Amino acid dipepetide frequency for Vibrio phage S4-7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.709AlaAla: 3.709 ± 0.591
0.412AlaCys: 0.412 ± 0.117
3.05AlaAsp: 3.05 ± 0.358
2.83AlaGlu: 2.83 ± 0.301
2.143AlaPhe: 2.143 ± 0.23
3.352AlaGly: 3.352 ± 0.356
0.687AlaHis: 0.687 ± 0.135
2.61AlaIle: 2.61 ± 0.293
3.682AlaLys: 3.682 ± 0.363
4.176AlaLeu: 4.176 ± 0.372
1.154AlaMet: 1.154 ± 0.171
2.171AlaAsn: 2.171 ± 0.222
1.429AlaPro: 1.429 ± 0.202
1.429AlaGln: 1.429 ± 0.261
1.896AlaArg: 1.896 ± 0.194
3.077AlaSer: 3.077 ± 0.32
3.407AlaThr: 3.407 ± 0.401
3.05AlaVal: 3.05 ± 0.304
0.522AlaTrp: 0.522 ± 0.137
2.061AlaTyr: 2.061 ± 0.212
0.0AlaXaa: 0.0 ± 0.0
Cys
0.55CysAla: 0.55 ± 0.125
0.302CysCys: 0.302 ± 0.087
0.907CysAsp: 0.907 ± 0.155
1.319CysGlu: 1.319 ± 0.218
0.769CysPhe: 0.769 ± 0.14
1.676CysGly: 1.676 ± 0.242
0.357CysHis: 0.357 ± 0.116
1.044CysIle: 1.044 ± 0.17
1.978CysLys: 1.978 ± 0.299
1.236CysLeu: 1.236 ± 0.195
0.302CysMet: 0.302 ± 0.088
1.044CysAsn: 1.044 ± 0.16
0.907CysPro: 0.907 ± 0.189
0.357CysGln: 0.357 ± 0.092
0.934CysArg: 0.934 ± 0.147
1.236CysSer: 1.236 ± 0.246
0.907CysThr: 0.907 ± 0.176
0.824CysVal: 0.824 ± 0.15
0.44CysTrp: 0.44 ± 0.101
0.879CysTyr: 0.879 ± 0.167
0.0CysXaa: 0.0 ± 0.0
Asp
2.83AspAla: 2.83 ± 0.292
1.401AspCys: 1.401 ± 0.234
3.132AspAsp: 3.132 ± 0.292
4.643AspGlu: 4.643 ± 0.317
3.297AspPhe: 3.297 ± 0.335
5.22AspGly: 5.22 ± 0.416
1.401AspHis: 1.401 ± 0.22
4.836AspIle: 4.836 ± 0.377
5.358AspLys: 5.358 ± 0.43
5.11AspLeu: 5.11 ± 0.37
1.813AspMet: 1.813 ± 0.223
3.517AspAsn: 3.517 ± 0.266
1.621AspPro: 1.621 ± 0.235
1.841AspGln: 1.841 ± 0.216
2.555AspArg: 2.555 ± 0.269
5.11AspSer: 5.11 ± 0.304
4.094AspThr: 4.094 ± 0.357
3.764AspVal: 3.764 ± 0.25
1.154AspTrp: 1.154 ± 0.212
2.912AspTyr: 2.912 ± 0.276
0.0AspXaa: 0.0 ± 0.0
Glu
3.407GluAla: 3.407 ± 0.416
1.676GluCys: 1.676 ± 0.234
7.034GluAsp: 7.034 ± 0.487
6.841GluGlu: 6.841 ± 0.551
3.544GluPhe: 3.544 ± 0.308
5.056GluGly: 5.056 ± 0.288
1.319GluHis: 1.319 ± 0.176
4.588GluIle: 4.588 ± 0.283
5.001GluLys: 5.001 ± 0.433
6.484GluLeu: 6.484 ± 0.434
2.226GluMet: 2.226 ± 0.275
3.352GluAsn: 3.352 ± 0.295
1.539GluPro: 1.539 ± 0.217
2.473GluGln: 2.473 ± 0.257
3.462GluArg: 3.462 ± 0.335
4.781GluSer: 4.781 ± 0.363
3.379GluThr: 3.379 ± 0.342
5.935GluVal: 5.935 ± 0.536
1.319GluTrp: 1.319 ± 0.18
3.462GluTyr: 3.462 ± 0.296
0.0GluXaa: 0.0 ± 0.0
Phe
1.401PheAla: 1.401 ± 0.188
0.659PheCys: 0.659 ± 0.13
3.544PheAsp: 3.544 ± 0.327
3.737PheGlu: 3.737 ± 0.284
1.126PhePhe: 1.126 ± 0.226
2.583PheGly: 2.583 ± 0.243
0.879PheHis: 0.879 ± 0.144
3.242PheIle: 3.242 ± 0.346
3.489PheLys: 3.489 ± 0.322
3.654PheLeu: 3.654 ± 0.312
1.209PheMet: 1.209 ± 0.166
3.022PheAsn: 3.022 ± 0.25
1.511PhePro: 1.511 ± 0.212
0.989PheGln: 0.989 ± 0.171
1.566PheArg: 1.566 ± 0.224
3.407PheSer: 3.407 ± 0.313
2.72PheThr: 2.72 ± 0.286
2.83PheVal: 2.83 ± 0.256
0.55PheTrp: 0.55 ± 0.132
1.868PheTyr: 1.868 ± 0.228
0.0PheXaa: 0.0 ± 0.0
Gly
3.022GlyAla: 3.022 ± 0.363
1.484GlyCys: 1.484 ± 0.22
4.863GlyAsp: 4.863 ± 0.382
4.369GlyGlu: 4.369 ± 0.331
2.967GlyPhe: 2.967 ± 0.248
5.165GlyGly: 5.165 ± 0.502
1.126GlyHis: 1.126 ± 0.166
3.984GlyIle: 3.984 ± 0.295
4.863GlyLys: 4.863 ± 0.424
4.424GlyLeu: 4.424 ± 0.326
1.429GlyMet: 1.429 ± 0.199
3.544GlyAsn: 3.544 ± 0.309
0.495GlyPro: 0.495 ± 0.155
1.703GlyGln: 1.703 ± 0.22
2.418GlyArg: 2.418 ± 0.214
4.369GlySer: 4.369 ± 0.432
3.792GlyThr: 3.792 ± 0.363
5.33GlyVal: 5.33 ± 0.393
1.291GlyTrp: 1.291 ± 0.195
4.039GlyTyr: 4.039 ± 0.345
0.0GlyXaa: 0.0 ± 0.0
His
0.797HisAla: 0.797 ± 0.157
0.275HisCys: 0.275 ± 0.08
1.099HisAsp: 1.099 ± 0.205
1.319HisGlu: 1.319 ± 0.186
1.126HisPhe: 1.126 ± 0.184
1.484HisGly: 1.484 ± 0.231
0.385HisHis: 0.385 ± 0.147
1.319HisIle: 1.319 ± 0.183
1.841HisLys: 1.841 ± 0.213
1.786HisLeu: 1.786 ± 0.25
0.495HisMet: 0.495 ± 0.117
1.209HisAsn: 1.209 ± 0.208
0.604HisPro: 0.604 ± 0.133
0.714HisGln: 0.714 ± 0.133
0.824HisArg: 0.824 ± 0.144
1.264HisSer: 1.264 ± 0.203
1.236HisThr: 1.236 ± 0.184
0.989HisVal: 0.989 ± 0.177
0.275HisTrp: 0.275 ± 0.082
1.346HisTyr: 1.346 ± 0.202
0.0HisXaa: 0.0 ± 0.0
Ile
3.27IleAla: 3.27 ± 0.383
0.989IleCys: 0.989 ± 0.188
4.314IleAsp: 4.314 ± 0.354
4.643IleGlu: 4.643 ± 0.346
2.363IlePhe: 2.363 ± 0.323
3.627IleGly: 3.627 ± 0.305
1.264IleHis: 1.264 ± 0.169
3.434IleIle: 3.434 ± 0.335
5.742IleLys: 5.742 ± 0.375
4.808IleLeu: 4.808 ± 0.32
1.484IleMet: 1.484 ± 0.187
3.654IleAsn: 3.654 ± 0.287
1.978IlePro: 1.978 ± 0.216
2.088IleGln: 2.088 ± 0.222
2.995IleArg: 2.995 ± 0.309
4.451IleSer: 4.451 ± 0.359
4.918IleThr: 4.918 ± 0.381
3.654IleVal: 3.654 ± 0.271
0.659IleTrp: 0.659 ± 0.15
2.693IleTyr: 2.693 ± 0.228
0.0IleXaa: 0.0 ± 0.0
Lys
3.132LysAla: 3.132 ± 0.326
1.154LysCys: 1.154 ± 0.218
5.303LysAsp: 5.303 ± 0.471
7.501LysGlu: 7.501 ± 0.516
3.572LysPhe: 3.572 ± 0.315
5.22LysGly: 5.22 ± 0.452
2.088LysHis: 2.088 ± 0.251
4.479LysIle: 4.479 ± 0.376
4.671LysLys: 4.671 ± 0.452
6.677LysLeu: 6.677 ± 0.469
1.978LysMet: 1.978 ± 0.275
3.215LysAsn: 3.215 ± 0.33
2.088LysPro: 2.088 ± 0.198
3.077LysGln: 3.077 ± 0.344
3.654LysArg: 3.654 ± 0.339
5.165LysSer: 5.165 ± 0.396
4.671LysThr: 4.671 ± 0.326
6.072LysVal: 6.072 ± 0.462
0.907LysTrp: 0.907 ± 0.165
3.27LysTyr: 3.27 ± 0.356
0.0LysXaa: 0.0 ± 0.0
Leu
3.874LeuAla: 3.874 ± 0.305
1.456LeuCys: 1.456 ± 0.189
5.852LeuAsp: 5.852 ± 0.328
6.319LeuGlu: 6.319 ± 0.394
2.638LeuPhe: 2.638 ± 0.322
5.193LeuGly: 5.193 ± 0.334
2.088LeuHis: 2.088 ± 0.249
5.028LeuIle: 5.028 ± 0.383
6.704LeuLys: 6.704 ± 0.433
7.721LeuLeu: 7.721 ± 0.61
2.061LeuMet: 2.061 ± 0.246
3.874LeuAsn: 3.874 ± 0.315
3.105LeuPro: 3.105 ± 0.264
3.242LeuGln: 3.242 ± 0.324
3.297LeuArg: 3.297 ± 0.32
7.363LeuSer: 7.363 ± 0.495
4.836LeuThr: 4.836 ± 0.387
4.176LeuVal: 4.176 ± 0.339
0.989LeuTrp: 0.989 ± 0.177
3.407LeuTyr: 3.407 ± 0.264
0.0LeuXaa: 0.0 ± 0.0
Met
1.236MetAla: 1.236 ± 0.2
0.275MetCys: 0.275 ± 0.08
1.154MetAsp: 1.154 ± 0.149
2.061MetGlu: 2.061 ± 0.212
1.154MetPhe: 1.154 ± 0.186
1.154MetGly: 1.154 ± 0.17
0.385MetHis: 0.385 ± 0.126
1.539MetIle: 1.539 ± 0.222
2.28MetLys: 2.28 ± 0.238
1.868MetLeu: 1.868 ± 0.246
0.659MetMet: 0.659 ± 0.125
1.896MetAsn: 1.896 ± 0.224
0.687MetPro: 0.687 ± 0.147
0.769MetGln: 0.769 ± 0.13
0.879MetArg: 0.879 ± 0.132
2.226MetSer: 2.226 ± 0.209
1.511MetThr: 1.511 ± 0.196
1.154MetVal: 1.154 ± 0.16
0.632MetTrp: 0.632 ± 0.15
0.879MetTyr: 0.879 ± 0.159
0.0MetXaa: 0.0 ± 0.0
Asn
2.253AsnAla: 2.253 ± 0.258
1.099AsnCys: 1.099 ± 0.19
2.033AsnAsp: 2.033 ± 0.215
3.16AsnGlu: 3.16 ± 0.306
2.775AsnPhe: 2.775 ± 0.213
3.764AsnGly: 3.764 ± 0.312
1.099AsnHis: 1.099 ± 0.156
3.599AsnIle: 3.599 ± 0.278
5.22AsnLys: 5.22 ± 0.404
4.039AsnLeu: 4.039 ± 0.307
1.374AsnMet: 1.374 ± 0.216
3.187AsnAsn: 3.187 ± 0.329
2.473AsnPro: 2.473 ± 0.245
1.539AsnGln: 1.539 ± 0.186
2.061AsnArg: 2.061 ± 0.207
3.27AsnSer: 3.27 ± 0.337
4.451AsnThr: 4.451 ± 0.314
2.995AsnVal: 2.995 ± 0.28
0.769AsnTrp: 0.769 ± 0.135
2.693AsnTyr: 2.693 ± 0.34
0.0AsnXaa: 0.0 ± 0.0
Pro
1.401ProAla: 1.401 ± 0.196
0.55ProCys: 0.55 ± 0.131
2.088ProAsp: 2.088 ± 0.226
2.885ProGlu: 2.885 ± 0.254
1.566ProPhe: 1.566 ± 0.222
0.082ProGly: 0.082 ± 0.04
0.659ProHis: 0.659 ± 0.14
1.841ProIle: 1.841 ± 0.241
1.841ProLys: 1.841 ± 0.216
2.803ProLeu: 2.803 ± 0.296
0.55ProMet: 0.55 ± 0.123
1.676ProAsn: 1.676 ± 0.238
0.659ProPro: 0.659 ± 0.138
1.044ProGln: 1.044 ± 0.145
1.154ProArg: 1.154 ± 0.225
2.308ProSer: 2.308 ± 0.263
1.896ProThr: 1.896 ± 0.235
2.143ProVal: 2.143 ± 0.318
0.412ProTrp: 0.412 ± 0.116
1.649ProTyr: 1.649 ± 0.203
0.0ProXaa: 0.0 ± 0.0
Gln
2.061GlnAla: 2.061 ± 0.229
0.467GlnCys: 0.467 ± 0.108
2.363GlnAsp: 2.363 ± 0.256
2.803GlnGlu: 2.803 ± 0.376
1.209GlnPhe: 1.209 ± 0.167
2.143GlnGly: 2.143 ± 0.25
0.687GlnHis: 0.687 ± 0.134
1.951GlnIle: 1.951 ± 0.232
1.896GlnLys: 1.896 ± 0.276
2.72GlnLeu: 2.72 ± 0.273
0.824GlnMet: 0.824 ± 0.139
1.676GlnAsn: 1.676 ± 0.208
1.072GlnPro: 1.072 ± 0.191
1.566GlnGln: 1.566 ± 0.193
1.456GlnArg: 1.456 ± 0.233
1.649GlnSer: 1.649 ± 0.235
1.649GlnThr: 1.649 ± 0.222
1.923GlnVal: 1.923 ± 0.239
0.604GlnTrp: 0.604 ± 0.135
1.346GlnTyr: 1.346 ± 0.175
0.0GlnXaa: 0.0 ± 0.0
Arg
1.511ArgAla: 1.511 ± 0.19
0.824ArgCys: 0.824 ± 0.161
2.803ArgAsp: 2.803 ± 0.283
3.352ArgGlu: 3.352 ± 0.309
1.951ArgPhe: 1.951 ± 0.249
2.418ArgGly: 2.418 ± 0.301
0.852ArgHis: 0.852 ± 0.163
2.445ArgIle: 2.445 ± 0.261
3.819ArgLys: 3.819 ± 0.348
3.709ArgLeu: 3.709 ± 0.333
0.824ArgMet: 0.824 ± 0.129
2.665ArgAsn: 2.665 ± 0.3
1.044ArgPro: 1.044 ± 0.155
1.264ArgGln: 1.264 ± 0.165
1.786ArgArg: 1.786 ± 0.259
2.528ArgSer: 2.528 ± 0.257
2.198ArgThr: 2.198 ± 0.212
2.83ArgVal: 2.83 ± 0.267
0.687ArgTrp: 0.687 ± 0.119
1.731ArgTyr: 1.731 ± 0.207
0.0ArgXaa: 0.0 ± 0.0
Ser
3.544SerAla: 3.544 ± 0.331
1.319SerCys: 1.319 ± 0.222
3.847SerAsp: 3.847 ± 0.321
4.781SerGlu: 4.781 ± 0.454
3.489SerPhe: 3.489 ± 0.324
4.946SerGly: 4.946 ± 0.529
1.401SerHis: 1.401 ± 0.176
4.671SerIle: 4.671 ± 0.327
5.578SerLys: 5.578 ± 0.53
6.1SerLeu: 6.1 ± 0.352
1.621SerMet: 1.621 ± 0.196
3.764SerAsn: 3.764 ± 0.353
1.758SerPro: 1.758 ± 0.219
1.951SerGln: 1.951 ± 0.22
3.105SerArg: 3.105 ± 0.311
5.028SerSer: 5.028 ± 0.399
4.066SerThr: 4.066 ± 0.37
4.781SerVal: 4.781 ± 0.361
1.236SerTrp: 1.236 ± 0.188
3.187SerTyr: 3.187 ± 0.314
0.0SerXaa: 0.0 ± 0.0
Thr
3.022ThrAla: 3.022 ± 0.295
0.714ThrCys: 0.714 ± 0.142
3.379ThrAsp: 3.379 ± 0.354
4.176ThrGlu: 4.176 ± 0.289
2.665ThrPhe: 2.665 ± 0.275
4.286ThrGly: 4.286 ± 0.438
1.126ThrHis: 1.126 ± 0.161
4.616ThrIle: 4.616 ± 0.445
4.314ThrLys: 4.314 ± 0.326
5.935ThrLeu: 5.935 ± 0.391
1.291ThrMet: 1.291 ± 0.205
2.83ThrAsn: 2.83 ± 0.252
2.72ThrPro: 2.72 ± 0.312
1.896ThrGln: 1.896 ± 0.234
2.061ThrArg: 2.061 ± 0.241
4.231ThrSer: 4.231 ± 0.331
4.286ThrThr: 4.286 ± 0.461
3.984ThrVal: 3.984 ± 0.315
0.824ThrTrp: 0.824 ± 0.142
3.105ThrTyr: 3.105 ± 0.285
0.0ThrXaa: 0.0 ± 0.0
Val
3.077ValAla: 3.077 ± 0.323
1.621ValCys: 1.621 ± 0.237
4.588ValAsp: 4.588 ± 0.408
5.55ValGlu: 5.55 ± 0.4
2.803ValPhe: 2.803 ± 0.287
3.709ValGly: 3.709 ± 0.295
1.181ValHis: 1.181 ± 0.165
3.956ValIle: 3.956 ± 0.345
4.918ValLys: 4.918 ± 0.443
5.22ValLeu: 5.22 ± 0.394
1.676ValMet: 1.676 ± 0.222
4.149ValAsn: 4.149 ± 0.364
1.786ValPro: 1.786 ± 0.233
1.841ValGln: 1.841 ± 0.221
2.28ValArg: 2.28 ± 0.267
4.918ValSer: 4.918 ± 0.342
3.599ValThr: 3.599 ± 0.379
5.468ValVal: 5.468 ± 0.392
0.659ValTrp: 0.659 ± 0.124
3.05ValTyr: 3.05 ± 0.263
0.0ValXaa: 0.0 ± 0.0
Trp
0.495TrpAla: 0.495 ± 0.128
0.247TrpCys: 0.247 ± 0.087
1.566TrpAsp: 1.566 ± 0.2
1.264TrpGlu: 1.264 ± 0.164
1.044TrpPhe: 1.044 ± 0.166
0.687TrpGly: 0.687 ± 0.138
0.247TrpHis: 0.247 ± 0.08
0.797TrpIle: 0.797 ± 0.153
1.511TrpLys: 1.511 ± 0.224
1.319TrpLeu: 1.319 ± 0.206
0.412TrpMet: 0.412 ± 0.118
0.412TrpAsn: 0.412 ± 0.105
0.11TrpPro: 0.11 ± 0.059
0.55TrpGln: 0.55 ± 0.127
0.769TrpArg: 0.769 ± 0.124
0.687TrpSer: 0.687 ± 0.134
0.687TrpThr: 0.687 ± 0.137
1.429TrpVal: 1.429 ± 0.237
0.302TrpTrp: 0.302 ± 0.088
0.467TrpTyr: 0.467 ± 0.109
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.253TyrAla: 2.253 ± 0.354
1.044TyrCys: 1.044 ± 0.172
2.693TyrAsp: 2.693 ± 0.285
3.325TyrGlu: 3.325 ± 0.34
1.786TyrPhe: 1.786 ± 0.199
2.912TyrGly: 2.912 ± 0.267
1.154TyrHis: 1.154 ± 0.217
3.05TyrIle: 3.05 ± 0.284
3.187TyrLys: 3.187 ± 0.334
3.434TyrLeu: 3.434 ± 0.308
0.989TyrMet: 0.989 ± 0.152
3.022TyrAsn: 3.022 ± 0.301
1.621TyrPro: 1.621 ± 0.211
1.731TyrGln: 1.731 ± 0.212
2.088TyrArg: 2.088 ± 0.23
3.105TyrSer: 3.105 ± 0.258
3.16TyrThr: 3.16 ± 0.33
2.72TyrVal: 2.72 ± 0.228
0.769TyrTrp: 0.769 ± 0.152
2.006TyrTyr: 2.006 ± 0.282
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 176 proteins (36397 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski