Amino acid dipepetide frequency for Albidiferax sp. OV413

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.374AlaAla: 17.374 ± 0.168
1.344AlaCys: 1.344 ± 0.026
6.474AlaAsp: 6.474 ± 0.06
6.488AlaGlu: 6.488 ± 0.073
4.035AlaPhe: 4.035 ± 0.056
9.922AlaGly: 9.922 ± 0.08
2.765AlaHis: 2.765 ± 0.042
5.412AlaIle: 5.412 ± 0.059
4.243AlaLys: 4.243 ± 0.062
15.48AlaLeu: 15.48 ± 0.135
3.537AlaMet: 3.537 ± 0.04
3.086AlaAsn: 3.086 ± 0.051
5.789AlaPro: 5.789 ± 0.071
6.856AlaGln: 6.856 ± 0.086
7.592AlaArg: 7.592 ± 0.077
7.185AlaSer: 7.185 ± 0.085
6.419AlaThr: 6.419 ± 0.064
9.343AlaVal: 9.343 ± 0.078
1.924AlaTrp: 1.924 ± 0.033
2.623AlaTyr: 2.623 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.187CysAla: 1.187 ± 0.028
0.109CysCys: 0.109 ± 0.008
0.515CysAsp: 0.515 ± 0.018
0.472CysGlu: 0.472 ± 0.015
0.318CysPhe: 0.318 ± 0.014
0.922CysGly: 0.922 ± 0.024
0.249CysHis: 0.249 ± 0.013
0.453CysIle: 0.453 ± 0.017
0.245CysLys: 0.245 ± 0.012
0.837CysLeu: 0.837 ± 0.021
0.229CysMet: 0.229 ± 0.012
0.26CysAsn: 0.26 ± 0.012
0.434CysPro: 0.434 ± 0.019
0.314CysGln: 0.314 ± 0.013
0.523CysArg: 0.523 ± 0.017
0.542CysSer: 0.542 ± 0.02
0.499CysThr: 0.499 ± 0.016
0.743CysVal: 0.743 ± 0.022
0.12CysTrp: 0.12 ± 0.008
0.21CysTyr: 0.21 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.995AspAla: 6.995 ± 0.078
0.475AspCys: 0.475 ± 0.016
2.341AspAsp: 2.341 ± 0.038
2.683AspGlu: 2.683 ± 0.037
2.102AspPhe: 2.102 ± 0.038
4.418AspGly: 4.418 ± 0.067
1.04AspHis: 1.04 ± 0.026
2.524AspIle: 2.524 ± 0.041
1.785AspLys: 1.785 ± 0.036
5.307AspLeu: 5.307 ± 0.055
1.241AspMet: 1.241 ± 0.024
1.31AspAsn: 1.31 ± 0.03
2.666AspPro: 2.666 ± 0.043
1.773AspGln: 1.773 ± 0.035
2.889AspArg: 2.889 ± 0.045
2.564AspSer: 2.564 ± 0.04
2.733AspThr: 2.733 ± 0.043
3.867AspVal: 3.867 ± 0.044
0.952AspTrp: 0.952 ± 0.028
1.372AspTyr: 1.372 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
6.114GluAla: 6.114 ± 0.072
0.366GluCys: 0.366 ± 0.014
2.053GluAsp: 2.053 ± 0.034
2.175GluGlu: 2.175 ± 0.038
1.727GluPhe: 1.727 ± 0.036
3.143GluGly: 3.143 ± 0.044
1.208GluHis: 1.208 ± 0.031
2.632GluIle: 2.632 ± 0.039
1.893GluLys: 1.893 ± 0.038
5.552GluLeu: 5.552 ± 0.064
1.218GluMet: 1.218 ± 0.025
1.26GluAsn: 1.26 ± 0.028
2.321GluPro: 2.321 ± 0.041
2.466GluGln: 2.466 ± 0.046
3.846GluArg: 3.846 ± 0.054
2.515GluSer: 2.515 ± 0.044
2.404GluThr: 2.404 ± 0.037
3.908GluVal: 3.908 ± 0.049
0.652GluTrp: 0.652 ± 0.02
0.952GluTyr: 0.952 ± 0.023
0.0GluXaa: 0.0 ± 0.0
Phe
4.329PheAla: 4.329 ± 0.053
0.399PheCys: 0.399 ± 0.017
2.533PheAsp: 2.533 ± 0.041
1.993PheGlu: 1.993 ± 0.038
1.402PhePhe: 1.402 ± 0.033
3.371PheGly: 3.371 ± 0.053
0.719PheHis: 0.719 ± 0.021
1.567PheIle: 1.567 ± 0.033
1.327PheLys: 1.327 ± 0.031
3.059PheLeu: 3.059 ± 0.045
0.87PheMet: 0.87 ± 0.022
1.214PheAsn: 1.214 ± 0.029
1.484PhePro: 1.484 ± 0.028
1.223PheGln: 1.223 ± 0.025
1.743PheArg: 1.743 ± 0.033
2.351PheSer: 2.351 ± 0.042
1.92PheThr: 1.92 ± 0.034
2.782PheVal: 2.782 ± 0.046
0.53PheTrp: 0.53 ± 0.02
0.908PheTyr: 0.908 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
8.473GlyAla: 8.473 ± 0.074
0.909GlyCys: 0.909 ± 0.024
3.697GlyAsp: 3.697 ± 0.055
3.806GlyGlu: 3.806 ± 0.051
3.297GlyPhe: 3.297 ± 0.045
6.543GlyGly: 6.543 ± 0.077
1.868GlyHis: 1.868 ± 0.031
4.099GlyIle: 4.099 ± 0.046
3.281GlyLys: 3.281 ± 0.05
9.222GlyLeu: 9.222 ± 0.079
2.288GlyMet: 2.288 ± 0.034
2.224GlyAsn: 2.224 ± 0.043
3.012GlyPro: 3.012 ± 0.044
3.631GlyGln: 3.631 ± 0.052
4.774GlyArg: 4.774 ± 0.059
4.775GlySer: 4.775 ± 0.069
4.293GlyThr: 4.293 ± 0.058
6.583GlyVal: 6.583 ± 0.068
1.419GlyTrp: 1.419 ± 0.03
2.359GlyTyr: 2.359 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
2.844HisAla: 2.844 ± 0.039
0.28HisCys: 0.28 ± 0.013
1.138HisAsp: 1.138 ± 0.025
0.976HisGlu: 0.976 ± 0.025
0.892HisPhe: 0.892 ± 0.02
2.057HisGly: 2.057 ± 0.037
0.655HisHis: 0.655 ± 0.023
1.073HisIle: 1.073 ± 0.026
0.641HisLys: 0.641 ± 0.018
2.246HisLeu: 2.246 ± 0.038
0.534HisMet: 0.534 ± 0.016
0.578HisAsn: 0.578 ± 0.02
1.451HisPro: 1.451 ± 0.032
0.872HisGln: 0.872 ± 0.022
1.365HisArg: 1.365 ± 0.027
1.218HisSer: 1.218 ± 0.025
1.229HisThr: 1.229 ± 0.028
1.472HisVal: 1.472 ± 0.028
0.434HisTrp: 0.434 ± 0.016
0.646HisTyr: 0.646 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.259IleAla: 6.259 ± 0.05
0.44IleCys: 0.44 ± 0.018
2.85IleAsp: 2.85 ± 0.042
2.697IleGlu: 2.697 ± 0.045
1.438IlePhe: 1.438 ± 0.032
4.044IleGly: 4.044 ± 0.057
0.923IleHis: 0.923 ± 0.022
1.507IleIle: 1.507 ± 0.038
1.574IleLys: 1.574 ± 0.035
3.551IleLeu: 3.551 ± 0.046
0.763IleMet: 0.763 ± 0.022
1.445IleAsn: 1.445 ± 0.033
2.125IlePro: 2.125 ± 0.034
1.567IleGln: 1.567 ± 0.028
2.443IleArg: 2.443 ± 0.041
2.698IleSer: 2.698 ± 0.043
2.584IleThr: 2.584 ± 0.04
3.334IleVal: 3.334 ± 0.042
0.476IleTrp: 0.476 ± 0.019
1.004IleTyr: 1.004 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
4.105LysAla: 4.105 ± 0.063
0.161LysCys: 0.161 ± 0.01
1.732LysAsp: 1.732 ± 0.034
1.51LysGlu: 1.51 ± 0.03
1.056LysPhe: 1.056 ± 0.026
2.376LysGly: 2.376 ± 0.041
0.68LysHis: 0.68 ± 0.023
1.734LysIle: 1.734 ± 0.037
1.544LysLys: 1.544 ± 0.04
3.808LysLeu: 3.808 ± 0.053
0.892LysMet: 0.892 ± 0.026
1.151LysAsn: 1.151 ± 0.03
2.123LysPro: 2.123 ± 0.035
1.3LysGln: 1.3 ± 0.029
2.02LysArg: 2.02 ± 0.033
1.966LysSer: 1.966 ± 0.034
2.221LysThr: 2.221 ± 0.041
2.56LysVal: 2.56 ± 0.044
0.354LysTrp: 0.354 ± 0.015
0.678LysTyr: 0.678 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
15.545LeuAla: 15.545 ± 0.129
1.077LeuCys: 1.077 ± 0.028
5.928LeuAsp: 5.928 ± 0.069
5.049LeuGlu: 5.049 ± 0.063
3.564LeuPhe: 3.564 ± 0.059
9.092LeuGly: 9.092 ± 0.094
2.472LeuHis: 2.472 ± 0.038
3.89LeuIle: 3.89 ± 0.05
3.704LeuLys: 3.704 ± 0.049
12.246LeuLeu: 12.246 ± 0.132
2.492LeuMet: 2.492 ± 0.037
2.964LeuAsn: 2.964 ± 0.046
6.287LeuPro: 6.287 ± 0.064
5.438LeuGln: 5.438 ± 0.067
7.387LeuArg: 7.387 ± 0.084
6.357LeuSer: 6.357 ± 0.06
5.429LeuThr: 5.429 ± 0.073
8.809LeuVal: 8.809 ± 0.084
1.378LeuTrp: 1.378 ± 0.033
2.066LeuTyr: 2.066 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
3.267MetAla: 3.267 ± 0.047
0.159MetCys: 0.159 ± 0.009
1.294MetAsp: 1.294 ± 0.031
1.085MetGlu: 1.085 ± 0.024
0.719MetPhe: 0.719 ± 0.023
2.015MetGly: 2.015 ± 0.038
0.621MetHis: 0.621 ± 0.021
0.738MetIle: 0.738 ± 0.022
0.925MetLys: 0.925 ± 0.024
2.813MetLeu: 2.813 ± 0.047
0.493MetMet: 0.493 ± 0.018
0.764MetAsn: 0.764 ± 0.018
1.453MetPro: 1.453 ± 0.031
1.278MetGln: 1.278 ± 0.025
1.578MetArg: 1.578 ± 0.029
1.383MetSer: 1.383 ± 0.025
1.394MetThr: 1.394 ± 0.028
2.025MetVal: 2.025 ± 0.037
0.193MetTrp: 0.193 ± 0.012
0.405MetTyr: 0.405 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.466AsnAla: 3.466 ± 0.049
0.25AsnCys: 0.25 ± 0.011
1.41AsnAsp: 1.41 ± 0.031
1.145AsnGlu: 1.145 ± 0.026
1.094AsnPhe: 1.094 ± 0.028
2.342AsnGly: 2.342 ± 0.048
0.595AsnHis: 0.595 ± 0.016
1.353AsnIle: 1.353 ± 0.032
0.899AsnLys: 0.899 ± 0.027
2.889AsnLeu: 2.889 ± 0.043
0.6AsnMet: 0.6 ± 0.02
0.826AsnAsn: 0.826 ± 0.03
1.897AsnPro: 1.897 ± 0.035
1.105AsnGln: 1.105 ± 0.028
1.603AsnArg: 1.603 ± 0.036
1.415AsnSer: 1.415 ± 0.034
1.653AsnThr: 1.653 ± 0.035
1.931AsnVal: 1.931 ± 0.034
0.406AsnTrp: 0.406 ± 0.016
0.762AsnTyr: 0.762 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
6.816ProAla: 6.816 ± 0.083
0.339ProCys: 0.339 ± 0.013
2.934ProAsp: 2.934 ± 0.045
2.995ProGlu: 2.995 ± 0.048
1.811ProPhe: 1.811 ± 0.033
4.296ProGly: 4.296 ± 0.047
1.17ProHis: 1.17 ± 0.028
1.965ProIle: 1.965 ± 0.032
1.635ProLys: 1.635 ± 0.035
5.497ProLeu: 5.497 ± 0.056
1.283ProMet: 1.283 ± 0.03
1.347ProAsn: 1.347 ± 0.033
2.392ProPro: 2.392 ± 0.044
2.331ProGln: 2.331 ± 0.035
2.586ProArg: 2.586 ± 0.04
2.846ProSer: 2.846 ± 0.043
2.729ProThr: 2.729 ± 0.046
4.169ProVal: 4.169 ± 0.05
0.789ProTrp: 0.789 ± 0.021
1.21ProTyr: 1.21 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
6.583GlnAla: 6.583 ± 0.078
0.31GlnCys: 0.31 ± 0.013
1.793GlnAsp: 1.793 ± 0.034
1.666GlnGlu: 1.666 ± 0.041
1.425GlnPhe: 1.425 ± 0.025
3.363GlnGly: 3.363 ± 0.051
1.195GlnHis: 1.195 ± 0.027
2.092GlnIle: 2.092 ± 0.037
1.319GlnLys: 1.319 ± 0.031
5.088GlnLeu: 5.088 ± 0.066
1.068GlnMet: 1.068 ± 0.024
1.081GlnAsn: 1.081 ± 0.03
2.58GlnPro: 2.58 ± 0.036
2.443GlnGln: 2.443 ± 0.044
3.719GlnArg: 3.719 ± 0.054
2.315GlnSer: 2.315 ± 0.04
2.388GlnThr: 2.388 ± 0.037
3.361GlnVal: 3.361 ± 0.052
0.711GlnTrp: 0.711 ± 0.023
0.865GlnTyr: 0.865 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
6.84ArgAla: 6.84 ± 0.077
0.554ArgCys: 0.554 ± 0.017
3.082ArgAsp: 3.082 ± 0.045
3.274ArgGlu: 3.274 ± 0.044
2.521ArgPhe: 2.521 ± 0.038
4.035ArgGly: 4.035 ± 0.053
1.538ArgHis: 1.538 ± 0.031
3.241ArgIle: 3.241 ± 0.043
2.091ArgLys: 2.091 ± 0.037
7.147ArgLeu: 7.147 ± 0.073
1.772ArgMet: 1.772 ± 0.03
1.857ArgAsn: 1.857 ± 0.031
2.799ArgPro: 2.799 ± 0.043
2.869ArgGln: 2.869 ± 0.046
3.969ArgArg: 3.969 ± 0.047
3.675ArgSer: 3.675 ± 0.052
3.015ArgThr: 3.015 ± 0.046
4.555ArgVal: 4.555 ± 0.055
1.109ArgTrp: 1.109 ± 0.029
1.688ArgTyr: 1.688 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
6.937SerAla: 6.937 ± 0.073
0.447SerCys: 0.447 ± 0.018
2.712SerAsp: 2.712 ± 0.046
2.419SerGlu: 2.419 ± 0.043
2.306SerPhe: 2.306 ± 0.038
5.161SerGly: 5.161 ± 0.058
1.244SerHis: 1.244 ± 0.027
2.677SerIle: 2.677 ± 0.047
1.802SerLys: 1.802 ± 0.04
6.301SerLeu: 6.301 ± 0.064
1.414SerMet: 1.414 ± 0.031
1.598SerAsn: 1.598 ± 0.04
2.945SerPro: 2.945 ± 0.045
2.227SerGln: 2.227 ± 0.037
3.21SerArg: 3.21 ± 0.044
3.539SerSer: 3.539 ± 0.057
3.364SerThr: 3.364 ± 0.061
4.301SerVal: 4.301 ± 0.056
0.783SerTrp: 0.783 ± 0.025
1.429SerTyr: 1.429 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.487ThrAla: 6.487 ± 0.076
0.388ThrCys: 0.388 ± 0.015
2.592ThrAsp: 2.592 ± 0.039
2.512ThrGlu: 2.512 ± 0.041
1.631ThrPhe: 1.631 ± 0.033
4.671ThrGly: 4.671 ± 0.059
1.223ThrHis: 1.223 ± 0.024
2.125ThrIle: 2.125 ± 0.037
1.398ThrLys: 1.398 ± 0.028
6.581ThrLeu: 6.581 ± 0.079
1.157ThrMet: 1.157 ± 0.028
1.327ThrAsn: 1.327 ± 0.043
3.637ThrPro: 3.637 ± 0.045
2.322ThrGln: 2.322 ± 0.039
3.023ThrArg: 3.023 ± 0.039
3.058ThrSer: 3.058 ± 0.05
3.135ThrThr: 3.135 ± 0.069
4.443ThrVal: 4.443 ± 0.054
0.669ThrTrp: 0.669 ± 0.02
1.11ThrTyr: 1.11 ± 0.025
0.0ThrXaa: 0.0 ± 0.0
Val
10.005ValAla: 10.005 ± 0.086
0.762ValCys: 0.762 ± 0.021
4.192ValAsp: 4.192 ± 0.05
3.92ValGlu: 3.92 ± 0.052
2.896ValPhe: 2.896 ± 0.043
5.808ValGly: 5.808 ± 0.056
1.666ValHis: 1.666 ± 0.029
3.15ValIle: 3.15 ± 0.046
2.447ValLys: 2.447 ± 0.045
8.937ValLeu: 8.937 ± 0.09
1.871ValMet: 1.871 ± 0.037
2.222ValAsn: 2.222 ± 0.04
3.837ValPro: 3.837 ± 0.051
3.481ValGln: 3.481 ± 0.049
4.678ValArg: 4.678 ± 0.056
4.269ValSer: 4.269 ± 0.051
3.991ValThr: 3.991 ± 0.054
6.689ValVal: 6.689 ± 0.077
1.067ValTrp: 1.067 ± 0.023
1.672ValTyr: 1.672 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.468TrpAla: 1.468 ± 0.03
0.16TrpCys: 0.16 ± 0.01
0.643TrpAsp: 0.643 ± 0.021
0.522TrpGlu: 0.522 ± 0.017
0.545TrpPhe: 0.545 ± 0.02
0.971TrpGly: 0.971 ± 0.025
0.35TrpHis: 0.35 ± 0.015
0.638TrpIle: 0.638 ± 0.021
0.462TrpLys: 0.462 ± 0.017
2.09TrpLeu: 2.09 ± 0.046
0.434TrpMet: 0.434 ± 0.017
0.492TrpAsn: 0.492 ± 0.017
0.694TrpPro: 0.694 ± 0.021
0.829TrpGln: 0.829 ± 0.023
1.096TrpArg: 1.096 ± 0.027
0.861TrpSer: 0.861 ± 0.026
0.779TrpThr: 0.779 ± 0.023
1.029TrpVal: 1.029 ± 0.024
0.305TrpTrp: 0.305 ± 0.016
0.292TrpTyr: 0.292 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.8TyrAla: 2.8 ± 0.039
0.251TyrCys: 0.251 ± 0.01
1.124TyrAsp: 1.124 ± 0.027
1.017TyrGlu: 1.017 ± 0.029
0.944TyrPhe: 0.944 ± 0.026
2.003TyrGly: 2.003 ± 0.039
0.421TyrHis: 0.421 ± 0.017
0.852TyrIle: 0.852 ± 0.024
0.756TyrLys: 0.756 ± 0.023
2.521TyrLeu: 2.521 ± 0.041
0.442TyrMet: 0.442 ± 0.017
0.636TyrAsn: 0.636 ± 0.022
1.213TyrPro: 1.213 ± 0.029
1.042TyrGln: 1.042 ± 0.023
1.59TyrArg: 1.59 ± 0.033
1.284TyrSer: 1.284 ± 0.029
1.311TyrThr: 1.311 ± 0.033
1.655TyrVal: 1.655 ± 0.029
0.389TyrTrp: 0.389 ± 0.016
0.591TyrTyr: 0.591 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5186 proteins (1745074 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski