Amino acid dipepetide frequency for Patulibacter medicamentivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.217AlaAla: 23.217 ± 0.219	1.03AlaCys: 1.03 ± 0.028	8.503AlaAsp: 8.503 ± 0.074	7.606AlaGlu: 7.606 ± 0.098	3.763AlaPhe: 3.763 ± 0.054	14.325AlaGly: 14.325 ± 0.121	2.396AlaHis: 2.396 ± 0.045	6.264AlaIle: 6.264 ± 0.076	2.613AlaLys: 2.613 ± 0.063	15.15AlaLeu: 15.15 ± 0.182	2.651AlaMet: 2.651 ± 0.047	2.069AlaAsn: 2.069 ± 0.048	7.305AlaPro: 7.305 ± 0.078	3.428AlaGln: 3.428 ± 0.056	11.395AlaArg: 11.395 ± 0.11	6.394AlaSer: 6.394 ± 0.079	8.503AlaThr: 8.503 ± 0.084	11.548AlaVal: 11.548 ± 0.113	1.858AlaTrp: 1.858 ± 0.041	2.254AlaTyr: 2.254 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.882CysAla: 0.882 ± 0.024	0.089CysCys: 0.089 ± 0.008	0.544CysAsp: 0.544 ± 0.019	0.368CysGlu: 0.368 ± 0.018	0.223CysPhe: 0.223 ± 0.013	0.948CysGly: 0.948 ± 0.028	0.166CysHis: 0.166 ± 0.01	0.185CysIle: 0.185 ± 0.013	0.131CysLys: 0.131 ± 0.011	0.553CysLeu: 0.553 ± 0.018	0.109CysMet: 0.109 ± 0.009	0.141CysAsn: 0.141 ± 0.01	0.486CysPro: 0.486 ± 0.019	0.164CysGln: 0.164 ± 0.01	0.58CysArg: 0.58 ± 0.021	0.43CysSer: 0.43 ± 0.016	0.366CysThr: 0.366 ± 0.02	0.607CysVal: 0.607 ± 0.021	0.091CysTrp: 0.091 ± 0.009	0.125CysTyr: 0.125 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	9.163AspAla: 9.163 ± 0.097	0.356AspCys: 0.356 ± 0.018	4.477AspAsp: 4.477 ± 0.078	4.388AspGlu: 4.388 ± 0.066	1.245AspPhe: 1.245 ± 0.031	7.692AspGly: 7.692 ± 0.085	1.49AspHis: 1.49 ± 0.033	1.4AspIle: 1.4 ± 0.032	0.766AspLys: 0.766 ± 0.032	6.557AspLeu: 6.557 ± 0.076	0.618AspMet: 0.618 ± 0.02	0.692AspAsn: 0.692 ± 0.024	5.304AspPro: 5.304 ± 0.06	1.749AspGln: 1.749 ± 0.031	6.165AspArg: 6.165 ± 0.088	1.867AspSer: 1.867 ± 0.034	2.111AspThr: 2.111 ± 0.04	5.575AspVal: 5.575 ± 0.07	0.771AspTrp: 0.771 ± 0.023	1.029AspTyr: 1.029 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.858GluAla: 6.858 ± 0.085	0.275GluCys: 0.275 ± 0.015	2.805GluAsp: 2.805 ± 0.053	2.644GluGlu: 2.644 ± 0.053	1.1GluPhe: 1.1 ± 0.026	3.96GluGly: 3.96 ± 0.06	1.645GluHis: 1.645 ± 0.04	2.547GluIle: 2.547 ± 0.046	0.891GluLys: 0.891 ± 0.032	7.007GluLeu: 7.007 ± 0.101	0.73GluMet: 0.73 ± 0.022	0.753GluAsn: 0.753 ± 0.026	3.301GluPro: 3.301 ± 0.049	2.637GluGln: 2.637 ± 0.045	6.943GluArg: 6.943 ± 0.104	2.016GluSer: 2.016 ± 0.037	2.526GluThr: 2.526 ± 0.044	4.344GluVal: 4.344 ± 0.061	0.566GluTrp: 0.566 ± 0.022	0.756GluTyr: 0.756 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.766PheAla: 3.766 ± 0.057	0.25PheCys: 0.25 ± 0.013	2.064PheAsp: 2.064 ± 0.04	1.451PheGlu: 1.451 ± 0.033	0.763PhePhe: 0.763 ± 0.026	3.068PheGly: 3.068 ± 0.055	0.544PheHis: 0.544 ± 0.022	0.665PheIle: 0.665 ± 0.026	0.447PheLys: 0.447 ± 0.018	2.479PheLeu: 2.479 ± 0.043	0.322PheMet: 0.322 ± 0.015	0.49PheAsn: 0.49 ± 0.018	1.335PhePro: 1.335 ± 0.034	0.689PheGln: 0.689 ± 0.021	1.804PheArg: 1.804 ± 0.039	1.418PheSer: 1.418 ± 0.035	1.407PheThr: 1.407 ± 0.034	2.3PheVal: 2.3 ± 0.042	0.351PheTrp: 0.351 ± 0.017	0.525PheTyr: 0.525 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	12.214GlyAla: 12.214 ± 0.098	0.776GlyCys: 0.776 ± 0.026	6.167GlyAsp: 6.167 ± 0.075	5.234GlyGlu: 5.234 ± 0.071	2.862GlyPhe: 2.862 ± 0.047	10.22GlyGly: 10.22 ± 0.111	2.042GlyHis: 2.042 ± 0.037	3.924GlyIle: 3.924 ± 0.054	2.01GlyLys: 2.01 ± 0.049	9.52GlyLeu: 9.52 ± 0.1	1.894GlyMet: 1.894 ± 0.038	1.672GlyAsn: 1.672 ± 0.046	5.56GlyPro: 5.56 ± 0.063	2.696GlyGln: 2.696 ± 0.048	8.999GlyArg: 8.999 ± 0.095	5.63GlySer: 5.63 ± 0.081	5.602GlyThr: 5.602 ± 0.08	7.695GlyVal: 7.695 ± 0.075	1.583GlyTrp: 1.583 ± 0.032	1.963GlyTyr: 1.963 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.627HisAla: 2.627 ± 0.045	0.167HisCys: 0.167 ± 0.01	1.55HisAsp: 1.55 ± 0.032	1.323HisGlu: 1.323 ± 0.029	0.517HisPhe: 0.517 ± 0.022	2.465HisGly: 2.465 ± 0.046	0.668HisHis: 0.668 ± 0.027	0.385HisIle: 0.385 ± 0.016	0.246HisLys: 0.246 ± 0.016	2.04HisLeu: 2.04 ± 0.043	0.241HisMet: 0.241 ± 0.013	0.322HisAsn: 0.322 ± 0.015	1.523HisPro: 1.523 ± 0.035	0.598HisGln: 0.598 ± 0.023	1.963HisArg: 1.963 ± 0.042	0.654HisSer: 0.654 ± 0.021	0.708HisThr: 0.708 ± 0.02	1.877HisVal: 1.877 ± 0.035	0.288HisTrp: 0.288 ± 0.014	0.406HisTyr: 0.406 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.394IleAla: 6.394 ± 0.079	0.309IleCys: 0.309 ± 0.012	3.133IleAsp: 3.133 ± 0.047	2.534IleGlu: 2.534 ± 0.048	0.838IlePhe: 0.838 ± 0.028	4.382IleGly: 4.382 ± 0.06	0.702IleHis: 0.702 ± 0.021	0.809IleIle: 0.809 ± 0.03	0.654IleLys: 0.654 ± 0.03	2.825IleLeu: 2.825 ± 0.05	0.379IleMet: 0.379 ± 0.017	0.685IleAsn: 0.685 ± 0.024	1.91IlePro: 1.91 ± 0.038	0.85IleGln: 0.85 ± 0.021	2.644IleArg: 2.644 ± 0.045	1.763IleSer: 1.763 ± 0.041	2.009IleThr: 2.009 ± 0.042	3.793IleVal: 3.793 ± 0.057	0.359IleTrp: 0.359 ± 0.016	0.573IleTyr: 0.573 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.275LysAla: 2.275 ± 0.062	0.092LysCys: 0.092 ± 0.008	0.963LysAsp: 0.963 ± 0.034	0.693LysGlu: 0.693 ± 0.027	0.334LysPhe: 0.334 ± 0.016	1.56LysGly: 1.56 ± 0.037	0.342LysHis: 0.342 ± 0.015	0.788LysIle: 0.788 ± 0.029	0.551LysLys: 0.551 ± 0.025	1.913LysLeu: 1.913 ± 0.05	0.274LysMet: 0.274 ± 0.015	0.338LysAsn: 0.338 ± 0.018	1.157LysPro: 1.157 ± 0.033	0.684LysGln: 0.684 ± 0.027	1.613LysArg: 1.613 ± 0.041	0.819LysSer: 0.819 ± 0.027	1.122LysThr: 1.122 ± 0.037	1.545LysVal: 1.545 ± 0.046	0.174LysTrp: 0.174 ± 0.014	0.302LysTyr: 0.302 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.434LeuAla: 15.434 ± 0.16	0.711LeuCys: 0.711 ± 0.026	7.124LeuAsp: 7.124 ± 0.079	5.608LeuGlu: 5.608 ± 0.075	2.351LeuPhe: 2.351 ± 0.047	9.726LeuGly: 9.726 ± 0.103	2.107LeuHis: 2.107 ± 0.046	3.407LeuIle: 3.407 ± 0.056	1.664LeuLys: 1.664 ± 0.044	11.536LeuLeu: 11.536 ± 0.151	1.372LeuMet: 1.372 ± 0.039	1.443LeuAsn: 1.443 ± 0.032	6.259LeuPro: 6.259 ± 0.066	2.747LeuGln: 2.747 ± 0.046	10.15LeuArg: 10.15 ± 0.097	4.743LeuSer: 4.743 ± 0.051	5.517LeuThr: 5.517 ± 0.077	9.117LeuVal: 9.117 ± 0.111	1.138LeuTrp: 1.138 ± 0.032	1.434LeuTyr: 1.434 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.154MetAla: 2.154 ± 0.039	0.093MetCys: 0.093 ± 0.008	0.644MetAsp: 0.644 ± 0.022	0.589MetGlu: 0.589 ± 0.02	0.359MetPhe: 0.359 ± 0.017	1.121MetGly: 1.121 ± 0.028	0.301MetHis: 0.301 ± 0.016	0.684MetIle: 0.684 ± 0.023	0.294MetLys: 0.294 ± 0.016	1.649MetLeu: 1.649 ± 0.034	0.246MetMet: 0.246 ± 0.013	0.311MetAsn: 0.311 ± 0.013	1.119MetPro: 1.119 ± 0.031	0.419MetGln: 0.419 ± 0.018	1.426MetArg: 1.426 ± 0.035	1.323MetSer: 1.323 ± 0.03	1.189MetThr: 1.189 ± 0.032	1.239MetVal: 1.239 ± 0.028	0.148MetTrp: 0.148 ± 0.01	0.194MetTyr: 0.194 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.118AsnAla: 2.118 ± 0.041	0.14AsnCys: 0.14 ± 0.009	0.883AsnAsp: 0.883 ± 0.026	0.758AsnGlu: 0.758 ± 0.026	0.392AsnPhe: 0.392 ± 0.017	1.795AsnGly: 1.795 ± 0.048	0.325AsnHis: 0.325 ± 0.015	0.431AsnIle: 0.431 ± 0.021	0.268AsnLys: 0.268 ± 0.016	1.597AsnLeu: 1.597 ± 0.031	0.216AsnMet: 0.216 ± 0.011	0.316AsnAsn: 0.316 ± 0.016	1.28AsnPro: 1.28 ± 0.03	0.479AsnGln: 0.479 ± 0.018	1.237AsnArg: 1.237 ± 0.031	0.663AsnSer: 0.663 ± 0.027	0.76AsnThr: 0.76 ± 0.028	1.6AsnVal: 1.6 ± 0.036	0.239AsnTrp: 0.239 ± 0.015	0.332AsnTyr: 0.332 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	8.984ProAla: 8.984 ± 0.091	0.326ProCys: 0.326 ± 0.015	4.496ProAsp: 4.496 ± 0.061	3.751ProGlu: 3.751 ± 0.054	1.63ProPhe: 1.63 ± 0.033	6.27ProGly: 6.27 ± 0.075	1.047ProHis: 1.047 ± 0.032	2.167ProIle: 2.167 ± 0.041	1.107ProLys: 1.107 ± 0.03	5.758ProLeu: 5.758 ± 0.073	0.844ProMet: 0.844 ± 0.026	0.997ProAsn: 0.997 ± 0.032	3.751ProPro: 3.751 ± 0.066	1.571ProGln: 1.571 ± 0.035	4.565ProArg: 4.565 ± 0.061	3.133ProSer: 3.133 ± 0.048	3.666ProThr: 3.666 ± 0.059	4.948ProVal: 4.948 ± 0.063	0.877ProTrp: 0.877 ± 0.027	0.985ProTyr: 0.985 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.01GlnAla: 4.01 ± 0.055	0.131GlnCys: 0.131 ± 0.01	1.285GlnAsp: 1.285 ± 0.032	1.297GlnGlu: 1.297 ± 0.026	0.651GlnPhe: 0.651 ± 0.025	1.997GlnGly: 1.997 ± 0.043	0.596GlnHis: 0.596 ± 0.021	1.227GlnIle: 1.227 ± 0.034	0.502GlnLys: 0.502 ± 0.023	3.431GlnLeu: 3.431 ± 0.049	0.437GlnMet: 0.437 ± 0.018	0.4GlnAsn: 0.4 ± 0.018	1.754GlnPro: 1.754 ± 0.04	1.176GlnGln: 1.176 ± 0.036	3.038GlnArg: 3.038 ± 0.054	1.072GlnSer: 1.072 ± 0.028	1.342GlnThr: 1.342 ± 0.03	2.556GlnVal: 2.556 ± 0.045	0.337GlnTrp: 0.337 ± 0.017	0.436GlnTyr: 0.436 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	11.254ArgAla: 11.254 ± 0.125	0.696ArgCys: 0.696 ± 0.024	5.403ArgAsp: 5.403 ± 0.064	5.229ArgGlu: 5.229 ± 0.079	2.856ArgPhe: 2.856 ± 0.048	6.981ArgGly: 6.981 ± 0.074	1.966ArgHis: 1.966 ± 0.043	4.119ArgIle: 4.119 ± 0.054	1.466ArgLys: 1.466 ± 0.035	9.403ArgLeu: 9.403 ± 0.107	1.797ArgMet: 1.797 ± 0.031	1.355ArgAsn: 1.355 ± 0.032	5.637ArgPro: 5.637 ± 0.082	2.581ArgGln: 2.581 ± 0.057	9.923ArgArg: 9.923 ± 0.149	4.606ArgSer: 4.606 ± 0.062	5.069ArgThr: 5.069 ± 0.05	6.781ArgVal: 6.781 ± 0.08	1.518ArgTrp: 1.518 ± 0.036	1.756ArgTyr: 1.756 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.158SerAla: 6.158 ± 0.064	0.41SerCys: 0.41 ± 0.02	2.827SerAsp: 2.827 ± 0.055	2.042SerGlu: 2.042 ± 0.037	1.652SerPhe: 1.652 ± 0.036	5.808SerGly: 5.808 ± 0.08	0.889SerHis: 0.889 ± 0.025	1.92SerIle: 1.92 ± 0.041	0.915SerLys: 0.915 ± 0.033	4.352SerLeu: 4.352 ± 0.062	0.896SerMet: 0.896 ± 0.026	0.834SerAsn: 0.834 ± 0.027	2.857SerPro: 2.857 ± 0.047	1.148SerGln: 1.148 ± 0.031	3.73SerArg: 3.73 ± 0.055	2.852SerSer: 2.852 ± 0.066	2.952SerThr: 2.952 ± 0.053	3.589SerVal: 3.589 ± 0.054	0.8SerTrp: 0.8 ± 0.024	0.951SerTyr: 0.951 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	7.738ThrAla: 7.738 ± 0.09	0.406ThrCys: 0.406 ± 0.019	2.784ThrAsp: 2.784 ± 0.047	2.24ThrGlu: 2.24 ± 0.047	1.657ThrPhe: 1.657 ± 0.039	5.543ThrGly: 5.543 ± 0.077	0.932ThrHis: 0.932 ± 0.027	2.726ThrIle: 2.726 ± 0.052	1.065ThrLys: 1.065 ± 0.035	5.601ThrLeu: 5.601 ± 0.067	0.881ThrMet: 0.881 ± 0.023	0.938ThrAsn: 0.938 ± 0.029	3.725ThrPro: 3.725 ± 0.057	1.13ThrGln: 1.13 ± 0.034	3.899ThrArg: 3.899 ± 0.051	2.798ThrSer: 2.798 ± 0.06	4.047ThrThr: 4.047 ± 0.079	5.582ThrVal: 5.582 ± 0.06	0.737ThrTrp: 0.737 ± 0.028	0.991ThrTyr: 0.991 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	13.403ValAla: 13.403 ± 0.132	0.637ValCys: 0.637 ± 0.021	5.754ValAsp: 5.754 ± 0.071	4.978ValGlu: 4.978 ± 0.064	1.991ValPhe: 1.991 ± 0.044	7.665ValGly: 7.665 ± 0.089	1.735ValHis: 1.735 ± 0.038	2.946ValIle: 2.946 ± 0.048	1.388ValLys: 1.388 ± 0.04	9.028ValLeu: 9.028 ± 0.11	1.101ValMet: 1.101 ± 0.031	1.472ValAsn: 1.472 ± 0.036	5.025ValPro: 5.025 ± 0.055	2.03ValGln: 2.03 ± 0.04	7.268ValArg: 7.268 ± 0.071	3.758ValSer: 3.758 ± 0.053	4.881ValThr: 4.881 ± 0.068	8.568ValVal: 8.568 ± 0.09	0.891ValTrp: 0.891 ± 0.027	1.232ValTyr: 1.232 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.411TrpAla: 1.411 ± 0.031	0.133TrpCys: 0.133 ± 0.009	0.732TrpAsp: 0.732 ± 0.022	0.572TrpGlu: 0.572 ± 0.023	0.445TrpPhe: 0.445 ± 0.019	0.946TrpGly: 0.946 ± 0.026	0.312TrpHis: 0.312 ± 0.015	0.601TrpIle: 0.601 ± 0.022	0.279TrpLys: 0.279 ± 0.014	1.457TrpLeu: 1.457 ± 0.035	0.296TrpMet: 0.296 ± 0.014	0.28TrpAsn: 0.28 ± 0.014	0.685TrpPro: 0.685 ± 0.023	0.457TrpGln: 0.457 ± 0.018	1.379TrpArg: 1.379 ± 0.038	0.917TrpSer: 0.917 ± 0.025	0.889TrpThr: 0.889 ± 0.028	0.927TrpVal: 0.927 ± 0.03	0.306TrpTrp: 0.306 ± 0.015	0.27TrpTyr: 0.27 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.212TyrAla: 2.212 ± 0.041	0.159TyrCys: 0.159 ± 0.011	1.275TyrAsp: 1.275 ± 0.048	0.998TyrGlu: 0.998 ± 0.027	0.51TyrPhe: 0.51 ± 0.019	1.792TyrGly: 1.792 ± 0.038	0.363TyrHis: 0.363 ± 0.017	0.352TyrIle: 0.352 ± 0.017	0.285TyrLys: 0.285 ± 0.017	1.73TyrLeu: 1.73 ± 0.031	0.197TyrMet: 0.197 ± 0.011	0.32TyrAsn: 0.32 ± 0.016	0.901TyrPro: 0.901 ± 0.025	0.44TyrGln: 0.44 ± 0.018	1.674TyrArg: 1.674 ± 0.037	0.728TyrSer: 0.728 ± 0.027	0.753TyrThr: 0.753 ± 0.024	1.563TyrVal: 1.563 ± 0.035	0.263TyrTrp: 0.263 ± 0.015	0.35TyrTyr: 0.35 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4372 proteins (1416978 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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