Amino acid dipepetide frequency for Parabacteroides sp. An277

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.279AlaAla: 6.279 ± 0.102	1.155AlaCys: 1.155 ± 0.036	4.528AlaAsp: 4.528 ± 0.069	5.512AlaGlu: 5.512 ± 0.084	3.38AlaPhe: 3.38 ± 0.066	5.637AlaGly: 5.637 ± 0.085	1.548AlaHis: 1.548 ± 0.043	4.897AlaIle: 4.897 ± 0.08	4.155AlaLys: 4.155 ± 0.07	7.349AlaLeu: 7.349 ± 0.1	2.032AlaMet: 2.032 ± 0.045	3.281AlaAsn: 3.281 ± 0.063	2.478AlaPro: 2.478 ± 0.053	3.073AlaGln: 3.073 ± 0.056	3.618AlaArg: 3.618 ± 0.062	4.73AlaSer: 4.73 ± 0.091	4.197AlaThr: 4.197 ± 0.073	4.796AlaVal: 4.796 ± 0.084	1.066AlaTrp: 1.066 ± 0.034	3.393AlaTyr: 3.393 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.873CysAla: 0.873 ± 0.029	0.19CysCys: 0.19 ± 0.014	0.598CysAsp: 0.598 ± 0.027	0.708CysGlu: 0.708 ± 0.03	0.613CysPhe: 0.613 ± 0.025	1.026CysGly: 1.026 ± 0.036	0.299CysHis: 0.299 ± 0.021	0.806CysIle: 0.806 ± 0.029	0.559CysLys: 0.559 ± 0.025	1.219CysLeu: 1.219 ± 0.036	0.323CysMet: 0.323 ± 0.016	0.459CysAsn: 0.459 ± 0.021	0.553CysPro: 0.553 ± 0.027	0.418CysGln: 0.418 ± 0.021	0.668CysArg: 0.668 ± 0.026	0.694CysSer: 0.694 ± 0.028	0.679CysThr: 0.679 ± 0.026	0.736CysVal: 0.736 ± 0.03	0.185CysTrp: 0.185 ± 0.013	0.494CysTyr: 0.494 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.448AspAla: 4.448 ± 0.067	0.632AspCys: 0.632 ± 0.028	2.57AspAsp: 2.57 ± 0.06	4.224AspGlu: 4.224 ± 0.071	2.881AspPhe: 2.881 ± 0.053	4.184AspGly: 4.184 ± 0.082	0.796AspHis: 0.796 ± 0.029	3.812AspIle: 3.812 ± 0.058	3.375AspLys: 3.375 ± 0.072	4.871AspLeu: 4.871 ± 0.073	1.542AspMet: 1.542 ± 0.039	2.565AspAsn: 2.565 ± 0.062	1.957AspPro: 1.957 ± 0.048	1.31AspGln: 1.31 ± 0.033	2.44AspArg: 2.44 ± 0.047	2.903AspSer: 2.903 ± 0.059	2.884AspThr: 2.884 ± 0.054	3.613AspVal: 3.613 ± 0.061	0.938AspTrp: 0.938 ± 0.031	2.9AspTyr: 2.9 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	6.134GluAla: 6.134 ± 0.088	0.587GluCys: 0.587 ± 0.025	3.298GluAsp: 3.298 ± 0.065	5.894GluGlu: 5.894 ± 0.092	2.249GluPhe: 2.249 ± 0.046	4.853GluGly: 4.853 ± 0.077	1.304GluHis: 1.304 ± 0.029	4.555GluIle: 4.555 ± 0.081	4.873GluLys: 4.873 ± 0.09	5.945GluLeu: 5.945 ± 0.088	2.211GluMet: 2.211 ± 0.049	3.368GluAsn: 3.368 ± 0.064	2.151GluPro: 2.151 ± 0.05	2.933GluGln: 2.933 ± 0.068	3.744GluArg: 3.744 ± 0.076	3.201GluSer: 3.201 ± 0.057	3.876GluThr: 3.876 ± 0.063	4.745GluVal: 4.745 ± 0.077	0.962GluTrp: 0.962 ± 0.034	2.749GluTyr: 2.749 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.249PheAla: 3.249 ± 0.061	0.609PheCys: 0.609 ± 0.023	2.707PheAsp: 2.707 ± 0.058	2.498PheGlu: 2.498 ± 0.046	2.14PhePhe: 2.14 ± 0.049	3.103PheGly: 3.103 ± 0.062	1.012PheHis: 1.012 ± 0.035	2.753PheIle: 2.753 ± 0.052	2.021PheLys: 2.021 ± 0.054	4.137PheLeu: 4.137 ± 0.07	1.085PheMet: 1.085 ± 0.034	2.017PheAsn: 2.017 ± 0.051	1.882PhePro: 1.882 ± 0.045	1.567PheGln: 1.567 ± 0.041	2.392PheArg: 2.392 ± 0.058	3.125PheSer: 3.125 ± 0.061	2.644PheThr: 2.644 ± 0.054	2.933PheVal: 2.933 ± 0.054	0.579PheTrp: 0.579 ± 0.024	1.908PheTyr: 1.908 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.624GlyAla: 4.624 ± 0.079	0.953GlyCys: 0.953 ± 0.034	3.708GlyAsp: 3.708 ± 0.071	4.598GlyGlu: 4.598 ± 0.077	3.16GlyPhe: 3.16 ± 0.054	4.767GlyGly: 4.767 ± 0.085	1.285GlyHis: 1.285 ± 0.033	5.203GlyIle: 5.203 ± 0.085	5.082GlyLys: 5.082 ± 0.083	5.95GlyLeu: 5.95 ± 0.083	2.112GlyMet: 2.112 ± 0.054	3.573GlyAsn: 3.573 ± 0.07	1.347GlyPro: 1.347 ± 0.035	2.26GlyGln: 2.26 ± 0.047	3.21GlyArg: 3.21 ± 0.059	3.882GlySer: 3.882 ± 0.066	4.377GlyThr: 4.377 ± 0.076	4.777GlyVal: 4.777 ± 0.084	1.102GlyTrp: 1.102 ± 0.034	3.283GlyTyr: 3.283 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	1.425HisAla: 1.425 ± 0.037	0.292HisCys: 0.292 ± 0.017	0.929HisAsp: 0.929 ± 0.029	1.203HisGlu: 1.203 ± 0.038	1.181HisPhe: 1.181 ± 0.035	1.228HisGly: 1.228 ± 0.034	0.522HisHis: 0.522 ± 0.024	1.548HisIle: 1.548 ± 0.04	0.897HisLys: 0.897 ± 0.03	1.979HisLeu: 1.979 ± 0.043	0.374HisMet: 0.374 ± 0.019	0.876HisAsn: 0.876 ± 0.025	1.192HisPro: 1.192 ± 0.035	0.736HisGln: 0.736 ± 0.028	1.033HisArg: 1.033 ± 0.032	1.028HisSer: 1.028 ± 0.031	1.159HisThr: 1.159 ± 0.034	1.266HisVal: 1.266 ± 0.038	0.286HisTrp: 0.286 ± 0.016	0.963HisTyr: 0.963 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.145IleAla: 5.145 ± 0.09	0.889IleCys: 0.889 ± 0.028	3.894IleAsp: 3.894 ± 0.066	4.407IleGlu: 4.407 ± 0.071	2.378IlePhe: 2.378 ± 0.06	4.57IleGly: 4.57 ± 0.081	1.443IleHis: 1.443 ± 0.043	3.725IleIle: 3.725 ± 0.078	3.243IleLys: 3.243 ± 0.061	5.525IleLeu: 5.525 ± 0.086	1.274IleMet: 1.274 ± 0.037	2.781IleAsn: 2.781 ± 0.06	3.099IlePro: 3.099 ± 0.056	2.764IleGln: 2.764 ± 0.058	3.647IleArg: 3.647 ± 0.065	4.092IleSer: 4.092 ± 0.065	3.813IleThr: 3.813 ± 0.071	4.151IleVal: 4.151 ± 0.067	0.688IleTrp: 0.688 ± 0.024	2.589IleTyr: 2.589 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.747LysAla: 4.747 ± 0.09	0.455LysCys: 0.455 ± 0.022	3.366LysAsp: 3.366 ± 0.07	5.274LysGlu: 5.274 ± 0.095	1.818LysPhe: 1.818 ± 0.046	4.177LysGly: 4.177 ± 0.065	1.13LysHis: 1.13 ± 0.033	3.432LysIle: 3.432 ± 0.071	3.942LysLys: 3.942 ± 0.074	4.649LysLeu: 4.649 ± 0.073	1.789LysMet: 1.789 ± 0.041	2.818LysAsn: 2.818 ± 0.057	2.099LysPro: 2.099 ± 0.048	2.639LysGln: 2.639 ± 0.048	3.168LysArg: 3.168 ± 0.061	2.71LysSer: 2.71 ± 0.054	3.031LysThr: 3.031 ± 0.062	3.986LysVal: 3.986 ± 0.071	0.701LysTrp: 0.701 ± 0.028	2.519LysTyr: 2.519 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	7.157LeuAla: 7.157 ± 0.102	1.28LeuCys: 1.28 ± 0.035	4.876LeuAsp: 4.876 ± 0.073	5.37LeuGlu: 5.37 ± 0.089	4.587LeuPhe: 4.587 ± 0.085	5.828LeuGly: 5.828 ± 0.088	1.982LeuHis: 1.982 ± 0.048	4.976LeuIle: 4.976 ± 0.085	5.604LeuLys: 5.604 ± 0.076	9.039LeuLeu: 9.039 ± 0.123	2.388LeuMet: 2.388 ± 0.049	4.189LeuAsn: 4.189 ± 0.069	4.325LeuPro: 4.325 ± 0.059	3.763LeuGln: 3.763 ± 0.072	4.657LeuArg: 4.657 ± 0.083	6.402LeuSer: 6.402 ± 0.084	5.285LeuThr: 5.285 ± 0.076	5.473LeuVal: 5.473 ± 0.073	1.088LeuTrp: 1.088 ± 0.039	3.855LeuTyr: 3.855 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	2.298MetAla: 2.298 ± 0.051	0.249MetCys: 0.249 ± 0.016	1.522MetAsp: 1.522 ± 0.036	1.991MetGlu: 1.991 ± 0.052	0.915MetPhe: 0.915 ± 0.034	1.883MetGly: 1.883 ± 0.047	0.45MetHis: 0.45 ± 0.019	1.442MetIle: 1.442 ± 0.039	2.115MetLys: 2.115 ± 0.042	2.36MetLeu: 2.36 ± 0.048	0.711MetMet: 0.711 ± 0.027	1.437MetAsn: 1.437 ± 0.038	1.184MetPro: 1.184 ± 0.034	1.158MetGln: 1.158 ± 0.031	1.465MetArg: 1.465 ± 0.041	1.263MetSer: 1.263 ± 0.039	1.332MetThr: 1.332 ± 0.037	1.6MetVal: 1.6 ± 0.04	0.242MetTrp: 0.242 ± 0.017	0.869MetTyr: 0.869 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.591AsnAla: 3.591 ± 0.072	0.443AsnCys: 0.443 ± 0.023	2.33AsnAsp: 2.33 ± 0.057	2.984AsnGlu: 2.984 ± 0.067	1.924AsnPhe: 1.924 ± 0.043	3.614AsnGly: 3.614 ± 0.075	0.964AsnHis: 0.964 ± 0.03	3.112AsnIle: 3.112 ± 0.062	2.437AsnLys: 2.437 ± 0.061	4.06AsnLeu: 4.06 ± 0.065	1.19AsnMet: 1.19 ± 0.036	2.249AsnAsn: 2.249 ± 0.062	2.542AsnPro: 2.542 ± 0.047	1.642AsnGln: 1.642 ± 0.043	2.491AsnArg: 2.491 ± 0.051	2.373AsnSer: 2.373 ± 0.061	2.573AsnThr: 2.573 ± 0.062	3.074AsnVal: 3.074 ± 0.054	0.67AsnTrp: 0.67 ± 0.028	2.183AsnTyr: 2.183 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	3.082ProAla: 3.082 ± 0.056	0.373ProCys: 0.373 ± 0.015	2.685ProAsp: 2.685 ± 0.06	3.785ProGlu: 3.785 ± 0.066	1.944ProPhe: 1.944 ± 0.04	2.436ProGly: 2.436 ± 0.054	0.867ProHis: 0.867 ± 0.03	2.437ProIle: 2.437 ± 0.046	2.0ProLys: 2.0 ± 0.048	3.474ProLeu: 3.474 ± 0.059	0.939ProMet: 0.939 ± 0.03	1.771ProAsn: 1.771 ± 0.037	0.87ProPro: 0.87 ± 0.032	1.437ProGln: 1.437 ± 0.041	1.486ProArg: 1.486 ± 0.037	2.359ProSer: 2.359 ± 0.05	2.192ProThr: 2.192 ± 0.05	3.019ProVal: 3.019 ± 0.054	0.482ProTrp: 0.482 ± 0.022	1.793ProTyr: 1.793 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	3.094GlnAla: 3.094 ± 0.058	0.334GlnCys: 0.334 ± 0.017	1.762GlnAsp: 1.762 ± 0.043	2.707GlnGlu: 2.707 ± 0.064	1.426GlnPhe: 1.426 ± 0.035	2.257GlnGly: 2.257 ± 0.042	0.774GlnHis: 0.774 ± 0.03	2.552GlnIle: 2.552 ± 0.047	2.364GlnLys: 2.364 ± 0.049	3.592GlnLeu: 3.592 ± 0.073	1.102GlnMet: 1.102 ± 0.032	1.57GlnAsn: 1.57 ± 0.044	1.44GlnPro: 1.44 ± 0.039	1.649GlnGln: 1.649 ± 0.049	1.853GlnArg: 1.853 ± 0.043	1.953GlnSer: 1.953 ± 0.044	2.505GlnThr: 2.505 ± 0.046	2.516GlnVal: 2.516 ± 0.053	0.522GlnTrp: 0.522 ± 0.023	1.518GlnTyr: 1.518 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	3.389ArgAla: 3.389 ± 0.068	0.528ArgCys: 0.528 ± 0.024	2.436ArgAsp: 2.436 ± 0.056	3.536ArgGlu: 3.536 ± 0.059	2.558ArgPhe: 2.558 ± 0.055	2.655ArgGly: 2.655 ± 0.05	1.064ArgHis: 1.064 ± 0.031	3.851ArgIle: 3.851 ± 0.065	3.278ArgLys: 3.278 ± 0.067	5.038ArgLeu: 5.038 ± 0.08	1.663ArgMet: 1.663 ± 0.043	2.368ArgAsn: 2.368 ± 0.051	1.987ArgPro: 1.987 ± 0.045	1.985ArgGln: 1.985 ± 0.049	2.732ArgArg: 2.732 ± 0.06	2.418ArgSer: 2.418 ± 0.06	2.725ArgThr: 2.725 ± 0.052	3.025ArgVal: 3.025 ± 0.05	0.724ArgTrp: 0.724 ± 0.028	2.396ArgTyr: 2.396 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	4.186SerAla: 4.186 ± 0.063	0.835SerCys: 0.835 ± 0.031	3.161SerAsp: 3.161 ± 0.059	3.471SerGlu: 3.471 ± 0.063	3.232SerPhe: 3.232 ± 0.066	4.39SerGly: 4.39 ± 0.083	1.096SerHis: 1.096 ± 0.034	3.88SerIle: 3.88 ± 0.062	2.718SerLys: 2.718 ± 0.06	5.958SerLeu: 5.958 ± 0.089	1.393SerMet: 1.393 ± 0.036	2.402SerAsn: 2.402 ± 0.054	2.342SerPro: 2.342 ± 0.048	1.813SerGln: 1.813 ± 0.042	2.622SerArg: 2.622 ± 0.057	3.51SerSer: 3.51 ± 0.066	3.087SerThr: 3.087 ± 0.062	4.062SerVal: 4.062 ± 0.064	0.777SerTrp: 0.777 ± 0.027	2.653SerTyr: 2.653 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	4.094ThrAla: 4.094 ± 0.073	0.587ThrCys: 0.587 ± 0.027	3.473ThrAsp: 3.473 ± 0.064	3.648ThrGlu: 3.648 ± 0.064	2.692ThrPhe: 2.692 ± 0.055	4.274ThrGly: 4.274 ± 0.064	1.176ThrHis: 1.176 ± 0.036	3.823ThrIle: 3.823 ± 0.072	2.608ThrLys: 2.608 ± 0.053	5.791ThrLeu: 5.791 ± 0.085	1.193ThrMet: 1.193 ± 0.03	2.492ThrAsn: 2.492 ± 0.055	2.899ThrPro: 2.899 ± 0.052	1.888ThrGln: 1.888 ± 0.044	2.434ThrArg: 2.434 ± 0.048	3.306ThrSer: 3.306 ± 0.059	3.27ThrThr: 3.27 ± 0.075	3.819ThrVal: 3.819 ± 0.077	0.736ThrTrp: 0.736 ± 0.03	2.547ThrTyr: 2.547 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.975ValAla: 4.975 ± 0.081	1.016ValCys: 1.016 ± 0.035	3.71ValAsp: 3.71 ± 0.069	4.357ValGlu: 4.357 ± 0.064	2.661ValPhe: 2.661 ± 0.053	4.472ValGly: 4.472 ± 0.082	1.17ValHis: 1.17 ± 0.036	3.9ValIle: 3.9 ± 0.074	3.876ValLys: 3.876 ± 0.06	5.884ValLeu: 5.884 ± 0.077	1.629ValMet: 1.629 ± 0.045	3.224ValAsn: 3.224 ± 0.071	2.771ValPro: 2.771 ± 0.053	2.186ValGln: 2.186 ± 0.054	3.555ValArg: 3.555 ± 0.066	4.528ValSer: 4.528 ± 0.064	3.621ValThr: 3.621 ± 0.073	4.705ValVal: 4.705 ± 0.078	0.884ValTrp: 0.884 ± 0.033	2.687ValTyr: 2.687 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.885TrpAla: 0.885 ± 0.032	0.185TrpCys: 0.185 ± 0.014	0.763TrpAsp: 0.763 ± 0.029	0.874TrpGlu: 0.874 ± 0.031	0.562TrpPhe: 0.562 ± 0.026	0.975TrpGly: 0.975 ± 0.032	0.302TrpHis: 0.302 ± 0.017	0.855TrpIle: 0.855 ± 0.031	0.943TrpLys: 0.943 ± 0.034	1.316TrpLeu: 1.316 ± 0.038	0.518TrpMet: 0.518 ± 0.024	0.797TrpAsn: 0.797 ± 0.028	0.303TrpPro: 0.303 ± 0.018	0.547TrpGln: 0.547 ± 0.024	0.667TrpArg: 0.667 ± 0.026	0.699TrpSer: 0.699 ± 0.029	0.733TrpThr: 0.733 ± 0.028	0.78TrpVal: 0.78 ± 0.031	0.191TrpTrp: 0.191 ± 0.012	0.553TrpTyr: 0.553 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.429TyrAla: 3.429 ± 0.059	0.507TyrCys: 0.507 ± 0.023	2.526TyrAsp: 2.526 ± 0.057	2.591TyrGlu: 2.591 ± 0.045	2.06TyrPhe: 2.06 ± 0.053	2.921TyrGly: 2.921 ± 0.064	0.932TyrHis: 0.932 ± 0.029	2.555TyrIle: 2.555 ± 0.048	2.36TyrLys: 2.36 ± 0.046	3.989TyrLeu: 3.989 ± 0.067	1.02TyrMet: 1.02 ± 0.03	2.214TyrAsn: 2.214 ± 0.06	2.011TyrPro: 2.011 ± 0.053	1.724TyrGln: 1.724 ± 0.046	2.474TyrArg: 2.474 ± 0.054	2.409TyrSer: 2.409 ± 0.055	2.766TyrThr: 2.766 ± 0.062	2.736TyrVal: 2.736 ± 0.058	0.626TyrTrp: 0.626 ± 0.027	2.248TyrTyr: 2.248 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2949 proteins (1065573 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---