Amino acid dipepetide frequency for Candidatus Accumulibacter sp. BA-93

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.651AlaAla: 17.651 ± 0.156	1.375AlaCys: 1.375 ± 0.035	6.81AlaAsp: 6.81 ± 0.086	7.163AlaGlu: 7.163 ± 0.087	4.103AlaPhe: 4.103 ± 0.058	10.609AlaGly: 10.609 ± 0.108	2.438AlaHis: 2.438 ± 0.045	5.73AlaIle: 5.73 ± 0.074	3.523AlaLys: 3.523 ± 0.069	14.414AlaLeu: 14.414 ± 0.136	2.998AlaMet: 2.998 ± 0.052	3.045AlaAsn: 3.045 ± 0.057	5.126AlaPro: 5.126 ± 0.074	4.755AlaGln: 4.755 ± 0.07	9.075AlaArg: 9.075 ± 0.09	7.023AlaSer: 7.023 ± 0.077	5.975AlaThr: 5.975 ± 0.073	8.767AlaVal: 8.767 ± 0.098	1.666AlaTrp: 1.666 ± 0.043	2.556AlaTyr: 2.556 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.218CysAla: 1.218 ± 0.032	0.176CysCys: 0.176 ± 0.012	0.579CysAsp: 0.579 ± 0.021	0.525CysGlu: 0.525 ± 0.02	0.375CysPhe: 0.375 ± 0.016	0.993CysGly: 0.993 ± 0.03	0.324CysHis: 0.324 ± 0.018	0.39CysIle: 0.39 ± 0.019	0.256CysLys: 0.256 ± 0.014	1.021CysLeu: 1.021 ± 0.032	0.191CysMet: 0.191 ± 0.011	0.253CysAsn: 0.253 ± 0.014	0.587CysPro: 0.587 ± 0.022	0.36CysGln: 0.36 ± 0.019	0.774CysArg: 0.774 ± 0.023	0.624CysSer: 0.624 ± 0.022	0.474CysThr: 0.474 ± 0.021	0.645CysVal: 0.645 ± 0.021	0.147CysTrp: 0.147 ± 0.011	0.241CysTyr: 0.241 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.63AspAla: 6.63 ± 0.082	0.557AspCys: 0.557 ± 0.025	3.291AspAsp: 3.291 ± 0.055	3.557AspGlu: 3.557 ± 0.059	2.335AspPhe: 2.335 ± 0.045	4.88AspGly: 4.88 ± 0.083	1.102AspHis: 1.102 ± 0.034	2.45AspIle: 2.45 ± 0.048	1.631AspLys: 1.631 ± 0.043	5.799AspLeu: 5.799 ± 0.068	0.971AspMet: 0.971 ± 0.026	1.316AspAsn: 1.316 ± 0.043	3.007AspPro: 3.007 ± 0.049	1.795AspGln: 1.795 ± 0.037	3.749AspArg: 3.749 ± 0.06	2.852AspSer: 2.852 ± 0.049	2.217AspThr: 2.217 ± 0.052	3.785AspVal: 3.785 ± 0.062	0.964AspTrp: 0.964 ± 0.031	1.526AspTyr: 1.526 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.794GluAla: 6.794 ± 0.09	0.426GluCys: 0.426 ± 0.019	2.292GluAsp: 2.292 ± 0.042	2.925GluGlu: 2.925 ± 0.063	1.884GluPhe: 1.884 ± 0.039	3.474GluGly: 3.474 ± 0.056	1.427GluHis: 1.427 ± 0.032	3.24GluIle: 3.24 ± 0.056	2.298GluLys: 2.298 ± 0.048	6.5GluLeu: 6.5 ± 0.092	1.393GluMet: 1.393 ± 0.037	1.531GluAsn: 1.531 ± 0.032	2.302GluPro: 2.302 ± 0.043	2.819GluGln: 2.819 ± 0.051	5.103GluArg: 5.103 ± 0.075	2.885GluSer: 2.885 ± 0.053	2.799GluThr: 2.799 ± 0.047	4.263GluVal: 4.263 ± 0.063	0.792GluTrp: 0.792 ± 0.024	1.213GluTyr: 1.213 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.658PheAla: 4.658 ± 0.068	0.418PheCys: 0.418 ± 0.018	2.434PheAsp: 2.434 ± 0.043	2.029PheGlu: 2.029 ± 0.04	1.552PhePhe: 1.552 ± 0.04	3.237PheGly: 3.237 ± 0.053	0.757PheHis: 0.757 ± 0.027	1.517PheIle: 1.517 ± 0.035	1.023PheLys: 1.023 ± 0.03	3.532PheLeu: 3.532 ± 0.057	0.712PheMet: 0.712 ± 0.025	1.07PheAsn: 1.07 ± 0.033	1.588PhePro: 1.588 ± 0.039	1.022PheGln: 1.022 ± 0.026	2.203PheArg: 2.203 ± 0.041	2.511PheSer: 2.511 ± 0.044	1.702PheThr: 1.702 ± 0.039	2.855PheVal: 2.855 ± 0.051	0.52PheTrp: 0.52 ± 0.019	0.919PheTyr: 0.919 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	8.264GlyAla: 8.264 ± 0.096	0.946GlyCys: 0.946 ± 0.029	4.446GlyAsp: 4.446 ± 0.076	5.25GlyGlu: 5.25 ± 0.07	3.163GlyPhe: 3.163 ± 0.053	6.703GlyGly: 6.703 ± 0.106	1.84GlyHis: 1.84 ± 0.041	4.051GlyIle: 4.051 ± 0.07	3.52GlyLys: 3.52 ± 0.059	8.21GlyLeu: 8.21 ± 0.075	2.113GlyMet: 2.113 ± 0.041	2.281GlyAsn: 2.281 ± 0.067	2.577GlyPro: 2.577 ± 0.045	3.358GlyGln: 3.358 ± 0.052	5.895GlyArg: 5.895 ± 0.069	4.936GlySer: 4.936 ± 0.094	3.81GlyThr: 3.81 ± 0.079	6.366GlyVal: 6.366 ± 0.094	1.246GlyTrp: 1.246 ± 0.032	2.186GlyTyr: 2.186 ± 0.042	0.001GlyXaa: 0.001 ± 0.001
His	2.574HisAla: 2.574 ± 0.049	0.282HisCys: 0.282 ± 0.016	1.27HisAsp: 1.27 ± 0.031	1.146HisGlu: 1.146 ± 0.03	0.961HisPhe: 0.961 ± 0.027	1.982HisGly: 1.982 ± 0.041	0.598HisHis: 0.598 ± 0.021	0.819HisIle: 0.819 ± 0.024	0.502HisLys: 0.502 ± 0.021	2.493HisLeu: 2.493 ± 0.047	0.396HisMet: 0.396 ± 0.016	0.499HisAsn: 0.499 ± 0.018	1.426HisPro: 1.426 ± 0.034	0.813HisGln: 0.813 ± 0.027	1.665HisArg: 1.665 ± 0.042	1.197HisSer: 1.197 ± 0.031	0.885HisThr: 0.885 ± 0.026	1.391HisVal: 1.391 ± 0.03	0.339HisTrp: 0.339 ± 0.018	0.659HisTyr: 0.659 ± 0.025	0.001HisXaa: 0.001 ± 0.001
Ile	6.236IleAla: 6.236 ± 0.069	0.434IleCys: 0.434 ± 0.017	3.418IleAsp: 3.418 ± 0.053	3.259IleGlu: 3.259 ± 0.063	1.514IlePhe: 1.514 ± 0.037	4.478IleGly: 4.478 ± 0.062	0.924IleHis: 0.924 ± 0.027	1.883IleIle: 1.883 ± 0.043	1.54IleLys: 1.54 ± 0.042	3.965IleLeu: 3.965 ± 0.058	0.739IleMet: 0.739 ± 0.028	1.494IleAsn: 1.494 ± 0.04	2.119IlePro: 2.119 ± 0.038	1.172IleGln: 1.172 ± 0.032	2.93IleArg: 2.93 ± 0.053	2.644IleSer: 2.644 ± 0.052	2.287IleThr: 2.287 ± 0.054	3.931IleVal: 3.931 ± 0.062	0.478IleTrp: 0.478 ± 0.021	1.033IleTyr: 1.033 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.857LysAla: 3.857 ± 0.067	0.194LysCys: 0.194 ± 0.013	1.51LysAsp: 1.51 ± 0.038	1.633LysGlu: 1.633 ± 0.047	0.841LysPhe: 0.841 ± 0.027	2.371LysGly: 2.371 ± 0.051	0.678LysHis: 0.678 ± 0.023	1.504LysIle: 1.504 ± 0.04	1.343LysLys: 1.343 ± 0.041	3.557LysLeu: 3.557 ± 0.056	0.81LysMet: 0.81 ± 0.029	0.865LysAsn: 0.865 ± 0.03	1.884LysPro: 1.884 ± 0.047	1.261LysGln: 1.261 ± 0.035	2.379LysArg: 2.379 ± 0.043	1.739LysSer: 1.739 ± 0.046	1.739LysThr: 1.739 ± 0.046	2.436LysVal: 2.436 ± 0.057	0.344LysTrp: 0.344 ± 0.018	0.649LysTyr: 0.649 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	16.227LeuAla: 16.227 ± 0.155	1.185LeuCys: 1.185 ± 0.033	6.193LeuAsp: 6.193 ± 0.074	5.641LeuGlu: 5.641 ± 0.073	3.877LeuPhe: 3.877 ± 0.062	8.383LeuGly: 8.383 ± 0.088	2.369LeuHis: 2.369 ± 0.044	4.998LeuIle: 4.998 ± 0.068	3.456LeuLys: 3.456 ± 0.059	13.477LeuLeu: 13.477 ± 0.163	2.127LeuMet: 2.127 ± 0.043	2.628LeuAsn: 2.628 ± 0.054	6.512LeuPro: 6.512 ± 0.08	4.063LeuGln: 4.063 ± 0.064	8.37LeuArg: 8.37 ± 0.11	6.538LeuSer: 6.538 ± 0.078	5.292LeuThr: 5.292 ± 0.082	7.757LeuVal: 7.757 ± 0.09	1.29LeuTrp: 1.29 ± 0.04	2.155LeuTyr: 2.155 ± 0.041	0.003LeuXaa: 0.003 ± 0.001
Met	2.752MetAla: 2.752 ± 0.054	0.141MetCys: 0.141 ± 0.01	0.946MetAsp: 0.946 ± 0.027	0.978MetGlu: 0.978 ± 0.027	0.668MetPhe: 0.668 ± 0.023	1.485MetGly: 1.485 ± 0.036	0.495MetHis: 0.495 ± 0.02	1.112MetIle: 1.112 ± 0.029	0.96MetLys: 0.96 ± 0.029	2.509MetLeu: 2.509 ± 0.049	0.51MetMet: 0.51 ± 0.023	0.803MetAsn: 0.803 ± 0.027	1.266MetPro: 1.266 ± 0.034	0.839MetGln: 0.839 ± 0.029	1.572MetArg: 1.572 ± 0.036	1.506MetSer: 1.506 ± 0.037	1.318MetThr: 1.318 ± 0.031	1.55MetVal: 1.55 ± 0.038	0.18MetTrp: 0.18 ± 0.011	0.321MetTyr: 0.321 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.112AsnAla: 3.112 ± 0.055	0.321AsnCys: 0.321 ± 0.017	1.443AsnAsp: 1.443 ± 0.048	1.382AsnGlu: 1.382 ± 0.033	0.931AsnPhe: 0.931 ± 0.024	2.276AsnGly: 2.276 ± 0.077	0.521AsnHis: 0.521 ± 0.017	1.232AsnIle: 1.232 ± 0.041	0.762AsnLys: 0.762 ± 0.026	2.73AsnLeu: 2.73 ± 0.05	0.533AsnMet: 0.533 ± 0.022	0.745AsnAsn: 0.745 ± 0.037	1.746AsnPro: 1.746 ± 0.036	0.839AsnGln: 0.839 ± 0.028	1.878AsnArg: 1.878 ± 0.041	1.354AsnSer: 1.354 ± 0.035	1.291AsnThr: 1.291 ± 0.038	1.839AsnVal: 1.839 ± 0.049	0.457AsnTrp: 0.457 ± 0.017	0.694AsnTyr: 0.694 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.636ProAla: 6.636 ± 0.083	0.45ProCys: 0.45 ± 0.02	3.051ProAsp: 3.051 ± 0.049	3.335ProGlu: 3.335 ± 0.055	1.714ProPhe: 1.714 ± 0.038	4.447ProGly: 4.447 ± 0.066	0.945ProHis: 0.945 ± 0.029	1.972ProIle: 1.972 ± 0.039	1.304ProLys: 1.304 ± 0.033	5.409ProLeu: 5.409 ± 0.077	1.085ProMet: 1.085 ± 0.026	1.134ProAsn: 1.134 ± 0.028	2.818ProPro: 2.818 ± 0.06	1.881ProGln: 1.881 ± 0.038	2.888ProArg: 2.888 ± 0.05	2.545ProSer: 2.545 ± 0.049	2.429ProThr: 2.429 ± 0.047	3.816ProVal: 3.816 ± 0.054	0.686ProTrp: 0.686 ± 0.025	1.15ProTyr: 1.15 ± 0.026	0.001ProXaa: 0.001 ± 0.001
Gln	5.034GlnAla: 5.034 ± 0.07	0.309GlnCys: 0.309 ± 0.019	1.446GlnAsp: 1.446 ± 0.034	1.825GlnGlu: 1.825 ± 0.036	1.175GlnPhe: 1.175 ± 0.026	2.725GlnGly: 2.725 ± 0.047	0.913GlnHis: 0.913 ± 0.027	1.84GlnIle: 1.84 ± 0.039	1.184GlnLys: 1.184 ± 0.033	4.526GlnLeu: 4.526 ± 0.068	0.928GlnMet: 0.928 ± 0.029	0.854GlnAsn: 0.854 ± 0.031	2.062GlnPro: 2.062 ± 0.043	1.874GlnGln: 1.874 ± 0.05	3.541GlnArg: 3.541 ± 0.055	1.924GlnSer: 1.924 ± 0.042	1.775GlnThr: 1.775 ± 0.038	2.858GlnVal: 2.858 ± 0.048	0.534GlnTrp: 0.534 ± 0.021	0.704GlnTyr: 0.704 ± 0.025	0.001GlnXaa: 0.001 ± 0.001
Arg	7.454ArgAla: 7.454 ± 0.087	0.761ArgCys: 0.761 ± 0.025	3.692ArgAsp: 3.692 ± 0.055	4.469ArgGlu: 4.469 ± 0.081	3.02ArgPhe: 3.02 ± 0.05	4.757ArgGly: 4.757 ± 0.058	1.963ArgHis: 1.963 ± 0.045	3.79ArgIle: 3.79 ± 0.056	2.34ArgLys: 2.34 ± 0.05	9.185ArgLeu: 9.185 ± 0.099	1.79ArgMet: 1.79 ± 0.039	1.937ArgAsn: 1.937 ± 0.041	3.36ArgPro: 3.36 ± 0.057	3.693ArgGln: 3.693 ± 0.054	6.131ArgArg: 6.131 ± 0.098	4.043ArgSer: 4.043 ± 0.052	2.944ArgThr: 2.944 ± 0.048	5.25ArgVal: 5.25 ± 0.065	1.086ArgTrp: 1.086 ± 0.028	2.028ArgTyr: 2.028 ± 0.039	0.001ArgXaa: 0.001 ± 0.001
Ser	6.711SerAla: 6.711 ± 0.077	0.545SerCys: 0.545 ± 0.023	3.075SerAsp: 3.075 ± 0.055	3.229SerGlu: 3.229 ± 0.053	2.213SerPhe: 2.213 ± 0.043	5.709SerGly: 5.709 ± 0.088	1.141SerHis: 1.141 ± 0.027	2.522SerIle: 2.522 ± 0.046	1.602SerLys: 1.602 ± 0.041	6.254SerLeu: 6.254 ± 0.085	1.272SerMet: 1.272 ± 0.033	1.44SerAsn: 1.44 ± 0.039	2.976SerPro: 2.976 ± 0.044	1.756SerGln: 1.756 ± 0.041	3.928SerArg: 3.928 ± 0.055	3.376SerSer: 3.376 ± 0.067	2.784SerThr: 2.784 ± 0.056	4.035SerVal: 4.035 ± 0.06	0.801SerTrp: 0.801 ± 0.025	1.373SerTyr: 1.373 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.683ThrAla: 5.683 ± 0.072	0.422ThrCys: 0.422 ± 0.019	2.252ThrAsp: 2.252 ± 0.042	2.019ThrGlu: 2.019 ± 0.04	1.529ThrPhe: 1.529 ± 0.034	4.11ThrGly: 4.11 ± 0.061	1.023ThrHis: 1.023 ± 0.027	2.37ThrIle: 2.37 ± 0.059	1.069ThrLys: 1.069 ± 0.031	6.197ThrLeu: 6.197 ± 0.094	0.979ThrMet: 0.979 ± 0.026	1.171ThrAsn: 1.171 ± 0.041	3.133ThrPro: 3.133 ± 0.053	1.662ThrGln: 1.662 ± 0.039	3.385ThrArg: 3.385 ± 0.054	2.509ThrSer: 2.509 ± 0.053	2.593ThrThr: 2.593 ± 0.055	3.751ThrVal: 3.751 ± 0.068	0.583ThrTrp: 0.583 ± 0.021	1.05ThrTyr: 1.05 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.521ValAla: 9.521 ± 0.105	0.781ValCys: 0.781 ± 0.024	4.496ValAsp: 4.496 ± 0.061	4.264ValGlu: 4.264 ± 0.058	2.921ValPhe: 2.921 ± 0.055	5.775ValGly: 5.775 ± 0.081	1.547ValHis: 1.547 ± 0.04	3.652ValIle: 3.652 ± 0.056	2.22ValLys: 2.22 ± 0.055	8.016ValLeu: 8.016 ± 0.086	1.653ValMet: 1.653 ± 0.04	2.012ValAsn: 2.012 ± 0.046	3.368ValPro: 3.368 ± 0.051	2.255ValGln: 2.255 ± 0.042	4.956ValArg: 4.956 ± 0.063	4.415ValSer: 4.415 ± 0.064	3.559ValThr: 3.559 ± 0.05	6.194ValVal: 6.194 ± 0.085	0.941ValTrp: 0.941 ± 0.028	1.497ValTyr: 1.497 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.149TrpAla: 1.149 ± 0.032	0.158TrpCys: 0.158 ± 0.011	0.571TrpAsp: 0.571 ± 0.024	0.603TrpGlu: 0.603 ± 0.023	0.496TrpPhe: 0.496 ± 0.022	0.824TrpGly: 0.824 ± 0.024	0.352TrpHis: 0.352 ± 0.016	0.647TrpIle: 0.647 ± 0.02	0.443TrpLys: 0.443 ± 0.018	2.088TrpLeu: 2.088 ± 0.051	0.318TrpMet: 0.318 ± 0.018	0.42TrpAsn: 0.42 ± 0.019	0.673TrpPro: 0.673 ± 0.026	0.847TrpGln: 0.847 ± 0.027	1.214TrpArg: 1.214 ± 0.033	0.818TrpSer: 0.818 ± 0.026	0.58TrpThr: 0.58 ± 0.021	0.913TrpVal: 0.913 ± 0.032	0.239TrpTrp: 0.239 ± 0.015	0.309TrpTyr: 0.309 ± 0.015	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.641TyrAla: 2.641 ± 0.043	0.274TyrCys: 0.274 ± 0.016	1.202TyrAsp: 1.202 ± 0.035	1.127TyrGlu: 1.127 ± 0.033	0.987TyrPhe: 0.987 ± 0.025	1.94TyrGly: 1.94 ± 0.034	0.537TyrHis: 0.537 ± 0.021	0.759TyrIle: 0.759 ± 0.026	0.62TyrLys: 0.62 ± 0.025	2.66TyrLeu: 2.66 ± 0.046	0.39TyrMet: 0.39 ± 0.018	0.59TyrAsn: 0.59 ± 0.024	1.162TyrPro: 1.162 ± 0.033	0.969TyrGln: 0.969 ± 0.029	2.054TyrArg: 2.054 ± 0.04	1.3TyrSer: 1.3 ± 0.031	1.039TyrThr: 1.039 ± 0.031	1.643TyrVal: 1.643 ± 0.036	0.369TyrTrp: 0.369 ± 0.017	0.643TyrTyr: 0.643 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.002	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.06XaaXaa: 0.06 ± 0.02

Statistics based on 4038 proteins (1337804 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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