Amino acid dipepetide frequency for Porphyromonas sp. COT-239 OH1446

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.206AlaAla: 6.206 ± 0.151
0.881AlaCys: 0.881 ± 0.047
4.097AlaAsp: 4.097 ± 0.08
6.304AlaGlu: 6.304 ± 0.138
3.154AlaPhe: 3.154 ± 0.087
5.227AlaGly: 5.227 ± 0.099
1.878AlaHis: 1.878 ± 0.056
4.973AlaIle: 4.973 ± 0.112
3.692AlaLys: 3.692 ± 0.1
9.859AlaLeu: 9.859 ± 0.173
2.077AlaMet: 2.077 ± 0.064
2.4AlaAsn: 2.4 ± 0.082
3.115AlaPro: 3.115 ± 0.081
3.943AlaGln: 3.943 ± 0.081
5.19AlaArg: 5.19 ± 0.112
5.733AlaSer: 5.733 ± 0.107
3.705AlaThr: 3.705 ± 0.082
4.551AlaVal: 4.551 ± 0.098
0.912AlaTrp: 0.912 ± 0.047
3.314AlaTyr: 3.314 ± 0.083
0.0AlaXaa: 0.0 ± 0.0
Cys
0.717CysAla: 0.717 ± 0.042
0.14CysCys: 0.14 ± 0.016
0.468CysAsp: 0.468 ± 0.029
0.532CysGlu: 0.532 ± 0.034
0.362CysPhe: 0.362 ± 0.028
0.779CysGly: 0.779 ± 0.047
0.275CysHis: 0.275 ± 0.023
0.676CysIle: 0.676 ± 0.04
0.345CysLys: 0.345 ± 0.025
1.147CysLeu: 1.147 ± 0.049
0.208CysMet: 0.208 ± 0.021
0.353CysAsn: 0.353 ± 0.028
0.616CysPro: 0.616 ± 0.035
0.395CysGln: 0.395 ± 0.03
0.701CysArg: 0.701 ± 0.037
0.847CysSer: 0.847 ± 0.047
0.454CysThr: 0.454 ± 0.028
0.59CysVal: 0.59 ± 0.037
0.103CysTrp: 0.103 ± 0.014
0.394CysTyr: 0.394 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.808AspAla: 3.808 ± 0.091
0.452AspCys: 0.452 ± 0.028
2.032AspAsp: 2.032 ± 0.077
4.019AspGlu: 4.019 ± 0.108
2.453AspPhe: 2.453 ± 0.077
3.393AspGly: 3.393 ± 0.087
1.071AspHis: 1.071 ± 0.049
3.066AspIle: 3.066 ± 0.085
2.718AspLys: 2.718 ± 0.081
5.716AspLeu: 5.716 ± 0.115
1.264AspMet: 1.264 ± 0.057
1.782AspAsn: 1.782 ± 0.059
2.295AspPro: 2.295 ± 0.068
1.594AspGln: 1.594 ± 0.056
3.456AspArg: 3.456 ± 0.094
2.673AspSer: 2.673 ± 0.081
2.246AspThr: 2.246 ± 0.072
2.866AspVal: 2.866 ± 0.078
0.703AspTrp: 0.703 ± 0.038
2.419AspTyr: 2.419 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
7.777GluAla: 7.777 ± 0.15
0.522GluCys: 0.522 ± 0.031
3.314GluAsp: 3.314 ± 0.076
5.618GluGlu: 5.618 ± 0.129
2.018GluPhe: 2.018 ± 0.064
5.509GluGly: 5.509 ± 0.123
2.049GluHis: 2.049 ± 0.072
4.634GluIle: 4.634 ± 0.098
2.305GluLys: 2.305 ± 0.089
8.449GluLeu: 8.449 ± 0.176
1.73GluMet: 1.73 ± 0.057
1.634GluAsn: 1.634 ± 0.075
2.266GluPro: 2.266 ± 0.076
3.816GluGln: 3.816 ± 0.108
5.858GluArg: 5.858 ± 0.132
3.019GluSer: 3.019 ± 0.071
3.158GluThr: 3.158 ± 0.08
5.197GluVal: 5.197 ± 0.105
0.678GluTrp: 0.678 ± 0.034
2.305GluTyr: 2.305 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
3.567PheAla: 3.567 ± 0.083
0.409PheCys: 0.409 ± 0.028
2.568PheAsp: 2.568 ± 0.075
2.293PheGlu: 2.293 ± 0.058
1.856PhePhe: 1.856 ± 0.07
3.019PheGly: 3.019 ± 0.088
0.641PheHis: 0.641 ± 0.034
2.371PheIle: 2.371 ± 0.08
1.5PheLys: 1.5 ± 0.06
3.263PheLeu: 3.263 ± 0.09
0.898PheMet: 0.898 ± 0.044
1.336PheAsn: 1.336 ± 0.056
1.434PhePro: 1.434 ± 0.055
0.748PheGln: 0.748 ± 0.036
2.026PheArg: 2.026 ± 0.068
2.86PheSer: 2.86 ± 0.081
1.901PheThr: 1.901 ± 0.059
3.312PheVal: 3.312 ± 0.092
0.394PheTrp: 0.394 ± 0.03
1.348PheTyr: 1.348 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
5.675GlyAla: 5.675 ± 0.125
0.812GlyCys: 0.812 ± 0.039
3.273GlyAsp: 3.273 ± 0.078
4.969GlyGlu: 4.969 ± 0.112
2.936GlyPhe: 2.936 ± 0.079
5.367GlyGly: 5.367 ± 0.131
1.712GlyHis: 1.712 ± 0.051
4.792GlyIle: 4.792 ± 0.105
4.079GlyLys: 4.079 ± 0.101
8.098GlyLeu: 8.098 ± 0.163
2.043GlyMet: 2.043 ± 0.068
2.269GlyAsn: 2.269 ± 0.072
1.619GlyPro: 1.619 ± 0.064
2.877GlyGln: 2.877 ± 0.075
4.979GlyArg: 4.979 ± 0.094
4.699GlySer: 4.699 ± 0.102
3.323GlyThr: 3.323 ± 0.087
5.145GlyVal: 5.145 ± 0.101
0.921GlyTrp: 0.921 ± 0.042
3.561GlyTyr: 3.561 ± 0.08
0.0GlyXaa: 0.0 ± 0.0
His
1.56HisAla: 1.56 ± 0.056
0.331HisCys: 0.331 ± 0.028
0.937HisAsp: 0.937 ± 0.05
1.412HisGlu: 1.412 ± 0.049
1.044HisPhe: 1.044 ± 0.04
1.586HisGly: 1.586 ± 0.058
0.623HisHis: 0.623 ± 0.037
1.555HisIle: 1.555 ± 0.054
0.974HisLys: 0.974 ± 0.044
2.784HisLeu: 2.784 ± 0.083
0.45HisMet: 0.45 ± 0.03
0.884HisAsn: 0.884 ± 0.047
1.368HisPro: 1.368 ± 0.056
0.834HisGln: 0.834 ± 0.048
1.703HisArg: 1.703 ± 0.07
1.477HisSer: 1.477 ± 0.053
1.145HisThr: 1.145 ± 0.044
1.029HisVal: 1.029 ± 0.047
0.339HisTrp: 0.339 ± 0.027
1.073HisTyr: 1.073 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
5.653IleAla: 5.653 ± 0.115
0.723IleCys: 0.723 ± 0.041
4.212IleAsp: 4.212 ± 0.081
4.771IleGlu: 4.771 ± 0.101
2.301IlePhe: 2.301 ± 0.085
4.525IleGly: 4.525 ± 0.093
1.354IleHis: 1.354 ± 0.056
3.859IleIle: 3.859 ± 0.112
2.949IleLys: 2.949 ± 0.081
5.891IleLeu: 5.891 ± 0.114
1.303IleMet: 1.303 ± 0.05
2.486IleAsn: 2.486 ± 0.079
2.963IlePro: 2.963 ± 0.08
1.849IleGln: 1.849 ± 0.072
3.974IleArg: 3.974 ± 0.099
4.305IleSer: 4.305 ± 0.095
3.36IleThr: 3.36 ± 0.083
3.995IleVal: 3.995 ± 0.106
0.499IleTrp: 0.499 ± 0.03
2.227IleTyr: 2.227 ± 0.065
0.002IleXaa: 0.002 ± 0.002
Lys
4.155LysAla: 4.155 ± 0.096
0.312LysCys: 0.312 ± 0.027
2.427LysAsp: 2.427 ± 0.077
3.121LysGlu: 3.121 ± 0.1
1.295LysPhe: 1.295 ± 0.059
3.471LysGly: 3.471 ± 0.098
1.173LysHis: 1.173 ± 0.051
2.819LysIle: 2.819 ± 0.077
2.482LysLys: 2.482 ± 0.106
4.399LysLeu: 4.399 ± 0.097
1.28LysMet: 1.28 ± 0.064
1.5LysAsn: 1.5 ± 0.069
1.999LysPro: 1.999 ± 0.067
2.073LysGln: 2.073 ± 0.073
3.099LysArg: 3.099 ± 0.082
2.64LysSer: 2.64 ± 0.083
2.232LysThr: 2.232 ± 0.07
2.811LysVal: 2.811 ± 0.085
0.415LysTrp: 0.415 ± 0.029
1.631LysTyr: 1.631 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
7.888LeuAla: 7.888 ± 0.148
1.27LeuCys: 1.27 ± 0.042
5.277LeuAsp: 5.277 ± 0.106
8.273LeuGlu: 8.273 ± 0.171
3.925LeuPhe: 3.925 ± 0.09
8.384LeuGly: 8.384 ± 0.152
2.513LeuHis: 2.513 ± 0.075
6.051LeuIle: 6.051 ± 0.114
4.751LeuLys: 4.751 ± 0.088
11.871LeuLeu: 11.871 ± 0.244
2.871LeuMet: 2.871 ± 0.077
3.247LeuAsn: 3.247 ± 0.092
5.252LeuPro: 5.252 ± 0.109
3.475LeuGln: 3.475 ± 0.086
7.718LeuArg: 7.718 ± 0.141
10.19LeuSer: 10.19 ± 0.189
4.862LeuThr: 4.862 ± 0.096
6.565LeuVal: 6.565 ± 0.138
1.303LeuTrp: 1.303 ± 0.053
4.06LeuTyr: 4.06 ± 0.098
0.0LeuXaa: 0.0 ± 0.0
Met
2.281MetAla: 2.281 ± 0.062
0.199MetCys: 0.199 ± 0.021
1.214MetAsp: 1.214 ± 0.047
1.274MetGlu: 1.274 ± 0.052
0.549MetPhe: 0.549 ± 0.035
2.071MetGly: 2.071 ± 0.075
0.596MetHis: 0.596 ± 0.03
1.664MetIle: 1.664 ± 0.059
1.391MetLys: 1.391 ± 0.054
2.718MetLeu: 2.718 ± 0.081
0.699MetMet: 0.699 ± 0.043
1.124MetAsn: 1.124 ± 0.047
1.338MetPro: 1.338 ± 0.058
1.286MetGln: 1.286 ± 0.047
1.794MetArg: 1.794 ± 0.064
1.687MetSer: 1.687 ± 0.06
1.368MetThr: 1.368 ± 0.055
1.295MetVal: 1.295 ± 0.053
0.22MetTrp: 0.22 ± 0.021
0.67MetTyr: 0.67 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.686AsnAla: 2.686 ± 0.07
0.312AsnCys: 0.312 ± 0.027
1.482AsnAsp: 1.482 ± 0.065
1.864AsnGlu: 1.864 ± 0.07
1.41AsnPhe: 1.41 ± 0.06
2.135AsnGly: 2.135 ± 0.078
0.649AsnHis: 0.649 ± 0.031
2.314AsnIle: 2.314 ± 0.082
1.856AsnLys: 1.856 ± 0.073
3.353AsnLeu: 3.353 ± 0.089
0.806AsnMet: 0.806 ± 0.036
1.284AsnAsn: 1.284 ± 0.06
2.04AsnPro: 2.04 ± 0.062
1.021AsnGln: 1.021 ± 0.053
1.989AsnArg: 1.989 ± 0.065
1.775AsnSer: 1.775 ± 0.063
1.621AsnThr: 1.621 ± 0.06
2.008AsnVal: 2.008 ± 0.069
0.419AsnTrp: 0.419 ± 0.028
1.391AsnTyr: 1.391 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.805ProAla: 2.805 ± 0.09
0.36ProCys: 0.36 ± 0.027
2.016ProAsp: 2.016 ± 0.066
4.219ProGlu: 4.219 ± 0.096
1.609ProPhe: 1.609 ± 0.057
2.575ProGly: 2.575 ± 0.068
1.015ProHis: 1.015 ± 0.046
2.729ProIle: 2.729 ± 0.084
2.096ProLys: 2.096 ± 0.074
4.44ProLeu: 4.44 ± 0.093
1.225ProMet: 1.225 ± 0.043
1.486ProAsn: 1.486 ± 0.065
1.087ProPro: 1.087 ± 0.048
1.841ProGln: 1.841 ± 0.05
2.478ProArg: 2.478 ± 0.075
3.265ProSer: 3.265 ± 0.096
2.273ProThr: 2.273 ± 0.07
2.536ProVal: 2.536 ± 0.067
0.516ProTrp: 0.516 ± 0.031
1.759ProTyr: 1.759 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
3.302GlnAla: 3.302 ± 0.085
0.284GlnCys: 0.284 ± 0.023
1.769GlnAsp: 1.769 ± 0.057
3.22GlnGlu: 3.22 ± 0.098
1.077GlnPhe: 1.077 ± 0.046
2.834GlnGly: 2.834 ± 0.076
0.943GlnHis: 0.943 ± 0.043
2.589GlnIle: 2.589 ± 0.081
1.426GlnLys: 1.426 ± 0.055
4.192GlnLeu: 4.192 ± 0.096
1.237GlnMet: 1.237 ± 0.055
0.918GlnAsn: 0.918 ± 0.038
1.418GlnPro: 1.418 ± 0.057
1.759GlnGln: 1.759 ± 0.066
2.903GlnArg: 2.903 ± 0.073
2.501GlnSer: 2.501 ± 0.066
1.942GlnThr: 1.942 ± 0.061
2.34GlnVal: 2.34 ± 0.069
0.462GlnTrp: 0.462 ± 0.031
1.256GlnTyr: 1.256 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
5.106ArgAla: 5.106 ± 0.122
0.557ArgCys: 0.557 ± 0.032
2.903ArgAsp: 2.903 ± 0.072
5.266ArgGlu: 5.266 ± 0.117
2.466ArgPhe: 2.466 ± 0.07
4.683ArgGly: 4.683 ± 0.106
1.656ArgHis: 1.656 ± 0.071
4.453ArgIle: 4.453 ± 0.091
2.856ArgLys: 2.856 ± 0.078
7.975ArgLeu: 7.975 ± 0.154
1.946ArgMet: 1.946 ± 0.07
2.061ArgAsn: 2.061 ± 0.062
2.829ArgPro: 2.829 ± 0.078
2.62ArgGln: 2.62 ± 0.083
4.755ArgArg: 4.755 ± 0.121
4.58ArgSer: 4.58 ± 0.112
2.889ArgThr: 2.889 ± 0.064
3.869ArgVal: 3.869 ± 0.075
0.867ArgTrp: 0.867 ± 0.042
2.829ArgTyr: 2.829 ± 0.083
0.0ArgXaa: 0.0 ± 0.0
Ser
5.102SerAla: 5.102 ± 0.109
0.725SerCys: 0.725 ± 0.041
3.131SerAsp: 3.131 ± 0.074
4.282SerGlu: 4.282 ± 0.087
3.035SerPhe: 3.035 ± 0.073
5.192SerGly: 5.192 ± 0.117
1.352SerHis: 1.352 ± 0.057
4.463SerIle: 4.463 ± 0.09
2.938SerLys: 2.938 ± 0.078
8.303SerLeu: 8.303 ± 0.167
1.584SerMet: 1.584 ± 0.058
2.053SerAsn: 2.053 ± 0.06
3.314SerPro: 3.314 ± 0.086
2.231SerGln: 2.231 ± 0.067
4.161SerArg: 4.161 ± 0.105
5.277SerSer: 5.277 ± 0.128
3.366SerThr: 3.366 ± 0.088
4.198SerVal: 4.198 ± 0.101
0.873SerTrp: 0.873 ± 0.047
2.934SerTyr: 2.934 ± 0.089
0.0SerXaa: 0.0 ± 0.0
Thr
3.555ThrAla: 3.555 ± 0.085
0.39ThrCys: 0.39 ± 0.027
2.419ThrAsp: 2.419 ± 0.08
2.848ThrGlu: 2.848 ± 0.075
2.026ThrPhe: 2.026 ± 0.067
3.561ThrGly: 3.561 ± 0.083
1.155ThrHis: 1.155 ± 0.047
3.358ThrIle: 3.358 ± 0.078
2.118ThrLys: 2.118 ± 0.072
5.682ThrLeu: 5.682 ± 0.119
1.034ThrMet: 1.034 ± 0.049
1.584ThrAsn: 1.584 ± 0.058
2.871ThrPro: 2.871 ± 0.081
1.765ThrGln: 1.765 ± 0.062
2.492ThrArg: 2.492 ± 0.074
3.195ThrSer: 3.195 ± 0.082
2.696ThrThr: 2.696 ± 0.077
2.46ThrVal: 2.46 ± 0.066
0.392ThrTrp: 0.392 ± 0.025
1.837ThrTyr: 1.837 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
5.402ValAla: 5.402 ± 0.117
0.814ValCys: 0.814 ± 0.045
3.649ValAsp: 3.649 ± 0.079
4.593ValGlu: 4.593 ± 0.11
2.209ValPhe: 2.209 ± 0.073
4.899ValGly: 4.899 ± 0.114
1.21ValHis: 1.21 ± 0.041
3.805ValIle: 3.805 ± 0.093
2.77ValLys: 2.77 ± 0.103
6.265ValLeu: 6.265 ± 0.123
1.533ValMet: 1.533 ± 0.055
2.149ValAsn: 2.149 ± 0.07
2.392ValPro: 2.392 ± 0.071
2.195ValGln: 2.195 ± 0.071
4.093ValArg: 4.093 ± 0.088
4.352ValSer: 4.352 ± 0.082
2.25ValThr: 2.25 ± 0.086
4.549ValVal: 4.549 ± 0.108
0.602ValTrp: 0.602 ± 0.033
2.342ValTyr: 2.342 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.953TrpAla: 0.953 ± 0.042
0.134TrpCys: 0.134 ± 0.017
0.602TrpAsp: 0.602 ± 0.036
0.621TrpGlu: 0.621 ± 0.034
0.399TrpPhe: 0.399 ± 0.027
1.036TrpGly: 1.036 ± 0.053
0.267TrpHis: 0.267 ± 0.022
0.645TrpIle: 0.645 ± 0.034
0.394TrpLys: 0.394 ± 0.031
1.221TrpLeu: 1.221 ± 0.054
0.327TrpMet: 0.327 ± 0.023
0.331TrpAsn: 0.331 ± 0.023
0.316TrpPro: 0.316 ± 0.026
0.672TrpGln: 0.672 ± 0.033
0.861TrpArg: 0.861 ± 0.042
0.766TrpSer: 0.766 ± 0.04
0.512TrpThr: 0.512 ± 0.031
0.68TrpVal: 0.68 ± 0.039
0.177TrpTrp: 0.177 ± 0.021
0.392TrpTyr: 0.392 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.01TyrAla: 3.01 ± 0.075
0.475TyrCys: 0.475 ± 0.031
2.24TyrAsp: 2.24 ± 0.063
2.355TyrGlu: 2.355 ± 0.071
1.617TyrPhe: 1.617 ± 0.059
2.903TyrGly: 2.903 ± 0.088
0.976TyrHis: 0.976 ± 0.046
2.384TyrIle: 2.384 ± 0.07
1.695TyrLys: 1.695 ± 0.063
4.124TyrLeu: 4.124 ± 0.098
0.918TyrMet: 0.918 ± 0.043
1.533TyrAsn: 1.533 ± 0.055
1.804TyrPro: 1.804 ± 0.063
1.377TyrGln: 1.377 ± 0.055
2.936TyrArg: 2.936 ± 0.088
2.671TyrSer: 2.671 ± 0.073
2.133TyrThr: 2.133 ± 0.066
2.077TyrVal: 2.077 ± 0.07
0.512TyrTrp: 0.512 ± 0.03
1.73TyrTyr: 1.73 ± 0.068
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.002XaaGln: 0.002 ± 0.002
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1412 proteins (513336 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski