Amino acid dipepetide frequency for Alistipes finegoldii CAG:68

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.078AlaAla: 12.078 ± 0.183	1.265AlaCys: 1.265 ± 0.041	6.103AlaAsp: 6.103 ± 0.094	6.9AlaGlu: 6.9 ± 0.123	3.533AlaPhe: 3.533 ± 0.077	8.163AlaGly: 8.163 ± 0.115	1.478AlaHis: 1.478 ± 0.05	4.052AlaIle: 4.052 ± 0.084	3.848AlaLys: 3.848 ± 0.08	8.604AlaLeu: 8.604 ± 0.12	2.246AlaMet: 2.246 ± 0.055	2.893AlaAsn: 2.893 ± 0.066	3.645AlaPro: 3.645 ± 0.072	3.328AlaGln: 3.328 ± 0.07	5.184AlaArg: 5.184 ± 0.092	4.907AlaSer: 4.907 ± 0.085	4.397AlaThr: 4.397 ± 0.077	7.745AlaVal: 7.745 ± 0.116	1.176AlaTrp: 1.176 ± 0.042	3.08AlaTyr: 3.08 ± 0.07	0.002AlaXaa: 0.002 ± 0.002
Cys	1.096CysAla: 1.096 ± 0.034	0.201CysCys: 0.201 ± 0.014	0.782CysAsp: 0.782 ± 0.033	0.701CysGlu: 0.701 ± 0.027	0.517CysPhe: 0.517 ± 0.024	1.326CysGly: 1.326 ± 0.046	0.244CysHis: 0.244 ± 0.019	0.757CysIle: 0.757 ± 0.029	0.498CysLys: 0.498 ± 0.027	0.913CysLeu: 0.913 ± 0.034	0.327CysMet: 0.327 ± 0.018	0.481CysAsn: 0.481 ± 0.026	0.57CysPro: 0.57 ± 0.031	0.262CysGln: 0.262 ± 0.016	1.013CysArg: 1.013 ± 0.036	0.793CysSer: 0.793 ± 0.027	0.769CysThr: 0.769 ± 0.032	0.819CysVal: 0.819 ± 0.03	0.143CysTrp: 0.143 ± 0.012	0.523CysTyr: 0.523 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	5.506AspAla: 5.506 ± 0.09	0.615AspCys: 0.615 ± 0.03	3.124AspAsp: 3.124 ± 0.068	3.618AspGlu: 3.618 ± 0.073	2.78AspPhe: 2.78 ± 0.06	4.821AspGly: 4.821 ± 0.083	0.902AspHis: 0.902 ± 0.037	3.567AspIle: 3.567 ± 0.073	2.966AspLys: 2.966 ± 0.055	4.637AspLeu: 4.637 ± 0.069	1.512AspMet: 1.512 ± 0.042	2.335AspAsn: 2.335 ± 0.062	2.669AspPro: 2.669 ± 0.063	1.163AspGln: 1.163 ± 0.049	3.633AspArg: 3.633 ± 0.076	2.87AspSer: 2.87 ± 0.081	2.765AspThr: 2.765 ± 0.06	3.767AspVal: 3.767 ± 0.09	0.835AspTrp: 0.835 ± 0.038	2.645AspTyr: 2.645 ± 0.067	0.0AspXaa: 0.0 ± 0.0
Glu	5.395GluAla: 5.395 ± 0.096	0.68GluCys: 0.68 ± 0.03	2.568GluAsp: 2.568 ± 0.065	4.33GluGlu: 4.33 ± 0.095	2.6GluPhe: 2.6 ± 0.056	4.595GluGly: 4.595 ± 0.072	1.226GluHis: 1.226 ± 0.038	4.186GluIle: 4.186 ± 0.073	3.682GluLys: 3.682 ± 0.069	5.86GluLeu: 5.86 ± 0.097	1.879GluMet: 1.879 ± 0.053	2.801GluAsn: 2.801 ± 0.064	2.188GluPro: 2.188 ± 0.069	2.486GluGln: 2.486 ± 0.064	4.422GluArg: 4.422 ± 0.087	2.923GluSer: 2.923 ± 0.061	3.46GluThr: 3.46 ± 0.063	4.357GluVal: 4.357 ± 0.089	0.856GluTrp: 0.856 ± 0.032	2.55GluTyr: 2.55 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	4.094PheAla: 4.094 ± 0.079	0.637PheCys: 0.637 ± 0.03	3.031PheAsp: 3.031 ± 0.064	2.531PheGlu: 2.531 ± 0.058	1.983PhePhe: 1.983 ± 0.063	3.67PheGly: 3.67 ± 0.077	0.708PheHis: 0.708 ± 0.026	2.214PheIle: 2.214 ± 0.049	1.556PheLys: 1.556 ± 0.046	3.35PheLeu: 3.35 ± 0.069	1.057PheMet: 1.057 ± 0.038	1.729PheAsn: 1.729 ± 0.049	1.683PhePro: 1.683 ± 0.047	0.847PheGln: 0.847 ± 0.032	2.933PheArg: 2.933 ± 0.065	2.982PheSer: 2.982 ± 0.067	2.799PheThr: 2.799 ± 0.06	2.966PheVal: 2.966 ± 0.065	0.513PheTrp: 0.513 ± 0.026	1.7PheTyr: 1.7 ± 0.049	0.001PheXaa: 0.001 ± 0.001
Gly	6.559GlyAla: 6.559 ± 0.091	1.13GlyCys: 1.13 ± 0.043	4.373GlyAsp: 4.373 ± 0.071	4.937GlyGlu: 4.937 ± 0.088	3.565GlyPhe: 3.565 ± 0.075	6.274GlyGly: 6.274 ± 0.109	1.481GlyHis: 1.481 ± 0.051	5.077GlyIle: 5.077 ± 0.089	3.804GlyLys: 3.804 ± 0.077	6.334GlyLeu: 6.334 ± 0.107	2.19GlyMet: 2.19 ± 0.049	3.025GlyAsn: 3.025 ± 0.069	1.732GlyPro: 1.732 ± 0.042	2.161GlyGln: 2.161 ± 0.055	5.247GlyArg: 5.247 ± 0.09	4.468GlySer: 4.468 ± 0.08	4.459GlyThr: 4.459 ± 0.088	6.139GlyVal: 6.139 ± 0.097	1.193GlyTrp: 1.193 ± 0.044	3.596GlyTyr: 3.596 ± 0.079	0.002GlyXaa: 0.002 ± 0.002
His	1.536HisAla: 1.536 ± 0.048	0.274HisCys: 0.274 ± 0.018	1.062HisAsp: 1.062 ± 0.037	0.985HisGlu: 0.985 ± 0.036	0.836HisPhe: 0.836 ± 0.034	1.436HisGly: 1.436 ± 0.044	0.419HisHis: 0.419 ± 0.025	1.226HisIle: 1.226 ± 0.04	0.801HisLys: 0.801 ± 0.027	1.599HisLeu: 1.599 ± 0.045	0.405HisMet: 0.405 ± 0.022	0.751HisAsn: 0.751 ± 0.031	1.081HisPro: 1.081 ± 0.042	0.468HisGln: 0.468 ± 0.028	1.188HisArg: 1.188 ± 0.045	0.916HisSer: 0.916 ± 0.037	1.087HisThr: 1.087 ± 0.038	1.136HisVal: 1.136 ± 0.044	0.191HisTrp: 0.191 ± 0.015	0.792HisTyr: 0.792 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.712IleAla: 5.712 ± 0.094	0.826IleCys: 0.826 ± 0.033	3.946IleAsp: 3.946 ± 0.078	3.648IleGlu: 3.648 ± 0.063	2.294IlePhe: 2.294 ± 0.062	4.467IleGly: 4.467 ± 0.081	1.023IleHis: 1.023 ± 0.038	2.964IleIle: 2.964 ± 0.082	2.249IleLys: 2.249 ± 0.061	4.896IleLeu: 4.896 ± 0.088	1.103IleMet: 1.103 ± 0.035	2.173IleAsn: 2.173 ± 0.056	2.836IlePro: 2.836 ± 0.068	1.296IleGln: 1.296 ± 0.042	3.947IleArg: 3.947 ± 0.067	3.458IleSer: 3.458 ± 0.074	3.163IleThr: 3.163 ± 0.065	4.386IleVal: 4.386 ± 0.077	0.591IleTrp: 0.591 ± 0.028	2.179IleTyr: 2.179 ± 0.057	0.001IleXaa: 0.001 ± 0.001
Lys	4.178LysAla: 4.178 ± 0.086	0.481LysCys: 0.481 ± 0.029	2.182LysAsp: 2.182 ± 0.058	3.089LysGlu: 3.089 ± 0.066	1.778LysPhe: 1.778 ± 0.053	3.367LysGly: 3.367 ± 0.07	0.81LysHis: 0.81 ± 0.033	3.177LysIle: 3.177 ± 0.06	2.656LysLys: 2.656 ± 0.069	4.06LysLeu: 4.06 ± 0.077	1.661LysMet: 1.661 ± 0.048	2.093LysAsn: 2.093 ± 0.055	1.965LysPro: 1.965 ± 0.056	1.561LysGln: 1.561 ± 0.046	2.827LysArg: 2.827 ± 0.071	2.548LysSer: 2.548 ± 0.061	2.673LysThr: 2.673 ± 0.063	3.191LysVal: 3.191 ± 0.065	0.629LysTrp: 0.629 ± 0.028	2.094LysTyr: 2.094 ± 0.047	0.001LysXaa: 0.001 ± 0.001
Leu	8.379LeuAla: 8.379 ± 0.107	1.378LeuCys: 1.378 ± 0.049	4.869LeuAsp: 4.869 ± 0.084	4.818LeuGlu: 4.818 ± 0.084	4.157LeuPhe: 4.157 ± 0.089	6.39LeuGly: 6.39 ± 0.1	1.743LeuHis: 1.743 ± 0.05	4.418LeuIle: 4.418 ± 0.081	4.302LeuLys: 4.302 ± 0.073	8.844LeuLeu: 8.844 ± 0.138	2.202LeuMet: 2.202 ± 0.058	3.238LeuAsn: 3.238 ± 0.063	4.141LeuPro: 4.141 ± 0.077	2.634LeuGln: 2.634 ± 0.056	6.508LeuArg: 6.508 ± 0.104	5.928LeuSer: 5.928 ± 0.097	5.665LeuThr: 5.665 ± 0.096	5.461LeuVal: 5.461 ± 0.106	1.113LeuTrp: 1.113 ± 0.041	3.189LeuTyr: 3.189 ± 0.062	0.002LeuXaa: 0.002 ± 0.002
Met	2.32MetAla: 2.32 ± 0.056	0.277MetCys: 0.277 ± 0.02	1.218MetAsp: 1.218 ± 0.037	1.505MetGlu: 1.505 ± 0.049	0.93MetPhe: 0.93 ± 0.03	1.709MetGly: 1.709 ± 0.043	0.49MetHis: 0.49 ± 0.024	1.441MetIle: 1.441 ± 0.044	1.952MetLys: 1.952 ± 0.051	2.561MetLeu: 2.561 ± 0.065	0.729MetMet: 0.729 ± 0.03	1.163MetAsn: 1.163 ± 0.039	1.411MetPro: 1.411 ± 0.045	1.02MetGln: 1.02 ± 0.03	1.731MetArg: 1.731 ± 0.042	1.548MetSer: 1.548 ± 0.047	1.579MetThr: 1.579 ± 0.042	1.438MetVal: 1.438 ± 0.04	0.306MetTrp: 0.306 ± 0.024	0.74MetTyr: 0.74 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.376AsnAla: 3.376 ± 0.067	0.438AsnCys: 0.438 ± 0.025	2.174AsnAsp: 2.174 ± 0.057	1.893AsnGlu: 1.893 ± 0.046	1.739AsnPhe: 1.739 ± 0.047	3.206AsnGly: 3.206 ± 0.077	0.646AsnHis: 0.646 ± 0.028	2.723AsnIle: 2.723 ± 0.063	1.868AsnLys: 1.868 ± 0.048	3.311AsnLeu: 3.311 ± 0.067	1.044AsnMet: 1.044 ± 0.038	1.744AsnAsn: 1.744 ± 0.056	2.284AsnPro: 2.284 ± 0.052	0.93AsnGln: 0.93 ± 0.035	2.447AsnArg: 2.447 ± 0.065	2.179AsnSer: 2.179 ± 0.061	2.189AsnThr: 2.189 ± 0.056	2.614AsnVal: 2.614 ± 0.069	0.477AsnTrp: 0.477 ± 0.022	1.807AsnTyr: 1.807 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	4.829ProAla: 4.829 ± 0.097	0.456ProCys: 0.456 ± 0.026	2.98ProAsp: 2.98 ± 0.063	3.75ProGlu: 3.75 ± 0.071	1.711ProPhe: 1.711 ± 0.044	3.018ProGly: 3.018 ± 0.063	0.789ProHis: 0.789 ± 0.032	1.776ProIle: 1.776 ± 0.045	1.742ProLys: 1.742 ± 0.046	3.687ProLeu: 3.687 ± 0.078	0.96ProMet: 0.96 ± 0.035	1.32ProAsn: 1.32 ± 0.04	1.133ProPro: 1.133 ± 0.038	1.621ProGln: 1.621 ± 0.04	2.2ProArg: 2.2 ± 0.052	2.35ProSer: 2.35 ± 0.056	2.011ProThr: 2.011 ± 0.052	3.498ProVal: 3.498 ± 0.061	0.49ProTrp: 0.49 ± 0.025	1.693ProTyr: 1.693 ± 0.049	0.002ProXaa: 0.002 ± 0.002
Gln	2.613GlnAla: 2.613 ± 0.062	0.263GlnCys: 0.263 ± 0.018	1.189GlnAsp: 1.189 ± 0.038	1.76GlnGlu: 1.76 ± 0.046	1.11GlnPhe: 1.11 ± 0.038	1.987GlnGly: 1.987 ± 0.044	0.639GlnHis: 0.639 ± 0.032	1.999GlnIle: 1.999 ± 0.05	1.506GlnLys: 1.506 ± 0.043	2.818GlnLeu: 2.818 ± 0.059	0.953GlnMet: 0.953 ± 0.032	1.359GlnAsn: 1.359 ± 0.05	1.383GlnPro: 1.383 ± 0.043	1.444GlnGln: 1.444 ± 0.048	1.983GlnArg: 1.983 ± 0.058	1.678GlnSer: 1.678 ± 0.049	2.033GlnThr: 2.033 ± 0.057	1.804GlnVal: 1.804 ± 0.046	0.397GlnTrp: 0.397 ± 0.027	1.257GlnTyr: 1.257 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	4.791ArgAla: 4.791 ± 0.08	0.735ArgCys: 0.735 ± 0.034	3.152ArgAsp: 3.152 ± 0.071	4.458ArgGlu: 4.458 ± 0.095	2.979ArgPhe: 2.979 ± 0.07	3.88ArgGly: 3.88 ± 0.078	1.481ArgHis: 1.481 ± 0.051	4.67ArgIle: 4.67 ± 0.078	3.066ArgLys: 3.066 ± 0.067	6.15ArgLeu: 6.15 ± 0.094	1.983ArgMet: 1.983 ± 0.049	2.796ArgAsn: 2.796 ± 0.058	2.492ArgPro: 2.492 ± 0.063	2.234ArgGln: 2.234 ± 0.064	5.28ArgArg: 5.28 ± 0.118	3.375ArgSer: 3.375 ± 0.076	3.817ArgThr: 3.817 ± 0.071	3.676ArgVal: 3.676 ± 0.075	0.846ArgTrp: 0.846 ± 0.035	2.754ArgTyr: 2.754 ± 0.061	0.001ArgXaa: 0.001 ± 0.001
Ser	5.379SerAla: 5.379 ± 0.104	0.731SerCys: 0.731 ± 0.028	3.275SerAsp: 3.275 ± 0.07	3.272SerGlu: 3.272 ± 0.072	2.601SerPhe: 2.601 ± 0.064	5.142SerGly: 5.142 ± 0.082	1.005SerHis: 1.005 ± 0.037	2.994SerIle: 2.994 ± 0.061	2.413SerLys: 2.413 ± 0.058	5.381SerLeu: 5.381 ± 0.091	1.397SerMet: 1.397 ± 0.04	2.071SerAsn: 2.071 ± 0.059	2.43SerPro: 2.43 ± 0.058	1.655SerGln: 1.655 ± 0.051	3.213SerArg: 3.213 ± 0.057	3.275SerSer: 3.275 ± 0.079	2.919SerThr: 2.919 ± 0.068	4.58SerVal: 4.58 ± 0.075	0.741SerTrp: 0.741 ± 0.03	2.557SerTyr: 2.557 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	5.705ThrAla: 5.705 ± 0.089	0.502ThrCys: 0.502 ± 0.024	3.501ThrAsp: 3.501 ± 0.076	3.247ThrGlu: 3.247 ± 0.065	2.508ThrPhe: 2.508 ± 0.056	4.769ThrGly: 4.769 ± 0.079	1.003ThrHis: 1.003 ± 0.038	3.147ThrIle: 3.147 ± 0.068	2.156ThrLys: 2.156 ± 0.056	5.737ThrLeu: 5.737 ± 0.084	1.236ThrMet: 1.236 ± 0.035	1.854ThrAsn: 1.854 ± 0.055	3.316ThrPro: 3.316 ± 0.067	1.69ThrGln: 1.69 ± 0.044	2.757ThrArg: 2.757 ± 0.052	3.131ThrSer: 3.131 ± 0.069	3.388ThrThr: 3.388 ± 0.079	4.579ThrVal: 4.579 ± 0.08	0.65ThrTrp: 0.65 ± 0.033	2.094ThrTyr: 2.094 ± 0.054	0.005ThrXaa: 0.005 ± 0.002
Val	6.599ValAla: 6.599 ± 0.098	1.066ValCys: 1.066 ± 0.035	3.862ValAsp: 3.862 ± 0.072	4.634ValGlu: 4.634 ± 0.095	2.957ValPhe: 2.957 ± 0.072	5.227ValGly: 5.227 ± 0.109	1.136ValHis: 1.136 ± 0.041	3.856ValIle: 3.856 ± 0.065	3.49ValLys: 3.49 ± 0.072	6.02ValLeu: 6.02 ± 0.093	1.816ValMet: 1.816 ± 0.047	2.725ValAsn: 2.725 ± 0.053	2.966ValPro: 2.966 ± 0.06	1.904ValGln: 1.904 ± 0.05	4.698ValArg: 4.698 ± 0.071	4.586ValSer: 4.586 ± 0.083	4.513ValThr: 4.513 ± 0.08	6.051ValVal: 6.051 ± 0.115	0.91ValTrp: 0.91 ± 0.034	2.467ValTyr: 2.467 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.875TrpAla: 0.875 ± 0.036	0.223TrpCys: 0.223 ± 0.018	0.656TrpAsp: 0.656 ± 0.03	0.692TrpGlu: 0.692 ± 0.028	0.612TrpPhe: 0.612 ± 0.033	1.064TrpGly: 1.064 ± 0.039	0.295TrpHis: 0.295 ± 0.021	0.725TrpIle: 0.725 ± 0.029	0.603TrpLys: 0.603 ± 0.026	1.228TrpLeu: 1.228 ± 0.042	0.369TrpMet: 0.369 ± 0.024	0.65TrpAsn: 0.65 ± 0.025	0.327TrpPro: 0.327 ± 0.022	0.529TrpGln: 0.529 ± 0.03	0.843TrpArg: 0.843 ± 0.036	0.835TrpSer: 0.835 ± 0.035	0.771TrpThr: 0.771 ± 0.037	0.782TrpVal: 0.782 ± 0.032	0.221TrpTrp: 0.221 ± 0.019	0.477TrpTyr: 0.477 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.609TyrAla: 3.609 ± 0.066	0.555TyrCys: 0.555 ± 0.026	2.685TyrAsp: 2.685 ± 0.062	2.272TyrGlu: 2.272 ± 0.056	1.799TyrPhe: 1.799 ± 0.049	3.233TyrGly: 3.233 ± 0.069	0.672TyrHis: 0.672 ± 0.029	2.185TyrIle: 2.185 ± 0.043	1.861TyrLys: 1.861 ± 0.048	3.388TyrLeu: 3.388 ± 0.066	0.996TyrMet: 0.996 ± 0.032	1.89TyrAsn: 1.89 ± 0.058	1.759TyrPro: 1.759 ± 0.054	0.942TyrGln: 0.942 ± 0.036	2.562TyrArg: 2.562 ± 0.063	2.28TyrSer: 2.28 ± 0.06	2.513TyrThr: 2.513 ± 0.067	2.495TyrVal: 2.495 ± 0.053	0.498TyrTrp: 0.498 ± 0.025	1.923TyrTyr: 1.923 ± 0.065	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.002XaaLeu: 0.002 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.002	0.001XaaVal: 0.001 ± 0.001	0.002XaaTrp: 0.002 ± 0.002	0.0XaaTyr: 0.0 ± 0.0	0.032XaaXaa: 0.032 ± 0.008

Statistics based on 2386 proteins (820531 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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