Amino acid dipepetide frequency for Rubella virus (strain M33) (RUBV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.824AlaAla: 19.824 ± 3.203
4.091AlaCys: 4.091 ± 1.402
5.664AlaAsp: 5.664 ± 1.595
5.979AlaGlu: 5.979 ± 2.299
5.035AlaPhe: 5.035 ± 0.344
12.587AlaGly: 12.587 ± 1.782
3.461AlaHis: 3.461 ± 0.699
3.461AlaIle: 3.461 ± 0.886
1.573AlaLys: 1.573 ± 0.355
16.048AlaLeu: 16.048 ± 2.669
1.573AlaMet: 1.573 ± 0.355
2.832AlaAsn: 2.832 ± 0.533
9.755AlaPro: 9.755 ± 2.978
5.349AlaGln: 5.349 ± 0.89
10.699AlaArg: 10.699 ± 2.307
5.664AlaSer: 5.664 ± 1.047
8.496AlaThr: 8.496 ± 0.014
7.552AlaVal: 7.552 ± 0.541
2.832AlaTrp: 2.832 ± 1.061
4.405AlaTyr: 4.405 ± 0.888
0.0AlaXaa: 0.0 ± 0.0
Cys
6.608CysAla: 6.608 ± 1.068
0.315CysCys: 0.315 ± 0.352
0.629CysAsp: 0.629 ± 0.353
1.888CysGlu: 1.888 ± 0.525
0.315CysPhe: 0.315 ± 0.352
5.035CysGly: 5.035 ± 1.4
1.888CysHis: 1.888 ± 1.054
0.629CysIle: 0.629 ± 0.175
0.629CysLys: 0.629 ± 0.353
0.944CysLeu: 0.944 ± 0.002
0.315CysMet: 0.315 ± 0.177
0.944CysAsn: 0.944 ± 0.527
2.517CysPro: 2.517 ± 0.885
0.629CysGln: 0.629 ± 0.175
3.461CysArg: 3.461 ± 0.358
0.944CysSer: 0.944 ± 0.527
2.203CysThr: 2.203 ± 0.18
1.259CysVal: 1.259 ± 0.35
0.944CysTrp: 0.944 ± 0.002
0.629CysTyr: 0.629 ± 0.703
0.0CysXaa: 0.0 ± 0.0
Asp
5.349AspAla: 5.349 ± 1.946
1.888AspCys: 1.888 ± 0.532
2.517AspAsp: 2.517 ± 0.356
1.888AspGlu: 1.888 ± 0.532
1.573AspPhe: 1.573 ± 0.173
4.72AspGly: 4.72 ± 0.008
1.888AspHis: 1.888 ± 0.532
1.573AspIle: 1.573 ± 0.883
0.0AspLys: 0.0 ± 0.0
4.405AspLeu: 4.405 ± 0.36
1.259AspMet: 1.259 ± 0.288
0.0AspAsn: 0.0 ± 0.0
5.979AspPro: 5.979 ± 0.186
0.315AspGln: 0.315 ± 0.177
4.72AspArg: 4.72 ± 1.593
1.888AspSer: 1.888 ± 1.054
3.147AspThr: 3.147 ± 0.347
4.405AspVal: 4.405 ± 0.36
1.259AspTrp: 1.259 ± 0.878
1.259AspTyr: 1.259 ± 0.707
0.0AspXaa: 0.0 ± 0.0
Glu
5.664GluAla: 5.664 ± 0.538
0.0GluCys: 0.0 ± 0.0
4.091GluAsp: 4.091 ± 0.183
2.517GluGlu: 2.517 ± 0.356
0.315GluPhe: 0.315 ± 0.177
4.091GluGly: 4.091 ± 0.183
1.259GluHis: 1.259 ± 0.35
2.203GluIle: 2.203 ± 0.708
0.315GluLys: 0.315 ± 0.177
4.72GluLeu: 4.72 ± 1.065
0.629GluMet: 0.629 ± 0.175
0.0GluAsn: 0.0 ± 0.0
3.461GluPro: 3.461 ± 0.886
1.259GluGln: 1.259 ± 0.178
6.608GluArg: 6.608 ± 1.596
1.573GluSer: 1.573 ± 0.702
2.203GluThr: 2.203 ± 0.349
5.979GluVal: 5.979 ± 1.771
2.203GluTrp: 2.203 ± 0.18
0.629GluTyr: 0.629 ± 0.175
0.0GluXaa: 0.0 ± 0.0
Phe
2.517PheAla: 2.517 ± 0.172
0.944PheCys: 0.944 ± 0.002
0.944PheAsp: 0.944 ± 0.53
0.944PheGlu: 0.944 ± 0.002
0.629PhePhe: 0.629 ± 0.353
1.888PheGly: 1.888 ± 0.525
0.944PheHis: 0.944 ± 0.002
0.0PheIle: 0.0 ± 0.0
0.944PheLys: 0.944 ± 0.002
2.203PheLeu: 2.203 ± 0.349
0.315PheMet: 0.315 ± 0.352
0.315PheAsn: 0.315 ± 0.352
1.259PhePro: 1.259 ± 0.35
0.944PheGln: 0.944 ± 0.002
1.573PheArg: 1.573 ± 0.355
0.629PheSer: 0.629 ± 0.353
2.203PheThr: 2.203 ± 0.349
1.573PheVal: 1.573 ± 0.173
0.629PheTrp: 0.629 ± 0.703
0.629PheTyr: 0.629 ± 0.175
0.0PheXaa: 0.0 ± 0.0
Gly
8.811GlyAla: 8.811 ± 0.866
4.72GlyCys: 4.72 ± 0.52
4.405GlyAsp: 4.405 ± 0.36
4.72GlyGlu: 4.72 ± 0.52
0.944GlyPhe: 0.944 ± 0.527
7.867GlyGly: 7.867 ± 1.924
3.776GlyHis: 3.776 ± 1.05
1.888GlyIle: 1.888 ± 1.06
1.259GlyLys: 1.259 ± 0.35
8.496GlyLeu: 8.496 ± 2.628
1.259GlyMet: 1.259 ± 0.707
1.573GlyAsn: 1.573 ± 0.702
8.181GlyPro: 8.181 ± 0.366
1.888GlyGln: 1.888 ± 1.054
5.035GlyArg: 5.035 ± 0.344
3.776GlySer: 3.776 ± 0.006
5.979GlyThr: 5.979 ± 1.399
4.091GlyVal: 4.091 ± 0.345
2.203GlyTrp: 2.203 ± 0.18
1.259GlyTyr: 1.259 ± 0.35
0.0GlyXaa: 0.0 ± 0.0
His
4.091HisAla: 4.091 ± 0.183
0.629HisCys: 0.629 ± 0.353
1.888HisAsp: 1.888 ± 0.525
1.573HisGlu: 1.573 ± 0.883
1.259HisPhe: 1.259 ± 0.178
2.517HisGly: 2.517 ± 1.229
1.888HisHis: 1.888 ± 1.582
1.259HisIle: 1.259 ± 0.178
0.315HisLys: 0.315 ± 0.352
3.461HisLeu: 3.461 ± 1.415
0.629HisMet: 0.629 ± 0.175
0.315HisAsn: 0.315 ± 0.177
4.405HisPro: 4.405 ± 0.697
1.259HisGln: 1.259 ± 0.35
1.259HisArg: 1.259 ± 0.35
1.259HisSer: 1.259 ± 0.35
2.517HisThr: 2.517 ± 1.229
2.832HisVal: 2.832 ± 0.533
0.944HisTrp: 0.944 ± 0.527
1.888HisTyr: 1.888 ± 0.532
0.0HisXaa: 0.0 ± 0.0
Ile
1.259IleAla: 1.259 ± 0.178
1.573IleCys: 1.573 ± 0.702
2.203IleAsp: 2.203 ± 0.708
1.259IleGlu: 1.259 ± 0.178
1.573IlePhe: 1.573 ± 0.355
0.944IleGly: 0.944 ± 0.002
0.944IleHis: 0.944 ± 0.002
0.629IleIle: 0.629 ± 0.353
0.944IleLys: 0.944 ± 0.53
0.315IleLeu: 0.315 ± 0.177
1.259IleMet: 1.259 ± 0.178
0.0IleAsn: 0.0 ± 0.0
2.203IlePro: 2.203 ± 0.708
1.259IleGln: 1.259 ± 0.707
1.888IleArg: 1.888 ± 0.003
0.944IleSer: 0.944 ± 0.53
0.629IleThr: 0.629 ± 0.175
2.517IleVal: 2.517 ± 0.885
0.629IleTrp: 0.629 ± 0.175
0.629IleTyr: 0.629 ± 0.353
0.0IleXaa: 0.0 ± 0.0
Lys
1.259LysAla: 1.259 ± 0.178
1.259LysCys: 1.259 ± 0.35
0.315LysAsp: 0.315 ± 0.352
0.944LysGlu: 0.944 ± 0.53
1.573LysPhe: 1.573 ± 0.702
1.259LysGly: 1.259 ± 0.178
0.629LysHis: 0.629 ± 0.175
0.629LysIle: 0.629 ± 0.175
0.0LysLys: 0.0 ± 0.0
1.259LysLeu: 1.259 ± 0.707
0.0LysMet: 0.0 ± 0.0
0.944LysAsn: 0.944 ± 0.53
0.944LysPro: 0.944 ± 0.002
0.315LysGln: 0.315 ± 0.352
0.944LysArg: 0.944 ± 0.53
0.629LysSer: 0.629 ± 0.353
1.259LysThr: 1.259 ± 0.35
0.629LysVal: 0.629 ± 0.353
0.315LysTrp: 0.315 ± 0.177
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
13.531LeuAla: 13.531 ± 1.784
2.203LeuCys: 2.203 ± 0.708
4.405LeuAsp: 4.405 ± 0.888
5.035LeuGlu: 5.035 ± 1.241
0.944LeuPhe: 0.944 ± 0.53
5.349LeuGly: 5.349 ± 0.696
4.405LeuHis: 4.405 ± 0.888
1.573LeuIle: 1.573 ± 0.173
1.888LeuLys: 1.888 ± 0.532
7.552LeuLeu: 7.552 ± 0.516
0.944LeuMet: 0.944 ± 0.002
1.573LeuAsn: 1.573 ± 0.173
4.72LeuPro: 4.72 ± 0.008
2.203LeuGln: 2.203 ± 0.877
8.181LeuArg: 8.181 ± 0.366
5.349LeuSer: 5.349 ± 0.361
4.405LeuThr: 4.405 ± 0.169
4.405LeuVal: 4.405 ± 1.225
2.203LeuTrp: 2.203 ± 0.18
1.888LeuTyr: 1.888 ± 0.532
0.0LeuXaa: 0.0 ± 0.0
Met
1.573MetAla: 1.573 ± 0.173
1.573MetCys: 1.573 ± 0.883
0.629MetAsp: 0.629 ± 0.175
1.259MetGlu: 1.259 ± 0.178
0.0MetPhe: 0.0 ± 0.0
0.629MetGly: 0.629 ± 0.175
0.629MetHis: 0.629 ± 0.353
0.0MetIle: 0.0 ± 0.0
0.315MetLys: 0.315 ± 0.177
0.315MetLeu: 0.315 ± 0.177
0.0MetMet: 0.0 ± 0.0
0.629MetAsn: 0.629 ± 0.175
1.573MetPro: 1.573 ± 0.702
0.944MetGln: 0.944 ± 0.002
2.203MetArg: 2.203 ± 0.18
0.944MetSer: 0.944 ± 0.002
0.315MetThr: 0.315 ± 0.177
0.944MetVal: 0.944 ± 0.002
0.315MetTrp: 0.315 ± 0.177
0.315MetTyr: 0.315 ± 0.352
0.0MetXaa: 0.0 ± 0.0
Asn
4.405AsnAla: 4.405 ± 0.888
0.944AsnCys: 0.944 ± 0.527
0.629AsnAsp: 0.629 ± 0.175
0.315AsnGlu: 0.315 ± 0.177
0.0AsnPhe: 0.0 ± 0.0
0.944AsnGly: 0.944 ± 0.527
0.629AsnHis: 0.629 ± 0.353
0.315AsnIle: 0.315 ± 0.177
0.315AsnLys: 0.315 ± 0.177
1.888AsnLeu: 1.888 ± 0.003
0.315AsnMet: 0.315 ± 0.177
0.315AsnAsn: 0.315 ± 0.177
1.573AsnPro: 1.573 ± 1.23
0.944AsnGln: 0.944 ± 0.527
0.629AsnArg: 0.629 ± 0.175
0.315AsnSer: 0.315 ± 0.352
1.259AsnThr: 1.259 ± 0.35
1.259AsnVal: 1.259 ± 0.35
0.0AsnTrp: 0.0 ± 0.0
0.315AsnTyr: 0.315 ± 0.352
0.0AsnXaa: 0.0 ± 0.0
Pro
10.699ProAla: 10.699 ± 0.334
1.888ProCys: 1.888 ± 0.525
5.035ProAsp: 5.035 ± 0.713
5.979ProGlu: 5.979 ± 0.342
1.888ProPhe: 1.888 ± 0.525
6.608ProGly: 6.608 ± 1.574
2.517ProHis: 2.517 ± 0.172
0.944ProIle: 0.944 ± 0.002
1.888ProLys: 1.888 ± 0.532
5.979ProLeu: 5.979 ± 0.714
1.259ProMet: 1.259 ± 0.878
0.944ProAsn: 0.944 ± 0.002
18.565ProPro: 18.565 ± 3.843
2.203ProGln: 2.203 ± 0.877
10.384ProArg: 10.384 ± 0.017
2.832ProSer: 2.832 ± 1.061
5.349ProThr: 5.349 ± 1.224
4.405ProVal: 4.405 ± 0.697
2.832ProTrp: 2.832 ± 1.052
1.888ProTyr: 1.888 ± 0.003
0.0ProXaa: 0.0 ± 0.0
Gln
3.776GlnAla: 3.776 ± 0.535
0.629GlnCys: 0.629 ± 0.175
0.944GlnAsp: 0.944 ± 0.002
0.944GlnGlu: 0.944 ± 0.002
0.315GlnPhe: 0.315 ± 0.177
2.832GlnGly: 2.832 ± 0.005
1.573GlnHis: 1.573 ± 0.702
0.315GlnIle: 0.315 ± 0.177
0.944GlnLys: 0.944 ± 0.002
1.888GlnLeu: 1.888 ± 1.582
0.944GlnMet: 0.944 ± 0.53
0.0GlnAsn: 0.0 ± 0.0
2.832GlnPro: 2.832 ± 1.052
1.259GlnGln: 1.259 ± 0.35
2.832GlnArg: 2.832 ± 0.524
1.888GlnSer: 1.888 ± 1.054
2.203GlnThr: 2.203 ± 0.877
2.517GlnVal: 2.517 ± 0.356
0.315GlnTrp: 0.315 ± 0.177
0.629GlnTyr: 0.629 ± 0.703
0.0GlnXaa: 0.0 ± 0.0
Arg
16.048ArgAla: 16.048 ± 1.612
3.147ArgCys: 3.147 ± 0.71
5.035ArgAsp: 5.035 ± 1.77
3.461ArgGlu: 3.461 ± 1.943
1.888ArgPhe: 1.888 ± 0.525
8.496ArgGly: 8.496 ± 0.514
4.091ArgHis: 4.091 ± 0.711
2.832ArgIle: 2.832 ± 0.005
1.259ArgLys: 1.259 ± 0.35
5.349ArgLeu: 5.349 ± 0.696
2.203ArgMet: 2.203 ± 0.204
0.944ArgAsn: 0.944 ± 0.527
7.552ArgPro: 7.552 ± 0.013
1.888ArgGln: 1.888 ± 0.525
7.237ArgArg: 7.237 ± 0.364
2.517ArgSer: 2.517 ± 0.356
4.091ArgThr: 4.091 ± 0.711
8.181ArgVal: 8.181 ± 1.423
2.832ArgTrp: 2.832 ± 0.524
2.203ArgTyr: 2.203 ± 1.236
0.0ArgXaa: 0.0 ± 0.0
Ser
5.035SerAla: 5.035 ± 0.713
1.573SerCys: 1.573 ± 1.23
3.461SerAsp: 3.461 ± 0.699
1.888SerGlu: 1.888 ± 0.003
0.629SerPhe: 0.629 ± 0.175
2.832SerGly: 2.832 ± 1.052
0.629SerHis: 0.629 ± 0.353
1.259SerIle: 1.259 ± 0.707
0.315SerLys: 0.315 ± 0.352
3.147SerLeu: 3.147 ± 0.71
0.0SerMet: 0.0 ± 0.0
0.629SerAsn: 0.629 ± 0.353
4.405SerPro: 4.405 ± 0.169
1.888SerGln: 1.888 ± 0.525
4.091SerArg: 4.091 ± 1.402
0.629SerSer: 0.629 ± 0.703
2.832SerThr: 2.832 ± 0.524
2.832SerVal: 2.832 ± 0.533
1.259SerTrp: 1.259 ± 0.178
1.888SerTyr: 1.888 ± 0.525
0.0SerXaa: 0.0 ± 0.0
Thr
10.384ThrAla: 10.384 ± 2.096
1.573ThrCys: 1.573 ± 0.173
2.203ThrAsp: 2.203 ± 0.18
4.091ThrGlu: 4.091 ± 0.345
0.629ThrPhe: 0.629 ± 0.175
3.461ThrGly: 3.461 ± 0.699
1.888ThrHis: 1.888 ± 0.003
0.944ThrIle: 0.944 ± 0.53
0.944ThrLys: 0.944 ± 0.002
5.035ThrLeu: 5.035 ± 1.77
0.315ThrMet: 0.315 ± 0.352
1.573ThrAsn: 1.573 ± 0.173
6.923ThrPro: 6.923 ± 1.926
1.259ThrGln: 1.259 ± 0.35
6.293ThrArg: 6.293 ± 0.166
2.832ThrSer: 2.832 ± 0.524
4.405ThrThr: 4.405 ± 1.754
4.405ThrVal: 4.405 ± 0.697
0.944ThrTrp: 0.944 ± 0.002
1.259ThrTyr: 1.259 ± 0.35
0.0ThrXaa: 0.0 ± 0.0
Val
9.44ValAla: 9.44 ± 3.186
2.517ValCys: 2.517 ± 0.172
2.517ValAsp: 2.517 ± 0.172
3.147ValGlu: 3.147 ± 0.875
1.888ValPhe: 1.888 ± 0.003
5.664ValGly: 5.664 ± 0.538
1.259ValHis: 1.259 ± 0.707
1.573ValIle: 1.573 ± 0.173
0.629ValLys: 0.629 ± 0.175
5.664ValLeu: 5.664 ± 0.538
1.259ValMet: 1.259 ± 0.178
1.259ValAsn: 1.259 ± 0.35
5.664ValPro: 5.664 ± 0.538
1.259ValGln: 1.259 ± 0.35
9.44ValArg: 9.44 ± 1.072
4.091ValSer: 4.091 ± 0.345
3.147ValThr: 3.147 ± 0.875
4.091ValVal: 4.091 ± 0.183
1.573ValTrp: 1.573 ± 0.702
1.888ValTyr: 1.888 ± 0.532
0.0ValXaa: 0.0 ± 0.0
Trp
3.776TrpAla: 3.776 ± 0.006
0.315TrpCys: 0.315 ± 0.352
1.888TrpAsp: 1.888 ± 0.003
1.259TrpGlu: 1.259 ± 0.178
0.315TrpPhe: 0.315 ± 0.177
2.203TrpGly: 2.203 ± 1.405
1.573TrpHis: 1.573 ± 0.702
0.944TrpIle: 0.944 ± 0.002
0.315TrpLys: 0.315 ± 0.177
2.832TrpLeu: 2.832 ± 0.005
0.0TrpMet: 0.0 ± 0.0
0.629TrpAsn: 0.629 ± 0.175
0.629TrpPro: 0.629 ± 0.353
1.573TrpGln: 1.573 ± 0.173
1.573TrpArg: 1.573 ± 0.355
1.259TrpSer: 1.259 ± 0.35
0.944TrpThr: 0.944 ± 0.002
2.203TrpVal: 2.203 ± 0.349
1.259TrpTrp: 1.259 ± 0.178
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.832TyrAla: 2.832 ± 0.533
0.944TyrCys: 0.944 ± 0.53
0.944TyrAsp: 0.944 ± 0.53
0.629TyrGlu: 0.629 ± 0.353
0.315TyrPhe: 0.315 ± 0.352
2.203TyrGly: 2.203 ± 0.877
0.315TyrHis: 0.315 ± 0.352
0.629TyrIle: 0.629 ± 0.175
0.315TyrLys: 0.315 ± 0.352
1.259TyrLeu: 1.259 ± 0.35
0.315TyrMet: 0.315 ± 0.177
1.888TyrAsn: 1.888 ± 1.054
0.944TyrPro: 0.944 ± 0.002
0.944TyrGln: 0.944 ± 0.527
2.203TyrArg: 2.203 ± 0.708
1.259TyrSer: 1.259 ± 0.178
3.776TyrThr: 3.776 ± 1.591
1.888TyrVal: 1.888 ± 0.532
0.0TyrTrp: 0.0 ± 0.0
1.888TyrTyr: 1.888 ± 0.003
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (3179 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski