Amino acid dipepetide frequency for Streptococcus phage phiARI0131-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.864AlaAla: 2.864 ± 0.822
0.253AlaCys: 0.253 ± 0.126
5.728AlaAsp: 5.728 ± 0.621
6.318AlaGlu: 6.318 ± 0.673
2.443AlaPhe: 2.443 ± 0.603
5.307AlaGly: 5.307 ± 0.877
0.842AlaHis: 0.842 ± 0.343
4.886AlaIle: 4.886 ± 1.07
7.16AlaLys: 7.16 ± 0.928
6.655AlaLeu: 6.655 ± 0.903
2.106AlaMet: 2.106 ± 0.358
3.875AlaAsn: 3.875 ± 0.656
1.937AlaPro: 1.937 ± 0.37
2.443AlaGln: 2.443 ± 0.545
2.948AlaArg: 2.948 ± 0.517
2.864AlaSer: 2.864 ± 0.825
5.223AlaThr: 5.223 ± 0.751
4.886AlaVal: 4.886 ± 0.657
0.842AlaTrp: 0.842 ± 0.246
1.685AlaTyr: 1.685 ± 0.363
0.0AlaXaa: 0.0 ± 0.0
Cys
0.253CysAla: 0.253 ± 0.122
0.084CysCys: 0.084 ± 0.091
0.421CysAsp: 0.421 ± 0.216
0.337CysGlu: 0.337 ± 0.162
0.505CysPhe: 0.505 ± 0.199
0.084CysGly: 0.084 ± 0.099
0.0CysHis: 0.0 ± 0.0
0.253CysIle: 0.253 ± 0.217
0.674CysLys: 0.674 ± 0.23
0.505CysLeu: 0.505 ± 0.196
0.0CysMet: 0.0 ± 0.0
0.168CysAsn: 0.168 ± 0.182
0.253CysPro: 0.253 ± 0.141
0.337CysGln: 0.337 ± 0.141
0.421CysArg: 0.421 ± 0.161
0.253CysSer: 0.253 ± 0.17
0.084CysThr: 0.084 ± 0.087
0.168CysVal: 0.168 ± 0.115
0.168CysTrp: 0.168 ± 0.102
0.253CysTyr: 0.253 ± 0.112
0.0CysXaa: 0.0 ± 0.0
Asp
3.959AspAla: 3.959 ± 0.806
0.59AspCys: 0.59 ± 0.266
3.454AspAsp: 3.454 ± 0.681
5.054AspGlu: 5.054 ± 1.083
2.527AspPhe: 2.527 ± 0.519
5.054AspGly: 5.054 ± 0.624
0.59AspHis: 0.59 ± 0.268
5.812AspIle: 5.812 ± 0.669
5.728AspLys: 5.728 ± 0.621
5.139AspLeu: 5.139 ± 0.695
1.769AspMet: 1.769 ± 0.377
2.443AspAsn: 2.443 ± 0.457
1.685AspPro: 1.685 ± 0.368
1.769AspGln: 1.769 ± 0.459
2.78AspArg: 2.78 ± 0.412
3.791AspSer: 3.791 ± 0.594
3.622AspThr: 3.622 ± 0.554
3.875AspVal: 3.875 ± 0.569
1.516AspTrp: 1.516 ± 0.428
2.696AspTyr: 2.696 ± 0.517
0.0AspXaa: 0.0 ± 0.0
Glu
6.823GluAla: 6.823 ± 0.97
0.253GluCys: 0.253 ± 0.132
4.38GluAsp: 4.38 ± 0.774
5.307GluGlu: 5.307 ± 1.039
3.538GluPhe: 3.538 ± 0.593
3.622GluGly: 3.622 ± 0.576
1.264GluHis: 1.264 ± 0.382
5.728GluIle: 5.728 ± 0.553
7.076GluLys: 7.076 ± 1.117
7.666GluLeu: 7.666 ± 0.942
2.022GluMet: 2.022 ± 0.504
3.875GluAsn: 3.875 ± 0.506
1.348GluPro: 1.348 ± 0.318
2.948GluGln: 2.948 ± 0.586
3.454GluArg: 3.454 ± 0.49
4.465GluSer: 4.465 ± 0.592
4.212GluThr: 4.212 ± 0.62
5.644GluVal: 5.644 ± 0.775
1.264GluTrp: 1.264 ± 0.246
2.864GluTyr: 2.864 ± 0.427
0.0GluXaa: 0.0 ± 0.0
Phe
2.78PheAla: 2.78 ± 0.649
0.253PheCys: 0.253 ± 0.159
4.296PheAsp: 4.296 ± 0.607
3.622PheGlu: 3.622 ± 0.515
1.937PhePhe: 1.937 ± 0.372
2.274PheGly: 2.274 ± 0.685
0.253PheHis: 0.253 ± 0.147
1.685PheIle: 1.685 ± 0.318
3.538PheLys: 3.538 ± 0.59
2.443PheLeu: 2.443 ± 0.397
1.095PheMet: 1.095 ± 0.337
3.033PheAsn: 3.033 ± 0.632
0.59PhePro: 0.59 ± 0.252
1.095PheGln: 1.095 ± 0.234
1.853PheArg: 1.853 ± 0.278
3.033PheSer: 3.033 ± 0.571
2.274PheThr: 2.274 ± 0.412
1.432PheVal: 1.432 ± 0.289
0.674PheTrp: 0.674 ± 0.204
1.601PheTyr: 1.601 ± 0.365
0.0PheXaa: 0.0 ± 0.0
Gly
2.948GlyAla: 2.948 ± 0.405
0.168GlyCys: 0.168 ± 0.139
4.549GlyAsp: 4.549 ± 0.834
4.38GlyGlu: 4.38 ± 0.633
2.696GlyPhe: 2.696 ± 0.418
4.465GlyGly: 4.465 ± 1.194
0.674GlyHis: 0.674 ± 0.214
3.285GlyIle: 3.285 ± 0.622
4.549GlyLys: 4.549 ± 0.584
6.571GlyLeu: 6.571 ± 1.015
1.769GlyMet: 1.769 ± 0.328
3.707GlyAsn: 3.707 ± 0.494
0.842GlyPro: 0.842 ± 0.279
3.622GlyGln: 3.622 ± 0.53
3.37GlyArg: 3.37 ± 0.618
3.875GlySer: 3.875 ± 0.837
2.696GlyThr: 2.696 ± 0.616
4.717GlyVal: 4.717 ± 0.708
1.095GlyTrp: 1.095 ± 0.452
3.117GlyTyr: 3.117 ± 0.446
0.0GlyXaa: 0.0 ± 0.0
His
0.59HisAla: 0.59 ± 0.254
0.0HisCys: 0.0 ± 0.0
0.674HisAsp: 0.674 ± 0.295
0.927HisGlu: 0.927 ± 0.248
0.59HisPhe: 0.59 ± 0.195
0.758HisGly: 0.758 ± 0.281
0.337HisHis: 0.337 ± 0.224
1.011HisIle: 1.011 ± 0.318
0.674HisLys: 0.674 ± 0.283
0.842HisLeu: 0.842 ± 0.249
0.084HisMet: 0.084 ± 0.094
1.095HisAsn: 1.095 ± 0.285
0.927HisPro: 0.927 ± 0.231
0.505HisGln: 0.505 ± 0.228
0.59HisArg: 0.59 ± 0.218
1.348HisSer: 1.348 ± 0.412
1.011HisThr: 1.011 ± 0.245
0.674HisVal: 0.674 ± 0.237
0.084HisTrp: 0.084 ± 0.091
0.842HisTyr: 0.842 ± 0.319
0.0HisXaa: 0.0 ± 0.0
Ile
5.981IleAla: 5.981 ± 0.67
0.674IleCys: 0.674 ± 0.184
3.875IleAsp: 3.875 ± 0.561
5.981IleGlu: 5.981 ± 0.663
2.274IlePhe: 2.274 ± 0.463
3.959IleGly: 3.959 ± 0.711
0.505IleHis: 0.505 ± 0.273
2.78IleIle: 2.78 ± 0.581
6.823IleLys: 6.823 ± 0.657
3.791IleLeu: 3.791 ± 0.832
1.264IleMet: 1.264 ± 0.359
3.791IleAsn: 3.791 ± 0.501
1.685IlePro: 1.685 ± 0.303
2.359IleGln: 2.359 ± 0.389
2.443IleArg: 2.443 ± 0.512
5.56IleSer: 5.56 ± 0.672
4.802IleThr: 4.802 ± 0.535
3.201IleVal: 3.201 ± 0.756
0.758IleTrp: 0.758 ± 0.227
2.359IleTyr: 2.359 ± 0.68
0.0IleXaa: 0.0 ± 0.0
Lys
5.812LysAla: 5.812 ± 0.841
0.337LysCys: 0.337 ± 0.165
5.897LysAsp: 5.897 ± 0.582
6.823LysGlu: 6.823 ± 0.955
3.622LysPhe: 3.622 ± 0.836
4.717LysGly: 4.717 ± 0.7
1.601LysHis: 1.601 ± 0.319
6.318LysIle: 6.318 ± 0.879
8.761LysLys: 8.761 ± 1.178
8.087LysLeu: 8.087 ± 0.599
2.696LysMet: 2.696 ± 0.413
4.296LysAsn: 4.296 ± 0.558
2.78LysPro: 2.78 ± 0.812
4.212LysGln: 4.212 ± 0.651
2.948LysArg: 2.948 ± 0.455
4.886LysSer: 4.886 ± 0.535
5.812LysThr: 5.812 ± 0.617
6.234LysVal: 6.234 ± 0.653
0.927LysTrp: 0.927 ± 0.317
3.707LysTyr: 3.707 ± 0.512
0.0LysXaa: 0.0 ± 0.0
Leu
7.497LeuAla: 7.497 ± 1.094
0.421LeuCys: 0.421 ± 0.278
5.307LeuAsp: 5.307 ± 0.544
7.329LeuGlu: 7.329 ± 0.99
2.359LeuPhe: 2.359 ± 0.416
5.981LeuGly: 5.981 ± 1.205
0.927LeuHis: 0.927 ± 0.282
4.128LeuIle: 4.128 ± 0.541
7.329LeuLys: 7.329 ± 0.739
5.644LeuLeu: 5.644 ± 0.801
1.853LeuMet: 1.853 ± 0.373
3.622LeuAsn: 3.622 ± 0.557
3.285LeuPro: 3.285 ± 0.625
3.201LeuGln: 3.201 ± 0.571
3.622LeuArg: 3.622 ± 0.657
5.476LeuSer: 5.476 ± 0.974
5.223LeuThr: 5.223 ± 0.858
4.38LeuVal: 4.38 ± 0.563
0.758LeuTrp: 0.758 ± 0.213
2.443LeuTyr: 2.443 ± 0.322
0.0LeuXaa: 0.0 ± 0.0
Met
1.937MetAla: 1.937 ± 0.446
0.0MetCys: 0.0 ± 0.0
1.432MetAsp: 1.432 ± 0.297
2.022MetGlu: 2.022 ± 0.45
0.505MetPhe: 0.505 ± 0.14
1.179MetGly: 1.179 ± 0.407
0.168MetHis: 0.168 ± 0.101
1.348MetIle: 1.348 ± 0.331
2.527MetLys: 2.527 ± 0.482
1.601MetLeu: 1.601 ± 0.326
0.337MetMet: 0.337 ± 0.145
1.601MetAsn: 1.601 ± 0.54
1.011MetPro: 1.011 ± 0.339
1.095MetGln: 1.095 ± 0.411
1.432MetArg: 1.432 ± 0.375
1.432MetSer: 1.432 ± 0.383
1.516MetThr: 1.516 ± 0.347
1.601MetVal: 1.601 ± 0.416
0.168MetTrp: 0.168 ± 0.106
0.927MetTyr: 0.927 ± 0.232
0.0MetXaa: 0.0 ± 0.0
Asn
4.128AsnAla: 4.128 ± 0.674
0.337AsnCys: 0.337 ± 0.148
2.78AsnAsp: 2.78 ± 0.521
3.538AsnGlu: 3.538 ± 0.59
2.611AsnPhe: 2.611 ± 0.409
3.791AsnGly: 3.791 ± 0.601
0.842AsnHis: 0.842 ± 0.27
2.864AsnIle: 2.864 ± 0.494
5.054AsnLys: 5.054 ± 0.534
4.465AsnLeu: 4.465 ± 0.534
1.179AsnMet: 1.179 ± 0.36
3.033AsnAsn: 3.033 ± 0.534
2.022AsnPro: 2.022 ± 0.44
3.285AsnGln: 3.285 ± 0.595
2.274AsnArg: 2.274 ± 0.517
3.959AsnSer: 3.959 ± 0.648
3.117AsnThr: 3.117 ± 0.645
2.78AsnVal: 2.78 ± 0.357
1.095AsnTrp: 1.095 ± 0.279
1.937AsnTyr: 1.937 ± 0.4
0.0AsnXaa: 0.0 ± 0.0
Pro
2.274ProAla: 2.274 ± 0.517
0.168ProCys: 0.168 ± 0.116
2.106ProAsp: 2.106 ± 0.601
3.285ProGlu: 3.285 ± 0.398
0.674ProPhe: 0.674 ± 0.348
1.011ProGly: 1.011 ± 0.238
0.421ProHis: 0.421 ± 0.134
1.937ProIle: 1.937 ± 0.419
3.201ProLys: 3.201 ± 0.464
1.264ProLeu: 1.264 ± 0.304
0.59ProMet: 0.59 ± 0.222
1.853ProAsn: 1.853 ± 0.483
0.927ProPro: 0.927 ± 0.397
0.927ProGln: 0.927 ± 0.309
1.095ProArg: 1.095 ± 0.273
1.853ProSer: 1.853 ± 0.412
0.59ProThr: 0.59 ± 0.24
1.769ProVal: 1.769 ± 0.435
0.421ProTrp: 0.421 ± 0.218
1.348ProTyr: 1.348 ± 0.425
0.0ProXaa: 0.0 ± 0.0
Gln
4.128GlnAla: 4.128 ± 0.517
0.253GlnCys: 0.253 ± 0.148
1.601GlnAsp: 1.601 ± 0.326
3.538GlnGlu: 3.538 ± 0.604
1.432GlnPhe: 1.432 ± 0.361
1.853GlnGly: 1.853 ± 0.375
0.59GlnHis: 0.59 ± 0.291
3.622GlnIle: 3.622 ± 0.493
3.875GlnLys: 3.875 ± 0.576
3.37GlnLeu: 3.37 ± 0.46
0.842GlnMet: 0.842 ± 0.216
1.769GlnAsn: 1.769 ± 0.365
1.179GlnPro: 1.179 ± 0.324
1.432GlnGln: 1.432 ± 0.326
1.601GlnArg: 1.601 ± 0.483
2.19GlnSer: 2.19 ± 0.37
3.033GlnThr: 3.033 ± 0.512
3.622GlnVal: 3.622 ± 0.585
0.505GlnTrp: 0.505 ± 0.149
1.011GlnTyr: 1.011 ± 0.291
0.0GlnXaa: 0.0 ± 0.0
Arg
2.78ArgAla: 2.78 ± 0.576
0.337ArgCys: 0.337 ± 0.17
2.106ArgAsp: 2.106 ± 0.512
2.78ArgGlu: 2.78 ± 0.551
1.432ArgPhe: 1.432 ± 0.345
2.19ArgGly: 2.19 ± 0.461
0.674ArgHis: 0.674 ± 0.242
2.864ArgIle: 2.864 ± 0.543
3.201ArgLys: 3.201 ± 0.749
4.717ArgLeu: 4.717 ± 0.814
2.106ArgMet: 2.106 ± 0.429
3.37ArgAsn: 3.37 ± 0.551
0.842ArgPro: 0.842 ± 0.222
1.769ArgGln: 1.769 ± 0.469
2.274ArgArg: 2.274 ± 0.538
2.19ArgSer: 2.19 ± 0.45
2.78ArgThr: 2.78 ± 0.608
2.19ArgVal: 2.19 ± 0.433
0.505ArgTrp: 0.505 ± 0.238
1.516ArgTyr: 1.516 ± 0.417
0.0ArgXaa: 0.0 ± 0.0
Ser
3.791SerAla: 3.791 ± 0.868
0.168SerCys: 0.168 ± 0.127
3.875SerAsp: 3.875 ± 0.534
3.875SerGlu: 3.875 ± 0.57
2.443SerPhe: 2.443 ± 0.467
5.139SerGly: 5.139 ± 0.844
1.264SerHis: 1.264 ± 0.408
4.128SerIle: 4.128 ± 0.758
4.97SerLys: 4.97 ± 0.763
5.897SerLeu: 5.897 ± 0.675
1.095SerMet: 1.095 ± 0.366
3.37SerAsn: 3.37 ± 0.565
1.432SerPro: 1.432 ± 0.33
2.78SerGln: 2.78 ± 0.434
3.285SerArg: 3.285 ± 0.728
3.201SerSer: 3.201 ± 0.684
3.959SerThr: 3.959 ± 0.656
3.285SerVal: 3.285 ± 0.731
1.095SerTrp: 1.095 ± 0.484
3.033SerTyr: 3.033 ± 0.512
0.0SerXaa: 0.0 ± 0.0
Thr
4.802ThrAla: 4.802 ± 0.811
0.253ThrCys: 0.253 ± 0.16
4.549ThrAsp: 4.549 ± 0.557
4.043ThrGlu: 4.043 ± 0.528
3.37ThrPhe: 3.37 ± 0.607
3.875ThrGly: 3.875 ± 0.72
0.927ThrHis: 0.927 ± 0.329
4.633ThrIle: 4.633 ± 0.562
4.717ThrLys: 4.717 ± 0.698
4.212ThrLeu: 4.212 ± 0.628
0.927ThrMet: 0.927 ± 0.22
3.875ThrAsn: 3.875 ± 0.532
1.348ThrPro: 1.348 ± 0.449
2.864ThrGln: 2.864 ± 0.572
1.432ThrArg: 1.432 ± 0.288
4.128ThrSer: 4.128 ± 0.639
4.717ThrThr: 4.717 ± 0.936
3.538ThrVal: 3.538 ± 0.679
0.927ThrTrp: 0.927 ± 0.386
2.864ThrTyr: 2.864 ± 0.579
0.0ThrXaa: 0.0 ± 0.0
Val
5.139ValAla: 5.139 ± 0.825
0.168ValCys: 0.168 ± 0.126
3.875ValAsp: 3.875 ± 0.534
5.307ValGlu: 5.307 ± 0.528
1.853ValPhe: 1.853 ± 0.452
5.139ValGly: 5.139 ± 0.615
0.674ValHis: 0.674 ± 0.26
4.38ValIle: 4.38 ± 0.867
5.728ValLys: 5.728 ± 0.749
3.791ValLeu: 3.791 ± 0.448
1.264ValMet: 1.264 ± 0.369
3.959ValAsn: 3.959 ± 0.539
1.769ValPro: 1.769 ± 0.374
1.516ValGln: 1.516 ± 0.343
2.106ValArg: 2.106 ± 0.33
4.465ValSer: 4.465 ± 0.621
4.212ValThr: 4.212 ± 0.631
4.465ValVal: 4.465 ± 0.746
0.337ValTrp: 0.337 ± 0.155
2.022ValTyr: 2.022 ± 0.365
0.0ValXaa: 0.0 ± 0.0
Trp
1.011TrpAla: 1.011 ± 0.316
0.168TrpCys: 0.168 ± 0.099
0.505TrpAsp: 0.505 ± 0.23
0.927TrpGlu: 0.927 ± 0.341
1.179TrpPhe: 1.179 ± 0.481
0.505TrpGly: 0.505 ± 0.167
0.084TrpHis: 0.084 ± 0.086
0.758TrpIle: 0.758 ± 0.224
1.432TrpLys: 1.432 ± 0.318
0.927TrpLeu: 0.927 ± 0.322
0.253TrpMet: 0.253 ± 0.147
1.011TrpAsn: 1.011 ± 0.285
0.0TrpPro: 0.0 ± 0.0
1.011TrpGln: 1.011 ± 0.38
0.253TrpArg: 0.253 ± 0.189
0.505TrpSer: 0.505 ± 0.171
0.927TrpThr: 0.927 ± 0.245
1.095TrpVal: 1.095 ± 0.221
0.168TrpTrp: 0.168 ± 0.104
0.842TrpTyr: 0.842 ± 0.528
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.769TyrAla: 1.769 ± 0.338
0.337TyrCys: 0.337 ± 0.146
2.443TyrAsp: 2.443 ± 0.429
2.359TyrGlu: 2.359 ± 0.488
1.769TyrPhe: 1.769 ± 0.517
2.19TyrGly: 2.19 ± 0.392
0.927TyrHis: 0.927 ± 0.287
2.443TyrIle: 2.443 ± 0.489
3.454TyrLys: 3.454 ± 0.608
3.201TyrLeu: 3.201 ± 0.55
0.505TyrMet: 0.505 ± 0.253
1.432TyrAsn: 1.432 ± 0.381
1.853TyrPro: 1.853 ± 0.403
2.274TyrGln: 2.274 ± 0.374
2.443TyrArg: 2.443 ± 0.617
2.611TyrSer: 2.611 ± 0.505
2.19TyrThr: 2.19 ± 0.377
2.611TyrVal: 2.611 ± 0.534
0.253TyrTrp: 0.253 ± 0.147
1.769TyrTyr: 1.769 ± 0.591
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (11872 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski