Amino acid dipepetide frequency for Pseudomonas virus H66

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.195AlaAla: 16.195 ± 1.359
0.845AlaCys: 0.845 ± 0.297
8.147AlaAsp: 8.147 ± 0.766
9.041AlaGlu: 9.041 ± 0.935
3.229AlaPhe: 3.229 ± 0.327
9.538AlaGly: 9.538 ± 0.797
1.888AlaHis: 1.888 ± 0.373
5.961AlaIle: 5.961 ± 0.562
5.862AlaLys: 5.862 ± 0.662
10.581AlaLeu: 10.581 ± 0.928
3.279AlaMet: 3.279 ± 0.387
3.13AlaAsn: 3.13 ± 0.329
6.16AlaPro: 6.16 ± 0.658
6.855AlaGln: 6.855 ± 0.733
9.29AlaArg: 9.29 ± 0.759
6.16AlaSer: 6.16 ± 0.581
5.663AlaThr: 5.663 ± 0.63
7.998AlaVal: 7.998 ± 0.669
1.987AlaTrp: 1.987 ± 0.277
2.981AlaTyr: 2.981 ± 0.493
0.0AlaXaa: 0.0 ± 0.0
Cys
0.745CysAla: 0.745 ± 0.255
0.248CysCys: 0.248 ± 0.121
0.646CysAsp: 0.646 ± 0.247
0.596CysGlu: 0.596 ± 0.213
0.05CysPhe: 0.05 ± 0.062
0.944CysGly: 0.944 ± 0.303
0.397CysHis: 0.397 ± 0.164
0.298CysIle: 0.298 ± 0.158
0.348CysLys: 0.348 ± 0.156
0.596CysLeu: 0.596 ± 0.187
0.099CysMet: 0.099 ± 0.091
0.099CysAsn: 0.099 ± 0.07
0.397CysPro: 0.397 ± 0.171
0.546CysGln: 0.546 ± 0.162
0.596CysArg: 0.596 ± 0.23
0.646CysSer: 0.646 ± 0.227
0.298CysThr: 0.298 ± 0.135
0.397CysVal: 0.397 ± 0.142
0.05CysTrp: 0.05 ± 0.05
0.397CysTyr: 0.397 ± 0.16
0.0CysXaa: 0.0 ± 0.0
Asp
9.24AspAla: 9.24 ± 0.864
0.348AspCys: 0.348 ± 0.166
3.875AspAsp: 3.875 ± 0.498
3.626AspGlu: 3.626 ± 0.319
1.838AspPhe: 1.838 ± 0.355
5.464AspGly: 5.464 ± 0.528
0.894AspHis: 0.894 ± 0.208
2.633AspIle: 2.633 ± 0.354
2.037AspLys: 2.037 ± 0.319
5.216AspLeu: 5.216 ± 0.466
1.838AspMet: 1.838 ± 0.328
1.49AspAsn: 1.49 ± 0.335
3.03AspPro: 3.03 ± 0.527
3.328AspGln: 3.328 ± 0.456
3.676AspArg: 3.676 ± 0.418
3.179AspSer: 3.179 ± 0.419
3.13AspThr: 3.13 ± 0.37
4.223AspVal: 4.223 ± 0.42
1.043AspTrp: 1.043 ± 0.28
1.49AspTyr: 1.49 ± 0.321
0.0AspXaa: 0.0 ± 0.0
Glu
8.197GluAla: 8.197 ± 0.906
0.348GluCys: 0.348 ± 0.138
3.279GluAsp: 3.279 ± 0.381
3.676GluGlu: 3.676 ± 0.42
2.037GluPhe: 2.037 ± 0.516
4.372GluGly: 4.372 ± 0.602
1.292GluHis: 1.292 ± 0.325
2.633GluIle: 2.633 ± 0.427
2.881GluLys: 2.881 ± 0.381
5.961GluLeu: 5.961 ± 0.501
1.192GluMet: 1.192 ± 0.264
1.49GluAsn: 1.49 ± 0.242
2.782GluPro: 2.782 ± 0.431
4.819GluGln: 4.819 ± 0.485
5.415GluArg: 5.415 ± 0.528
3.775GluSer: 3.775 ± 0.533
2.434GluThr: 2.434 ± 0.346
3.825GluVal: 3.825 ± 0.452
1.093GluTrp: 1.093 ± 0.286
1.987GluTyr: 1.987 ± 0.275
0.0GluXaa: 0.0 ± 0.0
Phe
3.378PheAla: 3.378 ± 0.399
0.248PheCys: 0.248 ± 0.127
2.136PheAsp: 2.136 ± 0.417
2.086PheGlu: 2.086 ± 0.325
0.646PhePhe: 0.646 ± 0.159
3.08PheGly: 3.08 ± 0.48
0.596PheHis: 0.596 ± 0.182
1.192PheIle: 1.192 ± 0.275
1.292PheLys: 1.292 ± 0.213
2.335PheLeu: 2.335 ± 0.305
0.497PheMet: 0.497 ± 0.127
0.894PheAsn: 0.894 ± 0.217
1.689PhePro: 1.689 ± 0.26
1.341PheGln: 1.341 ± 0.21
1.788PheArg: 1.788 ± 0.28
1.888PheSer: 1.888 ± 0.238
1.689PheThr: 1.689 ± 0.355
2.434PheVal: 2.434 ± 0.413
0.298PheTrp: 0.298 ± 0.154
0.994PheTyr: 0.994 ± 0.309
0.0PheXaa: 0.0 ± 0.0
Gly
7.998GlyAla: 7.998 ± 0.605
0.646GlyCys: 0.646 ± 0.216
4.719GlyAsp: 4.719 ± 0.507
5.166GlyGlu: 5.166 ± 0.593
3.229GlyPhe: 3.229 ± 0.524
6.607GlyGly: 6.607 ± 0.506
1.341GlyHis: 1.341 ± 0.269
3.676GlyIle: 3.676 ± 0.474
3.875GlyLys: 3.875 ± 0.489
5.912GlyLeu: 5.912 ± 0.553
2.235GlyMet: 2.235 ± 0.32
2.285GlyAsn: 2.285 ± 0.372
3.03GlyPro: 3.03 ± 0.383
4.471GlyGln: 4.471 ± 0.427
5.961GlyArg: 5.961 ± 0.595
3.825GlySer: 3.825 ± 0.404
4.719GlyThr: 4.719 ± 0.563
5.514GlyVal: 5.514 ± 0.586
1.49GlyTrp: 1.49 ± 0.257
2.235GlyTyr: 2.235 ± 0.345
0.0GlyXaa: 0.0 ± 0.0
His
2.136HisAla: 2.136 ± 0.283
0.298HisCys: 0.298 ± 0.129
0.944HisAsp: 0.944 ± 0.22
1.242HisGlu: 1.242 ± 0.206
0.944HisPhe: 0.944 ± 0.243
1.937HisGly: 1.937 ± 0.331
0.596HisHis: 0.596 ± 0.179
0.745HisIle: 0.745 ± 0.235
0.348HisLys: 0.348 ± 0.12
1.987HisLeu: 1.987 ± 0.502
0.348HisMet: 0.348 ± 0.14
0.596HisAsn: 0.596 ± 0.206
0.944HisPro: 0.944 ± 0.242
0.944HisGln: 0.944 ± 0.228
1.838HisArg: 1.838 ± 0.262
1.093HisSer: 1.093 ± 0.347
1.043HisThr: 1.043 ± 0.21
0.894HisVal: 0.894 ± 0.193
0.248HisTrp: 0.248 ± 0.117
0.596HisTyr: 0.596 ± 0.188
0.0HisXaa: 0.0 ± 0.0
Ile
5.266IleAla: 5.266 ± 0.59
0.447IleCys: 0.447 ± 0.14
3.626IleAsp: 3.626 ± 0.386
3.279IleGlu: 3.279 ± 0.389
0.596IlePhe: 0.596 ± 0.174
3.477IleGly: 3.477 ± 0.393
0.795IleHis: 0.795 ± 0.223
1.391IleIle: 1.391 ± 0.305
2.434IleLys: 2.434 ± 0.355
2.583IleLeu: 2.583 ± 0.293
0.596IleMet: 0.596 ± 0.152
1.937IleAsn: 1.937 ± 0.367
2.633IlePro: 2.633 ± 0.295
1.143IleGln: 1.143 ± 0.25
3.03IleArg: 3.03 ± 0.367
2.385IleSer: 2.385 ± 0.365
2.782IleThr: 2.782 ± 0.449
2.186IleVal: 2.186 ± 0.382
0.695IleTrp: 0.695 ± 0.193
1.292IleTyr: 1.292 ± 0.355
0.0IleXaa: 0.0 ± 0.0
Lys
5.315LysAla: 5.315 ± 0.79
0.397LysCys: 0.397 ± 0.152
2.434LysAsp: 2.434 ± 0.368
2.335LysGlu: 2.335 ± 0.338
1.192LysPhe: 1.192 ± 0.202
2.633LysGly: 2.633 ± 0.336
0.894LysHis: 0.894 ± 0.227
1.49LysIle: 1.49 ± 0.353
2.534LysLys: 2.534 ± 0.478
3.577LysLeu: 3.577 ± 0.398
1.192LysMet: 1.192 ± 0.255
0.994LysAsn: 0.994 ± 0.254
2.683LysPro: 2.683 ± 0.354
1.788LysGln: 1.788 ± 0.346
3.03LysArg: 3.03 ± 0.495
2.434LysSer: 2.434 ± 0.419
1.739LysThr: 1.739 ± 0.263
3.179LysVal: 3.179 ± 0.326
0.348LysTrp: 0.348 ± 0.115
1.093LysTyr: 1.093 ± 0.209
0.0LysXaa: 0.0 ± 0.0
Leu
11.724LeuAla: 11.724 ± 0.932
0.546LeuCys: 0.546 ± 0.225
5.117LeuAsp: 5.117 ± 0.486
5.315LeuGlu: 5.315 ± 0.462
2.633LeuPhe: 2.633 ± 0.376
5.663LeuGly: 5.663 ± 0.492
2.235LeuHis: 2.235 ± 0.359
2.484LeuIle: 2.484 ± 0.447
2.881LeuLys: 2.881 ± 0.334
6.557LeuLeu: 6.557 ± 0.811
2.086LeuMet: 2.086 ± 0.308
3.428LeuAsn: 3.428 ± 0.443
4.471LeuPro: 4.471 ± 0.484
3.179LeuGln: 3.179 ± 0.336
6.21LeuArg: 6.21 ± 0.543
5.017LeuSer: 5.017 ± 0.607
4.719LeuThr: 4.719 ± 0.646
5.961LeuVal: 5.961 ± 0.659
0.845LeuTrp: 0.845 ± 0.193
1.391LeuTyr: 1.391 ± 0.294
0.0LeuXaa: 0.0 ± 0.0
Met
2.981MetAla: 2.981 ± 0.532
0.0MetCys: 0.0 ± 0.0
1.292MetAsp: 1.292 ± 0.279
0.994MetGlu: 0.994 ± 0.253
0.447MetPhe: 0.447 ± 0.173
2.285MetGly: 2.285 ± 0.326
0.348MetHis: 0.348 ± 0.108
1.093MetIle: 1.093 ± 0.188
1.292MetLys: 1.292 ± 0.216
2.186MetLeu: 2.186 ± 0.279
0.298MetMet: 0.298 ± 0.117
0.845MetAsn: 0.845 ± 0.156
1.937MetPro: 1.937 ± 0.306
1.391MetGln: 1.391 ± 0.267
1.987MetArg: 1.987 ± 0.381
1.888MetSer: 1.888 ± 0.334
1.788MetThr: 1.788 ± 0.259
0.695MetVal: 0.695 ± 0.19
0.248MetTrp: 0.248 ± 0.095
0.447MetTyr: 0.447 ± 0.178
0.0MetXaa: 0.0 ± 0.0
Asn
3.626AsnAla: 3.626 ± 0.522
0.248AsnCys: 0.248 ± 0.115
1.54AsnAsp: 1.54 ± 0.258
1.639AsnGlu: 1.639 ± 0.254
0.695AsnPhe: 0.695 ± 0.143
1.937AsnGly: 1.937 ± 0.264
0.596AsnHis: 0.596 ± 0.188
1.242AsnIle: 1.242 ± 0.325
0.994AsnLys: 0.994 ± 0.195
2.484AsnLeu: 2.484 ± 0.391
1.143AsnMet: 1.143 ± 0.234
0.646AsnAsn: 0.646 ± 0.209
2.037AsnPro: 2.037 ± 0.306
1.441AsnGln: 1.441 ± 0.308
2.235AsnArg: 2.235 ± 0.266
2.086AsnSer: 2.086 ± 0.289
1.689AsnThr: 1.689 ± 0.226
1.54AsnVal: 1.54 ± 0.312
0.795AsnTrp: 0.795 ± 0.244
1.043AsnTyr: 1.043 ± 0.299
0.0AsnXaa: 0.0 ± 0.0
Pro
7.65ProAla: 7.65 ± 0.575
0.546ProCys: 0.546 ± 0.222
3.875ProAsp: 3.875 ± 0.524
3.577ProGlu: 3.577 ± 0.498
1.59ProPhe: 1.59 ± 0.343
3.676ProGly: 3.676 ± 0.62
0.894ProHis: 0.894 ± 0.25
2.335ProIle: 2.335 ± 0.425
2.037ProLys: 2.037 ± 0.331
3.577ProLeu: 3.577 ± 0.492
1.292ProMet: 1.292 ± 0.22
1.689ProAsn: 1.689 ± 0.3
3.428ProPro: 3.428 ± 0.926
2.285ProGln: 2.285 ± 0.375
2.832ProArg: 2.832 ± 0.409
2.832ProSer: 2.832 ± 0.353
3.229ProThr: 3.229 ± 0.368
3.924ProVal: 3.924 ± 0.392
0.596ProTrp: 0.596 ± 0.134
1.441ProTyr: 1.441 ± 0.314
0.0ProXaa: 0.0 ± 0.0
Gln
7.849GlnAla: 7.849 ± 0.736
0.348GlnCys: 0.348 ± 0.17
2.136GlnAsp: 2.136 ± 0.327
3.279GlnGlu: 3.279 ± 0.4
1.689GlnPhe: 1.689 ± 0.23
3.924GlnGly: 3.924 ± 0.429
1.441GlnHis: 1.441 ± 0.238
3.378GlnIle: 3.378 ± 0.623
1.341GlnLys: 1.341 ± 0.288
3.03GlnLeu: 3.03 ± 0.413
1.192GlnMet: 1.192 ± 0.265
1.341GlnAsn: 1.341 ± 0.375
2.534GlnPro: 2.534 ± 0.291
4.421GlnGln: 4.421 ± 0.699
3.279GlnArg: 3.279 ± 0.382
2.037GlnSer: 2.037 ± 0.351
2.086GlnThr: 2.086 ± 0.259
3.179GlnVal: 3.179 ± 0.334
0.795GlnTrp: 0.795 ± 0.247
1.838GlnTyr: 1.838 ± 0.273
0.0GlnXaa: 0.0 ± 0.0
Arg
7.998ArgAla: 7.998 ± 0.669
0.695ArgCys: 0.695 ± 0.256
4.372ArgAsp: 4.372 ± 0.536
4.67ArgGlu: 4.67 ± 0.786
3.03ArgPhe: 3.03 ± 0.346
5.067ArgGly: 5.067 ± 0.567
1.292ArgHis: 1.292 ± 0.342
4.024ArgIle: 4.024 ± 0.392
3.428ArgLys: 3.428 ± 0.501
6.657ArgLeu: 6.657 ± 0.707
1.391ArgMet: 1.391 ± 0.222
2.136ArgAsn: 2.136 ± 0.294
3.825ArgPro: 3.825 ± 0.569
3.924ArgGln: 3.924 ± 0.498
5.614ArgArg: 5.614 ± 0.644
3.875ArgSer: 3.875 ± 0.593
3.328ArgThr: 3.328 ± 0.466
4.918ArgVal: 4.918 ± 0.47
1.093ArgTrp: 1.093 ± 0.31
1.987ArgTyr: 1.987 ± 0.402
0.0ArgXaa: 0.0 ± 0.0
Ser
6.557SerAla: 6.557 ± 0.541
0.248SerCys: 0.248 ± 0.142
3.229SerAsp: 3.229 ± 0.499
3.527SerGlu: 3.527 ± 0.488
1.639SerPhe: 1.639 ± 0.25
5.315SerGly: 5.315 ± 0.639
1.043SerHis: 1.043 ± 0.26
1.689SerIle: 1.689 ± 0.285
2.385SerLys: 2.385 ± 0.279
4.471SerLeu: 4.471 ± 0.505
1.987SerMet: 1.987 ± 0.218
1.739SerAsn: 1.739 ± 0.284
2.881SerPro: 2.881 ± 0.506
2.434SerGln: 2.434 ± 0.306
3.428SerArg: 3.428 ± 0.346
3.825SerSer: 3.825 ± 0.554
3.428SerThr: 3.428 ± 0.461
3.726SerVal: 3.726 ± 0.338
0.795SerTrp: 0.795 ± 0.162
1.242SerTyr: 1.242 ± 0.309
0.0SerXaa: 0.0 ± 0.0
Thr
6.16ThrAla: 6.16 ± 0.686
0.397ThrCys: 0.397 ± 0.165
3.229ThrAsp: 3.229 ± 0.346
2.534ThrGlu: 2.534 ± 0.359
1.987ThrPhe: 1.987 ± 0.375
5.266ThrGly: 5.266 ± 0.433
0.745ThrHis: 0.745 ± 0.18
2.434ThrIle: 2.434 ± 0.384
1.441ThrLys: 1.441 ± 0.257
4.272ThrLeu: 4.272 ± 0.508
1.292ThrMet: 1.292 ± 0.244
1.49ThrAsn: 1.49 ± 0.261
3.577ThrPro: 3.577 ± 0.458
1.937ThrGln: 1.937 ± 0.281
3.626ThrArg: 3.626 ± 0.527
2.782ThrSer: 2.782 ± 0.334
3.03ThrThr: 3.03 ± 0.46
4.173ThrVal: 4.173 ± 0.507
0.695ThrTrp: 0.695 ± 0.167
1.49ThrTyr: 1.49 ± 0.252
0.0ThrXaa: 0.0 ± 0.0
Val
7.899ValAla: 7.899 ± 0.489
0.894ValCys: 0.894 ± 0.262
4.471ValAsp: 4.471 ± 0.423
4.719ValGlu: 4.719 ± 0.595
1.639ValPhe: 1.639 ± 0.404
4.521ValGly: 4.521 ± 0.572
1.739ValHis: 1.739 ± 0.314
2.931ValIle: 2.931 ± 0.375
2.484ValLys: 2.484 ± 0.391
6.11ValLeu: 6.11 ± 0.709
1.59ValMet: 1.59 ± 0.23
1.639ValAsn: 1.639 ± 0.299
3.825ValPro: 3.825 ± 0.488
3.179ValGln: 3.179 ± 0.451
5.464ValArg: 5.464 ± 0.607
3.477ValSer: 3.477 ± 0.5
3.378ValThr: 3.378 ± 0.366
4.272ValVal: 4.272 ± 0.463
0.745ValTrp: 0.745 ± 0.216
1.093ValTyr: 1.093 ± 0.304
0.0ValXaa: 0.0 ± 0.0
Trp
1.49TrpAla: 1.49 ± 0.228
0.199TrpCys: 0.199 ± 0.118
0.845TrpAsp: 0.845 ± 0.206
0.745TrpGlu: 0.745 ± 0.201
0.199TrpPhe: 0.199 ± 0.11
1.192TrpGly: 1.192 ± 0.281
0.447TrpHis: 0.447 ± 0.134
0.149TrpIle: 0.149 ± 0.091
0.596TrpLys: 0.596 ± 0.143
2.037TrpLeu: 2.037 ± 0.313
0.397TrpMet: 0.397 ± 0.142
0.646TrpAsn: 0.646 ± 0.182
0.546TrpPro: 0.546 ± 0.157
0.546TrpGln: 0.546 ± 0.133
1.242TrpArg: 1.242 ± 0.225
0.596TrpSer: 0.596 ± 0.203
0.894TrpThr: 0.894 ± 0.218
1.143TrpVal: 1.143 ± 0.287
0.248TrpTrp: 0.248 ± 0.111
0.348TrpTyr: 0.348 ± 0.151
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.385TyrAla: 2.385 ± 0.394
0.447TyrCys: 0.447 ± 0.16
1.689TyrAsp: 1.689 ± 0.23
1.441TyrGlu: 1.441 ± 0.312
1.192TyrPhe: 1.192 ± 0.241
2.037TyrGly: 2.037 ± 0.338
0.248TyrHis: 0.248 ± 0.119
0.795TyrIle: 0.795 ± 0.178
0.795TyrLys: 0.795 ± 0.207
2.335TyrLeu: 2.335 ± 0.326
0.447TyrMet: 0.447 ± 0.155
1.143TyrAsn: 1.143 ± 0.293
0.894TyrPro: 0.894 ± 0.17
1.143TyrGln: 1.143 ± 0.235
2.832TyrArg: 2.832 ± 0.34
1.788TyrSer: 1.788 ± 0.444
1.49TyrThr: 1.49 ± 0.267
1.888TyrVal: 1.888 ± 0.45
0.397TyrTrp: 0.397 ± 0.21
0.298TyrTyr: 0.298 ± 0.104
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (20131 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski