Amino acid dipepetide frequency for Dickeya phage vB_DsoM_JA11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.63AlaAla: 6.63 ± 0.415
0.627AlaCys: 0.627 ± 0.096
4.925AlaAsp: 4.925 ± 0.243
5.138AlaGlu: 5.138 ± 0.318
3.258AlaPhe: 3.258 ± 0.189
4.248AlaGly: 4.248 ± 0.302
1.541AlaHis: 1.541 ± 0.14
5.026AlaIle: 5.026 ± 0.28
5.991AlaLys: 5.991 ± 0.4
6.354AlaLeu: 6.354 ± 0.289
1.943AlaMet: 1.943 ± 0.161
3.797AlaAsn: 3.797 ± 0.246
3.07AlaPro: 3.07 ± 0.225
2.933AlaGln: 2.933 ± 0.2
4.211AlaArg: 4.211 ± 0.225
4.474AlaSer: 4.474 ± 0.247
4.349AlaThr: 4.349 ± 0.298
4.574AlaVal: 4.574 ± 0.239
0.614AlaTrp: 0.614 ± 0.075
2.481AlaTyr: 2.481 ± 0.221
0.0AlaXaa: 0.0 ± 0.0
Cys
0.739CysAla: 0.739 ± 0.102
0.138CysCys: 0.138 ± 0.041
0.727CysAsp: 0.727 ± 0.101
0.852CysGlu: 0.852 ± 0.122
0.539CysPhe: 0.539 ± 0.071
0.877CysGly: 0.877 ± 0.093
0.276CysHis: 0.276 ± 0.063
0.652CysIle: 0.652 ± 0.1
0.664CysLys: 0.664 ± 0.105
0.978CysLeu: 0.978 ± 0.115
0.326CysMet: 0.326 ± 0.061
0.326CysAsn: 0.326 ± 0.062
0.752CysPro: 0.752 ± 0.099
0.238CysGln: 0.238 ± 0.059
0.576CysArg: 0.576 ± 0.093
0.664CysSer: 0.664 ± 0.096
0.551CysThr: 0.551 ± 0.099
0.714CysVal: 0.714 ± 0.105
0.075CysTrp: 0.075 ± 0.03
0.376CysTyr: 0.376 ± 0.069
0.0CysXaa: 0.0 ± 0.0
Asp
4.7AspAla: 4.7 ± 0.293
0.614AspCys: 0.614 ± 0.098
5.213AspAsp: 5.213 ± 0.642
5.439AspGlu: 5.439 ± 0.591
3.346AspPhe: 3.346 ± 0.218
4.624AspGly: 4.624 ± 0.363
0.927AspHis: 0.927 ± 0.103
4.111AspIle: 4.111 ± 0.235
3.459AspLys: 3.459 ± 0.255
5.84AspLeu: 5.84 ± 0.304
1.516AspMet: 1.516 ± 0.148
2.506AspAsn: 2.506 ± 0.175
3.396AspPro: 3.396 ± 0.206
2.08AspGln: 2.08 ± 0.15
2.995AspArg: 2.995 ± 0.167
4.624AspSer: 4.624 ± 0.348
3.221AspThr: 3.221 ± 0.217
4.123AspVal: 4.123 ± 0.231
0.915AspTrp: 0.915 ± 0.114
2.406AspTyr: 2.406 ± 0.172
0.0AspXaa: 0.0 ± 0.0
Glu
4.975GluAla: 4.975 ± 0.253
0.551GluCys: 0.551 ± 0.089
5.502GluAsp: 5.502 ± 0.644
6.003GluGlu: 6.003 ± 0.679
2.983GluPhe: 2.983 ± 0.209
3.221GluGly: 3.221 ± 0.245
1.454GluHis: 1.454 ± 0.128
4.675GluIle: 4.675 ± 0.255
4.599GluLys: 4.599 ± 0.346
5.79GluLeu: 5.79 ± 0.338
1.98GluMet: 1.98 ± 0.157
3.547GluAsn: 3.547 ± 0.206
1.867GluPro: 1.867 ± 0.145
2.456GluGln: 2.456 ± 0.177
3.121GluArg: 3.121 ± 0.196
4.411GluSer: 4.411 ± 0.265
3.471GluThr: 3.471 ± 0.25
4.474GluVal: 4.474 ± 0.256
0.902GluTrp: 0.902 ± 0.106
2.381GluTyr: 2.381 ± 0.173
0.0GluXaa: 0.0 ± 0.0
Phe
3.133PheAla: 3.133 ± 0.214
0.639PheCys: 0.639 ± 0.105
3.647PheAsp: 3.647 ± 0.287
3.271PheGlu: 3.271 ± 0.21
1.516PhePhe: 1.516 ± 0.156
3.07PheGly: 3.07 ± 0.194
0.702PheHis: 0.702 ± 0.089
2.72PheIle: 2.72 ± 0.207
2.356PheLys: 2.356 ± 0.166
3.096PheLeu: 3.096 ± 0.22
0.952PheMet: 0.952 ± 0.102
2.331PheAsn: 2.331 ± 0.161
1.755PhePro: 1.755 ± 0.169
1.053PheGln: 1.053 ± 0.134
2.331PheArg: 2.331 ± 0.186
3.108PheSer: 3.108 ± 0.218
2.632PheThr: 2.632 ± 0.193
3.008PheVal: 3.008 ± 0.165
0.363PheTrp: 0.363 ± 0.069
1.541PheTyr: 1.541 ± 0.161
0.0PheXaa: 0.0 ± 0.0
Gly
4.436GlyAla: 4.436 ± 0.289
0.576GlyCys: 0.576 ± 0.079
3.634GlyAsp: 3.634 ± 0.244
3.847GlyGlu: 3.847 ± 0.22
2.682GlyPhe: 2.682 ± 0.161
3.797GlyGly: 3.797 ± 0.311
0.815GlyHis: 0.815 ± 0.105
3.647GlyIle: 3.647 ± 0.225
5.276GlyLys: 5.276 ± 0.271
4.098GlyLeu: 4.098 ± 0.284
1.704GlyMet: 1.704 ± 0.132
3.008GlyAsn: 3.008 ± 0.302
1.153GlyPro: 1.153 ± 0.246
1.729GlyGln: 1.729 ± 0.164
2.832GlyArg: 2.832 ± 0.195
4.662GlySer: 4.662 ± 0.333
4.286GlyThr: 4.286 ± 0.328
4.061GlyVal: 4.061 ± 0.229
0.764GlyTrp: 0.764 ± 0.103
2.494GlyTyr: 2.494 ± 0.191
0.0GlyXaa: 0.0 ± 0.0
His
1.341HisAla: 1.341 ± 0.142
0.389HisCys: 0.389 ± 0.084
0.852HisAsp: 0.852 ± 0.114
1.341HisGlu: 1.341 ± 0.119
0.927HisPhe: 0.927 ± 0.133
1.228HisGly: 1.228 ± 0.104
0.301HisHis: 0.301 ± 0.065
1.103HisIle: 1.103 ± 0.099
1.354HisLys: 1.354 ± 0.126
1.354HisLeu: 1.354 ± 0.135
0.489HisMet: 0.489 ± 0.069
0.927HisAsn: 0.927 ± 0.122
0.739HisPro: 0.739 ± 0.104
0.288HisGln: 0.288 ± 0.054
1.166HisArg: 1.166 ± 0.127
1.053HisSer: 1.053 ± 0.127
0.915HisThr: 0.915 ± 0.106
1.441HisVal: 1.441 ± 0.126
0.213HisTrp: 0.213 ± 0.049
0.89HisTyr: 0.89 ± 0.113
0.0HisXaa: 0.0 ± 0.0
Ile
4.863IleAla: 4.863 ± 0.241
0.777IleCys: 0.777 ± 0.092
4.023IleAsp: 4.023 ± 0.235
4.487IleGlu: 4.487 ± 0.252
2.168IlePhe: 2.168 ± 0.181
3.672IleGly: 3.672 ± 0.236
1.354IleHis: 1.354 ± 0.128
2.732IleIle: 2.732 ± 0.186
3.76IleLys: 3.76 ± 0.206
4.612IleLeu: 4.612 ± 0.26
1.354IleMet: 1.354 ± 0.142
2.933IleAsn: 2.933 ± 0.233
3.384IlePro: 3.384 ± 0.209
2.469IleGln: 2.469 ± 0.18
3.672IleArg: 3.672 ± 0.242
4.8IleSer: 4.8 ± 0.233
3.346IleThr: 3.346 ± 0.215
4.499IleVal: 4.499 ± 0.206
0.564IleTrp: 0.564 ± 0.087
1.817IleTyr: 1.817 ± 0.142
0.0IleXaa: 0.0 ± 0.0
Lys
5.163LysAla: 5.163 ± 0.387
0.439LysCys: 0.439 ± 0.075
3.634LysAsp: 3.634 ± 0.218
4.411LysGlu: 4.411 ± 0.286
2.933LysPhe: 2.933 ± 0.219
3.509LysGly: 3.509 ± 0.245
1.291LysHis: 1.291 ± 0.151
3.935LysIle: 3.935 ± 0.237
6.768LysLys: 6.768 ± 0.604
6.053LysLeu: 6.053 ± 0.324
1.767LysMet: 1.767 ± 0.154
3.208LysAsn: 3.208 ± 0.207
2.732LysPro: 2.732 ± 0.229
2.657LysGln: 2.657 ± 0.196
3.609LysArg: 3.609 ± 0.196
4.499LysSer: 4.499 ± 0.314
4.474LysThr: 4.474 ± 0.255
4.587LysVal: 4.587 ± 0.228
0.576LysTrp: 0.576 ± 0.087
2.494LysTyr: 2.494 ± 0.184
0.0LysXaa: 0.0 ± 0.0
Leu
6.392LeuAla: 6.392 ± 0.26
0.89LeuCys: 0.89 ± 0.116
5.151LeuAsp: 5.151 ± 0.245
5.602LeuGlu: 5.602 ± 0.32
3.509LeuPhe: 3.509 ± 0.24
4.123LeuGly: 4.123 ± 0.235
1.704LeuHis: 1.704 ± 0.145
4.662LeuIle: 4.662 ± 0.255
5.301LeuLys: 5.301 ± 0.335
6.392LeuLeu: 6.392 ± 0.257
2.168LeuMet: 2.168 ± 0.164
4.775LeuAsn: 4.775 ± 0.266
4.148LeuPro: 4.148 ± 0.246
2.369LeuGln: 2.369 ± 0.164
5.051LeuArg: 5.051 ± 0.249
6.83LeuSer: 6.83 ± 0.367
4.449LeuThr: 4.449 ± 0.239
5.213LeuVal: 5.213 ± 0.266
0.764LeuTrp: 0.764 ± 0.099
2.694LeuTyr: 2.694 ± 0.236
0.0LeuXaa: 0.0 ± 0.0
Met
1.892MetAla: 1.892 ± 0.157
0.401MetCys: 0.401 ± 0.077
1.454MetAsp: 1.454 ± 0.144
1.792MetGlu: 1.792 ± 0.153
1.128MetPhe: 1.128 ± 0.101
0.99MetGly: 0.99 ± 0.111
0.351MetHis: 0.351 ± 0.07
1.404MetIle: 1.404 ± 0.136
1.892MetLys: 1.892 ± 0.169
2.08MetLeu: 2.08 ± 0.161
0.652MetMet: 0.652 ± 0.105
0.978MetAsn: 0.978 ± 0.125
1.303MetPro: 1.303 ± 0.145
1.14MetGln: 1.14 ± 0.123
1.654MetArg: 1.654 ± 0.168
2.068MetSer: 2.068 ± 0.165
1.391MetThr: 1.391 ± 0.13
1.278MetVal: 1.278 ± 0.122
0.238MetTrp: 0.238 ± 0.056
0.84MetTyr: 0.84 ± 0.095
0.0MetXaa: 0.0 ± 0.0
Asn
4.111AsnAla: 4.111 ± 0.206
0.564AsnCys: 0.564 ± 0.089
2.682AsnAsp: 2.682 ± 0.202
2.707AsnGlu: 2.707 ± 0.198
2.369AsnPhe: 2.369 ± 0.197
3.547AsnGly: 3.547 ± 0.237
0.576AsnHis: 0.576 ± 0.086
3.309AsnIle: 3.309 ± 0.194
3.121AsnLys: 3.121 ± 0.174
3.973AsnLeu: 3.973 ± 0.246
1.228AsnMet: 1.228 ± 0.13
2.055AsnAsn: 2.055 ± 0.172
2.419AsnPro: 2.419 ± 0.168
1.717AsnGln: 1.717 ± 0.147
2.055AsnArg: 2.055 ± 0.173
3.309AsnSer: 3.309 ± 0.218
2.757AsnThr: 2.757 ± 0.207
3.522AsnVal: 3.522 ± 0.218
0.564AsnTrp: 0.564 ± 0.079
1.604AsnTyr: 1.604 ± 0.139
0.0AsnXaa: 0.0 ± 0.0
Pro
2.92ProAla: 2.92 ± 0.247
0.551ProCys: 0.551 ± 0.094
3.221ProAsp: 3.221 ± 0.202
3.346ProGlu: 3.346 ± 0.225
1.955ProPhe: 1.955 ± 0.157
1.98ProGly: 1.98 ± 0.185
0.677ProHis: 0.677 ± 0.096
2.682ProIle: 2.682 ± 0.153
3.471ProLys: 3.471 ± 0.252
3.196ProLeu: 3.196 ± 0.201
0.978ProMet: 0.978 ± 0.095
2.043ProAsn: 2.043 ± 0.147
1.203ProPro: 1.203 ± 0.129
1.178ProGln: 1.178 ± 0.135
1.943ProArg: 1.943 ± 0.176
2.882ProSer: 2.882 ± 0.227
2.882ProThr: 2.882 ± 0.227
3.396ProVal: 3.396 ± 0.208
0.301ProTrp: 0.301 ± 0.065
1.341ProTyr: 1.341 ± 0.147
0.0ProXaa: 0.0 ± 0.0
Gln
2.519GlnAla: 2.519 ± 0.163
0.276GlnCys: 0.276 ± 0.058
1.855GlnAsp: 1.855 ± 0.139
2.018GlnGlu: 2.018 ± 0.161
1.391GlnPhe: 1.391 ± 0.132
1.554GlnGly: 1.554 ± 0.156
0.677GlnHis: 0.677 ± 0.093
2.92GlnIle: 2.92 ± 0.186
2.331GlnLys: 2.331 ± 0.16
3.07GlnLeu: 3.07 ± 0.224
0.777GlnMet: 0.777 ± 0.099
1.855GlnAsn: 1.855 ± 0.159
1.228GlnPro: 1.228 ± 0.135
1.354GlnGln: 1.354 ± 0.157
1.792GlnArg: 1.792 ± 0.157
2.181GlnSer: 2.181 ± 0.183
2.143GlnThr: 2.143 ± 0.156
2.03GlnVal: 2.03 ± 0.187
0.476GlnTrp: 0.476 ± 0.084
1.441GlnTyr: 1.441 ± 0.137
0.0GlnXaa: 0.0 ± 0.0
Arg
3.735ArgAla: 3.735 ± 0.237
0.652ArgCys: 0.652 ± 0.097
3.283ArgAsp: 3.283 ± 0.192
3.058ArgGlu: 3.058 ± 0.206
2.306ArgPhe: 2.306 ± 0.175
2.995ArgGly: 2.995 ± 0.226
0.99ArgHis: 0.99 ± 0.113
3.835ArgIle: 3.835 ± 0.233
3.885ArgLys: 3.885 ± 0.283
4.687ArgLeu: 4.687 ± 0.245
1.604ArgMet: 1.604 ± 0.124
2.87ArgAsn: 2.87 ± 0.227
1.755ArgPro: 1.755 ± 0.174
1.892ArgGln: 1.892 ± 0.158
3.033ArgArg: 3.033 ± 0.228
3.296ArgSer: 3.296 ± 0.21
2.97ArgThr: 2.97 ± 0.184
3.772ArgVal: 3.772 ± 0.207
0.576ArgTrp: 0.576 ± 0.064
1.98ArgTyr: 1.98 ± 0.161
0.0ArgXaa: 0.0 ± 0.0
Ser
5.803SerAla: 5.803 ± 0.299
0.727SerCys: 0.727 ± 0.092
4.913SerAsp: 4.913 ± 0.281
4.812SerGlu: 4.812 ± 0.33
2.945SerPhe: 2.945 ± 0.227
4.875SerGly: 4.875 ± 0.271
1.216SerHis: 1.216 ± 0.109
4.161SerIle: 4.161 ± 0.231
4.186SerLys: 4.186 ± 0.299
5.928SerLeu: 5.928 ± 0.299
1.78SerMet: 1.78 ± 0.164
3.409SerAsn: 3.409 ± 0.221
2.908SerPro: 2.908 ± 0.209
2.105SerGln: 2.105 ± 0.173
3.096SerArg: 3.096 ± 0.213
4.7SerSer: 4.7 ± 0.338
3.985SerThr: 3.985 ± 0.253
5.063SerVal: 5.063 ± 0.277
0.576SerTrp: 0.576 ± 0.087
2.406SerTyr: 2.406 ± 0.198
0.0SerXaa: 0.0 ± 0.0
Thr
4.574ThrAla: 4.574 ± 0.281
0.652ThrCys: 0.652 ± 0.101
3.522ThrAsp: 3.522 ± 0.236
3.196ThrGlu: 3.196 ± 0.225
2.519ThrPhe: 2.519 ± 0.177
4.349ThrGly: 4.349 ± 0.317
1.178ThrHis: 1.178 ± 0.113
3.772ThrIle: 3.772 ± 0.23
3.584ThrLys: 3.584 ± 0.256
5.602ThrLeu: 5.602 ± 0.277
1.028ThrMet: 1.028 ± 0.128
2.506ThrAsn: 2.506 ± 0.192
3.045ThrPro: 3.045 ± 0.255
1.955ThrGln: 1.955 ± 0.196
2.632ThrArg: 2.632 ± 0.166
3.559ThrSer: 3.559 ± 0.224
2.857ThrThr: 2.857 ± 0.24
4.775ThrVal: 4.775 ± 0.295
0.702ThrTrp: 0.702 ± 0.095
1.943ThrTyr: 1.943 ± 0.188
0.0ThrXaa: 0.0 ± 0.0
Val
4.875ValAla: 4.875 ± 0.247
0.764ValCys: 0.764 ± 0.113
4.812ValAsp: 4.812 ± 0.259
4.587ValGlu: 4.587 ± 0.228
2.682ValPhe: 2.682 ± 0.171
3.91ValGly: 3.91 ± 0.236
1.128ValHis: 1.128 ± 0.116
3.509ValIle: 3.509 ± 0.219
4.173ValLys: 4.173 ± 0.267
5.615ValLeu: 5.615 ± 0.261
1.404ValMet: 1.404 ± 0.148
2.995ValAsn: 2.995 ± 0.198
3.459ValPro: 3.459 ± 0.219
2.519ValGln: 2.519 ± 0.168
4.487ValArg: 4.487 ± 0.222
5.276ValSer: 5.276 ± 0.273
4.324ValThr: 4.324 ± 0.238
5.752ValVal: 5.752 ± 0.311
0.89ValTrp: 0.89 ± 0.103
2.406ValTyr: 2.406 ± 0.202
0.0ValXaa: 0.0 ± 0.0
Trp
0.702TrpAla: 0.702 ± 0.097
0.175TrpCys: 0.175 ± 0.046
0.489TrpAsp: 0.489 ± 0.074
0.627TrpGlu: 0.627 ± 0.091
0.464TrpPhe: 0.464 ± 0.074
0.564TrpGly: 0.564 ± 0.095
0.401TrpHis: 0.401 ± 0.068
0.664TrpIle: 0.664 ± 0.09
0.639TrpLys: 0.639 ± 0.103
0.84TrpLeu: 0.84 ± 0.087
0.326TrpMet: 0.326 ± 0.071
0.501TrpAsn: 0.501 ± 0.089
0.414TrpPro: 0.414 ± 0.074
0.476TrpGln: 0.476 ± 0.069
0.727TrpArg: 0.727 ± 0.102
0.576TrpSer: 0.576 ± 0.084
0.777TrpThr: 0.777 ± 0.105
0.739TrpVal: 0.739 ± 0.1
0.05TrpTrp: 0.05 ± 0.031
0.338TrpTyr: 0.338 ± 0.064
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.682TyrAla: 2.682 ± 0.234
0.639TyrCys: 0.639 ± 0.102
2.519TyrAsp: 2.519 ± 0.163
1.83TyrGlu: 1.83 ± 0.152
1.604TyrPhe: 1.604 ± 0.143
2.369TyrGly: 2.369 ± 0.163
0.752TyrHis: 0.752 ± 0.104
1.767TyrIle: 1.767 ± 0.166
1.943TyrLys: 1.943 ± 0.168
2.632TyrLeu: 2.632 ± 0.196
0.94TyrMet: 0.94 ± 0.119
1.617TyrAsn: 1.617 ± 0.157
1.416TyrPro: 1.416 ± 0.142
1.278TyrGln: 1.278 ± 0.128
2.193TyrArg: 2.193 ± 0.205
2.619TyrSer: 2.619 ± 0.177
2.168TyrThr: 2.168 ± 0.2
2.544TyrVal: 2.544 ± 0.177
0.363TyrTrp: 0.363 ± 0.069
1.303TyrTyr: 1.303 ± 0.137
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 321 proteins (79794 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski