Amino acid dipepetide frequency for Pelecanus crispus (Dalmatian pelican)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.56AlaAla: 5.56 ± 0.054	1.363AlaCys: 1.363 ± 0.025	3.004AlaAsp: 3.004 ± 0.037	4.557AlaGlu: 4.557 ± 0.046	2.663AlaPhe: 2.663 ± 0.031	3.841AlaGly: 3.841 ± 0.041	1.339AlaHis: 1.339 ± 0.019	3.158AlaIle: 3.158 ± 0.032	3.762AlaLys: 3.762 ± 0.034	6.441AlaLeu: 6.441 ± 0.057	1.516AlaMet: 1.516 ± 0.018	2.321AlaAsn: 2.321 ± 0.026	2.846AlaPro: 2.846 ± 0.035	2.736AlaGln: 2.736 ± 0.034	2.91AlaArg: 2.91 ± 0.035	5.226AlaSer: 5.226 ± 0.05	3.358AlaThr: 3.358 ± 0.036	4.814AlaVal: 4.814 ± 0.041	0.681AlaTrp: 0.681 ± 0.015	1.671AlaTyr: 1.671 ± 0.026	0.001AlaXaa: 0.001 ± 0.0
Cys	1.184CysAla: 1.184 ± 0.023	0.668CysCys: 0.668 ± 0.017	1.073CysAsp: 1.073 ± 0.023	1.319CysGlu: 1.319 ± 0.026	0.932CysPhe: 0.932 ± 0.019	1.439CysGly: 1.439 ± 0.027	0.632CysHis: 0.632 ± 0.015	1.208CysIle: 1.208 ± 0.024	1.386CysLys: 1.386 ± 0.025	2.164CysLeu: 2.164 ± 0.029	0.469CysMet: 0.469 ± 0.014	0.936CysAsn: 0.936 ± 0.019	1.21CysPro: 1.21 ± 0.029	1.062CysGln: 1.062 ± 0.023	1.209CysArg: 1.209 ± 0.022	2.036CysSer: 2.036 ± 0.035	1.206CysThr: 1.206 ± 0.026	1.37CysVal: 1.37 ± 0.027	0.286CysTrp: 0.286 ± 0.009	0.674CysTyr: 0.674 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	2.914AspAla: 2.914 ± 0.026	1.135AspCys: 1.135 ± 0.023	2.888AspAsp: 2.888 ± 0.039	3.678AspGlu: 3.678 ± 0.041	2.232AspPhe: 2.232 ± 0.03	3.279AspGly: 3.279 ± 0.037	1.182AspHis: 1.182 ± 0.018	3.044AspIle: 3.044 ± 0.032	2.841AspLys: 2.841 ± 0.037	5.065AspLeu: 5.065 ± 0.042	1.248AspMet: 1.248 ± 0.017	1.989AspAsn: 1.989 ± 0.034	2.636AspPro: 2.636 ± 0.031	1.878AspGln: 1.878 ± 0.023	2.404AspArg: 2.404 ± 0.035	4.109AspSer: 4.109 ± 0.039	2.526AspThr: 2.526 ± 0.029	3.257AspVal: 3.257 ± 0.035	0.656AspTrp: 0.656 ± 0.016	1.671AspTyr: 1.671 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	4.642GluAla: 4.642 ± 0.047	1.352GluCys: 1.352 ± 0.037	4.519GluAsp: 4.519 ± 0.044	7.95GluGlu: 7.95 ± 0.092	2.24GluPhe: 2.24 ± 0.025	3.903GluGly: 3.903 ± 0.045	1.556GluHis: 1.556 ± 0.026	3.599GluIle: 3.599 ± 0.037	5.838GluLys: 5.838 ± 0.073	6.328GluLeu: 6.328 ± 0.057	1.774GluMet: 1.774 ± 0.021	3.503GluAsn: 3.503 ± 0.031	2.487GluPro: 2.487 ± 0.03	3.225GluGln: 3.225 ± 0.043	3.918GluArg: 3.918 ± 0.048	4.54GluSer: 4.54 ± 0.048	3.606GluThr: 3.606 ± 0.036	4.436GluVal: 4.436 ± 0.039	0.729GluTrp: 0.729 ± 0.016	1.859GluTyr: 1.859 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	2.222PheAla: 2.222 ± 0.029	1.011PheCys: 1.011 ± 0.016	1.839PheAsp: 1.839 ± 0.025	2.138PheGlu: 2.138 ± 0.03	1.921PhePhe: 1.921 ± 0.029	2.292PheGly: 2.292 ± 0.03	1.097PheHis: 1.097 ± 0.018	2.142PheIle: 2.142 ± 0.03	2.159PheLys: 2.159 ± 0.024	4.246PheLeu: 4.246 ± 0.048	0.829PheMet: 0.829 ± 0.015	1.56PheAsn: 1.56 ± 0.023	1.94PhePro: 1.94 ± 0.026	1.854PheGln: 1.854 ± 0.022	1.979PheArg: 1.979 ± 0.026	3.53PheSer: 3.53 ± 0.035	2.28PheThr: 2.28 ± 0.025	2.376PheVal: 2.376 ± 0.029	0.507PheTrp: 0.507 ± 0.014	1.337PheTyr: 1.337 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	3.438GlyAla: 3.438 ± 0.04	1.262GlyCys: 1.262 ± 0.024	3.015GlyAsp: 3.015 ± 0.038	3.729GlyGlu: 3.729 ± 0.044	2.541GlyPhe: 2.541 ± 0.039	3.749GlyGly: 3.749 ± 0.055	1.481GlyHis: 1.481 ± 0.022	3.176GlyIle: 3.176 ± 0.038	4.002GlyLys: 4.002 ± 0.042	5.158GlyLeu: 5.158 ± 0.054	1.381GlyMet: 1.381 ± 0.024	2.653GlyAsn: 2.653 ± 0.034	2.715GlyPro: 2.715 ± 0.074	2.483GlyGln: 2.483 ± 0.033	3.124GlyArg: 3.124 ± 0.035	4.959GlySer: 4.959 ± 0.056	3.382GlyThr: 3.382 ± 0.035	3.431GlyVal: 3.431 ± 0.034	0.76GlyTrp: 0.76 ± 0.02	1.894GlyTyr: 1.894 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	1.318HisAla: 1.318 ± 0.022	0.737HisCys: 0.737 ± 0.015	0.914HisAsp: 0.914 ± 0.017	1.38HisGlu: 1.38 ± 0.021	1.091HisPhe: 1.091 ± 0.018	1.434HisGly: 1.434 ± 0.021	0.849HisHis: 0.849 ± 0.018	1.367HisIle: 1.367 ± 0.02	1.414HisLys: 1.414 ± 0.022	2.827HisLeu: 2.827 ± 0.028	0.596HisMet: 0.596 ± 0.015	1.001HisAsn: 1.001 ± 0.018	1.417HisPro: 1.417 ± 0.023	1.185HisGln: 1.185 ± 0.02	1.417HisArg: 1.417 ± 0.019	2.199HisSer: 2.199 ± 0.032	1.307HisThr: 1.307 ± 0.022	1.522HisVal: 1.522 ± 0.022	0.411HisTrp: 0.411 ± 0.011	0.859HisTyr: 0.859 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	3.13IleAla: 3.13 ± 0.031	1.246IleCys: 1.246 ± 0.022	2.374IleAsp: 2.374 ± 0.028	2.986IleGlu: 2.986 ± 0.032	2.227IlePhe: 2.227 ± 0.03	2.55IleGly: 2.55 ± 0.035	1.4IleHis: 1.4 ± 0.021	2.834IleIle: 2.834 ± 0.034	3.108IleLys: 3.108 ± 0.032	5.052IleLeu: 5.052 ± 0.045	1.085IleMet: 1.085 ± 0.018	2.225IleAsn: 2.225 ± 0.025	2.885IlePro: 2.885 ± 0.034	2.48IleGln: 2.48 ± 0.024	2.614IleArg: 2.614 ± 0.028	4.19IleSer: 4.19 ± 0.034	2.889IleThr: 2.889 ± 0.033	2.968IleVal: 2.968 ± 0.034	0.582IleTrp: 0.582 ± 0.015	1.644IleTyr: 1.644 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.183LysAla: 4.183 ± 0.038	1.26LysCys: 1.26 ± 0.024	3.599LysAsp: 3.599 ± 0.036	5.743LysGlu: 5.743 ± 0.067	1.956LysPhe: 1.956 ± 0.023	3.53LysGly: 3.53 ± 0.05	1.674LysHis: 1.674 ± 0.024	3.236LysIle: 3.236 ± 0.035	5.464LysLys: 5.464 ± 0.055	5.893LysLeu: 5.893 ± 0.058	1.615LysMet: 1.615 ± 0.022	2.917LysAsn: 2.917 ± 0.031	3.034LysPro: 3.034 ± 0.037	3.038LysGln: 3.038 ± 0.037	3.572LysArg: 3.572 ± 0.035	4.315LysSer: 4.315 ± 0.044	3.455LysThr: 3.455 ± 0.039	3.8LysVal: 3.8 ± 0.032	0.691LysTrp: 0.691 ± 0.016	1.866LysTyr: 1.866 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	6.21LeuAla: 6.21 ± 0.052	2.171LeuCys: 2.171 ± 0.031	4.966LeuAsp: 4.966 ± 0.04	7.067LeuGlu: 7.067 ± 0.072	3.666LeuPhe: 3.666 ± 0.043	5.194LeuGly: 5.194 ± 0.044	2.693LeuHis: 2.693 ± 0.034	4.396LeuIle: 4.396 ± 0.049	6.528LeuLys: 6.528 ± 0.055	10.017LeuLeu: 10.017 ± 0.086	2.079LeuMet: 2.079 ± 0.027	3.955LeuAsn: 3.955 ± 0.038	5.338LeuPro: 5.338 ± 0.053	5.62LeuGln: 5.62 ± 0.057	5.086LeuArg: 5.086 ± 0.043	7.777LeuSer: 7.777 ± 0.055	4.963LeuThr: 4.963 ± 0.041	5.477LeuVal: 5.477 ± 0.044	1.094LeuTrp: 1.094 ± 0.019	2.842LeuTyr: 2.842 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	1.658MetAla: 1.658 ± 0.023	0.456MetCys: 0.456 ± 0.011	1.313MetAsp: 1.313 ± 0.017	1.915MetGlu: 1.915 ± 0.024	0.845MetPhe: 0.845 ± 0.017	1.268MetGly: 1.268 ± 0.023	0.53MetHis: 0.53 ± 0.014	1.031MetIle: 1.031 ± 0.021	1.626MetLys: 1.626 ± 0.021	2.089MetLeu: 2.089 ± 0.023	0.612MetMet: 0.612 ± 0.014	1.008MetAsn: 1.008 ± 0.017	1.039MetPro: 1.039 ± 0.018	1.058MetGln: 1.058 ± 0.02	1.107MetArg: 1.107 ± 0.018	1.569MetSer: 1.569 ± 0.021	1.177MetThr: 1.177 ± 0.019	1.459MetVal: 1.459 ± 0.021	0.253MetTrp: 0.253 ± 0.008	0.691MetTyr: 0.691 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.365AsnAla: 2.365 ± 0.027	1.002AsnCys: 1.002 ± 0.019	1.732AsnAsp: 1.732 ± 0.026	2.623AsnGlu: 2.623 ± 0.03	1.69AsnPhe: 1.69 ± 0.024	2.856AsnGly: 2.856 ± 0.04	1.018AsnHis: 1.018 ± 0.019	2.573AsnIle: 2.573 ± 0.03	2.677AsnLys: 2.677 ± 0.03	4.165AsnLeu: 4.165 ± 0.039	1.017AsnMet: 1.017 ± 0.016	1.888AsnAsn: 1.888 ± 0.028	2.316AsnPro: 2.316 ± 0.03	1.771AsnGln: 1.771 ± 0.022	2.133AsnArg: 2.133 ± 0.024	3.493AsnSer: 3.493 ± 0.038	2.296AsnThr: 2.296 ± 0.029	2.531AsnVal: 2.531 ± 0.03	0.512AsnTrp: 0.512 ± 0.015	1.324AsnTyr: 1.324 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	3.661ProAla: 3.661 ± 0.04	1.018ProCys: 1.018 ± 0.025	2.571ProAsp: 2.571 ± 0.028	3.862ProGlu: 3.862 ± 0.031	1.904ProPhe: 1.904 ± 0.024	3.601ProGly: 3.601 ± 0.121	1.221ProHis: 1.221 ± 0.021	1.97ProIle: 1.97 ± 0.029	2.741ProLys: 2.741 ± 0.037	4.537ProLeu: 4.537 ± 0.044	0.948ProMet: 0.948 ± 0.016	1.911ProAsn: 1.911 ± 0.027	4.148ProPro: 4.148 ± 0.076	2.294ProGln: 2.294 ± 0.038	2.437ProArg: 2.437 ± 0.029	4.898ProSer: 4.898 ± 0.061	2.659ProThr: 2.659 ± 0.038	3.686ProVal: 3.686 ± 0.042	0.563ProTrp: 0.563 ± 0.016	1.469ProTyr: 1.469 ± 0.026	0.001ProXaa: 0.001 ± 0.0
Gln	3.026GlnAla: 3.026 ± 0.031	0.995GlnCys: 0.995 ± 0.024	2.209GlnAsp: 2.209 ± 0.026	3.692GlnGlu: 3.692 ± 0.042	1.461GlnPhe: 1.461 ± 0.02	2.492GlnGly: 2.492 ± 0.035	1.3GlnHis: 1.3 ± 0.021	2.253GlnIle: 2.253 ± 0.022	3.253GlnLys: 3.253 ± 0.039	4.64GlnLeu: 4.64 ± 0.051	1.146GlnMet: 1.146 ± 0.019	2.058GlnAsn: 2.058 ± 0.024	2.348GlnPro: 2.348 ± 0.038	3.116GlnGln: 3.116 ± 0.064	2.605GlnArg: 2.605 ± 0.033	3.223GlnSer: 3.223 ± 0.037	2.385GlnThr: 2.385 ± 0.03	2.743GlnVal: 2.743 ± 0.03	0.504GlnTrp: 0.504 ± 0.013	1.378GlnTyr: 1.378 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	2.974ArgAla: 2.974 ± 0.031	1.084ArgCys: 1.084 ± 0.024	2.617ArgAsp: 2.617 ± 0.036	3.828ArgGlu: 3.828 ± 0.047	1.932ArgPhe: 1.932 ± 0.023	2.8ArgGly: 2.8 ± 0.041	1.375ArgHis: 1.375 ± 0.024	2.59ArgIle: 2.59 ± 0.032	3.994ArgLys: 3.994 ± 0.039	4.967ArgLeu: 4.967 ± 0.048	1.17ArgMet: 1.17 ± 0.018	2.284ArgAsn: 2.284 ± 0.026	2.36ArgPro: 2.36 ± 0.028	2.48ArgGln: 2.48 ± 0.031	3.596ArgArg: 3.596 ± 0.044	3.928ArgSer: 3.928 ± 0.052	2.698ArgThr: 2.698 ± 0.025	2.964ArgVal: 2.964 ± 0.029	0.625ArgTrp: 0.625 ± 0.013	1.558ArgTyr: 1.558 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	5.124SerAla: 5.124 ± 0.048	1.845SerCys: 1.845 ± 0.028	4.026SerAsp: 4.026 ± 0.037	5.126SerGlu: 5.126 ± 0.053	3.184SerPhe: 3.184 ± 0.033	4.912SerGly: 4.912 ± 0.048	1.993SerHis: 1.993 ± 0.029	3.619SerIle: 3.619 ± 0.031	4.501SerLys: 4.501 ± 0.045	7.955SerLeu: 7.955 ± 0.057	1.668SerMet: 1.668 ± 0.024	3.163SerAsn: 3.163 ± 0.035	5.087SerPro: 5.087 ± 0.07	3.652SerGln: 3.652 ± 0.042	4.067SerArg: 4.067 ± 0.049	9.054SerSer: 9.054 ± 0.112	4.542SerThr: 4.542 ± 0.045	5.173SerVal: 5.173 ± 0.052	0.967SerTrp: 0.967 ± 0.018	2.269SerTyr: 2.269 ± 0.03	0.001SerXaa: 0.001 ± 0.001
Thr	3.802ThrAla: 3.802 ± 0.033	1.288ThrCys: 1.288 ± 0.027	2.741ThrAsp: 2.741 ± 0.03	3.781ThrGlu: 3.781 ± 0.039	2.2ThrPhe: 2.2 ± 0.028	3.426ThrGly: 3.426 ± 0.038	1.178ThrHis: 1.178 ± 0.021	2.6ThrIle: 2.6 ± 0.031	2.943ThrLys: 2.943 ± 0.03	5.169ThrLeu: 5.169 ± 0.04	1.16ThrMet: 1.16 ± 0.016	1.981ThrAsn: 1.981 ± 0.025	3.123ThrPro: 3.123 ± 0.044	2.105ThrGln: 2.105 ± 0.031	2.304ThrArg: 2.304 ± 0.026	4.709ThrSer: 4.709 ± 0.052	3.023ThrThr: 3.023 ± 0.044	4.089ThrVal: 4.089 ± 0.041	0.653ThrTrp: 0.653 ± 0.014	1.566ThrTyr: 1.566 ± 0.023	0.001ThrXaa: 0.001 ± 0.0
Val	4.085ValAla: 4.085 ± 0.039	1.538ValCys: 1.538 ± 0.027	3.094ValAsp: 3.094 ± 0.031	4.007ValGlu: 4.007 ± 0.039	2.683ValPhe: 2.683 ± 0.032	3.302ValGly: 3.302 ± 0.038	1.612ValHis: 1.612 ± 0.023	3.358ValIle: 3.358 ± 0.033	3.96ValLys: 3.96 ± 0.037	6.301ValLeu: 6.301 ± 0.053	1.39ValMet: 1.39 ± 0.022	2.623ValAsn: 2.623 ± 0.029	3.399ValPro: 3.399 ± 0.031	2.881ValGln: 2.881 ± 0.029	2.97ValArg: 2.97 ± 0.031	4.917ValSer: 4.917 ± 0.041	3.809ValThr: 3.809 ± 0.038	4.329ValVal: 4.329 ± 0.047	0.714ValTrp: 0.714 ± 0.016	1.899ValTyr: 1.899 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	0.671TrpAla: 0.671 ± 0.015	0.238TrpCys: 0.238 ± 0.009	0.667TrpAsp: 0.667 ± 0.015	0.763TrpGlu: 0.763 ± 0.017	0.464TrpPhe: 0.464 ± 0.013	0.657TrpGly: 0.657 ± 0.018	0.305TrpHis: 0.305 ± 0.009	0.634TrpIle: 0.634 ± 0.015	0.907TrpLys: 0.907 ± 0.018	1.157TrpLeu: 1.157 ± 0.021	0.313TrpMet: 0.313 ± 0.011	0.686TrpAsn: 0.686 ± 0.017	0.417TrpPro: 0.417 ± 0.012	0.542TrpGln: 0.542 ± 0.014	0.635TrpArg: 0.635 ± 0.015	0.866TrpSer: 0.866 ± 0.016	0.639TrpThr: 0.639 ± 0.018	0.668TrpVal: 0.668 ± 0.017	0.188TrpTrp: 0.188 ± 0.007	0.377TrpTyr: 0.377 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.602TyrAla: 1.602 ± 0.022	0.795TyrCys: 0.795 ± 0.016	1.47TyrAsp: 1.47 ± 0.026	1.86TyrGlu: 1.86 ± 0.026	1.427TyrPhe: 1.427 ± 0.023	1.807TyrGly: 1.807 ± 0.027	0.811TyrHis: 0.811 ± 0.017	1.68TyrIle: 1.68 ± 0.025	1.737TyrLys: 1.737 ± 0.022	2.969TyrLeu: 2.969 ± 0.03	0.688TyrMet: 0.688 ± 0.014	1.32TyrAsn: 1.32 ± 0.021	1.356TyrPro: 1.356 ± 0.023	1.365TyrGln: 1.365 ± 0.024	1.738TyrArg: 1.738 ± 0.025	2.391TyrSer: 2.391 ± 0.027	1.639TyrThr: 1.639 ± 0.024	1.777TyrVal: 1.777 ± 0.027	0.416TyrTrp: 0.416 ± 0.014	1.108TyrTyr: 1.108 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.018XaaXaa: 0.018 ± 0.005

Statistics based on 8686 proteins (3626350 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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