Amino acid dipepetide frequency for Streptococcus sanguinis (strain SK36)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.253AlaAla: 7.253 ± 0.167	0.554AlaCys: 0.554 ± 0.029	4.7AlaAsp: 4.7 ± 0.106	5.904AlaGlu: 5.904 ± 0.105	3.528AlaPhe: 3.528 ± 0.078	5.912AlaGly: 5.912 ± 0.104	1.274AlaHis: 1.274 ± 0.045	5.438AlaIle: 5.438 ± 0.108	5.052AlaLys: 5.052 ± 0.103	7.87AlaLeu: 7.87 ± 0.12	1.811AlaMet: 1.811 ± 0.053	3.106AlaAsn: 3.106 ± 0.065	2.356AlaPro: 2.356 ± 0.084	3.48AlaGln: 3.48 ± 0.091	3.001AlaArg: 3.001 ± 0.079	5.235AlaSer: 5.235 ± 0.365	4.001AlaThr: 4.001 ± 0.087	5.836AlaVal: 5.836 ± 0.107	0.682AlaTrp: 0.682 ± 0.035	2.792AlaTyr: 2.792 ± 0.07	0.0AlaXaa: 0.0 ± 0.0
Cys	0.321CysAla: 0.321 ± 0.021	0.044CysCys: 0.044 ± 0.008	0.277CysAsp: 0.277 ± 0.021	0.234CysGlu: 0.234 ± 0.019	0.305CysPhe: 0.305 ± 0.024	0.45CysGly: 0.45 ± 0.028	0.146CysHis: 0.146 ± 0.015	0.314CysIle: 0.314 ± 0.02	0.23CysLys: 0.23 ± 0.017	0.676CysLeu: 0.676 ± 0.029	0.122CysMet: 0.122 ± 0.013	0.185CysAsn: 0.185 ± 0.014	0.217CysPro: 0.217 ± 0.019	0.327CysGln: 0.327 ± 0.023	0.251CysArg: 0.251 ± 0.019	0.379CysSer: 0.379 ± 0.023	0.209CysThr: 0.209 ± 0.017	0.312CysVal: 0.312 ± 0.021	0.053CysTrp: 0.053 ± 0.007	0.199CysTyr: 0.199 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.782AspAla: 3.782 ± 0.087	0.311AspCys: 0.311 ± 0.022	2.789AspAsp: 2.789 ± 0.077	4.002AspGlu: 4.002 ± 0.076	3.471AspPhe: 3.471 ± 0.084	3.98AspGly: 3.98 ± 0.099	0.926AspHis: 0.926 ± 0.039	4.144AspIle: 4.144 ± 0.088	4.281AspLys: 4.281 ± 0.084	6.027AspLeu: 6.027 ± 0.111	1.429AspMet: 1.429 ± 0.048	2.221AspAsn: 2.221 ± 0.067	1.744AspPro: 1.744 ± 0.062	2.17AspGln: 2.17 ± 0.053	2.102AspArg: 2.102 ± 0.06	3.44AspSer: 3.44 ± 0.111	2.559AspThr: 2.559 ± 0.059	3.588AspVal: 3.588 ± 0.08	0.744AspTrp: 0.744 ± 0.035	2.941AspTyr: 2.941 ± 0.075	0.0AspXaa: 0.0 ± 0.0
Glu	5.969GluAla: 5.969 ± 0.116	0.27GluCys: 0.27 ± 0.021	3.822GluAsp: 3.822 ± 0.075	6.451GluGlu: 6.451 ± 0.121	2.724GluPhe: 2.724 ± 0.067	3.907GluGly: 3.907 ± 0.077	1.282GluHis: 1.282 ± 0.046	5.12GluIle: 5.12 ± 0.102	6.091GluLys: 6.091 ± 0.096	7.077GluLeu: 7.077 ± 0.131	1.815GluMet: 1.815 ± 0.049	3.739GluAsn: 3.739 ± 0.075	1.723GluPro: 1.723 ± 0.056	3.181GluGln: 3.181 ± 0.077	3.401GluArg: 3.401 ± 0.073	3.595GluSer: 3.595 ± 0.086	3.734GluThr: 3.734 ± 0.083	4.717GluVal: 4.717 ± 0.105	0.598GluTrp: 0.598 ± 0.028	2.008GluTyr: 2.008 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	3.467PheAla: 3.467 ± 0.063	0.28PheCys: 0.28 ± 0.021	2.981PheAsp: 2.981 ± 0.063	3.08PheGlu: 3.08 ± 0.073	2.292PhePhe: 2.292 ± 0.073	3.37PheGly: 3.37 ± 0.089	0.827PheHis: 0.827 ± 0.034	2.958PheIle: 2.958 ± 0.077	2.522PheLys: 2.522 ± 0.073	4.854PheLeu: 4.854 ± 0.108	1.055PheMet: 1.055 ± 0.042	1.785PheAsn: 1.785 ± 0.053	1.569PhePro: 1.569 ± 0.052	1.638PheGln: 1.638 ± 0.054	1.52PheArg: 1.52 ± 0.05	3.441PheSer: 3.441 ± 0.078	2.409PheThr: 2.409 ± 0.082	3.176PheVal: 3.176 ± 0.074	0.516PheTrp: 0.516 ± 0.027	1.893PheTyr: 1.893 ± 0.068	0.0PheXaa: 0.0 ± 0.0
Gly	4.871GlyAla: 4.871 ± 0.09	0.419GlyCys: 0.419 ± 0.023	3.461GlyAsp: 3.461 ± 0.078	3.686GlyGlu: 3.686 ± 0.07	3.261GlyPhe: 3.261 ± 0.066	4.396GlyGly: 4.396 ± 0.093	1.302GlyHis: 1.302 ± 0.045	4.968GlyIle: 4.968 ± 0.095	4.761GlyLys: 4.761 ± 0.095	7.344GlyLeu: 7.344 ± 0.099	1.727GlyMet: 1.727 ± 0.056	2.74GlyAsn: 2.74 ± 0.08	1.501GlyPro: 1.501 ± 0.046	3.531GlyGln: 3.531 ± 0.097	2.919GlyArg: 2.919 ± 0.07	4.127GlySer: 4.127 ± 0.106	3.96GlyThr: 3.96 ± 0.135	4.572GlyVal: 4.572 ± 0.088	0.673GlyTrp: 0.673 ± 0.032	2.617GlyTyr: 2.617 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	1.169HisAla: 1.169 ± 0.04	0.112HisCys: 0.112 ± 0.013	0.933HisAsp: 0.933 ± 0.04	1.123HisGlu: 1.123 ± 0.045	1.072HisPhe: 1.072 ± 0.038	1.226HisGly: 1.226 ± 0.046	0.493HisHis: 0.493 ± 0.03	1.251HisIle: 1.251 ± 0.044	0.92HisLys: 0.92 ± 0.036	2.003HisLeu: 2.003 ± 0.055	0.395HisMet: 0.395 ± 0.024	0.65HisAsn: 0.65 ± 0.028	0.89HisPro: 0.89 ± 0.042	0.92HisGln: 0.92 ± 0.035	0.851HisArg: 0.851 ± 0.032	1.051HisSer: 1.051 ± 0.039	0.878HisThr: 0.878 ± 0.034	1.081HisVal: 1.081 ± 0.042	0.179HisTrp: 0.179 ± 0.014	0.917HisTyr: 0.917 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	5.685IleAla: 5.685 ± 0.111	0.499IleCys: 0.499 ± 0.027	3.751IleAsp: 3.751 ± 0.082	4.857IleGlu: 4.857 ± 0.099	3.404IlePhe: 3.404 ± 0.084	4.634IleGly: 4.634 ± 0.094	1.234IleHis: 1.234 ± 0.044	4.603IleIle: 4.603 ± 0.103	4.068IleLys: 4.068 ± 0.086	7.216IleLeu: 7.216 ± 0.135	1.572IleMet: 1.572 ± 0.058	2.744IleAsn: 2.744 ± 0.072	2.75IlePro: 2.75 ± 0.06	2.801IleGln: 2.801 ± 0.075	2.835IleArg: 2.835 ± 0.064	4.808IleSer: 4.808 ± 0.104	3.498IleThr: 3.498 ± 0.081	4.573IleVal: 4.573 ± 0.087	0.635IleTrp: 0.635 ± 0.032	2.571IleTyr: 2.571 ± 0.06	0.0IleXaa: 0.0 ± 0.0
Lys	5.008LysAla: 5.008 ± 0.091	0.19LysCys: 0.19 ± 0.017	4.093LysAsp: 4.093 ± 0.086	5.964LysGlu: 5.964 ± 0.098	2.115LysPhe: 2.115 ± 0.059	4.018LysGly: 4.018 ± 0.08	1.101LysHis: 1.101 ± 0.039	4.79LysIle: 4.79 ± 0.102	5.65LysLys: 5.65 ± 0.118	5.903LysLeu: 5.903 ± 0.086	1.929LysMet: 1.929 ± 0.046	3.333LysAsn: 3.333 ± 0.068	2.082LysPro: 2.082 ± 0.06	2.544LysGln: 2.544 ± 0.067	2.911LysArg: 2.911 ± 0.064	3.711LysSer: 3.711 ± 0.076	3.786LysThr: 3.786 ± 0.098	4.398LysVal: 4.398 ± 0.097	0.604LysTrp: 0.604 ± 0.032	2.233LysTyr: 2.233 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	9.54LeuAla: 9.54 ± 0.14	0.514LeuCys: 0.514 ± 0.026	5.939LeuAsp: 5.939 ± 0.095	7.097LeuGlu: 7.097 ± 0.129	4.489LeuPhe: 4.489 ± 0.098	6.731LeuGly: 6.731 ± 0.101	1.612LeuHis: 1.612 ± 0.052	6.567LeuIle: 6.567 ± 0.145	6.179LeuLys: 6.179 ± 0.11	10.791LeuLeu: 10.791 ± 0.192	2.396LeuMet: 2.396 ± 0.07	3.837LeuAsn: 3.837 ± 0.077	4.377LeuPro: 4.377 ± 0.092	3.722LeuGln: 3.722 ± 0.078	3.845LeuArg: 3.845 ± 0.08	7.235LeuSer: 7.235 ± 0.127	6.405LeuThr: 6.405 ± 0.102	6.971LeuVal: 6.971 ± 0.109	0.758LeuTrp: 0.758 ± 0.04	3.357LeuTyr: 3.357 ± 0.08	0.0LeuXaa: 0.0 ± 0.0
Met	1.993MetAla: 1.993 ± 0.06	0.088MetCys: 0.088 ± 0.011	1.312MetAsp: 1.312 ± 0.046	1.541MetGlu: 1.541 ± 0.043	0.751MetPhe: 0.751 ± 0.036	1.551MetGly: 1.551 ± 0.049	0.345MetHis: 0.345 ± 0.023	1.778MetIle: 1.778 ± 0.055	2.035MetLys: 2.035 ± 0.048	2.254MetLeu: 2.254 ± 0.061	0.689MetMet: 0.689 ± 0.031	1.165MetAsn: 1.165 ± 0.044	0.795MetPro: 0.795 ± 0.032	0.917MetGln: 0.917 ± 0.042	1.051MetArg: 1.051 ± 0.042	1.565MetSer: 1.565 ± 0.048	1.792MetThr: 1.792 ± 0.05	1.568MetVal: 1.568 ± 0.05	0.153MetTrp: 0.153 ± 0.015	0.523MetTyr: 0.523 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.933AsnAla: 2.933 ± 0.071	0.226AsnCys: 0.226 ± 0.018	2.095AsnAsp: 2.095 ± 0.069	2.255AsnGlu: 2.255 ± 0.062	1.977AsnPhe: 1.977 ± 0.055	3.184AsnGly: 3.184 ± 0.101	0.905AsnHis: 0.905 ± 0.034	2.988AsnIle: 2.988 ± 0.065	2.531AsnLys: 2.531 ± 0.076	4.366AsnLeu: 4.366 ± 0.091	1.018AsnMet: 1.018 ± 0.042	1.846AsnAsn: 1.846 ± 0.077	2.277AsnPro: 2.277 ± 0.057	2.311AsnGln: 2.311 ± 0.061	1.97AsnArg: 1.97 ± 0.053	2.539AsnSer: 2.539 ± 0.075	1.949AsnThr: 1.949 ± 0.053	2.649AsnVal: 2.649 ± 0.059	0.48AsnTrp: 0.48 ± 0.029	1.748AsnTyr: 1.748 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	2.914ProAla: 2.914 ± 0.087	0.156ProCys: 0.156 ± 0.016	2.37ProAsp: 2.37 ± 0.071	3.117ProGlu: 3.117 ± 0.082	1.622ProPhe: 1.622 ± 0.044	1.895ProGly: 1.895 ± 0.058	0.706ProHis: 0.706 ± 0.033	2.43ProIle: 2.43 ± 0.062	1.993ProLys: 1.993 ± 0.058	3.098ProLeu: 3.098 ± 0.075	0.694ProMet: 0.694 ± 0.035	1.592ProAsn: 1.592 ± 0.059	0.601ProPro: 0.601 ± 0.04	1.596ProGln: 1.596 ± 0.06	0.979ProArg: 0.979 ± 0.039	2.268ProSer: 2.268 ± 0.07	2.169ProThr: 2.169 ± 0.106	2.811ProVal: 2.811 ± 0.065	0.303ProTrp: 0.303 ± 0.018	1.348ProTyr: 1.348 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	4.242GlnAla: 4.242 ± 0.097	0.112GlnCys: 0.112 ± 0.012	2.277GlnAsp: 2.277 ± 0.059	3.886GlnGlu: 3.886 ± 0.083	1.572GlnPhe: 1.572 ± 0.055	2.784GlnGly: 2.784 ± 0.087	0.871GlnHis: 0.871 ± 0.036	2.961GlnIle: 2.961 ± 0.064	3.029GlnLys: 3.029 ± 0.075	4.4GlnLeu: 4.4 ± 0.099	1.038GlnMet: 1.038 ± 0.04	1.789GlnAsn: 1.789 ± 0.055	1.586GlnPro: 1.586 ± 0.066	1.832GlnGln: 1.832 ± 0.077	1.5GlnArg: 1.5 ± 0.052	2.318GlnSer: 2.318 ± 0.062	2.392GlnThr: 2.392 ± 0.061	3.328GlnVal: 3.328 ± 0.074	0.301GlnTrp: 0.301 ± 0.023	1.348GlnTyr: 1.348 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	2.698ArgAla: 2.698 ± 0.065	0.186ArgCys: 0.186 ± 0.016	2.282ArgAsp: 2.282 ± 0.059	3.123ArgGlu: 3.123 ± 0.07	1.959ArgPhe: 1.959 ± 0.051	2.218ArgGly: 2.218 ± 0.058	0.78ArgHis: 0.78 ± 0.033	2.909ArgIle: 2.909 ± 0.073	2.904ArgLys: 2.904 ± 0.068	4.258ArgLeu: 4.258 ± 0.08	1.065ArgMet: 1.065 ± 0.039	1.728ArgAsn: 1.728 ± 0.06	1.395ArgPro: 1.395 ± 0.039	2.089ArgGln: 2.089 ± 0.064	2.003ArgArg: 2.003 ± 0.058	2.241ArgSer: 2.241 ± 0.055	1.959ArgThr: 1.959 ± 0.055	2.828ArgVal: 2.828 ± 0.075	0.324ArgTrp: 0.324 ± 0.02	1.679ArgTyr: 1.679 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	4.505SerAla: 4.505 ± 0.36	0.327SerCys: 0.327 ± 0.02	3.617SerAsp: 3.617 ± 0.124	3.752SerGlu: 3.752 ± 0.085	3.041SerPhe: 3.041 ± 0.076	4.688SerGly: 4.688 ± 0.098	1.202SerHis: 1.202 ± 0.04	3.985SerIle: 3.985 ± 0.092	4.11SerLys: 4.11 ± 0.099	6.919SerLeu: 6.919 ± 0.128	1.486SerMet: 1.486 ± 0.051	2.7SerAsn: 2.7 ± 0.066	2.162SerPro: 2.162 ± 0.056	3.325SerGln: 3.325 ± 0.074	2.576SerArg: 2.576 ± 0.066	4.876SerSer: 4.876 ± 0.163	3.284SerThr: 3.284 ± 0.247	4.207SerVal: 4.207 ± 0.136	0.605SerTrp: 0.605 ± 0.029	2.703SerTyr: 2.703 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	4.646ThrAla: 4.646 ± 0.096	0.283ThrCys: 0.283 ± 0.021	3.349ThrAsp: 3.349 ± 0.077	3.508ThrGlu: 3.508 ± 0.069	2.593ThrPhe: 2.593 ± 0.107	4.231ThrGly: 4.231 ± 0.112	0.942ThrHis: 0.942 ± 0.033	4.104ThrIle: 4.104 ± 0.094	2.914ThrLys: 2.914 ± 0.07	4.984ThrLeu: 4.984 ± 0.086	1.085ThrMet: 1.085 ± 0.039	2.231ThrAsn: 2.231 ± 0.063	2.474ThrPro: 2.474 ± 0.179	1.76ThrGln: 1.76 ± 0.058	1.876ThrArg: 1.876 ± 0.066	3.724ThrSer: 3.724 ± 0.222	2.852ThrThr: 2.852 ± 0.08	4.318ThrVal: 4.318 ± 0.108	0.554ThrTrp: 0.554 ± 0.034	2.306ThrTyr: 2.306 ± 0.074	0.0ThrXaa: 0.0 ± 0.0
Val	5.643ValAla: 5.643 ± 0.097	0.408ValCys: 0.408 ± 0.025	3.86ValAsp: 3.86 ± 0.079	4.748ValGlu: 4.748 ± 0.101	3.103ValPhe: 3.103 ± 0.079	4.521ValGly: 4.521 ± 0.09	1.136ValHis: 1.136 ± 0.044	4.528ValIle: 4.528 ± 0.097	4.366ValLys: 4.366 ± 0.094	6.921ValLeu: 6.921 ± 0.128	1.54ValMet: 1.54 ± 0.044	2.767ValAsn: 2.767 ± 0.066	2.515ValPro: 2.515 ± 0.085	2.512ValGln: 2.512 ± 0.066	2.838ValArg: 2.838 ± 0.068	4.616ValSer: 4.616 ± 0.14	4.443ValThr: 4.443 ± 0.13	4.729ValVal: 4.729 ± 0.097	0.604ValTrp: 0.604 ± 0.031	2.511ValTyr: 2.511 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.621TrpAla: 0.621 ± 0.027	0.055TrpCys: 0.055 ± 0.01	0.51TrpAsp: 0.51 ± 0.029	0.525TrpGlu: 0.525 ± 0.025	0.435TrpPhe: 0.435 ± 0.029	0.643TrpGly: 0.643 ± 0.036	0.182TrpHis: 0.182 ± 0.016	0.618TrpIle: 0.618 ± 0.027	0.581TrpLys: 0.581 ± 0.034	1.143TrpLeu: 1.143 ± 0.045	0.237TrpMet: 0.237 ± 0.019	0.47TrpAsn: 0.47 ± 0.025	0.196TrpPro: 0.196 ± 0.017	0.496TrpGln: 0.496 ± 0.028	0.381TrpArg: 0.381 ± 0.023	0.628TrpSer: 0.628 ± 0.036	0.527TrpThr: 0.527 ± 0.031	0.506TrpVal: 0.506 ± 0.026	0.134TrpTrp: 0.134 ± 0.013	0.382TrpTyr: 0.382 ± 0.032	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.524TyrAla: 2.524 ± 0.059	0.219TyrCys: 0.219 ± 0.022	2.233TyrAsp: 2.233 ± 0.063	2.37TyrGlu: 2.37 ± 0.064	1.919TyrPhe: 1.919 ± 0.064	2.497TyrGly: 2.497 ± 0.075	0.851TyrHis: 0.851 ± 0.037	2.281TyrIle: 2.281 ± 0.061	2.145TyrLys: 2.145 ± 0.055	4.261TyrLeu: 4.261 ± 0.088	0.763TyrMet: 0.763 ± 0.033	1.616TyrAsn: 1.616 ± 0.061	1.451TyrPro: 1.451 ± 0.049	2.414TyrGln: 2.414 ± 0.06	1.819TyrArg: 1.819 ± 0.048	2.272TyrSer: 2.272 ± 0.064	1.93TyrThr: 1.93 ± 0.066	2.142TyrVal: 2.142 ± 0.058	0.371TyrTrp: 0.371 ± 0.024	1.622TyrTyr: 1.622 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2269 proteins (704109 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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