Amino acid dipepetide frequency for Aphanomyces euteiches

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.004AlaAla: 9.004 ± 0.062	1.485AlaCys: 1.485 ± 0.016	3.941AlaAsp: 3.941 ± 0.026	4.073AlaGlu: 4.073 ± 0.031	3.516AlaPhe: 3.516 ± 0.021	3.911AlaGly: 3.911 ± 0.031	1.999AlaHis: 1.999 ± 0.016	4.738AlaIle: 4.738 ± 0.027	5.006AlaLys: 5.006 ± 0.031	8.706AlaLeu: 8.706 ± 0.042	2.592AlaMet: 2.592 ± 0.021	3.229AlaAsn: 3.229 ± 0.023	4.336AlaPro: 4.336 ± 0.039	3.462AlaGln: 3.462 ± 0.026	4.117AlaArg: 4.117 ± 0.026	7.019AlaSer: 7.019 ± 0.037	5.957AlaThr: 5.957 ± 0.033	5.813AlaVal: 5.813 ± 0.029	1.156AlaTrp: 1.156 ± 0.013	2.15AlaTyr: 2.15 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	1.332CysAla: 1.332 ± 0.013	0.416CysCys: 0.416 ± 0.008	0.928CysAsp: 0.928 ± 0.011	0.784CysGlu: 0.784 ± 0.01	0.802CysPhe: 0.802 ± 0.011	1.269CysGly: 1.269 ± 0.017	0.512CysHis: 0.512 ± 0.008	1.004CysIle: 1.004 ± 0.012	0.78CysLys: 0.78 ± 0.011	1.743CysLeu: 1.743 ± 0.014	0.456CysMet: 0.456 ± 0.007	0.648CysAsn: 0.648 ± 0.009	0.935CysPro: 0.935 ± 0.014	0.716CysGln: 0.716 ± 0.009	1.069CysArg: 1.069 ± 0.012	1.348CysSer: 1.348 ± 0.017	1.139CysThr: 1.139 ± 0.015	1.343CysVal: 1.343 ± 0.015	0.241CysTrp: 0.241 ± 0.005	0.474CysTyr: 0.474 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.13AspAla: 5.13 ± 0.031	0.883AspCys: 0.883 ± 0.012	4.671AspAsp: 4.671 ± 0.066	4.306AspGlu: 4.306 ± 0.031	2.234AspPhe: 2.234 ± 0.017	3.478AspGly: 3.478 ± 0.024	1.344AspHis: 1.344 ± 0.014	3.061AspIle: 3.061 ± 0.019	2.752AspLys: 2.752 ± 0.023	5.047AspLeu: 5.047 ± 0.025	1.566AspMet: 1.566 ± 0.014	1.993AspAsn: 1.993 ± 0.014	2.613AspPro: 2.613 ± 0.017	1.865AspGln: 1.865 ± 0.014	2.57AspArg: 2.57 ± 0.02	3.644AspSer: 3.644 ± 0.024	2.843AspThr: 2.843 ± 0.021	4.425AspVal: 4.425 ± 0.024	0.686AspTrp: 0.686 ± 0.009	1.456AspTyr: 1.456 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	5.155GluAla: 5.155 ± 0.035	0.931GluCys: 0.931 ± 0.01	3.444GluAsp: 3.444 ± 0.023	4.394GluGlu: 4.394 ± 0.037	2.055GluPhe: 2.055 ± 0.018	2.585GluGly: 2.585 ± 0.02	1.411GluHis: 1.411 ± 0.013	2.953GluIle: 2.953 ± 0.02	3.36GluLys: 3.36 ± 0.032	5.591GluLeu: 5.591 ± 0.035	1.683GluMet: 1.683 ± 0.015	2.213GluAsn: 2.213 ± 0.019	2.284GluPro: 2.284 ± 0.018	2.229GluGln: 2.229 ± 0.018	3.398GluArg: 3.398 ± 0.027	4.146GluSer: 4.146 ± 0.025	3.457GluThr: 3.457 ± 0.024	3.493GluVal: 3.493 ± 0.022	0.926GluTrp: 0.926 ± 0.011	1.628GluTyr: 1.628 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	3.195PheAla: 3.195 ± 0.022	0.808PheCys: 0.808 ± 0.009	2.573PheAsp: 2.573 ± 0.02	2.268PheGlu: 2.268 ± 0.015	1.674PhePhe: 1.674 ± 0.018	2.795PheGly: 2.795 ± 0.025	1.174PheHis: 1.174 ± 0.011	1.772PheIle: 1.772 ± 0.017	1.703PheLys: 1.703 ± 0.014	3.815PheLeu: 3.815 ± 0.028	0.935PheMet: 0.935 ± 0.009	1.538PheAsn: 1.538 ± 0.014	1.763PhePro: 1.763 ± 0.015	1.77PheGln: 1.77 ± 0.015	2.04PheArg: 2.04 ± 0.015	2.813PheSer: 2.813 ± 0.021	2.106PheThr: 2.106 ± 0.018	3.222PheVal: 3.222 ± 0.021	0.494PheTrp: 0.494 ± 0.008	1.188PheTyr: 1.188 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	4.118GlyAla: 4.118 ± 0.031	1.173GlyCys: 1.173 ± 0.016	3.016GlyAsp: 3.016 ± 0.021	2.598GlyGlu: 2.598 ± 0.02	2.484GlyPhe: 2.484 ± 0.021	4.124GlyGly: 4.124 ± 0.059	1.753GlyHis: 1.753 ± 0.02	2.816GlyIle: 2.816 ± 0.019	2.831GlyLys: 2.831 ± 0.019	4.93GlyLeu: 4.93 ± 0.024	1.357GlyMet: 1.357 ± 0.012	2.175GlyAsn: 2.175 ± 0.023	2.014GlyPro: 2.014 ± 0.018	2.069GlyGln: 2.069 ± 0.019	2.947GlyArg: 2.947 ± 0.02	4.181GlySer: 4.181 ± 0.035	3.078GlyThr: 3.078 ± 0.025	3.913GlyVal: 3.913 ± 0.027	0.836GlyTrp: 0.836 ± 0.009	1.857GlyTyr: 1.857 ± 0.018	0.0GlyXaa: 0.0 ± 0.0
His	2.394HisAla: 2.394 ± 0.021	0.531HisCys: 0.531 ± 0.009	1.579HisAsp: 1.579 ± 0.014	1.653HisGlu: 1.653 ± 0.015	1.13HisPhe: 1.13 ± 0.012	1.894HisGly: 1.894 ± 0.018	0.945HisHis: 0.945 ± 0.012	1.299HisIle: 1.299 ± 0.012	1.1HisLys: 1.1 ± 0.012	2.802HisLeu: 2.802 ± 0.022	0.65HisMet: 0.65 ± 0.009	0.889HisAsn: 0.889 ± 0.01	1.453HisPro: 1.453 ± 0.015	1.107HisGln: 1.107 ± 0.012	1.7HisArg: 1.7 ± 0.014	1.763HisSer: 1.763 ± 0.015	1.336HisThr: 1.336 ± 0.012	2.216HisVal: 2.216 ± 0.017	0.376HisTrp: 0.376 ± 0.007	0.723HisTyr: 0.723 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.436IleAla: 4.436 ± 0.023	0.898IleCys: 0.898 ± 0.012	3.057IleAsp: 3.057 ± 0.02	3.006IleGlu: 3.006 ± 0.021	1.919IlePhe: 1.919 ± 0.018	2.558IleGly: 2.558 ± 0.02	1.44IleHis: 1.44 ± 0.014	1.863IleIle: 1.863 ± 0.017	2.298IleLys: 2.298 ± 0.019	4.587IleLeu: 4.587 ± 0.024	1.043IleMet: 1.043 ± 0.012	1.704IleAsn: 1.704 ± 0.014	2.569IlePro: 2.569 ± 0.019	2.53IleGln: 2.53 ± 0.019	2.582IleArg: 2.582 ± 0.02	3.358IleSer: 3.358 ± 0.025	2.408IleThr: 2.408 ± 0.017	3.907IleVal: 3.907 ± 0.019	0.563IleTrp: 0.563 ± 0.009	1.384IleTyr: 1.384 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	4.502LysAla: 4.502 ± 0.034	0.937LysCys: 0.937 ± 0.011	2.648LysAsp: 2.648 ± 0.019	3.274LysGlu: 3.274 ± 0.03	1.696LysPhe: 1.696 ± 0.016	2.257LysGly: 2.257 ± 0.02	1.411LysHis: 1.411 ± 0.014	2.343LysIle: 2.343 ± 0.02	3.784LysLys: 3.784 ± 0.04	4.908LysLeu: 4.908 ± 0.03	1.282LysMet: 1.282 ± 0.013	1.873LysAsn: 1.873 ± 0.018	2.643LysPro: 2.643 ± 0.022	2.478LysGln: 2.478 ± 0.02	3.422LysArg: 3.422 ± 0.026	3.931LysSer: 3.931 ± 0.025	3.35LysThr: 3.35 ± 0.026	2.973LysVal: 2.973 ± 0.019	0.79LysTrp: 0.79 ± 0.01	1.579LysTyr: 1.579 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	8.317LeuAla: 8.317 ± 0.032	1.769LeuCys: 1.769 ± 0.016	5.789LeuAsp: 5.789 ± 0.028	5.96LeuGlu: 5.96 ± 0.037	3.737LeuPhe: 3.737 ± 0.026	5.006LeuGly: 5.006 ± 0.027	3.195LeuHis: 3.195 ± 0.025	3.73LeuIle: 3.73 ± 0.025	4.933LeuLys: 4.933 ± 0.03	9.541LeuLeu: 9.541 ± 0.049	2.125LeuMet: 2.125 ± 0.016	3.555LeuAsn: 3.555 ± 0.025	4.938LeuPro: 4.938 ± 0.027	4.699LeuGln: 4.699 ± 0.03	5.634LeuArg: 5.634 ± 0.033	7.412LeuSer: 7.412 ± 0.033	5.41LeuThr: 5.41 ± 0.034	7.078LeuVal: 7.078 ± 0.03	1.254LeuTrp: 1.254 ± 0.013	2.54LeuTyr: 2.54 ± 0.016	0.0LeuXaa: 0.0 ± 0.0
Met	2.381MetAla: 2.381 ± 0.017	0.383MetCys: 0.383 ± 0.007	1.687MetAsp: 1.687 ± 0.015	1.719MetGlu: 1.719 ± 0.014	0.859MetPhe: 0.859 ± 0.01	1.297MetGly: 1.297 ± 0.012	0.706MetHis: 0.706 ± 0.009	1.045MetIle: 1.045 ± 0.01	1.367MetLys: 1.367 ± 0.013	2.394MetLeu: 2.394 ± 0.019	0.679MetMet: 0.679 ± 0.009	0.965MetAsn: 0.965 ± 0.012	1.21MetPro: 1.21 ± 0.011	1.209MetGln: 1.209 ± 0.013	1.347MetArg: 1.347 ± 0.013	1.886MetSer: 1.886 ± 0.015	1.657MetThr: 1.657 ± 0.015	1.527MetVal: 1.527 ± 0.015	0.328MetTrp: 0.328 ± 0.006	0.718MetTyr: 0.718 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	3.42AsnAla: 3.42 ± 0.02	0.662AsnCys: 0.662 ± 0.01	2.276AsnAsp: 2.276 ± 0.018	2.254AsnGlu: 2.254 ± 0.017	1.348AsnPhe: 1.348 ± 0.012	2.552AsnGly: 2.552 ± 0.024	0.972AsnHis: 0.972 ± 0.012	1.842AsnIle: 1.842 ± 0.016	1.721AsnLys: 1.721 ± 0.016	3.342AsnLeu: 3.342 ± 0.02	0.971AsnMet: 0.971 ± 0.011	1.477AsnAsn: 1.477 ± 0.017	2.06AsnPro: 2.06 ± 0.017	1.661AsnGln: 1.661 ± 0.016	1.909AsnArg: 1.909 ± 0.017	2.573AsnSer: 2.573 ± 0.02	2.016AsnThr: 2.016 ± 0.019	2.865AsnVal: 2.865 ± 0.02	0.484AsnTrp: 0.484 ± 0.008	1.032AsnTyr: 1.032 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	3.977ProAla: 3.977 ± 0.035	0.681ProCys: 0.681 ± 0.01	2.392ProAsp: 2.392 ± 0.015	2.637ProGlu: 2.637 ± 0.019	1.899ProPhe: 1.899 ± 0.016	2.225ProGly: 2.225 ± 0.02	1.264ProHis: 1.264 ± 0.013	2.23ProIle: 2.23 ± 0.019	2.548ProLys: 2.548 ± 0.02	4.673ProLeu: 4.673 ± 0.03	1.112ProMet: 1.112 ± 0.012	1.919ProAsn: 1.919 ± 0.017	4.155ProPro: 4.155 ± 0.044	2.026ProGln: 2.026 ± 0.018	2.754ProArg: 2.754 ± 0.021	5.228ProSer: 5.228 ± 0.037	4.166ProThr: 4.166 ± 0.044	3.332ProVal: 3.332 ± 0.023	0.668ProTrp: 0.668 ± 0.009	1.188ProTyr: 1.188 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	3.914GlnAla: 3.914 ± 0.027	0.799GlnCys: 0.799 ± 0.01	2.228GlnAsp: 2.228 ± 0.018	2.515GlnGlu: 2.515 ± 0.025	1.54GlnPhe: 1.54 ± 0.014	2.076GlnGly: 2.076 ± 0.017	1.22GlnHis: 1.22 ± 0.012	1.881GlnIle: 1.881 ± 0.014	1.948GlnLys: 1.948 ± 0.019	4.512GlnLeu: 4.512 ± 0.027	1.047GlnMet: 1.047 ± 0.011	1.459GlnAsn: 1.459 ± 0.015	2.049GlnPro: 2.049 ± 0.017	2.241GlnGln: 2.241 ± 0.026	2.752GlnArg: 2.752 ± 0.021	3.11GlnSer: 3.11 ± 0.022	2.516GlnThr: 2.516 ± 0.019	3.176GlnVal: 3.176 ± 0.022	0.699GlnTrp: 0.699 ± 0.01	1.205GlnTyr: 1.205 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.164ArgAla: 4.164 ± 0.028	0.974ArgCys: 0.974 ± 0.011	2.834ArgAsp: 2.834 ± 0.022	3.156ArgGlu: 3.156 ± 0.026	2.226ArgPhe: 2.226 ± 0.018	2.966ArgGly: 2.966 ± 0.023	1.772ArgHis: 1.772 ± 0.016	2.682ArgIle: 2.682 ± 0.019	2.943ArgLys: 2.943 ± 0.023	5.616ArgLeu: 5.616 ± 0.034	1.382ArgMet: 1.382 ± 0.013	2.0ArgAsn: 2.0 ± 0.016	2.53ArgPro: 2.53 ± 0.018	2.871ArgGln: 2.871 ± 0.022	4.421ArgArg: 4.421 ± 0.036	4.009ArgSer: 4.009 ± 0.023	2.812ArgThr: 2.812 ± 0.019	3.681ArgVal: 3.681 ± 0.021	0.807ArgTrp: 0.807 ± 0.011	1.495ArgTyr: 1.495 ± 0.014	0.0ArgXaa: 0.0 ± 0.0
Ser	5.763SerAla: 5.763 ± 0.034	1.269SerCys: 1.269 ± 0.014	3.898SerAsp: 3.898 ± 0.024	3.415SerGlu: 3.415 ± 0.023	3.289SerPhe: 3.289 ± 0.024	4.08SerGly: 4.08 ± 0.04	1.909SerHis: 1.909 ± 0.016	4.263SerIle: 4.263 ± 0.022	4.11SerLys: 4.11 ± 0.027	7.305SerLeu: 7.305 ± 0.037	2.135SerMet: 2.135 ± 0.016	3.118SerAsn: 3.118 ± 0.023	4.344SerPro: 4.344 ± 0.031	2.892SerGln: 2.892 ± 0.019	3.993SerArg: 3.993 ± 0.026	8.026SerSer: 8.026 ± 0.054	5.792SerThr: 5.792 ± 0.038	5.007SerVal: 5.007 ± 0.027	1.07SerTrp: 1.07 ± 0.011	1.958SerTyr: 1.958 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	5.24ThrAla: 5.24 ± 0.031	1.114ThrCys: 1.114 ± 0.015	2.853ThrAsp: 2.853 ± 0.024	2.833ThrGlu: 2.833 ± 0.02	2.409ThrPhe: 2.409 ± 0.022	2.914ThrGly: 2.914 ± 0.033	1.436ThrHis: 1.436 ± 0.014	3.322ThrIle: 3.322 ± 0.022	3.412ThrLys: 3.412 ± 0.022	5.917ThrLeu: 5.917 ± 0.028	1.553ThrMet: 1.553 ± 0.013	2.381ThrAsn: 2.381 ± 0.018	4.082ThrPro: 4.082 ± 0.05	2.339ThrGln: 2.339 ± 0.017	2.896ThrArg: 2.896 ± 0.019	5.356ThrSer: 5.356 ± 0.035	5.302ThrThr: 5.302 ± 0.045	3.767ThrVal: 3.767 ± 0.026	0.941ThrTrp: 0.941 ± 0.01	1.575ThrTyr: 1.575 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	6.655ValAla: 6.655 ± 0.031	1.346ValCys: 1.346 ± 0.014	4.455ValAsp: 4.455 ± 0.025	4.383ValGlu: 4.383 ± 0.025	2.875ValPhe: 2.875 ± 0.023	3.797ValGly: 3.797 ± 0.024	1.963ValHis: 1.963 ± 0.015	2.997ValIle: 2.997 ± 0.02	3.422ValLys: 3.422 ± 0.022	7.015ValLeu: 7.015 ± 0.035	1.627ValMet: 1.627 ± 0.015	2.485ValAsn: 2.485 ± 0.019	3.427ValPro: 3.427 ± 0.025	3.142ValGln: 3.142 ± 0.022	3.439ValArg: 3.439 ± 0.018	4.831ValSer: 4.831 ± 0.028	3.644ValThr: 3.644 ± 0.028	6.31ValVal: 6.31 ± 0.038	0.997ValTrp: 0.997 ± 0.012	2.025ValTyr: 2.025 ± 0.017	0.001ValXaa: 0.001 ± 0.0
Trp	0.894TrpAla: 0.894 ± 0.01	0.268TrpCys: 0.268 ± 0.005	0.672TrpAsp: 0.672 ± 0.011	0.662TrpGlu: 0.662 ± 0.008	0.614TrpPhe: 0.614 ± 0.008	0.66TrpGly: 0.66 ± 0.011	0.388TrpHis: 0.388 ± 0.007	0.879TrpIle: 0.879 ± 0.01	0.839TrpLys: 0.839 ± 0.011	1.459TrpLeu: 1.459 ± 0.014	0.42TrpMet: 0.42 ± 0.008	0.674TrpAsn: 0.674 ± 0.01	0.53TrpPro: 0.53 ± 0.009	0.566TrpGln: 0.566 ± 0.009	0.867TrpArg: 0.867 ± 0.012	1.099TrpSer: 1.099 ± 0.012	1.066TrpThr: 1.066 ± 0.013	0.746TrpVal: 0.746 ± 0.01	0.24TrpTrp: 0.24 ± 0.006	0.396TrpTyr: 0.396 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.221TyrAla: 2.221 ± 0.018	0.613TyrCys: 0.613 ± 0.009	1.624TyrAsp: 1.624 ± 0.015	1.446TyrGlu: 1.446 ± 0.013	1.337TyrPhe: 1.337 ± 0.014	1.825TyrGly: 1.825 ± 0.018	0.725TyrHis: 0.725 ± 0.011	1.393TyrIle: 1.393 ± 0.015	1.222TyrLys: 1.222 ± 0.012	2.723TyrLeu: 2.723 ± 0.019	0.748TyrMet: 0.748 ± 0.009	1.144TyrAsn: 1.144 ± 0.013	1.139TyrPro: 1.139 ± 0.014	1.017TyrGln: 1.017 ± 0.012	1.485TyrArg: 1.485 ± 0.012	1.903TyrSer: 1.903 ± 0.018	1.587TyrThr: 1.587 ± 0.014	2.04TyrVal: 2.04 ± 0.017	0.38TyrTrp: 0.38 ± 0.008	0.907TyrTyr: 0.907 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.046XaaXaa: 0.046 ± 0.017

Statistics based on 20021 proteins (9106444 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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