Amino acid dipepetide frequency for [Clostridium] thermoalcaliphilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.724AlaAla: 3.724 ± 0.118	0.651AlaCys: 0.651 ± 0.032	2.502AlaAsp: 2.502 ± 0.065	2.688AlaGlu: 2.688 ± 0.071	2.339AlaPhe: 2.339 ± 0.068	3.823AlaGly: 3.823 ± 0.102	0.952AlaHis: 0.952 ± 0.041	5.91AlaIle: 5.91 ± 0.117	4.488AlaLys: 4.488 ± 0.087	5.848AlaLeu: 5.848 ± 0.115	1.691AlaMet: 1.691 ± 0.054	2.699AlaAsn: 2.699 ± 0.064	1.433AlaPro: 1.433 ± 0.054	1.824AlaGln: 1.824 ± 0.062	2.224AlaArg: 2.224 ± 0.067	3.382AlaSer: 3.382 ± 0.079	2.742AlaThr: 2.742 ± 0.067	3.956AlaVal: 3.956 ± 0.106	0.291AlaTrp: 0.291 ± 0.023	1.987AlaTyr: 1.987 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.549CysAla: 0.549 ± 0.036	0.171CysCys: 0.171 ± 0.02	0.686CysAsp: 0.686 ± 0.036	0.768CysGlu: 0.768 ± 0.042	0.345CysPhe: 0.345 ± 0.025	0.967CysGly: 0.967 ± 0.044	0.194CysHis: 0.194 ± 0.017	1.096CysIle: 1.096 ± 0.048	0.929CysLys: 0.929 ± 0.04	0.673CysLeu: 0.673 ± 0.038	0.285CysMet: 0.285 ± 0.023	0.61CysAsn: 0.61 ± 0.036	0.49CysPro: 0.49 ± 0.032	0.255CysGln: 0.255 ± 0.022	0.35CysArg: 0.35 ± 0.027	0.725CysSer: 0.725 ± 0.033	0.477CysThr: 0.477 ± 0.032	0.604CysVal: 0.604 ± 0.034	0.049CysTrp: 0.049 ± 0.01	0.35CysTyr: 0.35 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	2.754AspAla: 2.754 ± 0.068	0.62AspCys: 0.62 ± 0.034	2.783AspAsp: 2.783 ± 0.071	5.129AspGlu: 5.129 ± 0.103	2.627AspPhe: 2.627 ± 0.06	3.149AspGly: 3.149 ± 0.074	0.679AspHis: 0.679 ± 0.034	7.636AspIle: 7.636 ± 0.129	5.496AspLys: 5.496 ± 0.094	5.088AspLeu: 5.088 ± 0.105	1.721AspMet: 1.721 ± 0.056	3.094AspAsn: 3.094 ± 0.065	1.571AspPro: 1.571 ± 0.049	0.952AspGln: 0.952 ± 0.039	1.959AspArg: 1.959 ± 0.054	2.903AspSer: 2.903 ± 0.071	2.614AspThr: 2.614 ± 0.073	3.803AspVal: 3.803 ± 0.083	0.342AspTrp: 0.342 ± 0.024	2.573AspTyr: 2.573 ± 0.075	0.0AspXaa: 0.0 ± 0.0
Glu	3.871GluAla: 3.871 ± 0.093	0.622GluCys: 0.622 ± 0.032	4.849GluAsp: 4.849 ± 0.1	6.935GluGlu: 6.935 ± 0.124	2.989GluPhe: 2.989 ± 0.071	4.367GluGly: 4.367 ± 0.086	0.987GluHis: 0.987 ± 0.041	8.034GluIle: 8.034 ± 0.115	7.562GluLys: 7.562 ± 0.13	6.286GluLeu: 6.286 ± 0.129	2.035GluMet: 2.035 ± 0.062	5.478GluAsn: 5.478 ± 0.11	1.328GluPro: 1.328 ± 0.05	1.591GluGln: 1.591 ± 0.055	2.912GluArg: 2.912 ± 0.086	3.823GluSer: 3.823 ± 0.081	2.803GluThr: 2.803 ± 0.073	4.976GluVal: 4.976 ± 0.097	0.364GluTrp: 0.364 ± 0.027	3.382GluTyr: 3.382 ± 0.081	0.0GluXaa: 0.0 ± 0.0
Phe	2.216PheAla: 2.216 ± 0.064	0.446PheCys: 0.446 ± 0.028	2.456PheAsp: 2.456 ± 0.06	2.981PheGlu: 2.981 ± 0.071	1.586PhePhe: 1.586 ± 0.059	2.829PheGly: 2.829 ± 0.074	0.508PheHis: 0.508 ± 0.028	4.415PheIle: 4.415 ± 0.107	3.491PheLys: 3.491 ± 0.071	3.719PheLeu: 3.719 ± 0.087	1.066PheMet: 1.066 ± 0.041	2.354PheAsn: 2.354 ± 0.063	1.114PhePro: 1.114 ± 0.046	0.798PheGln: 0.798 ± 0.04	1.459PheArg: 1.459 ± 0.047	2.665PheSer: 2.665 ± 0.074	2.079PheThr: 2.079 ± 0.06	2.726PheVal: 2.726 ± 0.074	0.271PheTrp: 0.271 ± 0.022	1.485PheTyr: 1.485 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.282GlyAla: 4.282 ± 0.101	0.878GlyCys: 0.878 ± 0.045	3.153GlyAsp: 3.153 ± 0.072	4.14GlyGlu: 4.14 ± 0.082	3.065GlyPhe: 3.065 ± 0.066	4.446GlyGly: 4.446 ± 0.111	1.096GlyHis: 1.096 ± 0.045	7.097GlyIle: 7.097 ± 0.115	5.468GlyLys: 5.468 ± 0.098	5.455GlyLeu: 5.455 ± 0.118	1.9GlyMet: 1.9 ± 0.065	3.025GlyAsn: 3.025 ± 0.075	1.433GlyPro: 1.433 ± 0.051	1.563GlyGln: 1.563 ± 0.057	2.438GlyArg: 2.438 ± 0.071	3.864GlySer: 3.864 ± 0.085	3.267GlyThr: 3.267 ± 0.072	4.886GlyVal: 4.886 ± 0.102	0.403GlyTrp: 0.403 ± 0.027	3.024GlyTyr: 3.024 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	0.767HisAla: 0.767 ± 0.037	0.166HisCys: 0.166 ± 0.016	0.689HisAsp: 0.689 ± 0.032	0.9HisGlu: 0.9 ± 0.036	0.65HisPhe: 0.65 ± 0.038	1.071HisGly: 1.071 ± 0.038	0.306HisHis: 0.306 ± 0.023	1.701HisIle: 1.701 ± 0.058	1.127HisLys: 1.127 ± 0.047	1.347HisLeu: 1.347 ± 0.042	0.373HisMet: 0.373 ± 0.02	0.814HisAsn: 0.814 ± 0.034	0.714HisPro: 0.714 ± 0.034	0.362HisGln: 0.362 ± 0.025	0.586HisArg: 0.586 ± 0.032	0.933HisSer: 0.933 ± 0.038	0.765HisThr: 0.765 ± 0.035	0.834HisVal: 0.834 ± 0.041	0.092HisTrp: 0.092 ± 0.012	0.651HisTyr: 0.651 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	5.942IleAla: 5.942 ± 0.098	1.178IleCys: 1.178 ± 0.047	6.98IleAsp: 6.98 ± 0.117	7.819IleGlu: 7.819 ± 0.125	3.833IlePhe: 3.833 ± 0.093	6.672IleGly: 6.672 ± 0.149	1.4IleHis: 1.4 ± 0.05	9.567IleIle: 9.567 ± 0.172	9.26IleLys: 9.26 ± 0.141	9.516IleLeu: 9.516 ± 0.148	2.285IleMet: 2.285 ± 0.066	6.682IleAsn: 6.682 ± 0.112	3.667IlePro: 3.667 ± 0.072	2.662IleGln: 2.662 ± 0.072	3.52IleArg: 3.52 ± 0.079	7.274IleSer: 7.274 ± 0.111	4.823IleThr: 4.823 ± 0.09	6.901IleVal: 6.901 ± 0.114	0.518IleTrp: 0.518 ± 0.03	3.775IleTyr: 3.775 ± 0.093	0.0IleXaa: 0.0 ± 0.0
Lys	4.724LysAla: 4.724 ± 0.101	0.795LysCys: 0.795 ± 0.038	6.016LysAsp: 6.016 ± 0.099	9.219LysGlu: 9.219 ± 0.153	2.88LysPhe: 2.88 ± 0.074	5.165LysGly: 5.165 ± 0.094	1.281LysHis: 1.281 ± 0.048	8.659LysIle: 8.659 ± 0.125	7.294LysLys: 7.294 ± 0.117	7.551LysLeu: 7.551 ± 0.12	2.389LysMet: 2.389 ± 0.052	5.756LysAsn: 5.756 ± 0.109	1.979LysPro: 1.979 ± 0.066	2.063LysGln: 2.063 ± 0.063	3.183LysArg: 3.183 ± 0.081	5.111LysSer: 5.111 ± 0.09	3.718LysThr: 3.718 ± 0.091	5.886LysVal: 5.886 ± 0.107	0.49LysTrp: 0.49 ± 0.027	4.019LysTyr: 4.019 ± 0.094	0.0LysXaa: 0.0 ± 0.0
Leu	4.974LeuAla: 4.974 ± 0.101	0.855LeuCys: 0.855 ± 0.038	5.613LeuAsp: 5.613 ± 0.097	6.664LeuGlu: 6.664 ± 0.109	3.494LeuPhe: 3.494 ± 0.095	6.568LeuGly: 6.568 ± 0.126	1.16LeuHis: 1.16 ± 0.042	8.107LeuIle: 8.107 ± 0.137	7.977LeuLys: 7.977 ± 0.121	7.276LeuLeu: 7.276 ± 0.115	2.267LeuMet: 2.267 ± 0.061	5.866LeuAsn: 5.866 ± 0.104	2.548LeuPro: 2.548 ± 0.072	1.979LeuGln: 1.979 ± 0.064	3.691LeuArg: 3.691 ± 0.092	6.85LeuSer: 6.85 ± 0.112	4.129LeuThr: 4.129 ± 0.082	5.603LeuVal: 5.603 ± 0.089	0.489LeuTrp: 0.489 ± 0.034	3.061LeuTyr: 3.061 ± 0.084	0.0LeuXaa: 0.0 ± 0.0
Met	1.798MetAla: 1.798 ± 0.063	0.248MetCys: 0.248 ± 0.019	1.586MetAsp: 1.586 ± 0.051	1.801MetGlu: 1.801 ± 0.057	0.952MetPhe: 0.952 ± 0.046	1.834MetGly: 1.834 ± 0.057	0.339MetHis: 0.339 ± 0.023	2.407MetIle: 2.407 ± 0.066	2.588MetLys: 2.588 ± 0.063	2.222MetLeu: 2.222 ± 0.065	0.712MetMet: 0.712 ± 0.037	1.796MetAsn: 1.796 ± 0.051	0.936MetPro: 0.936 ± 0.044	0.656MetGln: 0.656 ± 0.036	1.036MetArg: 1.036 ± 0.04	1.698MetSer: 1.698 ± 0.048	1.183MetThr: 1.183 ± 0.047	1.637MetVal: 1.637 ± 0.053	0.123MetTrp: 0.123 ± 0.014	0.892MetTyr: 0.892 ± 0.041	0.0MetXaa: 0.0 ± 0.0
Asn	2.8AsnAla: 2.8 ± 0.08	0.607AsnCys: 0.607 ± 0.032	2.713AsnAsp: 2.713 ± 0.06	4.542AsnGlu: 4.542 ± 0.09	2.37AsnPhe: 2.37 ± 0.06	3.135AsnGly: 3.135 ± 0.084	0.814AsnHis: 0.814 ± 0.036	7.837AsnIle: 7.837 ± 0.158	5.69AsnLys: 5.69 ± 0.106	5.856AsnLeu: 5.856 ± 0.113	1.744AsnMet: 1.744 ± 0.054	3.826AsnAsn: 3.826 ± 0.098	2.338AsnPro: 2.338 ± 0.065	1.337AsnGln: 1.337 ± 0.05	1.954AsnArg: 1.954 ± 0.06	3.431AsnSer: 3.431 ± 0.084	2.902AsnThr: 2.902 ± 0.076	3.741AsnVal: 3.741 ± 0.081	0.385AsnTrp: 0.385 ± 0.024	2.384AsnTyr: 2.384 ± 0.075	0.0AsnXaa: 0.0 ± 0.0
Pro	1.413ProAla: 1.413 ± 0.06	0.308ProCys: 0.308 ± 0.022	1.569ProAsp: 1.569 ± 0.049	2.04ProGlu: 2.04 ± 0.062	1.351ProPhe: 1.351 ± 0.047	1.859ProGly: 1.859 ± 0.059	0.6ProHis: 0.6 ± 0.029	2.882ProIle: 2.882 ± 0.083	2.328ProLys: 2.328 ± 0.064	2.468ProLeu: 2.468 ± 0.075	0.684ProMet: 0.684 ± 0.034	1.653ProAsn: 1.653 ± 0.056	0.709ProPro: 0.709 ± 0.039	0.967ProGln: 0.967 ± 0.042	1.059ProArg: 1.059 ± 0.037	1.936ProSer: 1.936 ± 0.062	1.602ProThr: 1.602 ± 0.059	2.165ProVal: 2.165 ± 0.06	0.24ProTrp: 0.24 ± 0.021	1.265ProTyr: 1.265 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	1.395GlnAla: 1.395 ± 0.053	0.222GlnCys: 0.222 ± 0.02	1.244GlnAsp: 1.244 ± 0.046	1.75GlnGlu: 1.75 ± 0.066	0.951GlnPhe: 0.951 ± 0.036	1.571GlnGly: 1.571 ± 0.048	0.314GlnHis: 0.314 ± 0.024	2.507GlnIle: 2.507 ± 0.067	2.222GlnLys: 2.222 ± 0.06	1.9GlnLeu: 1.9 ± 0.059	0.73GlnMet: 0.73 ± 0.034	1.675GlnAsn: 1.675 ± 0.05	0.661GlnPro: 0.661 ± 0.036	0.637GlnGln: 0.637 ± 0.039	1.17GlnArg: 1.17 ± 0.045	1.561GlnSer: 1.561 ± 0.052	1.147GlnThr: 1.147 ± 0.04	1.584GlnVal: 1.584 ± 0.044	0.166GlnTrp: 0.166 ± 0.017	0.928GlnTyr: 0.928 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.045ArgAla: 2.045 ± 0.061	0.387ArgCys: 0.387 ± 0.024	1.986ArgAsp: 1.986 ± 0.056	3.165ArgGlu: 3.165 ± 0.071	1.582ArgPhe: 1.582 ± 0.046	2.216ArgGly: 2.216 ± 0.07	0.582ArgHis: 0.582 ± 0.031	3.463ArgIle: 3.463 ± 0.075	3.496ArgLys: 3.496 ± 0.073	3.162ArgLeu: 3.162 ± 0.079	1.035ArgMet: 1.035 ± 0.045	2.352ArgAsn: 2.352 ± 0.07	1.071ArgPro: 1.071 ± 0.045	1.074ArgGln: 1.074 ± 0.056	1.632ArgArg: 1.632 ± 0.056	1.977ArgSer: 1.977 ± 0.062	1.568ArgThr: 1.568 ± 0.054	2.594ArgVal: 2.594 ± 0.07	0.276ArgTrp: 0.276 ± 0.022	1.642ArgTyr: 1.642 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	3.07SerAla: 3.07 ± 0.089	0.628SerCys: 0.628 ± 0.035	3.14SerAsp: 3.14 ± 0.072	3.974SerGlu: 3.974 ± 0.085	2.854SerPhe: 2.854 ± 0.074	4.196SerGly: 4.196 ± 0.077	1.066SerHis: 1.066 ± 0.04	7.016SerIle: 7.016 ± 0.131	5.878SerLys: 5.878 ± 0.087	6.126SerLeu: 6.126 ± 0.096	1.648SerMet: 1.648 ± 0.053	3.737SerAsn: 3.737 ± 0.078	1.757SerPro: 1.757 ± 0.057	1.782SerGln: 1.782 ± 0.061	2.42SerArg: 2.42 ± 0.065	4.2SerSer: 4.2 ± 0.109	3.109SerThr: 3.109 ± 0.075	3.83SerVal: 3.83 ± 0.088	0.35SerTrp: 0.35 ± 0.024	2.308SerTyr: 2.308 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	2.675ThrAla: 2.675 ± 0.076	0.487ThrCys: 0.487 ± 0.029	2.425ThrAsp: 2.425 ± 0.066	2.611ThrGlu: 2.611 ± 0.073	2.007ThrPhe: 2.007 ± 0.06	3.461ThrGly: 3.461 ± 0.077	0.865ThrHis: 0.865 ± 0.038	4.642ThrIle: 4.642 ± 0.092	3.642ThrLys: 3.642 ± 0.081	4.678ThrLeu: 4.678 ± 0.091	1.063ThrMet: 1.063 ± 0.043	2.517ThrAsn: 2.517 ± 0.064	1.763ThrPro: 1.763 ± 0.057	1.337ThrGln: 1.337 ± 0.047	1.629ThrArg: 1.629 ± 0.057	3.204ThrSer: 3.204 ± 0.085	2.481ThrThr: 2.481 ± 0.062	3.251ThrVal: 3.251 ± 0.078	0.329ThrTrp: 0.329 ± 0.025	1.757ThrTyr: 1.757 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	4.032ValAla: 4.032 ± 0.097	0.79ValCys: 0.79 ± 0.042	4.405ValAsp: 4.405 ± 0.087	4.729ValGlu: 4.729 ± 0.102	2.78ValPhe: 2.78 ± 0.074	4.558ValGly: 4.558 ± 0.102	1.007ValHis: 1.007 ± 0.045	6.267ValIle: 6.267 ± 0.109	5.303ValLys: 5.303 ± 0.107	6.029ValLeu: 6.029 ± 0.117	1.675ValMet: 1.675 ± 0.053	3.57ValAsn: 3.57 ± 0.079	2.107ValPro: 2.107 ± 0.059	1.471ValGln: 1.471 ± 0.055	2.449ValArg: 2.449 ± 0.07	4.481ValSer: 4.481 ± 0.098	3.153ValThr: 3.153 ± 0.081	4.905ValVal: 4.905 ± 0.115	0.359ValTrp: 0.359 ± 0.025	2.392ValTyr: 2.392 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	0.352TrpAla: 0.352 ± 0.024	0.066TrpCys: 0.066 ± 0.011	0.332TrpAsp: 0.332 ± 0.024	0.436TrpGlu: 0.436 ± 0.026	0.237TrpPhe: 0.237 ± 0.022	0.449TrpGly: 0.449 ± 0.031	0.086TrpHis: 0.086 ± 0.012	0.604TrpIle: 0.604 ± 0.032	0.443TrpLys: 0.443 ± 0.032	0.444TrpLeu: 0.444 ± 0.028	0.171TrpMet: 0.171 ± 0.016	0.415TrpAsn: 0.415 ± 0.032	0.168TrpPro: 0.168 ± 0.018	0.194TrpGln: 0.194 ± 0.021	0.209TrpArg: 0.209 ± 0.019	0.339TrpSer: 0.339 ± 0.027	0.252TrpThr: 0.252 ± 0.021	0.357TrpVal: 0.357 ± 0.025	0.082TrpTrp: 0.082 ± 0.013	0.23TrpTyr: 0.23 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.775TyrAla: 1.775 ± 0.049	0.451TyrCys: 0.451 ± 0.025	2.367TyrAsp: 2.367 ± 0.071	2.902TyrGlu: 2.902 ± 0.073	1.772TyrPhe: 1.772 ± 0.063	2.543TyrGly: 2.543 ± 0.071	0.61TyrHis: 0.61 ± 0.034	4.427TyrIle: 4.427 ± 0.089	3.499TyrLys: 3.499 ± 0.084	3.527TyrLeu: 3.527 ± 0.091	0.971TyrMet: 0.971 ± 0.04	2.486TyrAsn: 2.486 ± 0.069	1.313TyrPro: 1.313 ± 0.049	0.831TyrGln: 0.831 ± 0.04	1.423TyrArg: 1.423 ± 0.044	2.731TyrSer: 2.731 ± 0.072	2.01TyrThr: 2.01 ± 0.068	2.226TyrVal: 2.226 ± 0.056	0.243TyrTrp: 0.243 ± 0.021	1.632TyrTyr: 1.632 ± 0.064	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2026 proteins (607903 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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