Amino acid dipepetide frequency for Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.986AlaAla: 9.986 ± 0.112	1.186AlaCys: 1.186 ± 0.031	4.872AlaAsp: 4.872 ± 0.056	5.468AlaGlu: 5.468 ± 0.072	3.701AlaPhe: 3.701 ± 0.06	7.528AlaGly: 7.528 ± 0.067	1.982AlaHis: 1.982 ± 0.04	6.006AlaIle: 6.006 ± 0.074	3.762AlaLys: 3.762 ± 0.067	11.93AlaLeu: 11.93 ± 0.104	2.97AlaMet: 2.97 ± 0.049	3.124AlaAsn: 3.124 ± 0.051	3.708AlaPro: 3.708 ± 0.064	4.642AlaGln: 4.642 ± 0.065	5.732AlaArg: 5.732 ± 0.071	5.592AlaSer: 5.592 ± 0.066	4.871AlaThr: 4.871 ± 0.056	6.776AlaVal: 6.776 ± 0.073	1.67AlaTrp: 1.67 ± 0.037	1.953AlaTyr: 1.953 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.134CysAla: 1.134 ± 0.029	0.241CysCys: 0.241 ± 0.013	0.625CysAsp: 0.625 ± 0.023	0.639CysGlu: 0.639 ± 0.02	0.499CysPhe: 0.499 ± 0.018	1.087CysGly: 1.087 ± 0.028	0.384CysHis: 0.384 ± 0.016	0.626CysIle: 0.626 ± 0.022	0.343CysLys: 0.343 ± 0.016	1.072CysLeu: 1.072 ± 0.026	0.285CysMet: 0.285 ± 0.014	0.347CysAsn: 0.347 ± 0.018	0.562CysPro: 0.562 ± 0.021	0.525CysGln: 0.525 ± 0.021	0.757CysArg: 0.757 ± 0.025	0.727CysSer: 0.727 ± 0.021	0.534CysThr: 0.534 ± 0.02	0.811CysVal: 0.811 ± 0.027	0.214CysTrp: 0.214 ± 0.011	0.351CysTyr: 0.351 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.373AspAla: 5.373 ± 0.072	0.54AspCys: 0.54 ± 0.02	3.066AspAsp: 3.066 ± 0.05	3.494AspGlu: 3.494 ± 0.055	2.093AspPhe: 2.093 ± 0.036	3.745AspGly: 3.745 ± 0.06	0.985AspHis: 0.985 ± 0.029	3.485AspIle: 3.485 ± 0.05	2.476AspLys: 2.476 ± 0.045	4.509AspLeu: 4.509 ± 0.062	1.368AspMet: 1.368 ± 0.027	2.21AspAsn: 2.21 ± 0.044	2.169AspPro: 2.169 ± 0.04	1.526AspGln: 1.526 ± 0.039	2.615AspArg: 2.615 ± 0.047	2.752AspSer: 2.752 ± 0.048	2.564AspThr: 2.564 ± 0.045	3.901AspVal: 3.901 ± 0.06	0.788AspTrp: 0.788 ± 0.028	1.828AspTyr: 1.828 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.1GluAla: 5.1 ± 0.072	0.519GluCys: 0.519 ± 0.021	2.294GluAsp: 2.294 ± 0.04	3.34GluGlu: 3.34 ± 0.068	1.736GluPhe: 1.736 ± 0.031	3.641GluGly: 3.641 ± 0.043	1.425GluHis: 1.425 ± 0.035	3.249GluIle: 3.249 ± 0.05	3.244GluLys: 3.244 ± 0.057	5.647GluLeu: 5.647 ± 0.069	1.817GluMet: 1.817 ± 0.035	2.425GluAsn: 2.425 ± 0.045	2.054GluPro: 2.054 ± 0.053	3.368GluGln: 3.368 ± 0.056	3.571GluArg: 3.571 ± 0.054	2.882GluSer: 2.882 ± 0.052	2.992GluThr: 2.992 ± 0.049	3.55GluVal: 3.55 ± 0.046	0.768GluTrp: 0.768 ± 0.027	1.436GluTyr: 1.436 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.838PheAla: 3.838 ± 0.063	0.618PheCys: 0.618 ± 0.022	2.35PheAsp: 2.35 ± 0.039	1.715PheGlu: 1.715 ± 0.033	1.852PhePhe: 1.852 ± 0.049	3.157PheGly: 3.157 ± 0.051	0.875PheHis: 0.875 ± 0.024	2.658PheIle: 2.658 ± 0.05	1.22PheLys: 1.22 ± 0.028	3.488PheLeu: 3.488 ± 0.05	1.051PheMet: 1.051 ± 0.027	1.811PheAsn: 1.811 ± 0.037	1.577PhePro: 1.577 ± 0.035	1.161PheGln: 1.161 ± 0.03	1.998PheArg: 1.998 ± 0.038	3.228PheSer: 3.228 ± 0.046	2.573PheThr: 2.573 ± 0.047	2.627PheVal: 2.627 ± 0.047	0.629PheTrp: 0.629 ± 0.023	1.202PheTyr: 1.202 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	6.368GlyAla: 6.368 ± 0.09	1.052GlyCys: 1.052 ± 0.028	3.772GlyAsp: 3.772 ± 0.062	4.573GlyGlu: 4.573 ± 0.061	3.261GlyPhe: 3.261 ± 0.05	5.321GlyGly: 5.321 ± 0.075	1.673GlyHis: 1.673 ± 0.038	5.099GlyIle: 5.099 ± 0.084	3.909GlyLys: 3.909 ± 0.056	7.442GlyLeu: 7.442 ± 0.083	2.414GlyMet: 2.414 ± 0.044	2.766GlyAsn: 2.766 ± 0.053	1.973GlyPro: 1.973 ± 0.035	2.897GlyGln: 2.897 ± 0.045	3.811GlyArg: 3.811 ± 0.056	4.065GlySer: 4.065 ± 0.063	3.718GlyThr: 3.718 ± 0.058	5.895GlyVal: 5.895 ± 0.075	1.28GlyTrp: 1.28 ± 0.032	2.567GlyTyr: 2.567 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.056HisAla: 2.056 ± 0.036	0.367HisCys: 0.367 ± 0.016	1.24HisAsp: 1.24 ± 0.031	1.1HisGlu: 1.1 ± 0.031	1.163HisPhe: 1.163 ± 0.031	1.729HisGly: 1.729 ± 0.038	0.844HisHis: 0.844 ± 0.028	1.384HisIle: 1.384 ± 0.031	0.759HisLys: 0.759 ± 0.025	2.303HisLeu: 2.303 ± 0.041	0.547HisMet: 0.547 ± 0.019	0.893HisAsn: 0.893 ± 0.024	1.338HisPro: 1.338 ± 0.032	1.202HisGln: 1.202 ± 0.026	1.343HisArg: 1.343 ± 0.037	1.274HisSer: 1.274 ± 0.032	1.132HisThr: 1.132 ± 0.026	1.338HisVal: 1.338 ± 0.032	0.411HisTrp: 0.411 ± 0.017	0.918HisTyr: 0.918 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.574IleAla: 6.574 ± 0.078	0.75IleCys: 0.75 ± 0.022	3.474IleAsp: 3.474 ± 0.055	3.207IleGlu: 3.207 ± 0.055	2.223IlePhe: 2.223 ± 0.046	4.595IleGly: 4.595 ± 0.069	1.245IleHis: 1.245 ± 0.031	3.526IleIle: 3.526 ± 0.055	2.321IleLys: 2.321 ± 0.05	5.152IleLeu: 5.152 ± 0.079	1.338IleMet: 1.338 ± 0.037	2.678IleAsn: 2.678 ± 0.052	2.773IlePro: 2.773 ± 0.047	1.877IleGln: 1.877 ± 0.036	3.135IleArg: 3.135 ± 0.044	3.861IleSer: 3.861 ± 0.05	3.61IleThr: 3.61 ± 0.052	4.04IleVal: 4.04 ± 0.064	0.693IleTrp: 0.693 ± 0.023	1.546IleTyr: 1.546 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.08LysAla: 4.08 ± 0.073	0.311LysCys: 0.311 ± 0.016	1.98LysAsp: 1.98 ± 0.044	2.432LysGlu: 2.432 ± 0.048	1.12LysPhe: 1.12 ± 0.031	2.972LysGly: 2.972 ± 0.051	0.885LysHis: 0.885 ± 0.025	2.316LysIle: 2.316 ± 0.038	2.181LysLys: 2.181 ± 0.039	4.068LysLeu: 4.068 ± 0.055	1.281LysMet: 1.281 ± 0.03	1.79LysAsn: 1.79 ± 0.041	2.091LysPro: 2.091 ± 0.037	1.909LysGln: 1.909 ± 0.037	2.661LysArg: 2.661 ± 0.048	2.253LysSer: 2.253 ± 0.041	2.608LysThr: 2.608 ± 0.046	2.825LysVal: 2.825 ± 0.046	0.421LysTrp: 0.421 ± 0.021	1.142LysTyr: 1.142 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.311LeuAla: 11.311 ± 0.097	1.354LeuCys: 1.354 ± 0.033	5.278LeuAsp: 5.278 ± 0.063	5.34LeuGlu: 5.34 ± 0.061	4.467LeuPhe: 4.467 ± 0.062	7.032LeuGly: 7.032 ± 0.084	2.376LeuHis: 2.376 ± 0.044	5.927LeuIle: 5.927 ± 0.073	4.422LeuLys: 4.422 ± 0.056	11.975LeuLeu: 11.975 ± 0.151	3.039LeuMet: 3.039 ± 0.043	4.357LeuAsn: 4.357 ± 0.056	5.658LeuPro: 5.658 ± 0.079	4.019LeuGln: 4.019 ± 0.062	6.269LeuArg: 6.269 ± 0.073	7.279LeuSer: 7.279 ± 0.076	6.473LeuThr: 6.473 ± 0.063	6.953LeuVal: 6.953 ± 0.078	1.415LeuTrp: 1.415 ± 0.034	2.594LeuTyr: 2.594 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.936MetAla: 2.936 ± 0.047	0.236MetCys: 0.236 ± 0.011	1.22MetAsp: 1.22 ± 0.031	1.225MetGlu: 1.225 ± 0.027	0.921MetPhe: 0.921 ± 0.025	1.953MetGly: 1.953 ± 0.038	0.512MetHis: 0.512 ± 0.02	1.584MetIle: 1.584 ± 0.032	1.42MetLys: 1.42 ± 0.031	3.288MetLeu: 3.288 ± 0.05	0.984MetMet: 0.984 ± 0.028	1.118MetAsn: 1.118 ± 0.029	1.486MetPro: 1.486 ± 0.032	1.232MetGln: 1.232 ± 0.031	1.585MetArg: 1.585 ± 0.033	1.833MetSer: 1.833 ± 0.04	1.804MetThr: 1.804 ± 0.036	1.957MetVal: 1.957 ± 0.035	0.287MetTrp: 0.287 ± 0.013	0.53MetTyr: 0.53 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.739AsnAla: 3.739 ± 0.056	0.376AsnCys: 0.376 ± 0.016	2.077AsnAsp: 2.077 ± 0.042	1.898AsnGlu: 1.898 ± 0.043	1.385AsnPhe: 1.385 ± 0.034	3.078AsnGly: 3.078 ± 0.051	0.886AsnHis: 0.886 ± 0.028	2.403AsnIle: 2.403 ± 0.052	1.556AsnLys: 1.556 ± 0.042	3.546AsnLeu: 3.546 ± 0.052	0.955AsnMet: 0.955 ± 0.025	1.622AsnAsn: 1.622 ± 0.041	2.086AsnPro: 2.086 ± 0.04	1.577AsnGln: 1.577 ± 0.035	2.051AsnArg: 2.051 ± 0.039	2.041AsnSer: 2.041 ± 0.048	2.145AsnThr: 2.145 ± 0.041	2.734AsnVal: 2.734 ± 0.047	0.557AsnTrp: 0.557 ± 0.022	1.199AsnTyr: 1.199 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.577ProAla: 4.577 ± 0.053	0.437ProCys: 0.437 ± 0.016	2.808ProAsp: 2.808 ± 0.047	3.318ProGlu: 3.318 ± 0.063	1.916ProPhe: 1.916 ± 0.034	3.533ProGly: 3.533 ± 0.054	1.074ProHis: 1.074 ± 0.024	1.752ProIle: 1.752 ± 0.036	1.423ProLys: 1.423 ± 0.038	5.126ProLeu: 5.126 ± 0.07	1.082ProMet: 1.082 ± 0.026	1.225ProAsn: 1.225 ± 0.03	1.642ProPro: 1.642 ± 0.039	2.267ProGln: 2.267 ± 0.04	2.007ProArg: 2.007 ± 0.041	2.198ProSer: 2.198 ± 0.038	2.148ProThr: 2.148 ± 0.041	4.003ProVal: 4.003 ± 0.056	0.731ProTrp: 0.731 ± 0.027	1.2ProTyr: 1.2 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.505GlnAla: 4.505 ± 0.061	0.41GlnCys: 0.41 ± 0.019	1.833GlnAsp: 1.833 ± 0.035	2.245GlnGlu: 2.245 ± 0.046	1.532GlnPhe: 1.532 ± 0.035	3.058GlnGly: 3.058 ± 0.046	1.278GlnHis: 1.278 ± 0.029	2.3GlnIle: 2.3 ± 0.036	1.831GlnLys: 1.831 ± 0.045	4.901GlnLeu: 4.901 ± 0.083	1.224GlnMet: 1.224 ± 0.029	1.547GlnAsn: 1.547 ± 0.041	2.154GlnPro: 2.154 ± 0.045	3.279GlnGln: 3.279 ± 0.059	3.19GlnArg: 3.19 ± 0.049	2.287GlnSer: 2.287 ± 0.046	2.343GlnThr: 2.343 ± 0.043	2.988GlnVal: 2.988 ± 0.048	0.688GlnTrp: 0.688 ± 0.024	1.18GlnTyr: 1.18 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	4.598ArgAla: 4.598 ± 0.057	0.711ArgCys: 0.711 ± 0.024	3.069ArgAsp: 3.069 ± 0.05	3.75ArgGlu: 3.75 ± 0.06	2.729ArgPhe: 2.729 ± 0.05	3.394ArgGly: 3.394 ± 0.052	1.744ArgHis: 1.744 ± 0.038	3.496ArgIle: 3.496 ± 0.057	2.364ArgLys: 2.364 ± 0.041	6.409ArgLeu: 6.409 ± 0.071	1.671ArgMet: 1.671 ± 0.032	2.138ArgAsn: 2.138 ± 0.037	2.27ArgPro: 2.27 ± 0.041	3.274ArgGln: 3.274 ± 0.054	3.732ArgArg: 3.732 ± 0.064	2.81ArgSer: 2.81 ± 0.044	2.661ArgThr: 2.661 ± 0.044	3.879ArgVal: 3.879 ± 0.055	0.98ArgTrp: 0.98 ± 0.026	2.2ArgTyr: 2.2 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.719SerAla: 5.719 ± 0.067	0.638SerCys: 0.638 ± 0.021	3.039SerAsp: 3.039 ± 0.047	2.932SerGlu: 2.932 ± 0.046	2.33SerPhe: 2.33 ± 0.041	5.4SerGly: 5.4 ± 0.071	1.448SerHis: 1.448 ± 0.032	3.078SerIle: 3.078 ± 0.042	1.99SerLys: 1.99 ± 0.039	6.666SerLeu: 6.666 ± 0.064	1.531SerMet: 1.531 ± 0.036	1.879SerAsn: 1.879 ± 0.036	2.648SerPro: 2.648 ± 0.04	2.542SerGln: 2.542 ± 0.043	3.468SerArg: 3.468 ± 0.057	3.583SerSer: 3.583 ± 0.058	2.969SerThr: 2.969 ± 0.053	4.315SerVal: 4.315 ± 0.062	0.942SerTrp: 0.942 ± 0.028	1.647SerTyr: 1.647 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.974ThrAla: 4.974 ± 0.06	0.577ThrCys: 0.577 ± 0.018	2.593ThrAsp: 2.593 ± 0.042	2.655ThrGlu: 2.655 ± 0.043	2.183ThrPhe: 2.183 ± 0.039	4.7ThrGly: 4.7 ± 0.058	1.295ThrHis: 1.295 ± 0.03	2.918ThrIle: 2.918 ± 0.05	1.537ThrLys: 1.537 ± 0.036	7.56ThrLeu: 7.56 ± 0.076	1.178ThrMet: 1.178 ± 0.03	1.609ThrAsn: 1.609 ± 0.034	3.257ThrPro: 3.257 ± 0.053	2.31ThrGln: 2.31 ± 0.043	3.193ThrArg: 3.193 ± 0.047	2.945ThrSer: 2.945 ± 0.053	2.997ThrThr: 2.997 ± 0.05	3.982ThrVal: 3.982 ± 0.058	0.829ThrTrp: 0.829 ± 0.023	1.166ThrTyr: 1.166 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.088ValAla: 7.088 ± 0.082	0.852ValCys: 0.852 ± 0.025	3.743ValAsp: 3.743 ± 0.05	3.917ValGlu: 3.917 ± 0.053	2.652ValPhe: 2.652 ± 0.05	4.834ValGly: 4.834 ± 0.069	1.283ValHis: 1.283 ± 0.035	4.63ValIle: 4.63 ± 0.067	3.068ValLys: 3.068 ± 0.052	7.215ValLeu: 7.215 ± 0.081	2.309ValMet: 2.309 ± 0.048	2.86ValAsn: 2.86 ± 0.044	2.997ValPro: 2.997 ± 0.046	2.436ValGln: 2.436 ± 0.043	3.733ValArg: 3.733 ± 0.05	4.543ValSer: 4.543 ± 0.059	4.271ValThr: 4.271 ± 0.057	5.617ValVal: 5.617 ± 0.081	1.017ValTrp: 1.017 ± 0.027	1.731ValTyr: 1.731 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.009TrpAla: 1.009 ± 0.027	0.189TrpCys: 0.189 ± 0.011	0.631TrpAsp: 0.631 ± 0.02	0.597TrpGlu: 0.597 ± 0.021	0.704TrpPhe: 0.704 ± 0.026	0.913TrpGly: 0.913 ± 0.028	0.456TrpHis: 0.456 ± 0.019	0.708TrpIle: 0.708 ± 0.021	0.526TrpLys: 0.526 ± 0.022	2.278TrpLeu: 2.278 ± 0.048	0.462TrpMet: 0.462 ± 0.018	0.488TrpAsn: 0.488 ± 0.019	0.679TrpPro: 0.679 ± 0.022	1.179TrpGln: 1.179 ± 0.034	1.162TrpArg: 1.162 ± 0.035	0.848TrpSer: 0.848 ± 0.03	0.582TrpThr: 0.582 ± 0.019	0.937TrpVal: 0.937 ± 0.026	0.24TrpTrp: 0.24 ± 0.012	0.438TrpTyr: 0.438 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.495TyrAla: 2.495 ± 0.04	0.399TyrCys: 0.399 ± 0.016	1.521TyrAsp: 1.521 ± 0.034	1.214TyrGlu: 1.214 ± 0.032	1.161TyrPhe: 1.161 ± 0.028	2.185TyrGly: 2.185 ± 0.047	0.692TyrHis: 0.692 ± 0.022	1.473TyrIle: 1.473 ± 0.031	0.972TyrLys: 0.972 ± 0.028	2.965TyrLeu: 2.965 ± 0.046	0.604TyrMet: 0.604 ± 0.021	1.026TyrAsn: 1.026 ± 0.029	1.342TyrPro: 1.342 ± 0.03	1.55TyrGln: 1.55 ± 0.036	1.867TyrArg: 1.867 ± 0.041	1.764TyrSer: 1.764 ± 0.039	1.462TyrThr: 1.462 ± 0.035	1.672TyrVal: 1.672 ± 0.042	0.465TyrTrp: 0.465 ± 0.019	0.917TyrTyr: 0.917 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5019 proteins (1442289 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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