 0.563 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
7.575IleAla: 7.575 ± 0.072
0.485IleCys: 0.485 ± 0.019
3.822IleAsp: 3.822 ± 0.054
3.825IleGlu: 3.825 ± 0.063
1.739IlePhe: 1.739 ± 0.041
5.006IleGly: 5.006 ± 0.069
0.857IleHis: 0.857 ± 0.028
1.951IleIle: 1.951 ± 0.038
1.25IleLys: 1.25 ± 0.039
4.137IleLeu: 4.137 ± 0.057
0.759IleMet: 0.759 ± 0.026
1.052IleAsn: 1.052 ± 0.034
1.989IlePro: 1.989 ± 0.039
0.975IleGln: 0.975 ± 0.029
2.909IleArg: 2.909 ± 0.048
2.623IleSer: 2.623 ± 0.048
1.919IleThr: 1.919 ± 0.041
4.655IleVal: 4.655 ± 0.058
0.502IleTrp: 0.502 ± 0.02
1.031IleTyr: 1.031 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
4.102LysAla: 4.102 ± 0.065
0.186LysCys: 0.186 ± 0.011
1.619LysAsp: 1.619 ± 0.038
1.779LysGlu: 1.779 ± 0.044
1.052LysPhe: 1.052 ± 0.027
2.59LysGly: 2.59 ± 0.049
0.53LysHis: 0.53 ± 0.018
2.003LysIle: 2.003 ± 0.038
1.424LysLys: 1.424 ± 0.039
3.328LysLeu: 3.328 ± 0.053
0.689LysMet: 0.689 ± 0.025
0.89LysAsn: 0.89 ± 0.025
1.919LysPro: 1.919 ± 0.042
0.9LysGln: 0.9 ± 0.028
2.527LysArg: 2.527 ± 0.046
1.986LysSer: 1.986 ± 0.036
1.938LysThr: 1.938 ± 0.033
1.993LysVal: 1.993 ± 0.041
0.356LysTrp: 0.356 ± 0.019
0.648LysTyr: 0.648 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
15.486LeuAla: 15.486 ± 0.13
0.949LeuCys: 0.949 ± 0.029
6.343LeuAsp: 6.343 ± 0.073
6.044LeuGlu: 6.044 ± 0.077
3.934LeuPhe: 3.934 ± 0.071
8.089LeuGly: 8.089 ± 0.092
1.897LeuHis: 1.897 ± 0.038
4.457LeuIle: 4.457 ± 0.061
2.9LeuLys: 2.9 ± 0.049
10.075LeuLeu: 10.075 ± 0.112
1.851LeuMet: 1.851 ± 0.039
2.095LeuAsn: 2.095 ± 0.044
5.479LeuPro: 5.479 ± 0.06
2.622LeuGln: 2.622 ± 0.045
8.242LeuArg: 8.242 ± 0.082
6.545LeuSer: 6.545 ± 0.095
5.642LeuThr: 5.642 ± 0.102
7.247LeuVal: 7.247 ± 0.078
1.163LeuTrp: 1.163 ± 0.032
2.174LeuTyr: 2.174 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
2.504MetAla: 2.504 ± 0.049
0.125MetCys: 0.125 ± 0.009
0.829MetAsp: 0.829 ± 0.028
1.01MetGlu: 1.01 ± 0.026
0.625MetPhe: 0.625 ± 0.02
1.283MetGly: 1.283 ± 0.033
0.333MetHis: 0.333 ± 0.018
1.115MetIle: 1.115 ± 0.03
0.769MetLys: 0.769 ± 0.023
2.057MetLeu: 2.057 ± 0.043
0.415MetMet: 0.415 ± 0.02
0.572MetAsn: 0.572 ± 0.017
0.973MetPro: 0.973 ± 0.027
0.63MetGln: 0.63 ± 0.021
1.945MetArg: 1.945 ± 0.037
1.577MetSer: 1.577 ± 0.039
1.481MetThr: 1.481 ± 0.035
1.024MetVal: 1.024 ± 0.026
0.167MetTrp: 0.167 ± 0.011
0.211MetTyr: 0.211 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.947AsnAla: 2.947 ± 0.053
0.223AsnCys: 0.223 ± 0.011
1.254AsnAsp: 1.254 ± 0.029
1.238AsnGlu: 1.238 ± 0.033
1.101AsnPhe: 1.101 ± 0.031
2.261AsnGly: 2.261 ± 0.061
0.448AsnHis: 0.448 ± 0.021
1.256AsnIle: 1.256 ± 0.036
0.647AsnLys: 0.647 ± 0.023
2.386AsnLeu: 2.386 ± 0.046
0.433AsnMet: 0.433 ± 0.018
0.685AsnAsn: 0.685 ± 0.038
1.399AsnPro: 1.399 ± 0.037
0.644AsnGln: 0.644 ± 0.024
1.526AsnArg: 1.526 ± 0.032
1.306AsnSer: 1.306 ± 0.047
0.934AsnThr: 0.934 ± 0.034
2.045AsnVal: 2.045 ± 0.049
0.377AsnTrp: 0.377 ± 0.016
0.705AsnTyr: 0.705 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
6.725ProAla: 6.725 ± 0.088
0.342ProCys: 0.342 ± 0.015
2.981ProAsp: 2.981 ± 0.049
3.316ProGlu: 3.316 ± 0.07
2.04ProPhe: 2.04 ± 0.04
4.098ProGly: 4.098 ± 0.058
1.083ProHis: 1.083 ± 0.027
2.592ProIle: 2.592 ± 0.044
1.74ProLys: 1.74 ± 0.034
5.176ProLeu: 5.176 ± 0.068
0.948ProMet: 0.948 ± 0.026
1.278ProAsn: 1.278 ± 0.031
3.165ProPro: 3.165 ± 0.081
1.886ProGln: 1.886 ± 0.039
3.585ProArg: 3.585 ± 0.061
3.185ProSer: 3.185 ± 0.055
2.595ProThr: 2.595 ± 0.05
3.335ProVal: 3.335 ± 0.052
0.633ProTrp: 0.633 ± 0.022
1.17ProTyr: 1.17 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.571GlnAla: 3.571 ± 0.058
0.183GlnCys: 0.183 ± 0.011
1.293GlnAsp: 1.293 ± 0.031
1.538GlnGlu: 1.538 ± 0.033
1.079GlnPhe: 1.079 ± 0.031
2.062GlnGly: 2.062 ± 0.044
0.5GlnHis: 0.5 ± 0.019
1.882GlnIle: 1.882 ± 0.053
1.169GlnLys: 1.169 ± 0.031
2.711GlnLeu: 2.711 ± 0.046
0.671GlnMet: 0.671 ± 0.022
0.863GlnAsn: 0.863 ± 0.029
1.492GlnPro: 1.492 ± 0.033
1.007GlnGln: 1.007 ± 0.034
2.352GlnArg: 2.352 ± 0.046
1.882GlnSer: 1.882 ± 0.044
1.661GlnThr: 1.661 ± 0.038
1.565GlnVal: 1.565 ± 0.041
0.415GlnTrp: 0.415 ± 0.016
0.619GlnTyr: 0.619 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
10.221ArgAla: 10.221 ± 0.102
0.596ArgCys: 0.596 ± 0.021
4.328ArgAsp: 4.328 ± 0.064
4.988ArgGlu: 4.988 ± 0.075
3.271ArgPhe: 3.271 ± 0.049
5.392ArgGly: 5.392 ± 0.061
1.636ArgHis: 1.636 ± 0.032
4.133ArgIle: 4.133 ± 0.062
2.451ArgLys: 2.451 ± 0.045
9.256ArgLeu: 9.256 ± 0.099
1.67ArgMet: 1.67 ± 0.033
1.89ArgAsn: 1.89 ± 0.04
3.859ArgPro: 3.859 ± 0.066
2.253ArgGln: 2.253 ± 0.042
7.188ArgArg: 7.188 ± 0.107
4.204ArgSer: 4.204 ± 0.063
2.875ArgThr: 2.875 ± 0.043
4.989ArgVal: 4.989 ± 0.065
1.019ArgTrp: 1.019 ± 0.031
1.811ArgTyr: 1.811 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
7.429SerAla: 7.429 ± 0.09
0.529SerCys: 0.529 ± 0.021
3.02SerAsp: 3.02 ± 0.052
3.036SerGlu: 3.036 ± 0.054
2.641SerPhe: 2.641 ± 0.044
5.351SerGly: 5.351 ± 0.088
1.028SerHis: 1.028 ± 0.027
2.788SerIle: 2.788 ± 0.051
1.654SerLys: 1.654 ± 0.039
5.981SerLeu: 5.981 ± 0.084
1.094SerMet: 1.094 ± 0.027
1.374SerAsn: 1.374 ± 0.041
2.941SerPro: 2.941 ± 0.047
1.495SerGln: 1.495 ± 0.035
4.103SerArg: 4.103 ± 0.055
3.395SerSer: 3.395 ± 0.083
2.81SerThr: 2.81 ± 0.065
4.103SerVal: 4.103 ± 0.058
0.796SerTrp: 0.796 ± 0.023
1.468SerTyr: 1.468 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
5.819ThrAla: 5.819 ± 0.068
0.332ThrCys: 0.332 ± 0.016
2.168ThrAsp: 2.168 ± 0.044
2.335ThrGlu: 2.335 ± 0.044
1.768ThrPhe: 1.768 ± 0.037
4.226ThrGly: 4.226 ± 0.078
0.987ThrHis: 0.987 ± 0.026
2.999ThrIle: 2.999 ± 0.051
1.521ThrLys: 1.521 ± 0.038
5.793ThrLeu: 5.793 ± 0.074
0.893ThrMet: 0.893 ± 0.025
1.302ThrAsn: 1.302 ± 0.052
3.423ThrPro: 3.423 ± 0.062
1.606ThrGln: 1.606 ± 0.085
3.683ThrArg: 3.683 ± 0.052
2.751ThrSer: 2.751 ± 0.065
2.777ThrThr: 2.777 ± 0.105
3.203ThrVal: 3.203 ± 0.063
0.4ThrTrp: 0.4 ± 0.021
1.064ThrTyr: 1.064 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
9.974ValAla: 9.974 ± 0.091
0.595ValCys: 0.595 ± 0.024
4.395ValAsp: 4.395 ± 0.064
4.961ValGlu: 4.961 ± 0.065
2.732ValPhe: 2.732 ± 0.043
5.366ValGly: 5.366 ± 0.069
1.163ValHis: 1.163 ± 0.03
3.42ValIle: 3.42 ± 0.057
2.163ValLys: 2.163 ± 0.045
6.266ValLeu: 6.266 ± 0.072
1.348ValMet: 1.348 ± 0.032
1.799ValAsn: 1.799 ± 0.048
2.774ValPro: 2.774 ± 0.05
1.639ValGln: 1.639 ± 0.042
4.359ValArg: 4.359 ± 0.059
4.471ValSer: 4.471 ± 0.053
4.229ValThr: 4.229 ± 0.06
5.508ValVal: 5.508 ± 0.067
0.796ValTrp: 0.796 ± 0.025
1.547ValTyr: 1.547 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.148TrpAla: 1.148 ± 0.032
0.121TrpCys: 0.121 ± 0.01
0.512TrpAsp: 0.512 ± 0.019
0.514TrpGlu: 0.514 ± 0.022
0.493TrpPhe: 0.493 ± 0.019
0.808TrpGly: 0.808 ± 0.025
0.246TrpHis: 0.246 ± 0.014
0.641TrpIle: 0.641 ± 0.019
0.457TrpLys: 0.457 ± 0.02
1.522TrpLeu: 1.522 ± 0.039
0.287TrpMet: 0.287 ± 0.014
0.368TrpAsn: 0.368 ± 0.018
0.673TrpPro: 0.673 ± 0.025
0.341TrpGln: 0.341 ± 0.017
1.522TrpArg: 1.522 ± 0.032
0.887TrpSer: 0.887 ± 0.025
0.769TrpThr: 0.769 ± 0.027
0.596TrpVal: 0.596 ± 0.022
0.197TrpTrp: 0.197 ± 0.012
0.218TrpTyr: 0.218 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.707TyrAla: 2.707 ± 0.05
0.252TyrCys: 0.252 ± 0.015
1.483TyrAsp: 1.483 ± 0.039
1.343TyrGlu: 1.343 ± 0.034
1.041TyrPhe: 1.041 ± 0.026
2.07TyrGly: 2.07 ± 0.044
0.457TyrHis: 0.457 ± 0.017
0.812TyrIle: 0.812 ± 0.025
0.582TyrLys: 0.582 ± 0.022
2.286TyrLeu: 2.286 ± 0.043
0.364TyrMet: 0.364 ± 0.016
0.569TyrAsn: 0.569 ± 0.025
1.019TyrPro: 1.019 ± 0.03
0.679TyrGln: 0.679 ± 0.023
1.898TyrArg: 1.898 ± 0.039
1.262TyrSer: 1.262 ± 0.034
0.927TyrThr: 0.927 ± 0.027
1.709TyrVal: 1.709 ± 0.035
0.348TyrTrp: 0.348 ± 0.019
0.608TyrTyr: 0.608 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4368 proteins (1357770 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski