Amino acid dipepetide frequency for Gordonia polyisoprenivorans (strain DSM 44266 / VH2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.278AlaAla: 19.278 ± 0.158	0.961AlaCys: 0.961 ± 0.024	9.715AlaAsp: 9.715 ± 0.094	7.312AlaGlu: 7.312 ± 0.083	3.448AlaPhe: 3.448 ± 0.049	11.723AlaGly: 11.723 ± 0.099	2.954AlaHis: 2.954 ± 0.043	5.682AlaIle: 5.682 ± 0.058	2.454AlaLys: 2.454 ± 0.048	12.545AlaLeu: 12.545 ± 0.112	2.77AlaMet: 2.77 ± 0.038	2.201AlaAsn: 2.201 ± 0.045	6.398AlaPro: 6.398 ± 0.079	4.103AlaGln: 4.103 ± 0.048	8.911AlaArg: 8.911 ± 0.087	6.123AlaSer: 6.123 ± 0.057	8.003AlaThr: 8.003 ± 0.084	11.29AlaVal: 11.29 ± 0.113	1.545AlaTrp: 1.545 ± 0.028	2.241AlaTyr: 2.241 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	1.087CysAla: 1.087 ± 0.026	0.093CysCys: 0.093 ± 0.008	0.494CysAsp: 0.494 ± 0.017	0.359CysGlu: 0.359 ± 0.015	0.214CysPhe: 0.214 ± 0.011	0.916CysGly: 0.916 ± 0.025	0.188CysHis: 0.188 ± 0.01	0.261CysIle: 0.261 ± 0.013	0.1CysLys: 0.1 ± 0.008	0.63CysLeu: 0.63 ± 0.021	0.117CysMet: 0.117 ± 0.008	0.135CysAsn: 0.135 ± 0.009	0.432CysPro: 0.432 ± 0.017	0.161CysGln: 0.161 ± 0.01	0.588CysArg: 0.588 ± 0.02	0.482CysSer: 0.482 ± 0.016	0.478CysThr: 0.478 ± 0.017	0.643CysVal: 0.643 ± 0.022	0.133CysTrp: 0.133 ± 0.012	0.149CysTyr: 0.149 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.692AspAla: 8.692 ± 0.087	0.389AspCys: 0.389 ± 0.018	5.2AspAsp: 5.2 ± 0.072	4.349AspGlu: 4.349 ± 0.053	1.75AspPhe: 1.75 ± 0.038	6.113AspGly: 6.113 ± 0.072	1.827AspHis: 1.827 ± 0.031	2.604AspIle: 2.604 ± 0.04	1.221AspLys: 1.221 ± 0.033	6.903AspLeu: 6.903 ± 0.08	0.954AspMet: 0.954 ± 0.024	1.279AspAsn: 1.279 ± 0.028	4.789AspPro: 4.789 ± 0.054	1.624AspGln: 1.624 ± 0.032	5.033AspArg: 5.033 ± 0.053	3.203AspSer: 3.203 ± 0.05	3.7AspThr: 3.7 ± 0.054	5.367AspVal: 5.367 ± 0.069	0.908AspTrp: 0.908 ± 0.024	1.312AspTyr: 1.312 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	5.344GluAla: 5.344 ± 0.063	0.336GluCys: 0.336 ± 0.014	2.182GluAsp: 2.182 ± 0.038	2.295GluGlu: 2.295 ± 0.047	1.802GluPhe: 1.802 ± 0.036	2.969GluGly: 2.969 ± 0.047	1.554GluHis: 1.554 ± 0.031	3.034GluIle: 3.034 ± 0.046	1.297GluLys: 1.297 ± 0.032	6.056GluLeu: 6.056 ± 0.07	1.106GluMet: 1.106 ± 0.029	1.179GluAsn: 1.179 ± 0.028	2.843GluPro: 2.843 ± 0.045	2.058GluGln: 2.058 ± 0.039	4.251GluArg: 4.251 ± 0.063	3.07GluSer: 3.07 ± 0.048	2.693GluThr: 2.693 ± 0.044	4.557GluVal: 4.557 ± 0.059	0.818GluTrp: 0.818 ± 0.022	1.134GluTyr: 1.134 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.061PheAla: 4.061 ± 0.058	0.3PheCys: 0.3 ± 0.013	2.485PheAsp: 2.485 ± 0.051	1.38PheGlu: 1.38 ± 0.028	0.955PhePhe: 0.955 ± 0.025	3.466PheGly: 3.466 ± 0.056	0.62PheHis: 0.62 ± 0.021	1.083PheIle: 1.083 ± 0.025	0.395PheLys: 0.395 ± 0.017	2.493PheLeu: 2.493 ± 0.043	0.449PheMet: 0.449 ± 0.017	0.572PheAsn: 0.572 ± 0.022	1.349PhePro: 1.349 ± 0.032	0.562PheGln: 0.562 ± 0.02	1.646PheArg: 1.646 ± 0.032	1.681PheSer: 1.681 ± 0.034	2.135PheThr: 2.135 ± 0.032	2.667PheVal: 2.667 ± 0.039	0.441PheTrp: 0.441 ± 0.018	0.685PheTyr: 0.685 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.431GlyAla: 10.431 ± 0.098	0.745GlyCys: 0.745 ± 0.022	5.322GlyAsp: 5.322 ± 0.057	4.439GlyGlu: 4.439 ± 0.063	3.13GlyPhe: 3.13 ± 0.045	7.689GlyGly: 7.689 ± 0.099	2.136GlyHis: 2.136 ± 0.036	4.437GlyIle: 4.437 ± 0.058	2.136GlyLys: 2.136 ± 0.045	8.3GlyLeu: 8.3 ± 0.085	2.01GlyMet: 2.01 ± 0.032	1.816GlyAsn: 1.816 ± 0.033	4.491GlyPro: 4.491 ± 0.059	2.568GlyGln: 2.568 ± 0.046	6.5GlyArg: 6.5 ± 0.067	5.458GlySer: 5.458 ± 0.066	5.604GlyThr: 5.604 ± 0.066	7.964GlyVal: 7.964 ± 0.081	1.549GlyTrp: 1.549 ± 0.036	2.301GlyTyr: 2.301 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.589HisAla: 2.589 ± 0.045	0.198HisCys: 0.198 ± 0.011	1.506HisAsp: 1.506 ± 0.03	1.082HisGlu: 1.082 ± 0.024	0.651HisPhe: 0.651 ± 0.02	2.141HisGly: 2.141 ± 0.034	0.828HisHis: 0.828 ± 0.024	0.914HisIle: 0.914 ± 0.022	0.337HisLys: 0.337 ± 0.015	2.409HisLeu: 2.409 ± 0.042	0.356HisMet: 0.356 ± 0.016	0.457HisAsn: 0.457 ± 0.016	1.752HisPro: 1.752 ± 0.03	0.648HisGln: 0.648 ± 0.021	2.114HisArg: 2.114 ± 0.035	1.185HisSer: 1.185 ± 0.027	1.338HisThr: 1.338 ± 0.026	1.692HisVal: 1.692 ± 0.031	0.342HisTrp: 0.342 ± 0.014	0.53HisTyr: 0.53 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.876IleAla: 6.876 ± 0.071	0.392IleCys: 0.392 ± 0.016	3.871IleAsp: 3.871 ± 0.046	2.63IleGlu: 2.63 ± 0.042	1.072IlePhe: 1.072 ± 0.03	4.92IleGly: 4.92 ± 0.058	0.871IleHis: 0.871 ± 0.022	1.75IleIle: 1.75 ± 0.038	0.765IleLys: 0.765 ± 0.024	3.578IleLeu: 3.578 ± 0.047	0.657IleMet: 0.657 ± 0.021	1.081IleAsn: 1.081 ± 0.027	2.536IlePro: 2.536 ± 0.039	0.757IleGln: 0.757 ± 0.023	2.832IleArg: 2.832 ± 0.041	2.499IleSer: 2.499 ± 0.041	3.239IleThr: 3.239 ± 0.041	4.302IleVal: 4.302 ± 0.056	0.495IleTrp: 0.495 ± 0.017	0.801IleTyr: 0.801 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.317LysAla: 2.317 ± 0.051	0.1LysCys: 0.1 ± 0.008	0.995LysAsp: 0.995 ± 0.027	0.793LysGlu: 0.793 ± 0.023	0.498LysPhe: 0.498 ± 0.019	1.478LysGly: 1.478 ± 0.036	0.431LysHis: 0.431 ± 0.018	0.957LysIle: 0.957 ± 0.026	0.679LysLys: 0.679 ± 0.029	1.777LysLeu: 1.777 ± 0.034	0.406LysMet: 0.406 ± 0.016	0.503LysAsn: 0.503 ± 0.016	1.17LysPro: 1.17 ± 0.029	0.628LysGln: 0.628 ± 0.02	1.403LysArg: 1.403 ± 0.034	1.124LysSer: 1.124 ± 0.029	1.259LysThr: 1.259 ± 0.032	1.79LysVal: 1.79 ± 0.038	0.261LysTrp: 0.261 ± 0.013	0.437LysTyr: 0.437 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.536LeuAla: 13.536 ± 0.106	0.796LeuCys: 0.796 ± 0.02	7.114LeuAsp: 7.114 ± 0.083	4.004LeuGlu: 4.004 ± 0.055	2.58LeuPhe: 2.58 ± 0.034	8.846LeuGly: 8.846 ± 0.093	1.971LeuHis: 1.971 ± 0.034	4.417LeuIle: 4.417 ± 0.063	1.482LeuLys: 1.482 ± 0.035	8.902LeuLeu: 8.902 ± 0.098	1.671LeuMet: 1.671 ± 0.031	1.735LeuAsn: 1.735 ± 0.032	5.355LeuPro: 5.355 ± 0.068	2.164LeuGln: 2.164 ± 0.037	7.488LeuArg: 7.488 ± 0.087	5.559LeuSer: 5.559 ± 0.061	6.574LeuThr: 6.574 ± 0.069	8.315LeuVal: 8.315 ± 0.076	1.177LeuTrp: 1.177 ± 0.028	1.627LeuTyr: 1.627 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.373MetAla: 2.373 ± 0.041	0.174MetCys: 0.174 ± 0.011	0.825MetAsp: 0.825 ± 0.023	0.616MetGlu: 0.616 ± 0.02	0.63MetPhe: 0.63 ± 0.019	1.436MetGly: 1.436 ± 0.036	0.385MetHis: 0.385 ± 0.015	1.03MetIle: 1.03 ± 0.026	0.402MetLys: 0.402 ± 0.018	1.921MetLeu: 1.921 ± 0.033	0.478MetMet: 0.478 ± 0.018	0.503MetAsn: 0.503 ± 0.019	1.18MetPro: 1.18 ± 0.028	0.483MetGln: 0.483 ± 0.016	1.585MetArg: 1.585 ± 0.032	1.752MetSer: 1.752 ± 0.029	1.96MetThr: 1.96 ± 0.037	1.724MetVal: 1.724 ± 0.037	0.265MetTrp: 0.265 ± 0.015	0.344MetTyr: 0.344 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.441AsnAla: 2.441 ± 0.045	0.155AsnCys: 0.155 ± 0.009	1.139AsnAsp: 1.139 ± 0.03	0.898AsnGlu: 0.898 ± 0.026	0.561AsnPhe: 0.561 ± 0.017	1.934AsnGly: 1.934 ± 0.037	0.433AsnHis: 0.433 ± 0.016	0.902AsnIle: 0.902 ± 0.024	0.441AsnLys: 0.441 ± 0.019	1.843AsnLeu: 1.843 ± 0.041	0.401AsnMet: 0.401 ± 0.017	0.525AsnAsn: 0.525 ± 0.019	1.708AsnPro: 1.708 ± 0.036	0.541AsnGln: 0.541 ± 0.02	1.426AsnArg: 1.426 ± 0.027	1.203AsnSer: 1.203 ± 0.03	1.281AsnThr: 1.281 ± 0.027	1.552AsnVal: 1.552 ± 0.034	0.319AsnTrp: 0.319 ± 0.015	0.497AsnTyr: 0.497 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.206ProAla: 7.206 ± 0.079	0.266ProCys: 0.266 ± 0.014	4.905ProAsp: 4.905 ± 0.058	3.501ProGlu: 3.501 ± 0.047	1.551ProPhe: 1.551 ± 0.029	5.483ProGly: 5.483 ± 0.064	1.293ProHis: 1.293 ± 0.028	2.338ProIle: 2.338 ± 0.04	1.079ProLys: 1.079 ± 0.027	4.588ProLeu: 4.588 ± 0.053	1.19ProMet: 1.19 ± 0.029	1.139ProAsn: 1.139 ± 0.028	2.98ProPro: 2.98 ± 0.056	1.768ProGln: 1.768 ± 0.034	3.512ProArg: 3.512 ± 0.05	3.259ProSer: 3.259 ± 0.05	4.038ProThr: 4.038 ± 0.06	4.923ProVal: 4.923 ± 0.052	0.797ProTrp: 0.797 ± 0.023	1.038ProTyr: 1.038 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.164GlnAla: 3.164 ± 0.047	0.195GlnCys: 0.195 ± 0.011	0.932GlnAsp: 0.932 ± 0.024	0.993GlnGlu: 0.993 ± 0.025	0.89GlnPhe: 0.89 ± 0.025	1.936GlnGly: 1.936 ± 0.042	0.586GlnHis: 0.586 ± 0.017	1.647GlnIle: 1.647 ± 0.031	0.589GlnLys: 0.589 ± 0.02	2.876GlnLeu: 2.876 ± 0.044	0.682GlnMet: 0.682 ± 0.021	0.607GlnAsn: 0.607 ± 0.019	1.615GlnPro: 1.615 ± 0.038	1.153GlnGln: 1.153 ± 0.034	2.516GlnArg: 2.516 ± 0.035	1.486GlnSer: 1.486 ± 0.033	1.548GlnThr: 1.548 ± 0.034	2.469GlnVal: 2.469 ± 0.036	0.535GlnTrp: 0.535 ± 0.019	0.592GlnTyr: 0.592 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.562ArgAla: 8.562 ± 0.084	0.581ArgCys: 0.581 ± 0.021	4.335ArgAsp: 4.335 ± 0.052	3.994ArgGlu: 3.994 ± 0.052	2.359ArgPhe: 2.359 ± 0.039	5.239ArgGly: 5.239 ± 0.058	1.898ArgHis: 1.898 ± 0.033	3.702ArgIle: 3.702 ± 0.048	1.517ArgLys: 1.517 ± 0.035	7.135ArgLeu: 7.135 ± 0.081	1.838ArgMet: 1.838 ± 0.031	1.557ArgAsn: 1.557 ± 0.031	4.079ArgPro: 4.079 ± 0.058	1.965ArgGln: 1.965 ± 0.036	7.14ArgArg: 7.14 ± 0.08	4.433ArgSer: 4.433 ± 0.058	4.767ArgThr: 4.767 ± 0.062	5.772ArgVal: 5.772 ± 0.068	1.396ArgTrp: 1.396 ± 0.035	1.733ArgTyr: 1.733 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	7.766SerAla: 7.766 ± 0.065	0.374SerCys: 0.374 ± 0.015	3.444SerAsp: 3.444 ± 0.043	2.559SerGlu: 2.559 ± 0.036	1.622SerPhe: 1.622 ± 0.031	6.112SerGly: 6.112 ± 0.066	1.079SerHis: 1.079 ± 0.023	2.414SerIle: 2.414 ± 0.039	1.006SerLys: 1.006 ± 0.027	4.892SerLeu: 4.892 ± 0.055	1.42SerMet: 1.42 ± 0.031	1.053SerAsn: 1.053 ± 0.03	3.301SerPro: 3.301 ± 0.043	1.353SerGln: 1.353 ± 0.031	3.867SerArg: 3.867 ± 0.049	3.65SerSer: 3.65 ± 0.062	3.977SerThr: 3.977 ± 0.048	5.05SerVal: 5.05 ± 0.068	0.912SerTrp: 0.912 ± 0.024	1.161SerTyr: 1.161 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.265ThrAla: 8.265 ± 0.075	0.437ThrCys: 0.437 ± 0.017	4.664ThrAsp: 4.664 ± 0.058	3.389ThrGlu: 3.389 ± 0.043	1.846ThrPhe: 1.846 ± 0.03	6.175ThrGly: 6.175 ± 0.063	1.346ThrHis: 1.346 ± 0.027	2.864ThrIle: 2.864 ± 0.046	1.125ThrLys: 1.125 ± 0.03	5.816ThrLeu: 5.816 ± 0.054	1.272ThrMet: 1.272 ± 0.027	1.21ThrAsn: 1.21 ± 0.03	4.426ThrPro: 4.426 ± 0.053	1.53ThrGln: 1.53 ± 0.031	4.19ThrArg: 4.19 ± 0.047	3.783ThrSer: 3.783 ± 0.045	4.836ThrThr: 4.836 ± 0.069	6.065ThrVal: 6.065 ± 0.069	0.883ThrTrp: 0.883 ± 0.025	1.327ThrTyr: 1.327 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.869ValAla: 11.869 ± 0.111	0.793ValCys: 0.793 ± 0.022	6.052ValAsp: 6.052 ± 0.068	4.459ValGlu: 4.459 ± 0.051	2.6ValPhe: 2.6 ± 0.042	7.486ValGly: 7.486 ± 0.085	1.869ValHis: 1.869 ± 0.031	4.526ValIle: 4.526 ± 0.057	1.36ValLys: 1.36 ± 0.032	8.759ValLeu: 8.759 ± 0.091	1.652ValMet: 1.652 ± 0.034	1.82ValAsn: 1.82 ± 0.036	4.575ValPro: 4.575 ± 0.057	1.773ValGln: 1.773 ± 0.032	5.889ValArg: 5.889 ± 0.064	4.924ValSer: 4.924 ± 0.064	5.879ValThr: 5.879 ± 0.075	8.943ValVal: 8.943 ± 0.092	1.019ValTrp: 1.019 ± 0.025	1.516ValTyr: 1.516 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.543TrpAla: 1.543 ± 0.03	0.154TrpCys: 0.154 ± 0.009	0.745TrpAsp: 0.745 ± 0.022	0.599TrpGlu: 0.599 ± 0.02	0.545TrpPhe: 0.545 ± 0.019	1.033TrpGly: 1.033 ± 0.025	0.347TrpHis: 0.347 ± 0.014	0.696TrpIle: 0.696 ± 0.022	0.305TrpLys: 0.305 ± 0.014	1.599TrpLeu: 1.599 ± 0.036	0.351TrpMet: 0.351 ± 0.014	0.395TrpAsn: 0.395 ± 0.015	0.718TrpPro: 0.718 ± 0.02	0.559TrpGln: 0.559 ± 0.021	1.243TrpArg: 1.243 ± 0.029	0.969TrpSer: 0.969 ± 0.024	0.929TrpThr: 0.929 ± 0.025	1.082TrpVal: 1.082 ± 0.025	0.404TrpTrp: 0.404 ± 0.016	0.337TrpTyr: 0.337 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.259TyrAla: 2.259 ± 0.037	0.222TyrCys: 0.222 ± 0.013	1.294TyrAsp: 1.294 ± 0.032	0.928TyrGlu: 0.928 ± 0.023	0.718TyrPhe: 0.718 ± 0.022	1.93TyrGly: 1.93 ± 0.041	0.454TyrHis: 0.454 ± 0.017	0.664TyrIle: 0.664 ± 0.019	0.314TyrLys: 0.314 ± 0.015	2.291TyrLeu: 2.291 ± 0.04	0.291TyrMet: 0.291 ± 0.014	0.431TyrAsn: 0.431 ± 0.019	1.158TyrPro: 1.158 ± 0.029	0.612TyrGln: 0.612 ± 0.023	1.867TyrArg: 1.867 ± 0.033	1.167TyrSer: 1.167 ± 0.026	1.213TyrThr: 1.213 ± 0.029	1.595TyrVal: 1.595 ± 0.031	0.355TyrTrp: 0.355 ± 0.016	0.454TyrTyr: 0.454 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5097 proteins (1734384 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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