Amino acid dipepetide frequency for Helicobacter fennelliae MRY12-0050

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.673AlaAla: 2.673 ± 0.076	0.994AlaCys: 0.994 ± 0.042	2.719AlaAsp: 2.719 ± 0.071	2.753AlaGlu: 2.753 ± 0.077	3.578AlaPhe: 3.578 ± 0.09	3.48AlaGly: 3.48 ± 0.099	1.661AlaHis: 1.661 ± 0.045	5.984AlaIle: 5.984 ± 0.124	6.769AlaLys: 6.769 ± 0.117	8.769AlaLeu: 8.769 ± 0.145	1.932AlaMet: 1.932 ± 0.058	3.675AlaAsn: 3.675 ± 0.084	2.204AlaPro: 2.204 ± 0.057	3.998AlaGln: 3.998 ± 0.095	2.837AlaArg: 2.837 ± 0.068	4.403AlaSer: 4.403 ± 0.1	3.7AlaThr: 3.7 ± 0.085	2.766AlaVal: 2.766 ± 0.078	0.469AlaTrp: 0.469 ± 0.029	2.856AlaTyr: 2.856 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	1.206CysAla: 1.206 ± 0.05	0.16CysCys: 0.16 ± 0.017	0.863CysAsp: 0.863 ± 0.04	0.981CysGlu: 0.981 ± 0.042	0.867CysPhe: 0.867 ± 0.037	1.055CysGly: 1.055 ± 0.047	0.353CysHis: 0.353 ± 0.025	1.099CysIle: 1.099 ± 0.042	0.948CysLys: 0.948 ± 0.045	1.276CysLeu: 1.276 ± 0.052	0.289CysMet: 0.289 ± 0.021	0.509CysAsn: 0.509 ± 0.026	0.389CysPro: 0.389 ± 0.025	0.418CysGln: 0.418 ± 0.023	0.281CysArg: 0.281 ± 0.018	0.683CysSer: 0.683 ± 0.036	0.43CysThr: 0.43 ± 0.025	1.162CysVal: 1.162 ± 0.04	0.075CysTrp: 0.075 ± 0.013	0.496CysTyr: 0.496 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	2.463AspAla: 2.463 ± 0.065	0.827AspCys: 0.827 ± 0.036	2.385AspAsp: 2.385 ± 0.08	3.892AspGlu: 3.892 ± 0.083	4.012AspPhe: 4.012 ± 0.082	2.48AspGly: 2.48 ± 0.065	0.518AspHis: 0.518 ± 0.031	4.777AspIle: 4.777 ± 0.095	4.472AspLys: 4.472 ± 0.096	4.72AspLeu: 4.72 ± 0.092	1.438AspMet: 1.438 ± 0.05	2.443AspAsn: 2.443 ± 0.072	1.187AspPro: 1.187 ± 0.048	0.697AspGln: 0.697 ± 0.038	1.688AspArg: 1.688 ± 0.06	5.681AspSer: 5.681 ± 0.122	2.695AspThr: 2.695 ± 0.069	2.683AspVal: 2.683 ± 0.067	0.447AspTrp: 0.447 ± 0.027	2.129AspTyr: 2.129 ± 0.058	0.003AspXaa: 0.003 ± 0.002
Glu	3.901GluAla: 3.901 ± 0.096	0.841GluCys: 0.841 ± 0.038	2.297GluAsp: 2.297 ± 0.069	3.527GluGlu: 3.527 ± 0.097	3.187GluPhe: 3.187 ± 0.076	2.722GluGly: 2.722 ± 0.075	1.067GluHis: 1.067 ± 0.039	6.113GluIle: 6.113 ± 0.108	4.169GluLys: 4.169 ± 0.121	5.755GluLeu: 5.755 ± 0.106	1.509GluMet: 1.509 ± 0.054	3.584GluAsn: 3.584 ± 0.09	1.438GluPro: 1.438 ± 0.051	2.449GluGln: 2.449 ± 0.061	2.487GluArg: 2.487 ± 0.071	5.956GluSer: 5.956 ± 0.111	1.898GluThr: 1.898 ± 0.068	3.794GluVal: 3.794 ± 0.089	0.629GluTrp: 0.629 ± 0.033	2.339GluTyr: 2.339 ± 0.066	0.002GluXaa: 0.002 ± 0.002
Phe	3.92PheAla: 3.92 ± 0.088	1.162PheCys: 1.162 ± 0.044	3.063PheAsp: 3.063 ± 0.071	3.235PheGlu: 3.235 ± 0.075	2.906PhePhe: 2.906 ± 0.095	4.173PheGly: 4.173 ± 0.097	0.889PheHis: 0.889 ± 0.035	4.246PheIle: 4.246 ± 0.089	3.242PheLys: 3.242 ± 0.08	5.753PheLeu: 5.753 ± 0.126	1.341PheMet: 1.341 ± 0.051	2.278PheAsn: 2.278 ± 0.058	1.143PhePro: 1.143 ± 0.04	1.185PheGln: 1.185 ± 0.043	1.684PheArg: 1.684 ± 0.062	4.011PheSer: 4.011 ± 0.086	2.052PheThr: 2.052 ± 0.059	3.802PheVal: 3.802 ± 0.099	0.683PheTrp: 0.683 ± 0.035	2.399PheTyr: 2.399 ± 0.07	0.002PheXaa: 0.002 ± 0.001
Gly	4.224GlyAla: 4.224 ± 0.106	0.732GlyCys: 0.732 ± 0.044	2.967GlyAsp: 2.967 ± 0.07	3.48GlyGlu: 3.48 ± 0.093	3.94GlyPhe: 3.94 ± 0.081	4.587GlyGly: 4.587 ± 0.138	0.892GlyHis: 0.892 ± 0.041	5.684GlyIle: 5.684 ± 0.099	3.98GlyLys: 3.98 ± 0.093	5.417GlyLeu: 5.417 ± 0.085	1.348GlyMet: 1.348 ± 0.047	2.559GlyAsn: 2.559 ± 0.074	0.64GlyPro: 0.64 ± 0.041	1.564GlyGln: 1.564 ± 0.06	2.118GlyArg: 2.118 ± 0.062	3.494GlySer: 3.494 ± 0.086	2.083GlyThr: 2.083 ± 0.07	4.242GlyVal: 4.242 ± 0.104	0.476GlyTrp: 0.476 ± 0.027	2.565GlyTyr: 2.565 ± 0.066	0.016GlyXaa: 0.016 ± 0.014
His	1.146HisAla: 1.146 ± 0.042	0.383HisCys: 0.383 ± 0.024	0.7HisAsp: 0.7 ± 0.034	0.581HisGlu: 0.581 ± 0.03	1.435HisPhe: 1.435 ± 0.048	0.797HisGly: 0.797 ± 0.043	0.636HisHis: 0.636 ± 0.035	2.615HisIle: 2.615 ± 0.07	2.017HisLys: 2.017 ± 0.051	2.047HisLeu: 2.047 ± 0.054	0.284HisMet: 0.284 ± 0.02	1.512HisAsn: 1.512 ± 0.052	0.711HisPro: 0.711 ± 0.035	0.84HisGln: 0.84 ± 0.039	0.732HisArg: 0.732 ± 0.039	1.749HisSer: 1.749 ± 0.051	1.662HisThr: 1.662 ± 0.055	0.392HisVal: 0.392 ± 0.027	0.132HisTrp: 0.132 ± 0.015	0.997HisTyr: 0.997 ± 0.042	0.0HisXaa: 0.0 ± 0.0
Ile	7.46IleAla: 7.46 ± 0.128	1.275IleCys: 1.275 ± 0.046	5.279IleAsp: 5.279 ± 0.093	5.381IleGlu: 5.381 ± 0.097	4.319IlePhe: 4.319 ± 0.105	5.185IleGly: 5.185 ± 0.106	1.783IleHis: 1.783 ± 0.054	6.968IleIle: 6.968 ± 0.131	6.684IleLys: 6.684 ± 0.106	8.873IleLeu: 8.873 ± 0.132	1.692IleMet: 1.692 ± 0.055	4.289IleAsn: 4.289 ± 0.091	3.27IlePro: 3.27 ± 0.07	3.724IleGln: 3.724 ± 0.082	2.505IleArg: 2.505 ± 0.069	5.79IleSer: 5.79 ± 0.105	4.812IleThr: 4.812 ± 0.088	4.72IleVal: 4.72 ± 0.099	0.695IleTrp: 0.695 ± 0.033	3.46IleTyr: 3.46 ± 0.081	0.002IleXaa: 0.002 ± 0.001
Lys	5.589LysAla: 5.589 ± 0.112	0.669LysCys: 0.669 ± 0.034	5.121LysAsp: 5.121 ± 0.099	6.41LysGlu: 6.41 ± 0.13	2.48LysPhe: 2.48 ± 0.059	3.684LysGly: 3.684 ± 0.086	1.747LysHis: 1.747 ± 0.049	7.778LysIle: 7.778 ± 0.118	6.187LysLys: 6.187 ± 0.094	6.399LysLeu: 6.399 ± 0.112	2.002LysMet: 2.002 ± 0.057	5.731LysAsn: 5.731 ± 0.122	2.76LysPro: 2.76 ± 0.069	3.818LysGln: 3.818 ± 0.082	2.711LysArg: 2.711 ± 0.07	5.606LysSer: 5.606 ± 0.096	4.127LysThr: 4.127 ± 0.082	3.564LysVal: 3.564 ± 0.079	0.606LysTrp: 0.606 ± 0.034	2.615LysTyr: 2.615 ± 0.065	0.002LysXaa: 0.002 ± 0.002
Leu	7.238LeuAla: 7.238 ± 0.132	1.796LeuCys: 1.796 ± 0.056	6.253LeuAsp: 6.253 ± 0.111	7.187LeuGlu: 7.187 ± 0.117	4.854LeuPhe: 4.854 ± 0.114	6.116LeuGly: 6.116 ± 0.117	2.3LeuHis: 2.3 ± 0.073	6.876LeuIle: 6.876 ± 0.1	8.182LeuLys: 8.182 ± 0.119	8.979LeuLeu: 8.979 ± 0.166	2.0LeuMet: 2.0 ± 0.06	5.129LeuAsn: 5.129 ± 0.111	3.502LeuPro: 3.502 ± 0.073	4.777LeuGln: 4.777 ± 0.096	4.071LeuArg: 4.071 ± 0.081	7.866LeuSer: 7.866 ± 0.109	4.155LeuThr: 4.155 ± 0.093	4.49LeuVal: 4.49 ± 0.104	0.896LeuTrp: 0.896 ± 0.045	3.802LeuTyr: 3.802 ± 0.081	0.003LeuXaa: 0.003 ± 0.002
Met	1.595MetAla: 1.595 ± 0.042	0.325MetCys: 0.325 ± 0.024	1.05MetAsp: 1.05 ± 0.045	1.02MetGlu: 1.02 ± 0.038	0.929MetPhe: 0.929 ± 0.039	1.43MetGly: 1.43 ± 0.05	0.422MetHis: 0.422 ± 0.025	1.867MetIle: 1.867 ± 0.058	1.6MetLys: 1.6 ± 0.053	2.542MetLeu: 2.542 ± 0.071	0.535MetMet: 0.535 ± 0.029	1.058MetAsn: 1.058 ± 0.042	1.111MetPro: 1.111 ± 0.039	1.451MetGln: 1.451 ± 0.049	1.231MetArg: 1.231 ± 0.051	1.582MetSer: 1.582 ± 0.049	0.906MetThr: 0.906 ± 0.039	1.067MetVal: 1.067 ± 0.039	0.165MetTrp: 0.165 ± 0.017	0.625MetTyr: 0.625 ± 0.032	0.002MetXaa: 0.002 ± 0.002
Asn	4.695AsnAla: 4.695 ± 0.092	0.394AsnCys: 0.394 ± 0.028	2.802AsnAsp: 2.802 ± 0.065	3.071AsnGlu: 3.071 ± 0.081	2.615AsnPhe: 2.615 ± 0.068	3.206AsnGly: 3.206 ± 0.078	1.151AsnHis: 1.151 ± 0.043	4.925AsnIle: 4.925 ± 0.108	3.874AsnLys: 3.874 ± 0.09	6.337AsnLeu: 6.337 ± 0.113	0.97AsnMet: 0.97 ± 0.043	3.044AsnAsn: 3.044 ± 0.103	3.121AsnPro: 3.121 ± 0.076	2.447AsnGln: 2.447 ± 0.079	1.666AsnArg: 1.666 ± 0.052	2.804AsnSer: 2.804 ± 0.074	3.582AsnThr: 3.582 ± 0.105	2.639AsnVal: 2.639 ± 0.065	0.262AsnTrp: 0.262 ± 0.02	1.752AsnTyr: 1.752 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	1.615ProAla: 1.615 ± 0.053	0.345ProCys: 0.345 ± 0.025	1.232ProAsp: 1.232 ± 0.044	1.483ProGlu: 1.483 ± 0.05	1.848ProPhe: 1.848 ± 0.055	0.937ProGly: 0.937 ± 0.044	1.024ProHis: 1.024 ± 0.04	2.877ProIle: 2.877 ± 0.074	3.369ProLys: 3.369 ± 0.07	3.534ProLeu: 3.534 ± 0.073	0.695ProMet: 0.695 ± 0.036	2.411ProAsn: 2.411 ± 0.066	1.055ProPro: 1.055 ± 0.041	1.942ProGln: 1.942 ± 0.058	0.986ProArg: 0.986 ± 0.038	2.168ProSer: 2.168 ± 0.056	1.945ProThr: 1.945 ± 0.057	1.202ProVal: 1.202 ± 0.046	0.204ProTrp: 0.204 ± 0.02	1.429ProTyr: 1.429 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	3.022GlnAla: 3.022 ± 0.068	0.457GlnCys: 0.457 ± 0.025	2.532GlnAsp: 2.532 ± 0.072	3.323GlnGlu: 3.323 ± 0.086	1.229GlnPhe: 1.229 ± 0.042	1.945GlnGly: 1.945 ± 0.063	0.832GlnHis: 0.832 ± 0.036	4.074GlnIle: 4.074 ± 0.094	4.523GlnLys: 4.523 ± 0.078	2.314GlnLeu: 2.314 ± 0.062	0.967GlnMet: 0.967 ± 0.04	4.265GlnAsn: 4.265 ± 0.111	0.994GlnPro: 0.994 ± 0.042	1.488GlnGln: 1.488 ± 0.055	1.327GlnArg: 1.327 ± 0.044	3.557GlnSer: 3.557 ± 0.086	2.801GlnThr: 2.801 ± 0.071	1.783GlnVal: 1.783 ± 0.05	0.378GlnTrp: 0.378 ± 0.024	1.311GlnTyr: 1.311 ± 0.05	0.002GlnXaa: 0.002 ± 0.001
Arg	2.667ArgAla: 2.667 ± 0.074	0.297ArgCys: 0.297 ± 0.022	2.137ArgAsp: 2.137 ± 0.06	2.587ArgGlu: 2.587 ± 0.066	2.491ArgPhe: 2.491 ± 0.063	2.052ArgGly: 2.052 ± 0.062	0.664ArgHis: 0.664 ± 0.033	3.648ArgIle: 3.648 ± 0.077	2.254ArgLys: 2.254 ± 0.057	3.6ArgLeu: 3.6 ± 0.07	0.782ArgMet: 0.782 ± 0.034	1.708ArgAsn: 1.708 ± 0.057	0.953ArgPro: 0.953 ± 0.04	1.386ArgGln: 1.386 ± 0.045	1.223ArgArg: 1.223 ± 0.041	1.852ArgSer: 1.852 ± 0.06	1.389ArgThr: 1.389 ± 0.042	2.121ArgVal: 2.121 ± 0.062	0.261ArgTrp: 0.261 ± 0.02	1.62ArgTyr: 1.62 ± 0.052	0.002ArgXaa: 0.002 ± 0.002
Ser	5.077SerAla: 5.077 ± 0.094	0.777SerCys: 0.777 ± 0.038	3.223SerAsp: 3.223 ± 0.073	3.22SerGlu: 3.22 ± 0.08	3.975SerPhe: 3.975 ± 0.077	4.439SerGly: 4.439 ± 0.102	1.782SerHis: 1.782 ± 0.053	5.926SerIle: 5.926 ± 0.101	6.143SerLys: 6.143 ± 0.099	7.664SerLeu: 7.664 ± 0.128	1.597SerMet: 1.597 ± 0.046	3.744SerAsn: 3.744 ± 0.088	2.265SerPro: 2.265 ± 0.061	3.501SerGln: 3.501 ± 0.103	2.425SerArg: 2.425 ± 0.064	5.152SerSer: 5.152 ± 0.118	3.749SerThr: 3.749 ± 0.099	3.901SerVal: 3.901 ± 0.082	0.505SerTrp: 0.505 ± 0.031	2.714SerTyr: 2.714 ± 0.071	0.0SerXaa: 0.0 ± 0.0
Thr	2.567ThrAla: 2.567 ± 0.076	0.429ThrCys: 0.429 ± 0.027	1.964ThrAsp: 1.964 ± 0.057	1.78ThrGlu: 1.78 ± 0.05	2.399ThrPhe: 2.399 ± 0.068	2.016ThrGly: 2.016 ± 0.069	1.684ThrHis: 1.684 ± 0.054	4.317ThrIle: 4.317 ± 0.085	4.421ThrLys: 4.421 ± 0.099	6.213ThrLeu: 6.213 ± 0.095	0.953ThrMet: 0.953 ± 0.042	2.929ThrAsn: 2.929 ± 0.087	2.62ThrPro: 2.62 ± 0.07	3.757ThrGln: 3.757 ± 0.086	1.677ThrArg: 1.677 ± 0.056	3.408ThrSer: 3.408 ± 0.086	2.954ThrThr: 2.954 ± 0.083	0.516ThrVal: 0.516 ± 0.034	0.295ThrTrp: 0.295 ± 0.022	1.865ThrTyr: 1.865 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	3.832ValAla: 3.832 ± 0.103	1.019ValCys: 1.019 ± 0.05	2.658ValAsp: 2.658 ± 0.067	2.868ValGlu: 2.868 ± 0.08	3.325ValPhe: 3.325 ± 0.092	3.727ValGly: 3.727 ± 0.088	0.738ValHis: 0.738 ± 0.036	4.538ValIle: 4.538 ± 0.085	3.14ValLys: 3.14 ± 0.085	5.749ValLeu: 5.749 ± 0.107	1.248ValMet: 1.248 ± 0.048	1.987ValAsn: 1.987 ± 0.062	1.344ValPro: 1.344 ± 0.047	1.515ValGln: 1.515 ± 0.049	2.133ValArg: 2.133 ± 0.058	3.391ValSer: 3.391 ± 0.079	1.501ValThr: 1.501 ± 0.046	3.592ValVal: 3.592 ± 0.089	0.518ValTrp: 0.518 ± 0.033	1.867ValTyr: 1.867 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.537TrpAla: 0.537 ± 0.032	0.11TrpCys: 0.11 ± 0.013	0.422TrpAsp: 0.422 ± 0.03	0.466TrpGlu: 0.466 ± 0.032	0.399TrpPhe: 0.399 ± 0.025	0.608TrpGly: 0.608 ± 0.031	0.235TrpHis: 0.235 ± 0.023	0.76TrpIle: 0.76 ± 0.039	0.424TrpLys: 0.424 ± 0.026	0.983TrpLeu: 0.983 ± 0.044	0.138TrpMet: 0.138 ± 0.014	0.422TrpAsn: 0.422 ± 0.026	0.066TrpPro: 0.066 ± 0.011	0.516TrpGln: 0.516 ± 0.028	0.419TrpArg: 0.419 ± 0.026	0.446TrpSer: 0.446 ± 0.029	0.259TrpThr: 0.259 ± 0.022	0.463TrpVal: 0.463 ± 0.031	0.122TrpTrp: 0.122 ± 0.014	0.303TrpTyr: 0.303 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.794TyrAla: 2.794 ± 0.063	0.545TyrCys: 0.545 ± 0.027	1.969TyrAsp: 1.969 ± 0.06	2.419TyrGlu: 2.419 ± 0.066	2.378TyrPhe: 2.378 ± 0.063	2.353TyrGly: 2.353 ± 0.07	0.991TyrHis: 0.991 ± 0.042	3.093TyrIle: 3.093 ± 0.079	3.206TyrLys: 3.206 ± 0.085	3.546TyrLeu: 3.546 ± 0.073	0.791TyrMet: 0.791 ± 0.032	2.078TyrAsn: 2.078 ± 0.057	1.529TyrPro: 1.529 ± 0.052	1.651TyrGln: 1.651 ± 0.054	1.493TyrArg: 1.493 ± 0.053	2.179TyrSer: 2.179 ± 0.052	2.063TyrThr: 2.063 ± 0.067	1.786TyrVal: 1.786 ± 0.051	0.278TyrTrp: 0.278 ± 0.023	1.6TyrTyr: 1.6 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.005XaaCys: 0.005 ± 0.003	0.003XaaAsp: 0.003 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.016XaaGly: 0.016 ± 0.016	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.002	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.002XaaAsn: 0.002 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.002	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.002XaaVal: 0.002 ± 0.002	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.06XaaXaa: 0.06 ± 0.051

Statistics based on 2446 proteins (637015 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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