Amino acid dipepetide frequency for Candidatus Entotheonella factor

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.739AlaAla: 10.739 ± 0.082	1.168AlaCys: 1.168 ± 0.027	5.506AlaAsp: 5.506 ± 0.054	6.395AlaGlu: 6.395 ± 0.067	3.8AlaPhe: 3.8 ± 0.04	7.41AlaGly: 7.41 ± 0.069	2.496AlaHis: 2.496 ± 0.032	5.56AlaIle: 5.56 ± 0.054	3.15AlaLys: 3.15 ± 0.034	11.319AlaLeu: 11.319 ± 0.085	2.977AlaMet: 2.977 ± 0.04	2.794AlaAsn: 2.794 ± 0.043	4.453AlaPro: 4.453 ± 0.052	4.76AlaGln: 4.76 ± 0.055	5.909AlaArg: 5.909 ± 0.059	5.598AlaSer: 5.598 ± 0.048	5.133AlaThr: 5.133 ± 0.051	7.052AlaVal: 7.052 ± 0.057	1.515AlaTrp: 1.515 ± 0.025	3.067AlaTyr: 3.067 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	0.943CysAla: 0.943 ± 0.02	0.158CysCys: 0.158 ± 0.008	0.618CysAsp: 0.618 ± 0.016	0.606CysGlu: 0.606 ± 0.017	0.406CysPhe: 0.406 ± 0.012	0.97CysGly: 0.97 ± 0.021	0.384CysHis: 0.384 ± 0.013	0.525CysIle: 0.525 ± 0.014	0.262CysLys: 0.262 ± 0.011	1.124CysLeu: 1.124 ± 0.022	0.255CysMet: 0.255 ± 0.011	0.28CysAsn: 0.28 ± 0.011	0.604CysPro: 0.604 ± 0.017	0.508CysGln: 0.508 ± 0.016	0.779CysArg: 0.779 ± 0.018	0.54CysSer: 0.54 ± 0.017	0.569CysThr: 0.569 ± 0.016	0.706CysVal: 0.706 ± 0.017	0.15CysTrp: 0.15 ± 0.008	0.317CysTyr: 0.317 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	5.746AspAla: 5.746 ± 0.054	0.555AspCys: 0.555 ± 0.015	3.398AspAsp: 3.398 ± 0.05	3.597AspGlu: 3.597 ± 0.037	2.192AspPhe: 2.192 ± 0.033	4.431AspGly: 4.431 ± 0.06	1.591AspHis: 1.591 ± 0.026	3.499AspIle: 3.499 ± 0.039	1.467AspLys: 1.467 ± 0.028	6.009AspLeu: 6.009 ± 0.05	1.509AspMet: 1.509 ± 0.024	1.5AspAsn: 1.5 ± 0.027	3.175AspPro: 3.175 ± 0.036	2.301AspGln: 2.301 ± 0.037	3.738AspArg: 3.738 ± 0.044	2.192AspSer: 2.192 ± 0.03	3.012AspThr: 3.012 ± 0.04	4.437AspVal: 4.437 ± 0.045	0.911AspTrp: 0.911 ± 0.019	1.811AspTyr: 1.811 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.619GluAla: 7.619 ± 0.075	0.426GluCys: 0.426 ± 0.012	2.992GluAsp: 2.992 ± 0.038	3.451GluGlu: 3.451 ± 0.039	1.771GluPhe: 1.771 ± 0.025	3.985GluGly: 3.985 ± 0.042	1.718GluHis: 1.718 ± 0.03	3.277GluIle: 3.277 ± 0.035	1.757GluLys: 1.757 ± 0.037	6.234GluLeu: 6.234 ± 0.058	1.611GluMet: 1.611 ± 0.027	1.49GluAsn: 1.49 ± 0.025	3.162GluPro: 3.162 ± 0.038	3.227GluGln: 3.227 ± 0.043	4.95GluArg: 4.95 ± 0.048	2.961GluSer: 2.961 ± 0.038	3.687GluThr: 3.687 ± 0.044	4.454GluVal: 4.454 ± 0.047	0.793GluTrp: 0.793 ± 0.017	1.28GluTyr: 1.28 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.232PheAla: 3.232 ± 0.038	0.475PheCys: 0.475 ± 0.013	2.541PheAsp: 2.541 ± 0.027	2.328PheGlu: 2.328 ± 0.031	1.476PhePhe: 1.476 ± 0.028	3.113PheGly: 3.113 ± 0.04	0.945PheHis: 0.945 ± 0.02	1.745PheIle: 1.745 ± 0.029	0.972PheLys: 0.972 ± 0.018	3.46PheLeu: 3.46 ± 0.048	0.826PheMet: 0.826 ± 0.018	1.189PheAsn: 1.189 ± 0.023	1.662PhePro: 1.662 ± 0.028	1.415PheGln: 1.415 ± 0.025	2.245PheArg: 2.245 ± 0.033	2.132PheSer: 2.132 ± 0.03	2.114PheThr: 2.114 ± 0.029	2.576PheVal: 2.576 ± 0.032	0.603PheTrp: 0.603 ± 0.018	1.155PheTyr: 1.155 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	6.543GlyAla: 6.543 ± 0.062	0.902GlyCys: 0.902 ± 0.022	4.082GlyAsp: 4.082 ± 0.055	4.478GlyGlu: 4.478 ± 0.054	3.077GlyPhe: 3.077 ± 0.037	5.842GlyGly: 5.842 ± 0.074	2.081GlyHis: 2.081 ± 0.033	4.365GlyIle: 4.365 ± 0.043	2.656GlyLys: 2.656 ± 0.039	7.971GlyLeu: 7.971 ± 0.065	2.196GlyMet: 2.196 ± 0.03	2.203GlyAsn: 2.203 ± 0.044	3.126GlyPro: 3.126 ± 0.043	3.505GlyGln: 3.505 ± 0.035	4.885GlyArg: 4.885 ± 0.051	4.079GlySer: 4.079 ± 0.047	4.333GlyThr: 4.333 ± 0.052	5.709GlyVal: 5.709 ± 0.054	1.334GlyTrp: 1.334 ± 0.029	2.546GlyTyr: 2.546 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	2.581HisAla: 2.581 ± 0.04	0.327HisCys: 0.327 ± 0.011	1.56HisAsp: 1.56 ± 0.027	1.544HisGlu: 1.544 ± 0.028	1.051HisPhe: 1.051 ± 0.023	2.17HisGly: 2.17 ± 0.036	0.994HisHis: 0.994 ± 0.023	1.501HisIle: 1.501 ± 0.026	0.567HisLys: 0.567 ± 0.016	3.021HisLeu: 3.021 ± 0.044	0.644HisMet: 0.644 ± 0.014	0.682HisAsn: 0.682 ± 0.017	1.815HisPro: 1.815 ± 0.025	1.245HisGln: 1.245 ± 0.024	1.872HisArg: 1.872 ± 0.032	1.088HisSer: 1.088 ± 0.024	1.428HisThr: 1.428 ± 0.024	1.981HisVal: 1.981 ± 0.028	0.43HisTrp: 0.43 ± 0.013	0.893HisTyr: 0.893 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.672IleAla: 5.672 ± 0.05	0.626IleCys: 0.626 ± 0.016	3.66IleAsp: 3.66 ± 0.042	3.758IleGlu: 3.758 ± 0.043	1.727IlePhe: 1.727 ± 0.032	4.329IleGly: 4.329 ± 0.05	1.259IleHis: 1.259 ± 0.021	2.538IleIle: 2.538 ± 0.04	1.49IleLys: 1.49 ± 0.026	4.929IleLeu: 4.929 ± 0.044	1.115IleMet: 1.115 ± 0.025	1.613IleAsn: 1.613 ± 0.026	2.808IlePro: 2.808 ± 0.033	1.965IleGln: 1.965 ± 0.031	3.44IleArg: 3.44 ± 0.041	2.84IleSer: 2.84 ± 0.036	2.905IleThr: 2.905 ± 0.039	3.893IleVal: 3.893 ± 0.04	0.719IleTrp: 0.719 ± 0.018	1.471IleTyr: 1.471 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.15LysAla: 3.15 ± 0.042	0.207LysCys: 0.207 ± 0.008	1.344LysAsp: 1.344 ± 0.028	1.537LysGlu: 1.537 ± 0.028	0.85LysPhe: 0.85 ± 0.019	1.97LysGly: 1.97 ± 0.03	0.75LysHis: 0.75 ± 0.018	1.518LysIle: 1.518 ± 0.03	0.998LysLys: 0.998 ± 0.025	2.834LysLeu: 2.834 ± 0.039	0.721LysMet: 0.721 ± 0.02	0.72LysAsn: 0.72 ± 0.018	1.721LysPro: 1.721 ± 0.027	1.371LysGln: 1.371 ± 0.028	2.307LysArg: 2.307 ± 0.033	1.55LysSer: 1.55 ± 0.03	1.882LysThr: 1.882 ± 0.029	1.933LysVal: 1.933 ± 0.03	0.403LysTrp: 0.403 ± 0.013	0.77LysTyr: 0.77 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	11.213LeuAla: 11.213 ± 0.088	1.162LeuCys: 1.162 ± 0.022	6.31LeuAsp: 6.31 ± 0.052	6.244LeuGlu: 6.244 ± 0.058	3.489LeuPhe: 3.489 ± 0.043	7.896LeuGly: 7.896 ± 0.057	2.684LeuHis: 2.684 ± 0.038	5.227LeuIle: 5.227 ± 0.051	3.254LeuLys: 3.254 ± 0.043	10.228LeuLeu: 10.228 ± 0.102	2.503LeuMet: 2.503 ± 0.033	3.154LeuAsn: 3.154 ± 0.042	5.787LeuPro: 5.787 ± 0.057	4.922LeuGln: 4.922 ± 0.055	7.157LeuArg: 7.157 ± 0.055	6.67LeuSer: 6.67 ± 0.06	5.991LeuThr: 5.991 ± 0.054	6.836LeuVal: 6.836 ± 0.06	1.385LeuTrp: 1.385 ± 0.026	2.76LeuTyr: 2.76 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.232MetAla: 3.232 ± 0.034	0.241MetCys: 0.241 ± 0.01	1.251MetAsp: 1.251 ± 0.028	1.23MetGlu: 1.23 ± 0.022	0.703MetPhe: 0.703 ± 0.017	1.906MetGly: 1.906 ± 0.03	0.627MetHis: 0.627 ± 0.017	1.353MetIle: 1.353 ± 0.021	0.814MetLys: 0.814 ± 0.021	2.552MetLeu: 2.552 ± 0.037	0.728MetMet: 0.728 ± 0.017	0.71MetAsn: 0.71 ± 0.018	1.511MetPro: 1.511 ± 0.023	1.282MetGln: 1.282 ± 0.025	1.754MetArg: 1.754 ± 0.028	1.59MetSer: 1.59 ± 0.025	1.718MetThr: 1.718 ± 0.026	1.761MetVal: 1.761 ± 0.026	0.269MetTrp: 0.269 ± 0.012	0.5MetTyr: 0.5 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.755AsnAla: 2.755 ± 0.037	0.29AsnCys: 0.29 ± 0.01	1.465AsnAsp: 1.465 ± 0.032	1.349AsnGlu: 1.349 ± 0.023	0.971AsnPhe: 0.971 ± 0.021	2.256AsnGly: 2.256 ± 0.04	0.724AsnHis: 0.724 ± 0.018	1.513AsnIle: 1.513 ± 0.029	0.705AsnLys: 0.705 ± 0.02	3.003AsnLeu: 3.003 ± 0.039	0.712AsnMet: 0.712 ± 0.016	0.829AsnAsn: 0.829 ± 0.023	1.996AsnPro: 1.996 ± 0.031	1.15AsnGln: 1.15 ± 0.019	2.027AsnArg: 2.027 ± 0.028	1.22AsnSer: 1.22 ± 0.027	1.53AsnThr: 1.53 ± 0.029	1.965AsnVal: 1.965 ± 0.032	0.446AsnTrp: 0.446 ± 0.012	0.784AsnTyr: 0.784 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	4.705ProAla: 4.705 ± 0.042	0.473ProCys: 0.473 ± 0.017	3.707ProAsp: 3.707 ± 0.043	4.347ProGlu: 4.347 ± 0.047	2.016ProPhe: 2.016 ± 0.027	4.1ProGly: 4.1 ± 0.052	1.526ProHis: 1.526 ± 0.026	2.575ProIle: 2.575 ± 0.034	1.512ProLys: 1.512 ± 0.029	5.174ProLeu: 5.174 ± 0.052	1.323ProMet: 1.323 ± 0.025	1.558ProAsn: 1.558 ± 0.028	2.994ProPro: 2.994 ± 0.042	2.301ProGln: 2.301 ± 0.034	2.757ProArg: 2.757 ± 0.039	3.201ProSer: 3.201 ± 0.039	2.642ProThr: 2.642 ± 0.034	3.962ProVal: 3.962 ± 0.04	0.819ProTrp: 0.819 ± 0.019	1.578ProTyr: 1.578 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	5.594GlnAla: 5.594 ± 0.057	0.41GlnCys: 0.41 ± 0.013	2.29GlnAsp: 2.29 ± 0.033	2.574GlnGlu: 2.574 ± 0.036	1.453GlnPhe: 1.453 ± 0.024	3.375GlnGly: 3.375 ± 0.041	1.463GlnHis: 1.463 ± 0.024	2.144GlnIle: 2.144 ± 0.032	1.169GlnLys: 1.169 ± 0.024	4.824GlnLeu: 4.824 ± 0.047	1.047GlnMet: 1.047 ± 0.02	1.101GlnAsn: 1.101 ± 0.025	2.566GlnPro: 2.566 ± 0.038	2.746GlnGln: 2.746 ± 0.046	3.688GlnArg: 3.688 ± 0.045	2.334GlnSer: 2.334 ± 0.036	2.65GlnThr: 2.65 ± 0.033	3.353GlnVal: 3.353 ± 0.044	0.735GlnTrp: 0.735 ± 0.017	1.163GlnTyr: 1.163 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	5.869ArgAla: 5.869 ± 0.056	0.706ArgCys: 0.706 ± 0.02	3.709ArgAsp: 3.709 ± 0.039	4.29ArgGlu: 4.29 ± 0.046	2.786ArgPhe: 2.786 ± 0.038	4.304ArgGly: 4.304 ± 0.044	2.072ArgHis: 2.072 ± 0.033	3.634ArgIle: 3.634 ± 0.042	1.754ArgLys: 1.754 ± 0.027	7.797ArgLeu: 7.797 ± 0.068	1.776ArgMet: 1.776 ± 0.028	1.683ArgAsn: 1.683 ± 0.023	3.152ArgPro: 3.152 ± 0.038	3.977ArgGln: 3.977 ± 0.046	4.832ArgArg: 4.832 ± 0.056	3.349ArgSer: 3.349 ± 0.033	3.229ArgThr: 3.229 ± 0.038	4.702ArgVal: 4.702 ± 0.046	1.037ArgTrp: 1.037 ± 0.021	2.191ArgTyr: 2.191 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	4.799SerAla: 4.799 ± 0.046	0.568SerCys: 0.568 ± 0.014	3.045SerAsp: 3.045 ± 0.034	3.1SerGlu: 3.1 ± 0.038	1.978SerPhe: 1.978 ± 0.029	4.852SerGly: 4.852 ± 0.052	1.553SerHis: 1.553 ± 0.027	2.733SerIle: 2.733 ± 0.034	1.467SerLys: 1.467 ± 0.023	5.737SerLeu: 5.737 ± 0.053	1.467SerMet: 1.467 ± 0.026	1.392SerAsn: 1.392 ± 0.027	3.142SerPro: 3.142 ± 0.039	2.395SerGln: 2.395 ± 0.028	3.49SerArg: 3.49 ± 0.039	2.981SerSer: 2.981 ± 0.041	2.903SerThr: 2.903 ± 0.038	3.658SerVal: 3.658 ± 0.041	0.861SerTrp: 0.861 ± 0.019	1.552SerTyr: 1.552 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	5.417ThrAla: 5.417 ± 0.052	0.63ThrCys: 0.63 ± 0.019	2.878ThrAsp: 2.878 ± 0.038	2.919ThrGlu: 2.919 ± 0.033	2.159ThrPhe: 2.159 ± 0.029	4.604ThrGly: 4.604 ± 0.054	1.46ThrHis: 1.46 ± 0.029	2.996ThrIle: 2.996 ± 0.036	1.304ThrLys: 1.304 ± 0.024	6.451ThrLeu: 6.451 ± 0.062	1.324ThrMet: 1.324 ± 0.025	1.337ThrAsn: 1.337 ± 0.024	3.561ThrPro: 3.561 ± 0.041	2.364ThrGln: 2.364 ± 0.034	3.13ThrArg: 3.13 ± 0.037	3.05ThrSer: 3.05 ± 0.038	2.972ThrThr: 2.972 ± 0.043	4.2ThrVal: 4.2 ± 0.052	0.885ThrTrp: 0.885 ± 0.021	1.712ThrTyr: 1.712 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	7.155ValAla: 7.155 ± 0.066	0.829ValCys: 0.829 ± 0.018	4.114ValAsp: 4.114 ± 0.041	4.547ValGlu: 4.547 ± 0.046	2.633ValPhe: 2.633 ± 0.036	4.99ValGly: 4.99 ± 0.047	1.679ValHis: 1.679 ± 0.027	3.997ValIle: 3.997 ± 0.043	2.145ValLys: 2.145 ± 0.031	7.392ValLeu: 7.392 ± 0.061	1.98ValMet: 1.98 ± 0.028	2.178ValAsn: 2.178 ± 0.032	3.728ValPro: 3.728 ± 0.041	2.953ValGln: 2.953 ± 0.033	4.488ValArg: 4.488 ± 0.048	4.163ValSer: 4.163 ± 0.041	4.23ValThr: 4.23 ± 0.053	5.703ValVal: 5.703 ± 0.058	0.996ValTrp: 0.996 ± 0.022	1.928ValTyr: 1.928 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.167TrpAla: 1.167 ± 0.02	0.196TrpCys: 0.196 ± 0.008	0.767TrpAsp: 0.767 ± 0.018	0.846TrpGlu: 0.846 ± 0.019	0.56TrpPhe: 0.56 ± 0.015	1.055TrpGly: 1.055 ± 0.022	0.503TrpHis: 0.503 ± 0.016	0.686TrpIle: 0.686 ± 0.018	0.441TrpLys: 0.441 ± 0.013	1.812TrpLeu: 1.812 ± 0.032	0.397TrpMet: 0.397 ± 0.012	0.46TrpAsn: 0.46 ± 0.012	0.762TrpPro: 0.762 ± 0.021	0.967TrpGln: 0.967 ± 0.019	1.137TrpArg: 1.137 ± 0.021	0.838TrpSer: 0.838 ± 0.02	0.797TrpThr: 0.797 ± 0.019	0.988TrpVal: 0.988 ± 0.021	0.267TrpTrp: 0.267 ± 0.012	0.402TrpTyr: 0.402 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.672TyrAla: 2.672 ± 0.033	0.355TyrCys: 0.355 ± 0.013	1.832TyrAsp: 1.832 ± 0.029	1.707TyrGlu: 1.707 ± 0.028	1.105TyrPhe: 1.105 ± 0.022	2.355TyrGly: 2.355 ± 0.033	0.888TyrHis: 0.888 ± 0.021	1.368TyrIle: 1.368 ± 0.025	0.653TyrLys: 0.653 ± 0.017	3.002TyrLeu: 3.002 ± 0.037	0.62TyrMet: 0.62 ± 0.019	0.818TyrAsn: 0.818 ± 0.02	1.545TyrPro: 1.545 ± 0.027	1.323TyrGln: 1.323 ± 0.023	2.264TyrArg: 2.264 ± 0.027	1.298TyrSer: 1.298 ± 0.024	1.629TyrThr: 1.629 ± 0.025	1.96TyrVal: 1.96 ± 0.029	0.488TyrTrp: 0.488 ± 0.015	0.894TyrTyr: 0.894 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8429 proteins (2493613 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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