Amino acid dipepetide frequency for Leptospira interrogans serovar Bataviae str. HAI135

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.535AlaAla: 3.535 ± 0.077	0.527AlaCys: 0.527 ± 0.024	2.572AlaAsp: 2.572 ± 0.052	3.531AlaGlu: 3.531 ± 0.058	2.604AlaPhe: 2.604 ± 0.06	4.048AlaGly: 4.048 ± 0.074	0.834AlaHis: 0.834 ± 0.029	4.235AlaIle: 4.235 ± 0.069	3.762AlaLys: 3.762 ± 0.072	5.249AlaLeu: 5.249 ± 0.073	1.148AlaMet: 1.148 ± 0.034	2.346AlaAsn: 2.346 ± 0.051	1.66AlaPro: 1.66 ± 0.044	1.504AlaGln: 1.504 ± 0.039	2.292AlaArg: 2.292 ± 0.052	3.762AlaSer: 3.762 ± 0.076	2.517AlaThr: 2.517 ± 0.064	3.278AlaVal: 3.278 ± 0.064	0.582AlaTrp: 0.582 ± 0.025	1.72AlaTyr: 1.72 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.44CysAla: 0.44 ± 0.02	0.097CysCys: 0.097 ± 0.011	0.408CysAsp: 0.408 ± 0.022	0.528CysGlu: 0.528 ± 0.023	0.582CysPhe: 0.582 ± 0.022	0.796CysGly: 0.796 ± 0.026	0.157CysHis: 0.157 ± 0.013	0.753CysIle: 0.753 ± 0.023	0.699CysLys: 0.699 ± 0.025	0.85CysLeu: 0.85 ± 0.031	0.224CysMet: 0.224 ± 0.016	0.44CysAsn: 0.44 ± 0.023	0.379CysPro: 0.379 ± 0.019	0.201CysGln: 0.201 ± 0.012	0.38CysArg: 0.38 ± 0.019	0.754CysSer: 0.754 ± 0.03	0.41CysThr: 0.41 ± 0.019	0.547CysVal: 0.547 ± 0.021	0.103CysTrp: 0.103 ± 0.01	0.356CysTyr: 0.356 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	2.173AspAla: 2.173 ± 0.045	0.462AspCys: 0.462 ± 0.021	1.785AspAsp: 1.785 ± 0.044	2.768AspGlu: 2.768 ± 0.059	3.247AspPhe: 3.247 ± 0.056	2.851AspGly: 2.851 ± 0.058	0.916AspHis: 0.916 ± 0.027	3.11AspIle: 3.11 ± 0.064	3.201AspLys: 3.201 ± 0.05	5.834AspLeu: 5.834 ± 0.077	0.864AspMet: 0.864 ± 0.028	1.625AspAsn: 1.625 ± 0.041	2.514AspPro: 2.514 ± 0.053	1.766AspGln: 1.766 ± 0.038	2.577AspArg: 2.577 ± 0.049	4.076AspSer: 4.076 ± 0.059	2.061AspThr: 2.061 ± 0.048	2.473AspVal: 2.473 ± 0.051	0.693AspTrp: 0.693 ± 0.026	1.884AspTyr: 1.884 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	3.429GluAla: 3.429 ± 0.064	0.492GluCys: 0.492 ± 0.023	3.227GluAsp: 3.227 ± 0.058	6.029GluGlu: 6.029 ± 0.104	3.733GluPhe: 3.733 ± 0.065	3.677GluGly: 3.677 ± 0.059	0.869GluHis: 0.869 ± 0.031	6.831GluIle: 6.831 ± 0.089	6.993GluLys: 6.993 ± 0.086	6.698GluLeu: 6.698 ± 0.088	1.544GluMet: 1.544 ± 0.035	4.236GluAsn: 4.236 ± 0.061	1.791GluPro: 1.791 ± 0.04	1.846GluGln: 1.846 ± 0.039	3.041GluArg: 3.041 ± 0.059	4.91GluSer: 4.91 ± 0.068	3.958GluThr: 3.958 ± 0.063	3.99GluVal: 3.99 ± 0.064	0.784GluTrp: 0.784 ± 0.028	2.384GluTyr: 2.384 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	2.896PheAla: 2.896 ± 0.054	0.721PheCys: 0.721 ± 0.026	2.432PheAsp: 2.432 ± 0.052	3.274PheGlu: 3.274 ± 0.052	3.641PhePhe: 3.641 ± 0.073	3.558PheGly: 3.558 ± 0.06	1.237PheHis: 1.237 ± 0.029	3.823PheIle: 3.823 ± 0.067	3.341PheLys: 3.341 ± 0.052	7.189PheLeu: 7.189 ± 0.102	1.317PheMet: 1.317 ± 0.036	2.191PheAsn: 2.191 ± 0.047	2.583PhePro: 2.583 ± 0.05	2.647PheGln: 2.647 ± 0.05	2.991PheArg: 2.991 ± 0.049	4.859PheSer: 4.859 ± 0.073	2.727PheThr: 2.727 ± 0.055	3.091PheVal: 3.091 ± 0.058	0.832PheTrp: 0.832 ± 0.027	2.533PheTyr: 2.533 ± 0.051	0.002PheXaa: 0.002 ± 0.001
Gly	3.563GlyAla: 3.563 ± 0.074	0.602GlyCys: 0.602 ± 0.024	2.832GlyAsp: 2.832 ± 0.054	3.953GlyGlu: 3.953 ± 0.064	3.726GlyPhe: 3.726 ± 0.068	4.2GlyGly: 4.2 ± 0.088	1.08GlyHis: 1.08 ± 0.035	6.121GlyIle: 6.121 ± 0.094	5.733GlyLys: 5.733 ± 0.078	5.712GlyLeu: 5.712 ± 0.078	1.566GlyMet: 1.566 ± 0.038	3.47GlyAsn: 3.47 ± 0.069	1.635GlyPro: 1.635 ± 0.039	1.671GlyGln: 1.671 ± 0.038	2.624GlyArg: 2.624 ± 0.047	4.588GlySer: 4.588 ± 0.075	3.483GlyThr: 3.483 ± 0.065	3.943GlyVal: 3.943 ± 0.068	0.745GlyTrp: 0.745 ± 0.027	2.384GlyTyr: 2.384 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	0.73HisAla: 0.73 ± 0.024	0.207HisCys: 0.207 ± 0.014	0.619HisAsp: 0.619 ± 0.028	0.863HisGlu: 0.863 ± 0.03	1.192HisPhe: 1.192 ± 0.034	1.043HisGly: 1.043 ± 0.03	0.39HisHis: 0.39 ± 0.021	1.173HisIle: 1.173 ± 0.033	1.204HisLys: 1.204 ± 0.039	1.869HisLeu: 1.869 ± 0.046	0.249HisMet: 0.249 ± 0.014	0.746HisAsn: 0.746 ± 0.028	1.021HisPro: 1.021 ± 0.033	0.476HisGln: 0.476 ± 0.022	0.812HisArg: 0.812 ± 0.032	1.647HisSer: 1.647 ± 0.039	0.911HisThr: 0.911 ± 0.028	0.832HisVal: 0.832 ± 0.028	0.256HisTrp: 0.256 ± 0.016	0.673HisTyr: 0.673 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	4.406IleAla: 4.406 ± 0.073	0.891IleCys: 0.891 ± 0.03	3.454IleAsp: 3.454 ± 0.053	5.142IleGlu: 5.142 ± 0.074	4.642IlePhe: 4.642 ± 0.072	4.959IleGly: 4.959 ± 0.078	1.65IleHis: 1.65 ± 0.037	4.352IleIle: 4.352 ± 0.069	4.354IleLys: 4.354 ± 0.068	10.807IleLeu: 10.807 ± 0.123	1.263IleMet: 1.263 ± 0.045	2.95IleAsn: 2.95 ± 0.058	3.93IlePro: 3.93 ± 0.066	3.831IleGln: 3.831 ± 0.058	4.589IleArg: 4.589 ± 0.063	6.768IleSer: 6.768 ± 0.084	3.781IleThr: 3.781 ± 0.067	4.645IleVal: 4.645 ± 0.071	0.819IleTrp: 0.819 ± 0.028	2.768IleTyr: 2.768 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	3.595LysAla: 3.595 ± 0.065	0.428LysCys: 0.428 ± 0.02	4.142LysAsp: 4.142 ± 0.066	7.207LysGlu: 7.207 ± 0.091	3.526LysPhe: 3.526 ± 0.065	4.051LysGly: 4.051 ± 0.07	1.098LysHis: 1.098 ± 0.035	7.651LysIle: 7.651 ± 0.094	7.305LysLys: 7.305 ± 0.099	6.761LysLeu: 6.761 ± 0.087	1.819LysMet: 1.819 ± 0.04	5.455LysAsn: 5.455 ± 0.082	2.48LysPro: 2.48 ± 0.051	2.298LysGln: 2.298 ± 0.058	3.618LysArg: 3.618 ± 0.052	5.259LysSer: 5.259 ± 0.075	4.546LysThr: 4.546 ± 0.064	4.28LysVal: 4.28 ± 0.073	0.592LysTrp: 0.592 ± 0.025	2.444LysTyr: 2.444 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	5.253LeuAla: 5.253 ± 0.086	0.939LeuCys: 0.939 ± 0.024	5.102LeuAsp: 5.102 ± 0.072	7.928LeuGlu: 7.928 ± 0.102	5.932LeuPhe: 5.932 ± 0.091	6.474LeuGly: 6.474 ± 0.077	1.613LeuHis: 1.613 ± 0.038	7.652LeuIle: 7.652 ± 0.099	9.152LeuLys: 9.152 ± 0.11	9.6LeuLeu: 9.6 ± 0.151	2.056LeuMet: 2.056 ± 0.045	5.546LeuAsn: 5.546 ± 0.059	4.057LeuPro: 4.057 ± 0.07	3.309LeuGln: 3.309 ± 0.072	4.5LeuArg: 4.5 ± 0.066	8.598LeuSer: 8.598 ± 0.095	4.841LeuThr: 4.841 ± 0.071	5.564LeuVal: 5.564 ± 0.073	1.044LeuTrp: 1.044 ± 0.03	3.438LeuTyr: 3.438 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.312MetAla: 1.312 ± 0.037	0.12MetCys: 0.12 ± 0.011	1.305MetAsp: 1.305 ± 0.035	1.673MetGlu: 1.673 ± 0.037	0.925MetPhe: 0.925 ± 0.027	1.469MetGly: 1.469 ± 0.038	0.212MetHis: 0.212 ± 0.015	2.06MetIle: 2.06 ± 0.045	2.02MetLys: 2.02 ± 0.041	1.645MetLeu: 1.645 ± 0.046	0.43MetMet: 0.43 ± 0.018	1.384MetAsn: 1.384 ± 0.036	0.672MetPro: 0.672 ± 0.022	0.565MetGln: 0.565 ± 0.021	0.852MetArg: 0.852 ± 0.03	1.436MetSer: 1.436 ± 0.04	1.052MetThr: 1.052 ± 0.033	1.114MetVal: 1.114 ± 0.028	0.157MetTrp: 0.157 ± 0.011	0.507MetTyr: 0.507 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.533AsnAla: 2.533 ± 0.061	0.554AsnCys: 0.554 ± 0.028	1.927AsnAsp: 1.927 ± 0.044	2.89AsnGlu: 2.89 ± 0.051	3.046AsnPhe: 3.046 ± 0.061	3.14AsnGly: 3.14 ± 0.068	1.025AsnHis: 1.025 ± 0.036	3.384AsnIle: 3.384 ± 0.061	2.833AsnLys: 2.833 ± 0.047	6.127AsnLeu: 6.127 ± 0.078	0.934AsnMet: 0.934 ± 0.026	1.871AsnAsn: 1.871 ± 0.049	2.798AsnPro: 2.798 ± 0.047	2.189AsnGln: 2.189 ± 0.045	2.811AsnArg: 2.811 ± 0.055	4.623AsnSer: 4.623 ± 0.078	2.466AsnThr: 2.466 ± 0.052	2.944AsnVal: 2.944 ± 0.053	0.783AsnTrp: 0.783 ± 0.029	1.928AsnTyr: 1.928 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	1.896ProAla: 1.896 ± 0.039	0.256ProCys: 0.256 ± 0.017	2.312ProAsp: 2.312 ± 0.052	3.626ProGlu: 3.626 ± 0.059	2.149ProPhe: 2.149 ± 0.051	2.898ProGly: 2.898 ± 0.058	0.56ProHis: 0.56 ± 0.02	3.139ProIle: 3.139 ± 0.053	2.833ProLys: 2.833 ± 0.052	3.182ProLeu: 3.182 ± 0.051	0.834ProMet: 0.834 ± 0.027	2.185ProAsn: 2.185 ± 0.046	1.308ProPro: 1.308 ± 0.04	0.994ProGln: 0.994 ± 0.027	1.126ProArg: 1.126 ± 0.033	2.734ProSer: 2.734 ± 0.053	1.937ProThr: 1.937 ± 0.043	2.524ProVal: 2.524 ± 0.051	0.461ProTrp: 0.461 ± 0.022	1.267ProTyr: 1.267 ± 0.032	0.001ProXaa: 0.001 ± 0.001
Gln	1.694GlnAla: 1.694 ± 0.045	0.227GlnCys: 0.227 ± 0.016	1.55GlnAsp: 1.55 ± 0.041	2.555GlnGlu: 2.555 ± 0.056	1.701GlnPhe: 1.701 ± 0.039	1.853GlnGly: 1.853 ± 0.039	0.401GlnHis: 0.401 ± 0.022	3.119GlnIle: 3.119 ± 0.056	3.439GlnLys: 3.439 ± 0.057	2.583GlnLeu: 2.583 ± 0.058	0.717GlnMet: 0.717 ± 0.026	2.332GlnAsn: 2.332 ± 0.048	0.88GlnPro: 0.88 ± 0.026	0.724GlnGln: 0.724 ± 0.025	1.388GlnArg: 1.388 ± 0.04	2.339GlnSer: 2.339 ± 0.043	1.998GlnThr: 1.998 ± 0.042	1.846GlnVal: 1.846 ± 0.039	0.316GlnTrp: 0.316 ± 0.018	1.033GlnTyr: 1.033 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	2.16ArgAla: 2.16 ± 0.056	0.39ArgCys: 0.39 ± 0.02	2.07ArgAsp: 2.07 ± 0.049	3.272ArgGlu: 3.272 ± 0.061	2.96ArgPhe: 2.96 ± 0.056	2.338ArgGly: 2.338 ± 0.06	0.687ArgHis: 0.687 ± 0.024	4.502ArgIle: 4.502 ± 0.067	4.564ArgLys: 4.564 ± 0.074	4.236ArgLeu: 4.236 ± 0.064	1.263ArgMet: 1.263 ± 0.033	2.703ArgAsn: 2.703 ± 0.047	1.449ArgPro: 1.449 ± 0.037	1.213ArgGln: 1.213 ± 0.034	2.078ArgArg: 2.078 ± 0.049	3.271ArgSer: 3.271 ± 0.069	2.227ArgThr: 2.227 ± 0.048	2.512ArgVal: 2.512 ± 0.047	0.57ArgTrp: 0.57 ± 0.023	1.788ArgTyr: 1.788 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.961SerAla: 3.961 ± 0.07	0.668SerCys: 0.668 ± 0.026	3.644SerAsp: 3.644 ± 0.06	5.451SerGlu: 5.451 ± 0.081	4.987SerPhe: 4.987 ± 0.079	5.889SerGly: 5.889 ± 0.091	1.347SerHis: 1.347 ± 0.034	6.416SerIle: 6.416 ± 0.085	6.112SerLys: 6.112 ± 0.076	8.068SerLeu: 8.068 ± 0.086	1.634SerMet: 1.634 ± 0.04	3.702SerAsn: 3.702 ± 0.074	2.869SerPro: 2.869 ± 0.054	2.405SerGln: 2.405 ± 0.048	3.358SerArg: 3.358 ± 0.051	6.27SerSer: 6.27 ± 0.089	3.46SerThr: 3.46 ± 0.052	4.722SerVal: 4.722 ± 0.065	0.86SerTrp: 0.86 ± 0.031	2.852SerTyr: 2.852 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	2.769ThrAla: 2.769 ± 0.056	0.397ThrCys: 0.397 ± 0.018	2.473ThrAsp: 2.473 ± 0.048	3.134ThrGlu: 3.134 ± 0.061	2.752ThrPhe: 2.752 ± 0.052	3.905ThrGly: 3.905 ± 0.07	0.953ThrHis: 0.953 ± 0.03	4.134ThrIle: 4.134 ± 0.068	3.45ThrLys: 3.45 ± 0.064	5.192ThrLeu: 5.192 ± 0.074	0.923ThrMet: 0.923 ± 0.031	2.52ThrAsn: 2.52 ± 0.06	2.116ThrPro: 2.116 ± 0.054	1.642ThrGln: 1.642 ± 0.041	2.017ThrArg: 2.017 ± 0.044	3.827ThrSer: 3.827 ± 0.066	2.769ThrThr: 2.769 ± 0.061	3.071ThrVal: 3.071 ± 0.064	0.588ThrTrp: 0.588 ± 0.026	1.604ThrTyr: 1.604 ± 0.037	0.001ThrXaa: 0.001 ± 0.001
Val	3.227ValAla: 3.227 ± 0.058	0.623ValCys: 0.623 ± 0.025	2.691ValAsp: 2.691 ± 0.051	3.594ValGlu: 3.594 ± 0.067	3.497ValPhe: 3.497 ± 0.058	3.579ValGly: 3.579 ± 0.063	1.023ValHis: 1.023 ± 0.033	4.117ValIle: 4.117 ± 0.057	3.735ValLys: 3.735 ± 0.06	6.233ValLeu: 6.233 ± 0.078	1.179ValMet: 1.179 ± 0.037	2.541ValAsn: 2.541 ± 0.053	2.287ValPro: 2.287 ± 0.044	1.871ValGln: 1.871 ± 0.042	2.904ValArg: 2.904 ± 0.057	5.08ValSer: 5.08 ± 0.074	2.828ValThr: 2.828 ± 0.064	3.725ValVal: 3.725 ± 0.071	0.655ValTrp: 0.655 ± 0.024	2.089ValTyr: 2.089 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.519TrpAla: 0.519 ± 0.021	0.088TrpCys: 0.088 ± 0.008	0.583TrpAsp: 0.583 ± 0.023	0.84TrpGlu: 0.84 ± 0.027	0.571TrpPhe: 0.571 ± 0.025	0.691TrpGly: 0.691 ± 0.025	0.157TrpHis: 0.157 ± 0.013	1.203TrpIle: 1.203 ± 0.037	1.321TrpLys: 1.321 ± 0.04	0.919TrpLeu: 0.919 ± 0.028	0.297TrpMet: 0.297 ± 0.017	0.881TrpAsn: 0.881 ± 0.029	0.255TrpPro: 0.255 ± 0.017	0.252TrpGln: 0.252 ± 0.017	0.472TrpArg: 0.472 ± 0.023	0.736TrpSer: 0.736 ± 0.022	0.548TrpThr: 0.548 ± 0.026	0.633TrpVal: 0.633 ± 0.027	0.111TrpTrp: 0.111 ± 0.012	0.316TrpTyr: 0.316 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.616TyrAla: 1.616 ± 0.037	0.416TyrCys: 0.416 ± 0.018	1.75TyrAsp: 1.75 ± 0.041	2.203TyrGlu: 2.203 ± 0.045	2.471TyrPhe: 2.471 ± 0.047	2.218TyrGly: 2.218 ± 0.046	0.704TyrHis: 0.704 ± 0.023	2.222TyrIle: 2.222 ± 0.047	2.505TyrLys: 2.505 ± 0.048	3.844TyrLeu: 3.844 ± 0.065	0.647TyrMet: 0.647 ± 0.026	1.681TyrAsn: 1.681 ± 0.039	1.537TyrPro: 1.537 ± 0.036	1.291TyrGln: 1.291 ± 0.037	1.819TyrArg: 1.819 ± 0.042	3.138TyrSer: 3.138 ± 0.057	1.716TyrThr: 1.716 ± 0.038	1.746TyrVal: 1.746 ± 0.04	0.443TyrTrp: 0.443 ± 0.022	1.634TyrTyr: 1.634 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6014 proteins (1085766 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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