Amino acid dipepetide frequency for Hesseltinella vesiculosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.549AlaAla: 6.549 ± 0.072
1.166AlaCys: 1.166 ± 0.018
3.895AlaAsp: 3.895 ± 0.031
3.308AlaGlu: 3.308 ± 0.039
2.967AlaPhe: 2.967 ± 0.035
3.804AlaGly: 3.804 ± 0.039
1.899AlaHis: 1.899 ± 0.022
4.19AlaIle: 4.19 ± 0.035
4.261AlaLys: 4.261 ± 0.037
7.582AlaLeu: 7.582 ± 0.05
2.36AlaMet: 2.36 ± 0.026
3.184AlaAsn: 3.184 ± 0.03
3.935AlaPro: 3.935 ± 0.051
3.26AlaGln: 3.26 ± 0.035
3.501AlaArg: 3.501 ± 0.029
7.156AlaSer: 7.156 ± 0.056
5.144AlaThr: 5.144 ± 0.044
4.511AlaVal: 4.511 ± 0.037
0.933AlaTrp: 0.933 ± 0.016
2.218AlaTyr: 2.218 ± 0.024
0.0AlaXaa: 0.0 ± 0.0
Cys
0.883CysAla: 0.883 ± 0.017
0.339CysCys: 0.339 ± 0.01
0.743CysAsp: 0.743 ± 0.017
0.588CysGlu: 0.588 ± 0.013
0.691CysPhe: 0.691 ± 0.013
0.893CysGly: 0.893 ± 0.018
0.553CysHis: 0.553 ± 0.011
0.843CysIle: 0.843 ± 0.013
0.677CysLys: 0.677 ± 0.013
1.706CysLeu: 1.706 ± 0.021
0.383CysMet: 0.383 ± 0.009
0.538CysAsn: 0.538 ± 0.012
0.817CysPro: 0.817 ± 0.017
0.781CysGln: 0.781 ± 0.014
0.81CysArg: 0.81 ± 0.016
1.102CysSer: 1.102 ± 0.017
0.801CysThr: 0.801 ± 0.013
0.897CysVal: 0.897 ± 0.016
0.21CysTrp: 0.21 ± 0.007
0.49CysTyr: 0.49 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
4.519AspAla: 4.519 ± 0.038
0.713AspCys: 0.713 ± 0.012
5.514AspAsp: 5.514 ± 0.064
4.027AspGlu: 4.027 ± 0.039
2.242AspPhe: 2.242 ± 0.024
3.156AspGly: 3.156 ± 0.033
1.952AspHis: 1.952 ± 0.023
3.35AspIle: 3.35 ± 0.029
2.77AspLys: 2.77 ± 0.03
6.071AspLeu: 6.071 ± 0.044
1.735AspMet: 1.735 ± 0.026
2.332AspAsn: 2.332 ± 0.021
3.326AspPro: 3.326 ± 0.03
3.243AspGln: 3.243 ± 0.027
2.998AspArg: 2.998 ± 0.029
3.63AspSer: 3.63 ± 0.032
3.61AspThr: 3.61 ± 0.031
3.626AspVal: 3.626 ± 0.03
0.812AspTrp: 0.812 ± 0.016
1.915AspTyr: 1.915 ± 0.021
0.0AspXaa: 0.0 ± 0.0
Glu
4.096GluAla: 4.096 ± 0.041
0.649GluCys: 0.649 ± 0.014
3.585GluAsp: 3.585 ± 0.04
3.861GluGlu: 3.861 ± 0.049
1.759GluPhe: 1.759 ± 0.02
2.144GluGly: 2.144 ± 0.025
1.468GluHis: 1.468 ± 0.022
2.516GluIle: 2.516 ± 0.025
3.36GluLys: 3.36 ± 0.037
4.815GluLeu: 4.815 ± 0.038
1.362GluMet: 1.362 ± 0.02
2.091GluAsn: 2.091 ± 0.024
2.361GluPro: 2.361 ± 0.025
3.068GluGln: 3.068 ± 0.03
3.086GluArg: 3.086 ± 0.032
3.265GluSer: 3.265 ± 0.026
2.806GluThr: 2.806 ± 0.025
2.593GluVal: 2.593 ± 0.034
0.691GluTrp: 0.691 ± 0.014
1.57GluTyr: 1.57 ± 0.017
0.0GluXaa: 0.0 ± 0.0
Phe
2.896PheAla: 2.896 ± 0.028
0.697PheCys: 0.697 ± 0.013
2.662PheAsp: 2.662 ± 0.027
2.021PheGlu: 2.021 ± 0.022
1.899PhePhe: 1.899 ± 0.027
2.707PheGly: 2.707 ± 0.032
1.067PheHis: 1.067 ± 0.018
1.999PheIle: 1.999 ± 0.024
1.789PheLys: 1.789 ± 0.021
3.779PheLeu: 3.779 ± 0.033
1.034PheMet: 1.034 ± 0.015
1.546PheAsn: 1.546 ± 0.021
1.715PhePro: 1.715 ± 0.021
1.648PheGln: 1.648 ± 0.02
1.638PheArg: 1.638 ± 0.022
2.957PheSer: 2.957 ± 0.027
2.19PheThr: 2.19 ± 0.022
2.72PheVal: 2.72 ± 0.029
0.556PheTrp: 0.556 ± 0.01
1.441PheTyr: 1.441 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
3.472GlyAla: 3.472 ± 0.038
0.825GlyCys: 0.825 ± 0.014
2.844GlyAsp: 2.844 ± 0.033
2.276GlyGlu: 2.276 ± 0.029
2.269GlyPhe: 2.269 ± 0.026
3.287GlyGly: 3.287 ± 0.054
1.705GlyHis: 1.705 ± 0.024
2.918GlyIle: 2.918 ± 0.035
2.942GlyLys: 2.942 ± 0.028
4.924GlyLeu: 4.924 ± 0.042
1.393GlyMet: 1.393 ± 0.023
2.183GlyAsn: 2.183 ± 0.026
2.154GlyPro: 2.154 ± 0.027
2.426GlyGln: 2.426 ± 0.026
2.752GlyArg: 2.752 ± 0.029
4.157GlySer: 4.157 ± 0.047
3.021GlyThr: 3.021 ± 0.04
3.247GlyVal: 3.247 ± 0.031
0.774GlyTrp: 0.774 ± 0.014
2.013GlyTyr: 2.013 ± 0.025
0.0GlyXaa: 0.0 ± 0.0
His
2.133HisAla: 2.133 ± 0.026
0.514HisCys: 0.514 ± 0.012
1.85HisAsp: 1.85 ± 0.026
1.327HisGlu: 1.327 ± 0.017
1.188HisPhe: 1.188 ± 0.016
1.807HisGly: 1.807 ± 0.025
1.556HisHis: 1.556 ± 0.03
1.388HisIle: 1.388 ± 0.02
1.073HisLys: 1.073 ± 0.019
3.202HisLeu: 3.202 ± 0.03
0.66HisMet: 0.66 ± 0.014
0.919HisAsn: 0.919 ± 0.015
2.241HisPro: 2.241 ± 0.028
1.837HisGln: 1.837 ± 0.022
1.934HisArg: 1.934 ± 0.021
2.101HisSer: 2.101 ± 0.025
1.642HisThr: 1.642 ± 0.023
1.856HisVal: 1.856 ± 0.022
0.435HisTrp: 0.435 ± 0.01
0.931HisTyr: 0.931 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
3.756IleAla: 3.756 ± 0.032
0.819IleCys: 0.819 ± 0.016
3.275IleAsp: 3.275 ± 0.029
2.572IleGlu: 2.572 ± 0.024
1.946IlePhe: 1.946 ± 0.022
2.768IleGly: 2.768 ± 0.026
1.672IleHis: 1.672 ± 0.018
2.43IleIle: 2.43 ± 0.03
2.77IleLys: 2.77 ± 0.032
4.827IleLeu: 4.827 ± 0.037
1.206IleMet: 1.206 ± 0.017
2.014IleAsn: 2.014 ± 0.02
2.827IlePro: 2.827 ± 0.032
2.593IleGln: 2.593 ± 0.024
2.662IleArg: 2.662 ± 0.026
3.556IleSer: 3.556 ± 0.031
2.866IleThr: 2.866 ± 0.029
3.282IleVal: 3.282 ± 0.03
0.598IleTrp: 0.598 ± 0.015
1.579IleTyr: 1.579 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
3.782LysAla: 3.782 ± 0.031
0.629LysCys: 0.629 ± 0.012
3.216LysAsp: 3.216 ± 0.034
3.267LysGlu: 3.267 ± 0.041
1.575LysPhe: 1.575 ± 0.021
2.183LysGly: 2.183 ± 0.027
1.483LysHis: 1.483 ± 0.02
2.467LysIle: 2.467 ± 0.029
4.244LysLys: 4.244 ± 0.052
4.599LysLeu: 4.599 ± 0.04
1.251LysMet: 1.251 ± 0.016
2.123LysAsn: 2.123 ± 0.024
2.678LysPro: 2.678 ± 0.029
2.79LysGln: 2.79 ± 0.025
3.508LysArg: 3.508 ± 0.032
3.488LysSer: 3.488 ± 0.031
3.057LysThr: 3.057 ± 0.028
3.074LysVal: 3.074 ± 0.032
0.598LysTrp: 0.598 ± 0.012
1.654LysTyr: 1.654 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
8.222LeuAla: 8.222 ± 0.056
1.603LeuCys: 1.603 ± 0.024
6.49LeuAsp: 6.49 ± 0.045
5.406LeuGlu: 5.406 ± 0.043
3.885LeuPhe: 3.885 ± 0.034
5.147LeuGly: 5.147 ± 0.044
2.844LeuHis: 2.844 ± 0.028
4.443LeuIle: 4.443 ± 0.037
4.697LeuLys: 4.697 ± 0.041
9.86LeuLeu: 9.86 ± 0.071
2.404LeuMet: 2.404 ± 0.025
3.548LeuAsn: 3.548 ± 0.029
6.166LeuPro: 6.166 ± 0.047
5.044LeuGln: 5.044 ± 0.042
4.897LeuArg: 4.897 ± 0.036
7.484LeuSer: 7.484 ± 0.048
5.934LeuThr: 5.934 ± 0.038
6.353LeuVal: 6.353 ± 0.04
1.167LeuTrp: 1.167 ± 0.018
2.891LeuTyr: 2.891 ± 0.029
0.0LeuXaa: 0.0 ± 0.0
Met
2.485MetAla: 2.485 ± 0.023
0.286MetCys: 0.286 ± 0.008
2.036MetAsp: 2.036 ± 0.025
1.594MetGlu: 1.594 ± 0.021
0.894MetPhe: 0.894 ± 0.015
1.242MetGly: 1.242 ± 0.017
0.638MetHis: 0.638 ± 0.014
1.388MetIle: 1.388 ± 0.016
1.267MetLys: 1.267 ± 0.018
2.276MetLeu: 2.276 ± 0.025
0.817MetMet: 0.817 ± 0.014
1.104MetAsn: 1.104 ± 0.017
1.429MetPro: 1.429 ± 0.025
1.14MetGln: 1.14 ± 0.017
1.089MetArg: 1.089 ± 0.016
1.983MetSer: 1.983 ± 0.022
1.901MetThr: 1.901 ± 0.023
1.785MetVal: 1.785 ± 0.021
0.229MetTrp: 0.229 ± 0.008
0.759MetTyr: 0.759 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.103AsnAla: 3.103 ± 0.025
0.502AsnCys: 0.502 ± 0.012
2.762AsnAsp: 2.762 ± 0.026
2.173AsnGlu: 2.173 ± 0.022
1.313AsnPhe: 1.313 ± 0.02
2.431AsnGly: 2.431 ± 0.027
1.151AsnHis: 1.151 ± 0.016
2.102AsnIle: 2.102 ± 0.027
2.086AsnLys: 2.086 ± 0.024
3.489AsnLeu: 3.489 ± 0.03
1.089AsnMet: 1.089 ± 0.018
1.868AsnAsn: 1.868 ± 0.025
2.163AsnPro: 2.163 ± 0.026
1.85AsnGln: 1.85 ± 0.022
1.881AsnArg: 1.881 ± 0.026
2.423AsnSer: 2.423 ± 0.024
2.386AsnThr: 2.386 ± 0.025
2.703AsnVal: 2.703 ± 0.027
0.481AsnTrp: 0.481 ± 0.011
1.191AsnTyr: 1.191 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
4.842ProAla: 4.842 ± 0.058
0.701ProCys: 0.701 ± 0.014
2.992ProAsp: 2.992 ± 0.031
2.719ProGlu: 2.719 ± 0.027
2.256ProPhe: 2.256 ± 0.022
2.608ProGly: 2.608 ± 0.037
1.564ProHis: 1.564 ± 0.022
2.524ProIle: 2.524 ± 0.027
2.412ProLys: 2.412 ± 0.027
5.417ProLeu: 5.417 ± 0.042
1.462ProMet: 1.462 ± 0.019
2.186ProAsn: 2.186 ± 0.024
5.409ProPro: 5.409 ± 0.075
2.318ProGln: 2.318 ± 0.03
2.622ProArg: 2.622 ± 0.028
6.735ProSer: 6.735 ± 0.054
4.458ProThr: 4.458 ± 0.038
3.603ProVal: 3.603 ± 0.032
0.683ProTrp: 0.683 ± 0.013
1.455ProTyr: 1.455 ± 0.019
0.0ProXaa: 0.0 ± 0.0
Gln
3.795GlnAla: 3.795 ± 0.035
0.716GlnCys: 0.716 ± 0.015
3.012GlnAsp: 3.012 ± 0.029
2.75GlnGlu: 2.75 ± 0.029
1.67GlnPhe: 1.67 ± 0.018
2.449GlnGly: 2.449 ± 0.026
1.93GlnHis: 1.93 ± 0.029
1.992GlnIle: 1.992 ± 0.021
2.273GlnLys: 2.273 ± 0.027
5.281GlnLeu: 5.281 ± 0.043
1.164GlnMet: 1.164 ± 0.017
1.514GlnAsn: 1.514 ± 0.019
3.493GlnPro: 3.493 ± 0.045
4.727GlnGln: 4.727 ± 0.083
3.209GlnArg: 3.209 ± 0.028
3.332GlnSer: 3.332 ± 0.033
2.46GlnThr: 2.46 ± 0.024
3.027GlnVal: 3.027 ± 0.027
0.743GlnTrp: 0.743 ± 0.013
1.422GlnTyr: 1.422 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
3.335ArgAla: 3.335 ± 0.027
0.776ArgCys: 0.776 ± 0.015
2.627ArgAsp: 2.627 ± 0.025
2.412ArgGlu: 2.412 ± 0.028
2.162ArgPhe: 2.162 ± 0.023
2.392ArgGly: 2.392 ± 0.029
1.999ArgHis: 1.999 ± 0.023
2.575ArgIle: 2.575 ± 0.023
3.03ArgLys: 3.03 ± 0.033
5.644ArgLeu: 5.644 ± 0.045
1.325ArgMet: 1.325 ± 0.018
1.884ArgAsn: 1.884 ± 0.023
2.919ArgPro: 2.919 ± 0.031
3.184ArgGln: 3.184 ± 0.03
4.05ArgArg: 4.05 ± 0.046
4.123ArgSer: 4.123 ± 0.035
2.71ArgThr: 2.71 ± 0.026
2.835ArgVal: 2.835 ± 0.026
0.745ArgTrp: 0.745 ± 0.016
1.74ArgTyr: 1.74 ± 0.021
0.0ArgXaa: 0.0 ± 0.0
Ser
5.742SerAla: 5.742 ± 0.041
1.046SerCys: 1.046 ± 0.018
4.046SerAsp: 4.046 ± 0.032
2.98SerGlu: 2.98 ± 0.026
3.18SerPhe: 3.18 ± 0.027
3.803SerGly: 3.803 ± 0.038
2.302SerHis: 2.302 ± 0.027
4.082SerIle: 4.082 ± 0.035
3.766SerLys: 3.766 ± 0.036
8.17SerLeu: 8.17 ± 0.061
2.186SerMet: 2.186 ± 0.023
3.193SerAsn: 3.193 ± 0.031
5.698SerPro: 5.698 ± 0.052
3.465SerGln: 3.465 ± 0.028
3.733SerArg: 3.733 ± 0.041
9.658SerSer: 9.658 ± 0.09
5.957SerThr: 5.957 ± 0.053
4.566SerVal: 4.566 ± 0.036
0.96SerTrp: 0.96 ± 0.015
2.155SerTyr: 2.155 ± 0.023
0.0SerXaa: 0.0 ± 0.0
Thr
4.571ThrAla: 4.571 ± 0.041
0.942ThrCys: 0.942 ± 0.015
3.201ThrAsp: 3.201 ± 0.03
2.576ThrGlu: 2.576 ± 0.027
2.465ThrPhe: 2.465 ± 0.028
3.143ThrGly: 3.143 ± 0.044
1.607ThrHis: 1.607 ± 0.022
3.287ThrIle: 3.287 ± 0.028
3.097ThrLys: 3.097 ± 0.03
6.253ThrLeu: 6.253 ± 0.038
1.748ThrMet: 1.748 ± 0.02
2.666ThrAsn: 2.666 ± 0.027
4.171ThrPro: 4.171 ± 0.037
2.363ThrGln: 2.363 ± 0.026
2.79ThrArg: 2.79 ± 0.027
6.124ThrSer: 6.124 ± 0.048
4.754ThrThr: 4.754 ± 0.071
3.784ThrVal: 3.784 ± 0.044
0.78ThrTrp: 0.78 ± 0.012
1.723ThrTyr: 1.723 ± 0.021
0.0ThrXaa: 0.0 ± 0.0
Val
4.716ValAla: 4.716 ± 0.035
1.015ValCys: 1.015 ± 0.016
4.086ValAsp: 4.086 ± 0.036
3.129ValGlu: 3.129 ± 0.03
2.622ValPhe: 2.622 ± 0.025
3.167ValGly: 3.167 ± 0.037
1.749ValHis: 1.749 ± 0.02
3.252ValIle: 3.252 ± 0.035
3.085ValLys: 3.085 ± 0.032
6.016ValLeu: 6.016 ± 0.043
1.596ValMet: 1.596 ± 0.019
2.453ValAsn: 2.453 ± 0.029
3.394ValPro: 3.394 ± 0.034
2.825ValGln: 2.825 ± 0.025
2.87ValArg: 2.87 ± 0.029
4.461ValSer: 4.461 ± 0.031
3.752ValThr: 3.752 ± 0.043
4.152ValVal: 4.152 ± 0.042
0.764ValTrp: 0.764 ± 0.015
2.094ValTyr: 2.094 ± 0.023
0.0ValXaa: 0.0 ± 0.0
Trp
0.808TrpAla: 0.808 ± 0.015
0.232TrpCys: 0.232 ± 0.007
0.759TrpAsp: 0.759 ± 0.013
0.574TrpGlu: 0.574 ± 0.012
0.563TrpPhe: 0.563 ± 0.01
0.547TrpGly: 0.547 ± 0.013
0.431TrpHis: 0.431 ± 0.01
0.74TrpIle: 0.74 ± 0.013
0.717TrpLys: 0.717 ± 0.013
1.358TrpLeu: 1.358 ± 0.019
0.402TrpMet: 0.402 ± 0.01
0.55TrpAsn: 0.55 ± 0.014
0.498TrpPro: 0.498 ± 0.01
0.73TrpGln: 0.73 ± 0.014
0.704TrpArg: 0.704 ± 0.013
0.972TrpSer: 0.972 ± 0.015
0.851TrpThr: 0.851 ± 0.014
0.733TrpVal: 0.733 ± 0.014
0.215TrpTrp: 0.215 ± 0.008
0.413TrpTyr: 0.413 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.12TyrAla: 2.12 ± 0.024
0.575TyrCys: 0.575 ± 0.011
1.944TyrAsp: 1.944 ± 0.023
1.583TyrGlu: 1.583 ± 0.019
1.415TyrPhe: 1.415 ± 0.019
1.906TyrGly: 1.906 ± 0.022
1.026TyrHis: 1.026 ± 0.015
1.533TyrIle: 1.533 ± 0.019
1.351TyrLys: 1.351 ± 0.017
3.216TyrLeu: 3.216 ± 0.028
0.765TyrMet: 0.765 ± 0.014
1.25TyrAsn: 1.25 ± 0.017
1.572TyrPro: 1.572 ± 0.025
1.666TyrGln: 1.666 ± 0.018
1.734TyrArg: 1.734 ± 0.02
1.983TyrSer: 1.983 ± 0.024
1.743TyrThr: 1.743 ± 0.022
1.849TyrVal: 1.849 ± 0.024
0.421TyrTrp: 0.421 ± 0.009
1.167TyrTyr: 1.167 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11058 proteins (4440516 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski