Amino acid dipepetide frequency for Firmicutes bacterium CAG:41

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.325AlaAla: 5.325 ± 0.098
0.74AlaCys: 0.74 ± 0.034
4.882AlaAsp: 4.882 ± 0.086
5.244AlaGlu: 5.244 ± 0.106
2.652AlaPhe: 2.652 ± 0.066
4.47AlaGly: 4.47 ± 0.093
0.958AlaHis: 0.958 ± 0.038
5.167AlaIle: 5.167 ± 0.111
5.357AlaLys: 5.357 ± 0.095
5.545AlaLeu: 5.545 ± 0.101
2.075AlaMet: 2.075 ± 0.061
3.065AlaAsn: 3.065 ± 0.061
1.852AlaPro: 1.852 ± 0.052
2.05AlaGln: 2.05 ± 0.056
2.127AlaArg: 2.127 ± 0.058
3.469AlaSer: 3.469 ± 0.083
3.643AlaThr: 3.643 ± 0.094
6.129AlaVal: 6.129 ± 0.116
0.497AlaTrp: 0.497 ± 0.026
2.636AlaTyr: 2.636 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.931CysAla: 0.931 ± 0.034
0.236CysCys: 0.236 ± 0.024
1.022CysAsp: 1.022 ± 0.043
0.966CysGlu: 0.966 ± 0.038
0.582CysPhe: 0.582 ± 0.028
1.429CysGly: 1.429 ± 0.047
0.265CysHis: 0.265 ± 0.021
1.145CysIle: 1.145 ± 0.039
0.865CysLys: 0.865 ± 0.031
0.847CysLeu: 0.847 ± 0.034
0.397CysMet: 0.397 ± 0.022
0.689CysAsn: 0.689 ± 0.035
0.546CysPro: 0.546 ± 0.031
0.281CysGln: 0.281 ± 0.018
0.52CysArg: 0.52 ± 0.029
0.854CysSer: 0.854 ± 0.033
0.746CysThr: 0.746 ± 0.036
0.99CysVal: 0.99 ± 0.039
0.094CysTrp: 0.094 ± 0.014
0.56CysTyr: 0.56 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
3.644AspAla: 3.644 ± 0.075
0.89AspCys: 0.89 ± 0.037
4.12AspAsp: 4.12 ± 0.085
5.366AspGlu: 5.366 ± 0.094
2.916AspPhe: 2.916 ± 0.065
5.416AspGly: 5.416 ± 0.124
0.572AspHis: 0.572 ± 0.032
6.103AspIle: 6.103 ± 0.096
5.299AspLys: 5.299 ± 0.094
4.183AspLeu: 4.183 ± 0.071
2.192AspMet: 2.192 ± 0.057
3.935AspAsn: 3.935 ± 0.097
1.232AspPro: 1.232 ± 0.042
0.65AspGln: 0.65 ± 0.033
2.049AspArg: 2.049 ± 0.058
3.589AspSer: 3.589 ± 0.084
3.981AspThr: 3.981 ± 0.094
4.727AspVal: 4.727 ± 0.078
0.675AspTrp: 0.675 ± 0.035
3.098AspTyr: 3.098 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
3.66GluAla: 3.66 ± 0.078
0.923GluCys: 0.923 ± 0.035
3.948GluAsp: 3.948 ± 0.094
5.284GluGlu: 5.284 ± 0.109
2.988GluPhe: 2.988 ± 0.073
3.414GluGly: 3.414 ± 0.069
1.174GluHis: 1.174 ± 0.042
6.162GluIle: 6.162 ± 0.101
6.843GluLys: 6.843 ± 0.111
5.92GluLeu: 5.92 ± 0.094
2.269GluMet: 2.269 ± 0.06
5.486GluAsn: 5.486 ± 0.093
1.677GluPro: 1.677 ± 0.051
2.431GluGln: 2.431 ± 0.061
2.814GluArg: 2.814 ± 0.076
3.465GluSer: 3.465 ± 0.076
3.859GluThr: 3.859 ± 0.08
4.257GluVal: 4.257 ± 0.086
0.619GluTrp: 0.619 ± 0.031
3.603GluTyr: 3.603 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
2.872PheAla: 2.872 ± 0.061
0.697PheCys: 0.697 ± 0.033
3.119PheAsp: 3.119 ± 0.069
3.066PheGlu: 3.066 ± 0.071
1.664PhePhe: 1.664 ± 0.061
2.939PheGly: 2.939 ± 0.061
0.579PheHis: 0.579 ± 0.026
3.043PheIle: 3.043 ± 0.086
2.868PheLys: 2.868 ± 0.072
2.86PheLeu: 2.86 ± 0.073
1.097PheMet: 1.097 ± 0.038
2.259PheAsn: 2.259 ± 0.059
1.185PhePro: 1.185 ± 0.039
0.774PheGln: 0.774 ± 0.034
1.229PheArg: 1.229 ± 0.045
2.779PheSer: 2.779 ± 0.063
2.457PheThr: 2.457 ± 0.062
2.934PheVal: 2.934 ± 0.075
0.337PheTrp: 0.337 ± 0.019
1.58PheTyr: 1.58 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
4.485GlyAla: 4.485 ± 0.095
1.02GlyCys: 1.02 ± 0.039
4.241GlyAsp: 4.241 ± 0.081
4.802GlyGlu: 4.802 ± 0.087
2.819GlyPhe: 2.819 ± 0.062
5.026GlyGly: 5.026 ± 0.126
1.149GlyHis: 1.149 ± 0.038
6.065GlyIle: 6.065 ± 0.112
5.512GlyLys: 5.512 ± 0.093
4.818GlyLeu: 4.818 ± 0.089
2.042GlyMet: 2.042 ± 0.055
3.494GlyAsn: 3.494 ± 0.071
0.958GlyPro: 0.958 ± 0.039
1.624GlyGln: 1.624 ± 0.055
2.528GlyArg: 2.528 ± 0.066
3.818GlySer: 3.818 ± 0.088
4.268GlyThr: 4.268 ± 0.109
5.006GlyVal: 5.006 ± 0.087
0.618GlyTrp: 0.618 ± 0.033
3.284GlyTyr: 3.284 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
0.876HisAla: 0.876 ± 0.04
0.27HisCys: 0.27 ± 0.02
0.843HisAsp: 0.843 ± 0.037
0.825HisGlu: 0.825 ± 0.041
0.661HisPhe: 0.661 ± 0.026
1.07HisGly: 1.07 ± 0.043
0.318HisHis: 0.318 ± 0.03
1.496HisIle: 1.496 ± 0.04
1.03HisLys: 1.03 ± 0.039
1.133HisLeu: 1.133 ± 0.043
0.426HisMet: 0.426 ± 0.026
0.895HisAsn: 0.895 ± 0.037
0.636HisPro: 0.636 ± 0.032
0.38HisGln: 0.38 ± 0.022
0.607HisArg: 0.607 ± 0.032
0.975HisSer: 0.975 ± 0.034
0.954HisThr: 0.954 ± 0.035
0.715HisVal: 0.715 ± 0.034
0.17HisTrp: 0.17 ± 0.016
0.65HisTyr: 0.65 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.987IleAla: 5.987 ± 0.107
1.323IleCys: 1.323 ± 0.044
5.455IleAsp: 5.455 ± 0.088
5.545IleGlu: 5.545 ± 0.09
3.106IlePhe: 3.106 ± 0.073
5.236IleGly: 5.236 ± 0.102
1.149IleHis: 1.149 ± 0.041
6.385IleIle: 6.385 ± 0.129
6.387IleLys: 6.387 ± 0.106
6.467IleLeu: 6.467 ± 0.124
2.18IleMet: 2.18 ± 0.055
4.68IleAsn: 4.68 ± 0.082
3.066IlePro: 3.066 ± 0.062
1.91IleGln: 1.91 ± 0.05
2.913IleArg: 2.913 ± 0.056
5.888IleSer: 5.888 ± 0.086
5.2IleThr: 5.2 ± 0.094
5.378IleVal: 5.378 ± 0.098
0.546IleTrp: 0.546 ± 0.028
3.047IleTyr: 3.047 ± 0.065
0.0IleXaa: 0.0 ± 0.0
Lys
5.294LysAla: 5.294 ± 0.093
0.98LysCys: 0.98 ± 0.037
4.639LysAsp: 4.639 ± 0.094
5.74LysGlu: 5.74 ± 0.115
2.724LysPhe: 2.724 ± 0.064
4.277LysGly: 4.277 ± 0.082
1.171LysHis: 1.171 ± 0.037
6.588LysIle: 6.588 ± 0.095
6.855LysLys: 6.855 ± 0.123
5.947LysLeu: 5.947 ± 0.102
2.462LysMet: 2.462 ± 0.066
5.276LysAsn: 5.276 ± 0.089
2.353LysPro: 2.353 ± 0.054
2.368LysGln: 2.368 ± 0.056
3.039LysArg: 3.039 ± 0.071
4.593LysSer: 4.593 ± 0.091
4.821LysThr: 4.821 ± 0.087
4.663LysVal: 4.663 ± 0.077
0.715LysTrp: 0.715 ± 0.038
3.876LysTyr: 3.876 ± 0.081
0.0LysXaa: 0.0 ± 0.0
Leu
5.396LeuAla: 5.396 ± 0.099
1.225LeuCys: 1.225 ± 0.044
4.882LeuAsp: 4.882 ± 0.081
5.066LeuGlu: 5.066 ± 0.089
3.049LeuPhe: 3.049 ± 0.074
5.011LeuGly: 5.011 ± 0.091
1.133LeuHis: 1.133 ± 0.042
5.777LeuIle: 5.777 ± 0.126
6.336LeuLys: 6.336 ± 0.106
5.837LeuLeu: 5.837 ± 0.126
2.205LeuMet: 2.205 ± 0.058
4.196LeuAsn: 4.196 ± 0.078
2.73LeuPro: 2.73 ± 0.065
1.955LeuGln: 1.955 ± 0.053
2.815LeuArg: 2.815 ± 0.069
5.866LeuSer: 5.866 ± 0.092
4.697LeuThr: 4.697 ± 0.083
4.654LeuVal: 4.654 ± 0.078
0.619LeuTrp: 0.619 ± 0.029
3.04LeuTyr: 3.04 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.151MetAla: 2.151 ± 0.053
0.402MetCys: 0.402 ± 0.022
1.606MetAsp: 1.606 ± 0.043
1.699MetGlu: 1.699 ± 0.056
1.176MetPhe: 1.176 ± 0.042
1.964MetGly: 1.964 ± 0.058
0.402MetHis: 0.402 ± 0.024
2.149MetIle: 2.149 ± 0.068
2.429MetLys: 2.429 ± 0.057
2.587MetLeu: 2.587 ± 0.062
0.809MetMet: 0.809 ± 0.033
1.714MetAsn: 1.714 ± 0.054
1.107MetPro: 1.107 ± 0.041
0.947MetGln: 0.947 ± 0.034
1.167MetArg: 1.167 ± 0.038
1.963MetSer: 1.963 ± 0.054
1.807MetThr: 1.807 ± 0.051
1.621MetVal: 1.621 ± 0.047
0.232MetTrp: 0.232 ± 0.019
1.131MetTyr: 1.131 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
4.023AsnAla: 4.023 ± 0.081
0.757AsnCys: 0.757 ± 0.035
3.547AsnAsp: 3.547 ± 0.071
3.809AsnGlu: 3.809 ± 0.077
2.031AsnPhe: 2.031 ± 0.058
4.949AsnGly: 4.949 ± 0.106
0.84AsnHis: 0.84 ± 0.034
5.147AsnIle: 5.147 ± 0.082
4.006AsnLys: 4.006 ± 0.072
3.951AsnLeu: 3.951 ± 0.072
1.762AsnMet: 1.762 ± 0.043
3.462AsnAsn: 3.462 ± 0.081
2.158AsnPro: 2.158 ± 0.054
1.371AsnGln: 1.371 ± 0.043
1.912AsnArg: 1.912 ± 0.052
3.735AsnSer: 3.735 ± 0.092
3.386AsnThr: 3.386 ± 0.079
4.192AsnVal: 4.192 ± 0.08
0.447AsnTrp: 0.447 ± 0.025
2.292AsnTyr: 2.292 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
1.762ProAla: 1.762 ± 0.058
0.43ProCys: 0.43 ± 0.023
1.97ProAsp: 1.97 ± 0.056
2.491ProGlu: 2.491 ± 0.071
1.383ProPhe: 1.383 ± 0.046
1.427ProGly: 1.427 ± 0.046
0.533ProHis: 0.533 ± 0.025
2.507ProIle: 2.507 ± 0.053
2.232ProLys: 2.232 ± 0.053
2.265ProLeu: 2.265 ± 0.059
0.783ProMet: 0.783 ± 0.032
1.72ProAsn: 1.72 ± 0.041
0.757ProPro: 0.757 ± 0.034
1.062ProGln: 1.062 ± 0.038
0.793ProArg: 0.793 ± 0.031
1.93ProSer: 1.93 ± 0.052
2.162ProThr: 2.162 ± 0.076
2.368ProVal: 2.368 ± 0.053
0.268ProTrp: 0.268 ± 0.021
1.383ProTyr: 1.383 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
1.795GlnAla: 1.795 ± 0.044
0.316GlnCys: 0.316 ± 0.022
1.221GlnAsp: 1.221 ± 0.04
1.621GlnGlu: 1.621 ± 0.051
1.041GlnPhe: 1.041 ± 0.039
1.55GlnGly: 1.55 ± 0.043
0.37GlnHis: 0.37 ± 0.023
2.203GlnIle: 2.203 ± 0.048
2.341GlnLys: 2.341 ± 0.069
2.118GlnLeu: 2.118 ± 0.054
0.872GlnMet: 0.872 ± 0.04
1.781GlnAsn: 1.781 ± 0.051
0.762GlnPro: 0.762 ± 0.034
0.807GlnGln: 0.807 ± 0.037
1.131GlnArg: 1.131 ± 0.048
1.66GlnSer: 1.66 ± 0.042
1.641GlnThr: 1.641 ± 0.044
1.371GlnVal: 1.371 ± 0.041
0.243GlnTrp: 0.243 ± 0.018
1.165GlnTyr: 1.165 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.184ArgAla: 2.184 ± 0.059
0.502ArgCys: 0.502 ± 0.027
2.027ArgAsp: 2.027 ± 0.057
2.712ArgGlu: 2.712 ± 0.068
1.536ArgPhe: 1.536 ± 0.053
2.117ArgGly: 2.117 ± 0.056
0.674ArgHis: 0.674 ± 0.03
3.106ArgIle: 3.106 ± 0.064
2.865ArgLys: 2.865 ± 0.065
3.044ArgLeu: 3.044 ± 0.078
1.101ArgMet: 1.101 ± 0.039
2.054ArgAsn: 2.054 ± 0.053
1.122ArgPro: 1.122 ± 0.044
1.111ArgGln: 1.111 ± 0.041
1.651ArgArg: 1.651 ± 0.06
1.773ArgSer: 1.773 ± 0.054
1.885ArgThr: 1.885 ± 0.052
2.312ArgVal: 2.312 ± 0.049
0.314ArgTrp: 0.314 ± 0.02
1.607ArgTyr: 1.607 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.569SerAla: 4.569 ± 0.084
0.753SerCys: 0.753 ± 0.034
4.736SerAsp: 4.736 ± 0.095
4.502SerGlu: 4.502 ± 0.08
2.48SerPhe: 2.48 ± 0.063
4.878SerGly: 4.878 ± 0.096
0.975SerHis: 0.975 ± 0.037
4.537SerIle: 4.537 ± 0.089
4.376SerLys: 4.376 ± 0.077
4.709SerLeu: 4.709 ± 0.083
1.675SerMet: 1.675 ± 0.051
3.173SerAsn: 3.173 ± 0.074
1.76SerPro: 1.76 ± 0.057
1.738SerGln: 1.738 ± 0.049
2.152SerArg: 2.152 ± 0.054
4.098SerSer: 4.098 ± 0.119
3.338SerThr: 3.338 ± 0.082
4.985SerVal: 4.985 ± 0.096
0.525SerTrp: 0.525 ± 0.026
2.587SerTyr: 2.587 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
4.95ThrAla: 4.95 ± 0.103
0.608ThrCys: 0.608 ± 0.032
4.339ThrAsp: 4.339 ± 0.099
4.333ThrGlu: 4.333 ± 0.086
2.431ThrPhe: 2.431 ± 0.055
4.511ThrGly: 4.511 ± 0.089
0.957ThrHis: 0.957 ± 0.037
4.395ThrIle: 4.395 ± 0.094
3.648ThrLys: 3.648 ± 0.077
4.762ThrLeu: 4.762 ± 0.084
1.48ThrMet: 1.48 ± 0.047
2.807ThrAsn: 2.807 ± 0.072
2.388ThrPro: 2.388 ± 0.065
1.499ThrGln: 1.499 ± 0.041
1.845ThrArg: 1.845 ± 0.055
3.5ThrSer: 3.5 ± 0.094
3.364ThrThr: 3.364 ± 0.096
5.673ThrVal: 5.673 ± 0.132
0.443ThrTrp: 0.443 ± 0.025
2.457ThrTyr: 2.457 ± 0.078
0.0ThrXaa: 0.0 ± 0.0
Val
4.609ValAla: 4.609 ± 0.08
1.159ValCys: 1.159 ± 0.041
4.187ValAsp: 4.187 ± 0.072
4.358ValGlu: 4.358 ± 0.079
2.976ValPhe: 2.976 ± 0.068
4.31ValGly: 4.31 ± 0.088
0.939ValHis: 0.939 ± 0.037
5.675ValIle: 5.675 ± 0.088
5.523ValLys: 5.523 ± 0.09
5.619ValLeu: 5.619 ± 0.109
1.961ValMet: 1.961 ± 0.051
3.718ValAsn: 3.718 ± 0.065
2.516ValPro: 2.516 ± 0.071
1.757ValGln: 1.757 ± 0.039
2.447ValArg: 2.447 ± 0.061
5.156ValSer: 5.156 ± 0.096
4.829ValThr: 4.829 ± 0.125
4.591ValVal: 4.591 ± 0.092
0.582ValTrp: 0.582 ± 0.028
2.882ValTyr: 2.882 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.592TrpAla: 0.592 ± 0.028
0.139TrpCys: 0.139 ± 0.015
0.595TrpAsp: 0.595 ± 0.028
0.556TrpGlu: 0.556 ± 0.029
0.325TrpPhe: 0.325 ± 0.022
0.643TrpGly: 0.643 ± 0.036
0.17TrpHis: 0.17 ± 0.015
0.607TrpIle: 0.607 ± 0.034
0.519TrpLys: 0.519 ± 0.032
0.667TrpLeu: 0.667 ± 0.029
0.185TrpMet: 0.185 ± 0.015
0.608TrpAsn: 0.608 ± 0.027
0.1TrpPro: 0.1 ± 0.012
0.297TrpGln: 0.297 ± 0.018
0.358TrpArg: 0.358 ± 0.023
0.533TrpSer: 0.533 ± 0.027
0.467TrpThr: 0.467 ± 0.03
0.478TrpVal: 0.478 ± 0.027
0.098TrpTrp: 0.098 ± 0.011
0.433TrpTyr: 0.433 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.778TyrAla: 2.778 ± 0.059
0.596TyrCys: 0.596 ± 0.027
3.259TyrAsp: 3.259 ± 0.077
2.812TyrGlu: 2.812 ± 0.072
1.799TyrPhe: 1.799 ± 0.049
2.939TyrGly: 2.939 ± 0.072
0.605TyrHis: 0.605 ± 0.027
3.589TyrIle: 3.589 ± 0.071
3.089TyrLys: 3.089 ± 0.067
3.208TyrLeu: 3.208 ± 0.068
1.086TyrMet: 1.086 ± 0.038
2.765TyrAsn: 2.765 ± 0.074
1.321TyrPro: 1.321 ± 0.046
0.997TyrGln: 0.997 ± 0.039
1.602TyrArg: 1.602 ± 0.053
2.904TyrSer: 2.904 ± 0.067
2.886TyrThr: 2.886 ± 0.092
2.751TyrVal: 2.751 ± 0.066
0.327TyrTrp: 0.327 ± 0.024
1.969TyrTyr: 1.969 ± 0.066
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2447 proteins (776536 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski