Amino acid dipepetide frequency for Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.358AlaAla: 8.358 ± 0.072	0.878AlaCys: 0.878 ± 0.018	3.781AlaAsp: 3.781 ± 0.039	5.225AlaGlu: 5.225 ± 0.048	2.914AlaPhe: 2.914 ± 0.032	5.849AlaGly: 5.849 ± 0.049	1.821AlaHis: 1.821 ± 0.023	4.038AlaIle: 4.038 ± 0.04	4.338AlaLys: 4.338 ± 0.042	7.747AlaLeu: 7.747 ± 0.057	1.917AlaMet: 1.917 ± 0.025	2.743AlaAsn: 2.743 ± 0.028	5.154AlaPro: 5.154 ± 0.055	3.374AlaGln: 3.374 ± 0.036	4.797AlaArg: 4.797 ± 0.039	7.76AlaSer: 7.76 ± 0.056	4.832AlaThr: 4.832 ± 0.042	5.024AlaVal: 5.024 ± 0.041	1.052AlaTrp: 1.052 ± 0.016	2.022AlaTyr: 2.022 ± 0.02	0.001AlaXaa: 0.001 ± 0.001
Cys	0.74CysAla: 0.74 ± 0.017	0.184CysCys: 0.184 ± 0.008	0.514CysAsp: 0.514 ± 0.014	0.525CysGlu: 0.525 ± 0.013	0.445CysPhe: 0.445 ± 0.011	0.793CysGly: 0.793 ± 0.02	0.263CysHis: 0.263 ± 0.009	0.579CysIle: 0.579 ± 0.013	0.472CysLys: 0.472 ± 0.012	1.084CysLeu: 1.084 ± 0.021	0.235CysMet: 0.235 ± 0.008	0.321CysAsn: 0.321 ± 0.01	0.601CysPro: 0.601 ± 0.015	0.384CysGln: 0.384 ± 0.011	0.601CysArg: 0.601 ± 0.015	0.771CysSer: 0.771 ± 0.017	0.587CysThr: 0.587 ± 0.013	0.68CysVal: 0.68 ± 0.014	0.172CysTrp: 0.172 ± 0.006	0.286CysTyr: 0.286 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.023AspAla: 4.023 ± 0.035	0.496AspCys: 0.496 ± 0.012	4.0AspAsp: 4.0 ± 0.046	4.927AspGlu: 4.927 ± 0.048	1.829AspPhe: 1.829 ± 0.023	4.033AspGly: 4.033 ± 0.036	1.107AspHis: 1.107 ± 0.021	2.823AspIle: 2.823 ± 0.028	2.554AspLys: 2.554 ± 0.034	4.801AspLeu: 4.801 ± 0.04	1.24AspMet: 1.24 ± 0.02	1.678AspAsn: 1.678 ± 0.023	3.222AspPro: 3.222 ± 0.03	1.761AspGln: 1.761 ± 0.025	2.919AspArg: 2.919 ± 0.033	3.757AspSer: 3.757 ± 0.036	2.567AspThr: 2.567 ± 0.028	3.714AspVal: 3.714 ± 0.033	0.865AspTrp: 0.865 ± 0.017	1.446AspTyr: 1.446 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	5.375GluAla: 5.375 ± 0.045	0.552GluCys: 0.552 ± 0.015	4.532GluAsp: 4.532 ± 0.048	7.188GluGlu: 7.188 ± 0.089	1.736GluPhe: 1.736 ± 0.026	4.977GluGly: 4.977 ± 0.04	1.296GluHis: 1.296 ± 0.02	3.095GluIle: 3.095 ± 0.031	4.515GluLys: 4.515 ± 0.054	5.165GluLeu: 5.165 ± 0.046	1.711GluMet: 1.711 ± 0.019	2.252GluAsn: 2.252 ± 0.026	2.683GluPro: 2.683 ± 0.036	2.51GluGln: 2.51 ± 0.03	4.53GluArg: 4.53 ± 0.048	4.354GluSer: 4.354 ± 0.036	3.212GluThr: 3.212 ± 0.033	3.91GluVal: 3.91 ± 0.04	1.008GluTrp: 1.008 ± 0.018	1.54GluTyr: 1.54 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.831PheAla: 2.831 ± 0.029	0.459PheCys: 0.459 ± 0.012	2.009PheAsp: 2.009 ± 0.026	1.984PheGlu: 1.984 ± 0.025	1.481PhePhe: 1.481 ± 0.025	2.743PheGly: 2.743 ± 0.041	0.832PheHis: 0.832 ± 0.016	1.736PheIle: 1.736 ± 0.023	1.499PheLys: 1.499 ± 0.022	3.082PheLeu: 3.082 ± 0.038	0.696PheMet: 0.696 ± 0.015	1.273PheAsn: 1.273 ± 0.022	1.999PhePro: 1.999 ± 0.025	1.165PheGln: 1.165 ± 0.02	1.732PheArg: 1.732 ± 0.022	2.956PheSer: 2.956 ± 0.033	2.002PheThr: 2.002 ± 0.025	2.108PheVal: 2.108 ± 0.026	0.531PheTrp: 0.531 ± 0.013	0.94PheTyr: 0.94 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.192GlyAla: 5.192 ± 0.054	0.753GlyCys: 0.753 ± 0.014	3.717GlyAsp: 3.717 ± 0.032	4.74GlyGlu: 4.74 ± 0.049	2.457GlyPhe: 2.457 ± 0.03	6.512GlyGly: 6.512 ± 0.075	1.619GlyHis: 1.619 ± 0.027	3.342GlyIle: 3.342 ± 0.036	4.446GlyLys: 4.446 ± 0.047	6.045GlyLeu: 6.045 ± 0.047	1.865GlyMet: 1.865 ± 0.03	2.402GlyAsn: 2.402 ± 0.027	3.283GlyPro: 3.283 ± 0.039	2.762GlyGln: 2.762 ± 0.03	4.288GlyArg: 4.288 ± 0.044	5.749GlySer: 5.749 ± 0.062	3.794GlyThr: 3.794 ± 0.032	4.619GlyVal: 4.619 ± 0.038	1.379GlyTrp: 1.379 ± 0.025	1.985GlyTyr: 1.985 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	1.793HisAla: 1.793 ± 0.022	0.261HisCys: 0.261 ± 0.008	1.141HisAsp: 1.141 ± 0.018	1.212HisGlu: 1.212 ± 0.019	0.854HisPhe: 0.854 ± 0.016	1.505HisGly: 1.505 ± 0.023	0.852HisHis: 0.852 ± 0.018	1.209HisIle: 1.209 ± 0.018	0.878HisLys: 0.878 ± 0.017	2.442HisLeu: 2.442 ± 0.032	0.438HisMet: 0.438 ± 0.009	0.759HisAsn: 0.759 ± 0.014	2.054HisPro: 2.054 ± 0.025	0.932HisGln: 0.932 ± 0.017	1.426HisArg: 1.426 ± 0.019	2.096HisSer: 2.096 ± 0.028	1.31HisThr: 1.31 ± 0.021	1.344HisVal: 1.344 ± 0.019	0.282HisTrp: 0.282 ± 0.008	0.64HisTyr: 0.64 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.935IleAla: 3.935 ± 0.039	0.637IleCys: 0.637 ± 0.014	2.742IleAsp: 2.742 ± 0.031	2.864IleGlu: 2.864 ± 0.031	1.771IlePhe: 1.771 ± 0.027	3.169IleGly: 3.169 ± 0.035	1.201IleHis: 1.201 ± 0.018	2.519IleIle: 2.519 ± 0.032	2.368IleLys: 2.368 ± 0.027	4.382IleLeu: 4.382 ± 0.044	0.998IleMet: 0.998 ± 0.018	1.759IleAsn: 1.759 ± 0.027	3.437IlePro: 3.437 ± 0.034	1.732IleGln: 1.732 ± 0.025	2.603IleArg: 2.603 ± 0.027	4.155IleSer: 4.155 ± 0.033	2.749IleThr: 2.749 ± 0.029	3.065IleVal: 3.065 ± 0.036	0.668IleTrp: 0.668 ± 0.014	1.223IleTyr: 1.223 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.567LysAla: 4.567 ± 0.043	0.443LysCys: 0.443 ± 0.012	2.903LysAsp: 2.903 ± 0.031	4.302LysGlu: 4.302 ± 0.04	1.355LysPhe: 1.355 ± 0.023	3.855LysGly: 3.855 ± 0.038	1.094LysHis: 1.094 ± 0.02	2.317LysIle: 2.317 ± 0.033	4.045LysLys: 4.045 ± 0.059	4.04LysLeu: 4.04 ± 0.038	1.144LysMet: 1.144 ± 0.016	1.666LysAsn: 1.666 ± 0.02	2.828LysPro: 2.828 ± 0.036	1.853LysGln: 1.853 ± 0.024	3.805LysArg: 3.805 ± 0.038	3.768LysSer: 3.768 ± 0.035	2.78LysThr: 2.78 ± 0.032	3.145LysVal: 3.145 ± 0.038	0.745LysTrp: 0.745 ± 0.014	1.25LysTyr: 1.25 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	7.716LeuAla: 7.716 ± 0.058	1.029LeuCys: 1.029 ± 0.021	4.79LeuAsp: 4.79 ± 0.041	5.46LeuGlu: 5.46 ± 0.047	3.189LeuPhe: 3.189 ± 0.041	6.004LeuGly: 6.004 ± 0.045	2.223LeuHis: 2.223 ± 0.029	4.043LeuIle: 4.043 ± 0.042	4.257LeuLys: 4.257 ± 0.04	8.423LeuLeu: 8.423 ± 0.082	1.663LeuMet: 1.663 ± 0.022	2.976LeuAsn: 2.976 ± 0.029	6.621LeuPro: 6.621 ± 0.046	3.413LeuGln: 3.413 ± 0.032	5.337LeuArg: 5.337 ± 0.052	8.344LeuSer: 8.344 ± 0.057	4.907LeuThr: 4.907 ± 0.037	5.216LeuVal: 5.216 ± 0.042	1.062LeuTrp: 1.062 ± 0.018	2.169LeuTyr: 2.169 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	1.95MetAla: 1.95 ± 0.022	0.229MetCys: 0.229 ± 0.008	1.255MetAsp: 1.255 ± 0.018	1.429MetGlu: 1.429 ± 0.021	0.708MetPhe: 0.708 ± 0.014	1.69MetGly: 1.69 ± 0.027	0.356MetHis: 0.356 ± 0.01	0.961MetIle: 0.961 ± 0.017	1.027MetLys: 1.027 ± 0.017	1.787MetLeu: 1.787 ± 0.022	0.586MetMet: 0.586 ± 0.013	0.706MetAsn: 0.706 ± 0.013	1.381MetPro: 1.381 ± 0.022	0.695MetGln: 0.695 ± 0.014	1.29MetArg: 1.29 ± 0.02	2.181MetSer: 2.181 ± 0.027	1.287MetThr: 1.287 ± 0.02	1.266MetVal: 1.266 ± 0.02	0.265MetTrp: 0.265 ± 0.009	0.483MetTyr: 0.483 ± 0.011	0.001MetXaa: 0.001 ± 0.001
Asn	2.909AsnAla: 2.909 ± 0.025	0.335AsnCys: 0.335 ± 0.01	1.842AsnAsp: 1.842 ± 0.022	2.051AsnGlu: 2.051 ± 0.027	1.15AsnPhe: 1.15 ± 0.018	2.705AsnGly: 2.705 ± 0.033	0.768AsnHis: 0.768 ± 0.016	1.754AsnIle: 1.754 ± 0.025	1.608AsnLys: 1.608 ± 0.022	3.081AsnLeu: 3.081 ± 0.032	0.736AsnMet: 0.736 ± 0.016	1.303AsnAsn: 1.303 ± 0.026	2.482AsnPro: 2.482 ± 0.027	1.268AsnGln: 1.268 ± 0.019	1.779AsnArg: 1.779 ± 0.023	2.74AsnSer: 2.74 ± 0.028	1.951AsnThr: 1.951 ± 0.026	2.265AsnVal: 2.265 ± 0.023	0.457AsnTrp: 0.457 ± 0.011	0.867AsnTyr: 0.867 ± 0.016	0.001AsnXaa: 0.001 ± 0.0
Pro	5.552ProAla: 5.552 ± 0.067	0.45ProCys: 0.45 ± 0.012	2.941ProAsp: 2.941 ± 0.032	3.714ProGlu: 3.714 ± 0.037	2.241ProPhe: 2.241 ± 0.026	3.791ProGly: 3.791 ± 0.044	1.608ProHis: 1.608 ± 0.025	3.001ProIle: 3.001 ± 0.03	2.744ProLys: 2.744 ± 0.034	5.753ProLeu: 5.753 ± 0.043	1.071ProMet: 1.071 ± 0.017	2.233ProAsn: 2.233 ± 0.027	6.724ProPro: 6.724 ± 0.092	2.626ProGln: 2.626 ± 0.039	3.433ProArg: 3.433 ± 0.044	8.329ProSer: 8.329 ± 0.088	4.612ProThr: 4.612 ± 0.05	3.78ProVal: 3.78 ± 0.041	0.625ProTrp: 0.625 ± 0.014	1.594ProTyr: 1.594 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.535GlnAla: 3.535 ± 0.042	0.359GlnCys: 0.359 ± 0.011	1.721GlnAsp: 1.721 ± 0.024	2.389GlnGlu: 2.389 ± 0.028	1.084GlnPhe: 1.084 ± 0.018	2.559GlnGly: 2.559 ± 0.032	0.943GlnHis: 0.943 ± 0.015	1.746GlnIle: 1.746 ± 0.023	1.803GlnLys: 1.803 ± 0.024	3.302GlnLeu: 3.302 ± 0.034	0.878GlnMet: 0.878 ± 0.016	1.322GlnAsn: 1.322 ± 0.022	2.791GlnPro: 2.791 ± 0.04	2.357GlnGln: 2.357 ± 0.078	2.423GlnArg: 2.423 ± 0.026	3.427GlnSer: 3.427 ± 0.038	2.338GlnThr: 2.338 ± 0.031	2.173GlnVal: 2.173 ± 0.024	0.498GlnTrp: 0.498 ± 0.012	0.996GlnTyr: 0.996 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.718ArgAla: 4.718 ± 0.039	0.581ArgCys: 0.581 ± 0.015	3.084ArgAsp: 3.084 ± 0.034	4.189ArgGlu: 4.189 ± 0.046	1.883ArgPhe: 1.883 ± 0.024	3.846ArgGly: 3.846 ± 0.04	1.46ArgHis: 1.46 ± 0.024	2.722ArgIle: 2.722 ± 0.035	3.657ArgLys: 3.657 ± 0.039	5.298ArgLeu: 5.298 ± 0.048	1.367ArgMet: 1.367 ± 0.022	1.999ArgAsn: 1.999 ± 0.023	3.76ArgPro: 3.76 ± 0.039	2.529ArgGln: 2.529 ± 0.03	5.059ArgArg: 5.059 ± 0.06	4.904ArgSer: 4.904 ± 0.054	3.117ArgThr: 3.117 ± 0.031	3.278ArgVal: 3.278 ± 0.027	0.862ArgTrp: 0.862 ± 0.017	1.485ArgTyr: 1.485 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	7.471SerAla: 7.471 ± 0.067	0.753SerCys: 0.753 ± 0.017	4.175SerAsp: 4.175 ± 0.035	4.352SerGlu: 4.352 ± 0.043	3.132SerPhe: 3.132 ± 0.03	5.905SerGly: 5.905 ± 0.054	2.292SerHis: 2.292 ± 0.027	4.159SerIle: 4.159 ± 0.037	4.002SerLys: 4.002 ± 0.04	8.049SerLeu: 8.049 ± 0.049	1.689SerMet: 1.689 ± 0.023	3.107SerAsn: 3.107 ± 0.033	6.88SerPro: 6.88 ± 0.08	3.593SerGln: 3.593 ± 0.042	5.139SerArg: 5.139 ± 0.052	11.62SerSer: 11.62 ± 0.131	6.453SerThr: 6.453 ± 0.069	4.895SerVal: 4.895 ± 0.043	1.021SerTrp: 1.021 ± 0.017	2.128SerTyr: 2.128 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	5.001ThrAla: 5.001 ± 0.042	0.63ThrCys: 0.63 ± 0.016	2.53ThrAsp: 2.53 ± 0.027	2.887ThrGlu: 2.887 ± 0.026	2.171ThrPhe: 2.171 ± 0.023	3.917ThrGly: 3.917 ± 0.044	1.357ThrHis: 1.357 ± 0.02	2.906ThrIle: 2.906 ± 0.028	2.513ThrLys: 2.513 ± 0.029	5.318ThrLeu: 5.318 ± 0.042	1.081ThrMet: 1.081 ± 0.018	1.913ThrAsn: 1.913 ± 0.023	5.013ThrPro: 5.013 ± 0.056	1.961ThrGln: 1.961 ± 0.027	2.958ThrArg: 2.958 ± 0.033	6.211ThrSer: 6.211 ± 0.061	3.955ThrThr: 3.955 ± 0.041	3.453ThrVal: 3.453 ± 0.03	0.699ThrTrp: 0.699 ± 0.014	1.485ThrTyr: 1.485 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.861ValAla: 4.861 ± 0.038	0.697ValCys: 0.697 ± 0.015	3.614ValAsp: 3.614 ± 0.042	4.235ValGlu: 4.235 ± 0.053	2.188ValPhe: 2.188 ± 0.029	4.245ValGly: 4.245 ± 0.038	1.337ValHis: 1.337 ± 0.02	3.066ValIle: 3.066 ± 0.032	3.315ValLys: 3.315 ± 0.035	5.362ValLeu: 5.362 ± 0.044	1.316ValMet: 1.316 ± 0.017	2.122ValAsn: 2.122 ± 0.025	3.806ValPro: 3.806 ± 0.04	2.304ValGln: 2.304 ± 0.025	3.332ValArg: 3.332 ± 0.032	4.692ValSer: 4.692 ± 0.036	3.246ValThr: 3.246 ± 0.034	4.092ValVal: 4.092 ± 0.038	0.907ValTrp: 0.907 ± 0.017	1.62ValTyr: 1.62 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.069TrpAla: 1.069 ± 0.018	0.178TrpCys: 0.178 ± 0.007	0.896TrpAsp: 0.896 ± 0.019	0.998TrpGlu: 0.998 ± 0.017	0.464TrpPhe: 0.464 ± 0.011	0.993TrpGly: 0.993 ± 0.019	0.283TrpHis: 0.283 ± 0.009	0.684TrpIle: 0.684 ± 0.014	0.82TrpLys: 0.82 ± 0.016	1.195TrpLeu: 1.195 ± 0.02	0.368TrpMet: 0.368 ± 0.009	0.531TrpAsn: 0.531 ± 0.012	0.543TrpPro: 0.543 ± 0.013	0.49TrpGln: 0.49 ± 0.012	0.91TrpArg: 0.91 ± 0.014	1.017TrpSer: 1.017 ± 0.018	0.779TrpThr: 0.779 ± 0.016	0.858TrpVal: 0.858 ± 0.016	0.308TrpTrp: 0.308 ± 0.009	0.374TrpTyr: 0.374 ± 0.012	0.001TrpXaa: 0.001 ± 0.0
Tyr	2.028TyrAla: 2.028 ± 0.028	0.336TyrCys: 0.336 ± 0.009	1.574TyrAsp: 1.574 ± 0.021	1.466TyrGlu: 1.466 ± 0.019	1.005TyrPhe: 1.005 ± 0.019	1.857TyrGly: 1.857 ± 0.029	0.716TyrHis: 0.716 ± 0.012	1.277TyrIle: 1.277 ± 0.023	1.044TyrLys: 1.044 ± 0.018	2.486TyrLeu: 2.486 ± 0.028	0.534TyrMet: 0.534 ± 0.013	0.985TyrAsn: 0.985 ± 0.016	1.561TyrPro: 1.561 ± 0.022	0.934TyrGln: 0.934 ± 0.02	1.438TyrArg: 1.438 ± 0.022	1.987TyrSer: 1.987 ± 0.026	1.482TyrThr: 1.482 ± 0.021	1.474TyrVal: 1.474 ± 0.02	0.35TyrTrp: 0.35 ± 0.009	0.793TyrTyr: 0.793 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.007XaaXaa: 0.007 ± 0.007

Statistics based on 6746 proteins (3636027 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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