Amino acid dipepetide frequency for Tannerella sp. CAG:51

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.694AlaAla: 4.694 ± 0.083	0.82AlaCys: 0.82 ± 0.029	3.758AlaAsp: 3.758 ± 0.056	4.133AlaGlu: 4.133 ± 0.075	3.116AlaPhe: 3.116 ± 0.057	4.72AlaGly: 4.72 ± 0.081	1.028AlaHis: 1.028 ± 0.034	4.979AlaIle: 4.979 ± 0.079	3.858AlaLys: 3.858 ± 0.077	6.245AlaLeu: 6.245 ± 0.078	1.577AlaMet: 1.577 ± 0.05	2.757AlaAsn: 2.757 ± 0.053	2.022AlaPro: 2.022 ± 0.05	2.34AlaGln: 2.34 ± 0.057	2.776AlaArg: 2.776 ± 0.072	4.131AlaSer: 4.131 ± 0.066	3.46AlaThr: 3.46 ± 0.056	4.373AlaVal: 4.373 ± 0.082	0.759AlaTrp: 0.759 ± 0.029	2.733AlaTyr: 2.733 ± 0.052	0.003AlaXaa: 0.003 ± 0.002
Cys	0.686CysAla: 0.686 ± 0.028	0.187CysCys: 0.187 ± 0.014	0.651CysAsp: 0.651 ± 0.026	0.624CysGlu: 0.624 ± 0.028	0.651CysPhe: 0.651 ± 0.026	0.951CysGly: 0.951 ± 0.033	0.243CysHis: 0.243 ± 0.014	0.983CysIle: 0.983 ± 0.031	0.718CysLys: 0.718 ± 0.03	1.025CysLeu: 1.025 ± 0.034	0.268CysMet: 0.268 ± 0.017	0.643CysAsn: 0.643 ± 0.025	0.515CysPro: 0.515 ± 0.026	0.282CysGln: 0.282 ± 0.015	0.613CysArg: 0.613 ± 0.029	0.796CysSer: 0.796 ± 0.029	0.608CysThr: 0.608 ± 0.028	0.732CysVal: 0.732 ± 0.032	0.172CysTrp: 0.172 ± 0.012	0.524CysTyr: 0.524 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.578AspAla: 3.578 ± 0.061	0.647AspCys: 0.647 ± 0.031	2.636AspAsp: 2.636 ± 0.054	3.665AspGlu: 3.665 ± 0.062	3.059AspPhe: 3.059 ± 0.062	3.874AspGly: 3.874 ± 0.073	0.883AspHis: 0.883 ± 0.032	4.712AspIle: 4.712 ± 0.07	4.219AspLys: 4.219 ± 0.074	4.951AspLeu: 4.951 ± 0.06	1.596AspMet: 1.596 ± 0.041	3.044AspAsn: 3.044 ± 0.064	2.189AspPro: 2.189 ± 0.056	1.44AspGln: 1.44 ± 0.04	2.704AspArg: 2.704 ± 0.051	3.159AspSer: 3.159 ± 0.058	2.769AspThr: 2.769 ± 0.055	3.22AspVal: 3.22 ± 0.06	0.8AspTrp: 0.8 ± 0.033	2.912AspTyr: 2.912 ± 0.051	0.002AspXaa: 0.002 ± 0.001
Glu	4.121GluAla: 4.121 ± 0.072	0.619GluCys: 0.619 ± 0.027	3.104GluAsp: 3.104 ± 0.058	4.44GluGlu: 4.44 ± 0.092	2.396GluPhe: 2.396 ± 0.044	3.748GluGly: 3.748 ± 0.073	1.106GluHis: 1.106 ± 0.035	5.459GluIle: 5.459 ± 0.091	5.681GluLys: 5.681 ± 0.098	5.613GluLeu: 5.613 ± 0.081	1.894GluMet: 1.894 ± 0.052	4.348GluAsn: 4.348 ± 0.073	1.704GluPro: 1.704 ± 0.042	2.314GluGln: 2.314 ± 0.047	2.765GluArg: 2.765 ± 0.053	3.452GluSer: 3.452 ± 0.057	3.406GluThr: 3.406 ± 0.063	3.635GluVal: 3.635 ± 0.063	0.844GluTrp: 0.844 ± 0.031	2.829GluTyr: 2.829 ± 0.055	0.001GluXaa: 0.001 ± 0.001
Phe	2.927PheAla: 2.927 ± 0.057	0.71PheCys: 0.71 ± 0.029	3.045PheAsp: 3.045 ± 0.055	2.644PheGlu: 2.644 ± 0.055	2.516PhePhe: 2.516 ± 0.058	3.377PheGly: 3.377 ± 0.064	0.735PheHis: 0.735 ± 0.032	3.862PheIle: 3.862 ± 0.069	2.655PheLys: 2.655 ± 0.052	4.269PheLeu: 4.269 ± 0.08	1.216PheMet: 1.216 ± 0.036	2.392PheAsn: 2.392 ± 0.052	1.929PhePro: 1.929 ± 0.044	1.218PheGln: 1.218 ± 0.035	2.094PheArg: 2.094 ± 0.05	3.922PheSer: 3.922 ± 0.067	2.713PheThr: 2.713 ± 0.047	2.969PheVal: 2.969 ± 0.061	0.585PheTrp: 0.585 ± 0.028	2.091PheTyr: 2.091 ± 0.056	0.002PheXaa: 0.002 ± 0.002
Gly	4.207GlyAla: 4.207 ± 0.085	0.891GlyCys: 0.891 ± 0.035	3.598GlyAsp: 3.598 ± 0.067	4.216GlyGlu: 4.216 ± 0.064	3.261GlyPhe: 3.261 ± 0.056	4.607GlyGly: 4.607 ± 0.082	1.182GlyHis: 1.182 ± 0.038	6.114GlyIle: 6.114 ± 0.081	5.483GlyLys: 5.483 ± 0.078	5.53GlyLeu: 5.53 ± 0.08	1.918GlyMet: 1.918 ± 0.047	3.882GlyAsn: 3.882 ± 0.082	1.247GlyPro: 1.247 ± 0.04	1.927GlyGln: 1.927 ± 0.043	2.719GlyArg: 2.719 ± 0.054	4.086GlySer: 4.086 ± 0.076	3.923GlyThr: 3.923 ± 0.069	4.542GlyVal: 4.542 ± 0.062	0.956GlyTrp: 0.956 ± 0.034	3.369GlyTyr: 3.369 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.963HisAla: 0.963 ± 0.035	0.273HisCys: 0.273 ± 0.017	0.837HisAsp: 0.837 ± 0.033	0.889HisGlu: 0.889 ± 0.028	1.006HisPhe: 1.006 ± 0.028	1.068HisGly: 1.068 ± 0.037	0.445HisHis: 0.445 ± 0.022	1.58HisIle: 1.58 ± 0.04	1.042HisLys: 1.042 ± 0.035	1.665HisLeu: 1.665 ± 0.044	0.305HisMet: 0.305 ± 0.016	0.908HisAsn: 0.908 ± 0.035	1.026HisPro: 1.026 ± 0.035	0.538HisGln: 0.538 ± 0.023	0.792HisArg: 0.792 ± 0.032	1.094HisSer: 1.094 ± 0.035	0.979HisThr: 0.979 ± 0.032	0.899HisVal: 0.899 ± 0.036	0.21HisTrp: 0.21 ± 0.015	0.871HisTyr: 0.871 ± 0.032	0.001HisXaa: 0.001 ± 0.001
Ile	5.505IleAla: 5.505 ± 0.086	1.13IleCys: 1.13 ± 0.035	5.037IleAsp: 5.037 ± 0.081	5.181IleGlu: 5.181 ± 0.076	3.506IlePhe: 3.506 ± 0.062	5.108IleGly: 5.108 ± 0.091	1.353IleHis: 1.353 ± 0.043	5.821IleIle: 5.821 ± 0.089	5.036IleLys: 5.036 ± 0.087	7.067IleLeu: 7.067 ± 0.103	1.629IleMet: 1.629 ± 0.044	3.787IleAsn: 3.787 ± 0.074	3.763IlePro: 3.763 ± 0.066	2.451IleGln: 2.451 ± 0.055	3.721IleArg: 3.721 ± 0.06	5.9IleSer: 5.9 ± 0.087	4.487IleThr: 4.487 ± 0.081	4.647IleVal: 4.647 ± 0.077	0.825IleTrp: 0.825 ± 0.034	3.28IleTyr: 3.28 ± 0.065	0.001IleXaa: 0.001 ± 0.001
Lys	4.627LysAla: 4.627 ± 0.088	0.559LysCys: 0.559 ± 0.026	4.131LysAsp: 4.131 ± 0.063	5.498LysGlu: 5.498 ± 0.1	2.41LysPhe: 2.41 ± 0.057	4.505LysGly: 4.505 ± 0.08	1.172LysHis: 1.172 ± 0.028	5.28LysIle: 5.28 ± 0.083	5.611LysLys: 5.611 ± 0.092	5.269LysLeu: 5.269 ± 0.078	2.061LysMet: 2.061 ± 0.048	4.541LysAsn: 4.541 ± 0.077	2.215LysPro: 2.215 ± 0.056	2.567LysGln: 2.567 ± 0.059	3.103LysArg: 3.103 ± 0.068	4.047LysSer: 4.047 ± 0.065	3.817LysThr: 3.817 ± 0.065	4.091LysVal: 4.091 ± 0.073	0.771LysTrp: 0.771 ± 0.026	3.077LysTyr: 3.077 ± 0.059	0.002LysXaa: 0.002 ± 0.001
Leu	5.413LeuAla: 5.413 ± 0.088	1.209LeuCys: 1.209 ± 0.038	4.535LeuAsp: 4.535 ± 0.07	4.729LeuGlu: 4.729 ± 0.079	4.847LeuPhe: 4.847 ± 0.095	5.373LeuGly: 5.373 ± 0.086	1.537LeuHis: 1.537 ± 0.039	6.238LeuIle: 6.238 ± 0.095	6.552LeuLys: 6.552 ± 0.098	8.698LeuLeu: 8.698 ± 0.129	2.223LeuMet: 2.223 ± 0.047	4.842LeuAsn: 4.842 ± 0.083	4.074LeuPro: 4.074 ± 0.064	3.285LeuGln: 3.285 ± 0.07	3.949LeuArg: 3.949 ± 0.069	7.32LeuSer: 7.32 ± 0.097	4.838LeuThr: 4.838 ± 0.08	4.742LeuVal: 4.742 ± 0.087	1.004LeuTrp: 1.004 ± 0.036	3.849LeuTyr: 3.849 ± 0.063	0.002LeuXaa: 0.002 ± 0.001
Met	1.711MetAla: 1.711 ± 0.044	0.239MetCys: 0.239 ± 0.016	1.347MetAsp: 1.347 ± 0.038	1.48MetGlu: 1.48 ± 0.041	1.049MetPhe: 1.049 ± 0.038	1.765MetGly: 1.765 ± 0.045	0.457MetHis: 0.457 ± 0.023	1.755MetIle: 1.755 ± 0.046	2.394MetLys: 2.394 ± 0.047	2.223MetLeu: 2.223 ± 0.05	0.683MetMet: 0.683 ± 0.028	1.564MetAsn: 1.564 ± 0.034	1.047MetPro: 1.047 ± 0.036	1.034MetGln: 1.034 ± 0.03	1.17MetArg: 1.17 ± 0.036	1.604MetSer: 1.604 ± 0.039	1.354MetThr: 1.354 ± 0.03	1.362MetVal: 1.362 ± 0.038	0.251MetTrp: 0.251 ± 0.018	0.843MetTyr: 0.843 ± 0.03	0.001MetXaa: 0.001 ± 0.001
Asn	3.323AsnAla: 3.323 ± 0.064	0.578AsnCys: 0.578 ± 0.03	2.813AsnAsp: 2.813 ± 0.061	3.077AsnGlu: 3.077 ± 0.06	2.408AsnPhe: 2.408 ± 0.059	4.151AsnGly: 4.151 ± 0.078	0.949AsnHis: 0.949 ± 0.031	4.688AsnIle: 4.688 ± 0.077	3.673AsnLys: 3.673 ± 0.065	4.532AsnLeu: 4.532 ± 0.073	1.379AsnMet: 1.379 ± 0.039	3.072AsnAsn: 3.072 ± 0.068	2.682AsnPro: 2.682 ± 0.052	1.523AsnGln: 1.523 ± 0.048	2.728AsnArg: 2.728 ± 0.062	3.114AsnSer: 3.114 ± 0.066	3.002AsnThr: 3.002 ± 0.057	3.067AsnVal: 3.067 ± 0.056	0.686AsnTrp: 0.686 ± 0.027	2.479AsnTyr: 2.479 ± 0.056	0.001AsnXaa: 0.001 ± 0.001
Pro	2.504ProAla: 2.504 ± 0.052	0.371ProCys: 0.371 ± 0.019	2.797ProAsp: 2.797 ± 0.049	3.685ProGlu: 3.685 ± 0.052	1.913ProPhe: 1.913 ± 0.043	2.615ProGly: 2.615 ± 0.05	0.708ProHis: 0.708 ± 0.027	2.704ProIle: 2.704 ± 0.055	2.029ProLys: 2.029 ± 0.048	3.219ProLeu: 3.219 ± 0.056	0.839ProMet: 0.839 ± 0.031	1.773ProAsn: 1.773 ± 0.043	0.839ProPro: 0.839 ± 0.035	1.416ProGln: 1.416 ± 0.037	1.27ProArg: 1.27 ± 0.034	2.284ProSer: 2.284 ± 0.059	1.784ProThr: 1.784 ± 0.046	3.261ProVal: 3.261 ± 0.055	0.424ProTrp: 0.424 ± 0.025	1.779ProTyr: 1.779 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	1.952GlnAla: 1.952 ± 0.053	0.261GlnCys: 0.261 ± 0.017	1.596GlnAsp: 1.596 ± 0.04	2.194GlnGlu: 2.194 ± 0.051	1.36GlnPhe: 1.36 ± 0.04	1.893GlnGly: 1.893 ± 0.044	0.528GlnHis: 0.528 ± 0.024	2.823GlnIle: 2.823 ± 0.053	2.602GlnLys: 2.602 ± 0.053	2.98GlnLeu: 2.98 ± 0.054	1.005GlnMet: 1.005 ± 0.038	1.999GlnAsn: 1.999 ± 0.047	1.15GlnPro: 1.15 ± 0.038	1.322GlnGln: 1.322 ± 0.048	1.382GlnArg: 1.382 ± 0.037	1.902GlnSer: 1.902 ± 0.043	1.773GlnThr: 1.773 ± 0.043	1.924GlnVal: 1.924 ± 0.045	0.422GlnTrp: 0.422 ± 0.018	1.461GlnTyr: 1.461 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.318ArgAla: 2.318 ± 0.052	0.426ArgCys: 0.426 ± 0.022	2.075ArgAsp: 2.075 ± 0.048	2.933ArgGlu: 2.933 ± 0.057	2.345ArgPhe: 2.345 ± 0.051	2.309ArgGly: 2.309 ± 0.059	0.845ArgHis: 0.845 ± 0.032	4.014ArgIle: 4.014 ± 0.072	3.318ArgLys: 3.318 ± 0.065	4.2ArgLeu: 4.2 ± 0.069	1.389ArgMet: 1.389 ± 0.042	2.618ArgAsn: 2.618 ± 0.061	1.563ArgPro: 1.563 ± 0.045	1.58ArgGln: 1.58 ± 0.036	1.928ArgArg: 1.928 ± 0.051	2.554ArgSer: 2.554 ± 0.052	2.242ArgThr: 2.242 ± 0.052	2.564ArgVal: 2.564 ± 0.058	0.626ArgTrp: 0.626 ± 0.029	2.301ArgTyr: 2.301 ± 0.051	0.001ArgXaa: 0.001 ± 0.001
Ser	4.305SerAla: 4.305 ± 0.069	0.833SerCys: 0.833 ± 0.032	3.869SerAsp: 3.869 ± 0.067	3.986SerGlu: 3.986 ± 0.072	3.57SerPhe: 3.57 ± 0.075	5.398SerGly: 5.398 ± 0.085	1.133SerHis: 1.133 ± 0.035	5.017SerIle: 5.017 ± 0.08	3.605SerLys: 3.605 ± 0.069	6.227SerLeu: 6.227 ± 0.092	1.438SerMet: 1.438 ± 0.041	2.749SerAsn: 2.749 ± 0.053	2.543SerPro: 2.543 ± 0.049	1.964SerGln: 1.964 ± 0.05	2.812SerArg: 2.812 ± 0.065	4.493SerSer: 4.493 ± 0.083	3.265SerThr: 3.265 ± 0.074	4.762SerVal: 4.762 ± 0.083	0.828SerTrp: 0.828 ± 0.034	2.949SerTyr: 2.949 ± 0.063	0.002SerXaa: 0.002 ± 0.002
Thr	3.715ThrAla: 3.715 ± 0.063	0.555ThrCys: 0.555 ± 0.023	3.404ThrAsp: 3.404 ± 0.062	3.424ThrGlu: 3.424 ± 0.063	2.675ThrPhe: 2.675 ± 0.058	4.403ThrGly: 4.403 ± 0.08	1.01ThrHis: 1.01 ± 0.033	4.225ThrIle: 4.225 ± 0.074	2.738ThrLys: 2.738 ± 0.059	5.059ThrLeu: 5.059 ± 0.073	1.051ThrMet: 1.051 ± 0.036	2.372ThrAsn: 2.372 ± 0.057	2.83ThrPro: 2.83 ± 0.054	1.74ThrGln: 1.74 ± 0.046	2.163ThrArg: 2.163 ± 0.039	3.295ThrSer: 3.295 ± 0.054	3.14ThrThr: 3.14 ± 0.06	3.894ThrVal: 3.894 ± 0.083	0.59ThrTrp: 0.59 ± 0.024	2.275ThrTyr: 2.275 ± 0.057	0.002ThrXaa: 0.002 ± 0.001
Val	4.164ValAla: 4.164 ± 0.067	0.843ValCys: 0.843 ± 0.031	3.441ValAsp: 3.441 ± 0.067	3.616ValGlu: 3.616 ± 0.067	2.936ValPhe: 2.936 ± 0.058	3.873ValGly: 3.873 ± 0.066	0.978ValHis: 0.978 ± 0.029	4.713ValIle: 4.713 ± 0.086	4.339ValLys: 4.339 ± 0.071	5.438ValLeu: 5.438 ± 0.079	1.462ValMet: 1.462 ± 0.039	3.199ValAsn: 3.199 ± 0.057	2.526ValPro: 2.526 ± 0.048	1.709ValGln: 1.709 ± 0.042	2.695ValArg: 2.695 ± 0.063	4.9ValSer: 4.9 ± 0.068	3.635ValThr: 3.635 ± 0.07	3.891ValVal: 3.891 ± 0.077	0.751ValTrp: 0.751 ± 0.03	2.645ValTyr: 2.645 ± 0.052	0.002ValXaa: 0.002 ± 0.002
Trp	0.743TrpAla: 0.743 ± 0.031	0.185TrpCys: 0.185 ± 0.015	0.706TrpAsp: 0.706 ± 0.032	0.738TrpGlu: 0.738 ± 0.029	0.594TrpPhe: 0.594 ± 0.024	0.936TrpGly: 0.936 ± 0.032	0.243TrpHis: 0.243 ± 0.016	0.941TrpIle: 0.941 ± 0.034	0.891TrpLys: 0.891 ± 0.034	1.056TrpLeu: 1.056 ± 0.038	0.341TrpMet: 0.341 ± 0.02	0.822TrpAsn: 0.822 ± 0.03	0.254TrpPro: 0.254 ± 0.016	0.429TrpGln: 0.429 ± 0.023	0.542TrpArg: 0.542 ± 0.022	0.701TrpSer: 0.701 ± 0.03	0.64TrpThr: 0.64 ± 0.027	0.752TrpVal: 0.752 ± 0.028	0.181TrpTrp: 0.181 ± 0.013	0.556TrpTyr: 0.556 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.822TyrAla: 2.822 ± 0.063	0.535TyrCys: 0.535 ± 0.026	2.679TyrAsp: 2.679 ± 0.063	2.327TyrGlu: 2.327 ± 0.049	2.251TyrPhe: 2.251 ± 0.053	2.982TyrGly: 2.982 ± 0.062	0.855TyrHis: 0.855 ± 0.031	3.327TyrIle: 3.327 ± 0.06	2.908TyrLys: 2.908 ± 0.06	3.991TyrLeu: 3.991 ± 0.066	1.058TyrMet: 1.058 ± 0.032	2.614TyrAsn: 2.614 ± 0.056	2.099TyrPro: 2.099 ± 0.052	1.449TyrGln: 1.449 ± 0.046	2.221TyrArg: 2.221 ± 0.049	2.992TyrSer: 2.992 ± 0.058	2.723TyrThr: 2.723 ± 0.065	2.432TyrVal: 2.432 ± 0.048	0.562TyrTrp: 0.562 ± 0.029	2.2TyrTyr: 2.2 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.003XaaArg: 0.003 ± 0.002	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.002XaaTrp: 0.002 ± 0.002	0.003XaaTyr: 0.003 ± 0.002	0.023XaaXaa: 0.023 ± 0.007

Statistics based on 2586 proteins (968938 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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