Amino acid dipepetide frequency for Firmicutes bacterium CAG:460

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.012AlaAla: 2.012 ± 0.1
0.599AlaCys: 0.599 ± 0.048
2.291AlaAsp: 2.291 ± 0.088
2.291AlaGlu: 2.291 ± 0.101
2.067AlaPhe: 2.067 ± 0.076
2.893AlaGly: 2.893 ± 0.129
0.623AlaHis: 0.623 ± 0.041
4.767AlaIle: 4.767 ± 0.145
4.533AlaLys: 4.533 ± 0.132
4.699AlaLeu: 4.699 ± 0.12
1.1AlaMet: 1.1 ± 0.061
2.826AlaAsn: 2.826 ± 0.109
0.998AlaPro: 0.998 ± 0.065
0.909AlaGln: 0.909 ± 0.05
1.72AlaArg: 1.72 ± 0.08
3.735AlaSer: 3.735 ± 0.125
2.789AlaThr: 2.789 ± 0.114
2.607AlaVal: 2.607 ± 0.101
0.255AlaTrp: 0.255 ± 0.032
2.211AlaTyr: 2.211 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.485CysAla: 0.485 ± 0.037
0.132CysCys: 0.132 ± 0.025
0.719CysAsp: 0.719 ± 0.051
0.74CysGlu: 0.74 ± 0.052
0.479CysPhe: 0.479 ± 0.044
0.921CysGly: 0.921 ± 0.063
0.175CysHis: 0.175 ± 0.022
0.891CysIle: 0.891 ± 0.062
0.964CysLys: 0.964 ± 0.069
0.961CysLeu: 0.961 ± 0.053
0.23CysMet: 0.23 ± 0.027
0.737CysAsn: 0.737 ± 0.05
0.369CysPro: 0.369 ± 0.032
0.209CysGln: 0.209 ± 0.025
0.246CysArg: 0.246 ± 0.031
0.749CysSer: 0.749 ± 0.058
0.476CysThr: 0.476 ± 0.045
0.666CysVal: 0.666 ± 0.051
0.061CysTrp: 0.061 ± 0.012
0.59CysTyr: 0.59 ± 0.049
0.0CysXaa: 0.0 ± 0.0
Asp
3.418AspAla: 3.418 ± 0.113
0.565AspCys: 0.565 ± 0.043
3.314AspAsp: 3.314 ± 0.117
4.948AspGlu: 4.948 ± 0.136
3.243AspPhe: 3.243 ± 0.113
3.492AspGly: 3.492 ± 0.109
0.47AspHis: 0.47 ± 0.034
6.48AspIle: 6.48 ± 0.153
6.112AspLys: 6.112 ± 0.169
5.802AspLeu: 5.802 ± 0.156
1.373AspMet: 1.373 ± 0.063
4.813AspAsn: 4.813 ± 0.133
0.974AspPro: 0.974 ± 0.067
0.617AspGln: 0.617 ± 0.046
1.563AspArg: 1.563 ± 0.066
2.755AspSer: 2.755 ± 0.102
3.099AspThr: 3.099 ± 0.111
3.977AspVal: 3.977 ± 0.117
0.35AspTrp: 0.35 ± 0.038
3.87AspTyr: 3.87 ± 0.122
0.0AspXaa: 0.0 ± 0.0
Glu
3.507GluAla: 3.507 ± 0.13
0.725GluCys: 0.725 ± 0.051
4.42GluAsp: 4.42 ± 0.115
6.76GluGlu: 6.76 ± 0.176
3.17GluPhe: 3.17 ± 0.104
2.982GluGly: 2.982 ± 0.108
0.832GluHis: 0.832 ± 0.051
7.469GluIle: 7.469 ± 0.166
7.939GluLys: 7.939 ± 0.175
6.932GluLeu: 6.932 ± 0.177
1.929GluMet: 1.929 ± 0.078
5.869GluAsn: 5.869 ± 0.157
1.201GluPro: 1.201 ± 0.069
1.459GluGln: 1.459 ± 0.065
2.307GluArg: 2.307 ± 0.096
2.908GluSer: 2.908 ± 0.104
3.36GluThr: 3.36 ± 0.1
5.15GluVal: 5.15 ± 0.15
0.448GluTrp: 0.448 ± 0.041
4.036GluTyr: 4.036 ± 0.123
0.0GluXaa: 0.0 ± 0.0
Phe
2.055PheAla: 2.055 ± 0.094
0.464PheCys: 0.464 ± 0.035
2.942PheAsp: 2.942 ± 0.099
2.515PheGlu: 2.515 ± 0.106
1.855PhePhe: 1.855 ± 0.092
2.641PheGly: 2.641 ± 0.095
0.485PheHis: 0.485 ± 0.038
4.549PheIle: 4.549 ± 0.156
4.263PheLys: 4.263 ± 0.131
4.174PheLeu: 4.174 ± 0.131
1.152PheMet: 1.152 ± 0.05
3.286PheAsn: 3.286 ± 0.111
1.038PhePro: 1.038 ± 0.064
0.74PheGln: 0.74 ± 0.051
1.173PheArg: 1.173 ± 0.057
2.994PheSer: 2.994 ± 0.101
2.356PheThr: 2.356 ± 0.09
3.05PheVal: 3.05 ± 0.105
0.279PheTrp: 0.279 ± 0.031
2.214PheTyr: 2.214 ± 0.08
0.0PheXaa: 0.0 ± 0.0
Gly
2.887GlyAla: 2.887 ± 0.121
0.746GlyCys: 0.746 ± 0.044
2.927GlyAsp: 2.927 ± 0.107
3.48GlyGlu: 3.48 ± 0.122
2.629GlyPhe: 2.629 ± 0.086
3.191GlyGly: 3.191 ± 0.173
0.894GlyHis: 0.894 ± 0.059
5.319GlyIle: 5.319 ± 0.159
5.107GlyLys: 5.107 ± 0.14
4.653GlyLeu: 4.653 ± 0.128
1.394GlyMet: 1.394 ± 0.071
3.366GlyAsn: 3.366 ± 0.1
0.897GlyPro: 0.897 ± 0.06
0.943GlyGln: 0.943 ± 0.056
1.72GlyArg: 1.72 ± 0.087
3.464GlySer: 3.464 ± 0.114
3.188GlyThr: 3.188 ± 0.123
3.845GlyVal: 3.845 ± 0.109
0.372GlyTrp: 0.372 ± 0.034
3.108GlyTyr: 3.108 ± 0.108
0.0GlyXaa: 0.0 ± 0.0
His
0.608HisAla: 0.608 ± 0.046
0.111HisCys: 0.111 ± 0.017
0.706HisAsp: 0.706 ± 0.05
1.01HisGlu: 1.01 ± 0.048
0.541HisPhe: 0.541 ± 0.045
0.894HisGly: 0.894 ± 0.053
0.246HisHis: 0.246 ± 0.027
1.173HisIle: 1.173 ± 0.062
0.934HisLys: 0.934 ± 0.049
1.155HisLeu: 1.155 ± 0.065
0.255HisMet: 0.255 ± 0.031
0.765HisAsn: 0.765 ± 0.057
0.501HisPro: 0.501 ± 0.041
0.344HisGln: 0.344 ± 0.032
0.39HisArg: 0.39 ± 0.036
0.651HisSer: 0.651 ± 0.046
0.657HisThr: 0.657 ± 0.051
0.771HisVal: 0.771 ± 0.056
0.071HisTrp: 0.071 ± 0.015
0.67HisTyr: 0.67 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
4.653IleAla: 4.653 ± 0.133
1.155IleCys: 1.155 ± 0.062
6.447IleAsp: 6.447 ± 0.143
6.161IleGlu: 6.161 ± 0.147
4.152IlePhe: 4.152 ± 0.134
4.911IleGly: 4.911 ± 0.142
1.078IleHis: 1.078 ± 0.057
10.144IleIle: 10.144 ± 0.229
10.344IleLys: 10.344 ± 0.193
9.343IleLeu: 9.343 ± 0.191
2.138IleMet: 2.138 ± 0.074
8.025IleAsn: 8.025 ± 0.181
2.884IlePro: 2.884 ± 0.104
1.207IleGln: 1.207 ± 0.06
2.638IleArg: 2.638 ± 0.106
6.529IleSer: 6.529 ± 0.149
5.298IleThr: 5.298 ± 0.15
6.198IleVal: 6.198 ± 0.126
0.498IleTrp: 0.498 ± 0.041
4.438IleTyr: 4.438 ± 0.141
0.0IleXaa: 0.0 ± 0.0
Lys
3.857LysAla: 3.857 ± 0.101
1.053LysCys: 1.053 ± 0.061
6.975LysAsp: 6.975 ± 0.166
9.515LysGlu: 9.515 ± 0.181
3.455LysPhe: 3.455 ± 0.121
4.226LysGly: 4.226 ± 0.126
1.057LysHis: 1.057 ± 0.061
9.284LysIle: 9.284 ± 0.171
10.58LysLys: 10.58 ± 0.213
8.295LysLeu: 8.295 ± 0.172
2.994LysMet: 2.994 ± 0.099
8.707LysAsn: 8.707 ± 0.198
1.877LysPro: 1.877 ± 0.08
1.751LysGln: 1.751 ± 0.075
3.093LysArg: 3.093 ± 0.111
5.408LysSer: 5.408 ± 0.127
5.206LysThr: 5.206 ± 0.141
6.526LysVal: 6.526 ± 0.16
0.556LysTrp: 0.556 ± 0.042
5.774LysTyr: 5.774 ± 0.148
0.0LysXaa: 0.0 ± 0.0
Leu
4.3LeuAla: 4.3 ± 0.132
0.885LeuCys: 0.885 ± 0.054
5.774LeuAsp: 5.774 ± 0.159
7.472LeuGlu: 7.472 ± 0.17
4.122LeuPhe: 4.122 ± 0.151
5.028LeuGly: 5.028 ± 0.146
1.1LeuHis: 1.1 ± 0.065
8.286LeuIle: 8.286 ± 0.186
9.272LeuLys: 9.272 ± 0.209
7.97LeuLeu: 7.97 ± 0.193
2.082LeuMet: 2.082 ± 0.089
6.821LeuAsn: 6.821 ± 0.155
2.368LeuPro: 2.368 ± 0.094
1.769LeuGln: 1.769 ± 0.072
2.669LeuArg: 2.669 ± 0.092
6.502LeuSer: 6.502 ± 0.151
4.776LeuThr: 4.776 ± 0.128
6.167LeuVal: 6.167 ± 0.134
0.541LeuTrp: 0.541 ± 0.042
3.861LeuTyr: 3.861 ± 0.12
0.0LeuXaa: 0.0 ± 0.0
Met
1.29MetAla: 1.29 ± 0.074
0.27MetCys: 0.27 ± 0.024
1.511MetAsp: 1.511 ± 0.071
1.763MetGlu: 1.763 ± 0.068
1.112MetPhe: 1.112 ± 0.065
1.275MetGly: 1.275 ± 0.071
0.365MetHis: 0.365 ± 0.032
1.956MetIle: 1.956 ± 0.075
2.697MetLys: 2.697 ± 0.096
2.214MetLeu: 2.214 ± 0.099
0.596MetMet: 0.596 ± 0.044
1.88MetAsn: 1.88 ± 0.06
0.86MetPro: 0.86 ± 0.05
0.651MetGln: 0.651 ± 0.038
0.719MetArg: 0.719 ± 0.047
1.379MetSer: 1.379 ± 0.067
1.044MetThr: 1.044 ± 0.064
1.422MetVal: 1.422 ± 0.075
0.163MetTrp: 0.163 ± 0.018
1.155MetTyr: 1.155 ± 0.056
0.0MetXaa: 0.0 ± 0.0
Asn
3.096AsnAla: 3.096 ± 0.1
0.7AsnCys: 0.7 ± 0.056
4.367AsnAsp: 4.367 ± 0.118
5.992AsnGlu: 5.992 ± 0.156
2.951AsnPhe: 2.951 ± 0.105
4.119AsnGly: 4.119 ± 0.121
0.921AsnHis: 0.921 ± 0.051
8.354AsnIle: 8.354 ± 0.196
8.16AsnLys: 8.16 ± 0.184
6.609AsnLeu: 6.609 ± 0.159
1.984AsnMet: 1.984 ± 0.06
6.714AsnAsn: 6.714 ± 0.197
1.966AsnPro: 1.966 ± 0.068
1.228AsnGln: 1.228 ± 0.069
1.84AsnArg: 1.84 ± 0.076
4.033AsnSer: 4.033 ± 0.134
3.71AsnThr: 3.71 ± 0.122
4.496AsnVal: 4.496 ± 0.131
0.488AsnTrp: 0.488 ± 0.039
4.346AsnTyr: 4.346 ± 0.142
0.0AsnXaa: 0.0 ± 0.0
Pro
1.032ProAla: 1.032 ± 0.065
0.289ProCys: 0.289 ± 0.03
1.407ProAsp: 1.407 ± 0.07
2.058ProGlu: 2.058 ± 0.089
1.265ProPhe: 1.265 ± 0.064
1.198ProGly: 1.198 ± 0.063
0.408ProHis: 0.408 ± 0.035
2.174ProIle: 2.174 ± 0.079
2.214ProLys: 2.214 ± 0.08
2.009ProLeu: 2.009 ± 0.104
0.534ProMet: 0.534 ± 0.042
1.508ProAsn: 1.508 ± 0.074
0.347ProPro: 0.347 ± 0.032
0.408ProGln: 0.408 ± 0.037
0.651ProArg: 0.651 ± 0.046
1.68ProSer: 1.68 ± 0.067
1.514ProThr: 1.514 ± 0.068
1.643ProVal: 1.643 ± 0.073
0.206ProTrp: 0.206 ± 0.027
1.149ProTyr: 1.149 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
0.949GlnAla: 0.949 ± 0.053
0.111GlnCys: 0.111 ± 0.019
1.057GlnAsp: 1.057 ± 0.06
1.502GlnGlu: 1.502 ± 0.074
0.657GlnPhe: 0.657 ± 0.042
0.918GlnGly: 0.918 ± 0.058
0.169GlnHis: 0.169 ± 0.021
1.787GlnIle: 1.787 ± 0.071
1.837GlnLys: 1.837 ± 0.08
1.33GlnLeu: 1.33 ± 0.073
0.513GlnMet: 0.513 ± 0.04
1.468GlnAsn: 1.468 ± 0.072
0.347GlnPro: 0.347 ± 0.036
0.316GlnGln: 0.316 ± 0.035
0.703GlnArg: 0.703 ± 0.043
1.014GlnSer: 1.014 ± 0.059
0.952GlnThr: 0.952 ± 0.056
1.262GlnVal: 1.262 ± 0.071
0.086GlnTrp: 0.086 ± 0.018
0.811GlnTyr: 0.811 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
1.271ArgAla: 1.271 ± 0.076
0.362ArgCys: 0.362 ± 0.039
1.769ArgAsp: 1.769 ± 0.062
2.202ArgGlu: 2.202 ± 0.09
1.244ArgPhe: 1.244 ± 0.068
1.582ArgGly: 1.582 ± 0.079
0.519ArgHis: 0.519 ± 0.038
2.939ArgIle: 2.939 ± 0.104
2.869ArgLys: 2.869 ± 0.101
2.697ArgLeu: 2.697 ± 0.093
0.894ArgMet: 0.894 ± 0.055
2.067ArgAsn: 2.067 ± 0.086
0.771ArgPro: 0.771 ± 0.052
0.685ArgGln: 0.685 ± 0.056
1.213ArgArg: 1.213 ± 0.065
1.533ArgSer: 1.533 ± 0.064
1.41ArgThr: 1.41 ± 0.061
1.944ArgVal: 1.944 ± 0.086
0.236ArgTrp: 0.236 ± 0.032
1.49ArgTyr: 1.49 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
2.515SerAla: 2.515 ± 0.096
0.614SerCys: 0.614 ± 0.046
4.011SerAsp: 4.011 ± 0.122
3.888SerGlu: 3.888 ± 0.112
3.01SerPhe: 3.01 ± 0.103
3.956SerGly: 3.956 ± 0.127
0.795SerHis: 0.795 ± 0.05
5.759SerIle: 5.759 ± 0.138
5.891SerLys: 5.891 ± 0.137
5.946SerLeu: 5.946 ± 0.124
1.434SerMet: 1.434 ± 0.066
4.459SerAsn: 4.459 ± 0.133
1.253SerPro: 1.253 ± 0.059
1.069SerGln: 1.069 ± 0.059
1.889SerArg: 1.889 ± 0.083
4.146SerSer: 4.146 ± 0.163
3.087SerThr: 3.087 ± 0.105
3.664SerVal: 3.664 ± 0.121
0.436SerTrp: 0.436 ± 0.037
3.074SerTyr: 3.074 ± 0.098
0.0SerXaa: 0.0 ± 0.0
Thr
2.095ThrAla: 2.095 ± 0.09
0.633ThrCys: 0.633 ± 0.052
2.859ThrAsp: 2.859 ± 0.109
2.862ThrGlu: 2.862 ± 0.104
2.583ThrPhe: 2.583 ± 0.108
3.087ThrGly: 3.087 ± 0.111
0.752ThrHis: 0.752 ± 0.05
5.322ThrIle: 5.322 ± 0.154
5.163ThrLys: 5.163 ± 0.138
5.095ThrLeu: 5.095 ± 0.134
1.041ThrMet: 1.041 ± 0.053
3.937ThrAsn: 3.937 ± 0.145
1.686ThrPro: 1.686 ± 0.074
0.977ThrGln: 0.977 ± 0.059
1.514ThrArg: 1.514 ± 0.074
3.753ThrSer: 3.753 ± 0.125
3.246ThrThr: 3.246 ± 0.147
2.927ThrVal: 2.927 ± 0.093
0.39ThrTrp: 0.39 ± 0.041
2.74ThrTyr: 2.74 ± 0.103
0.0ThrXaa: 0.0 ± 0.0
Val
3.308ValAla: 3.308 ± 0.101
0.771ValCys: 0.771 ± 0.049
3.937ValAsp: 3.937 ± 0.11
3.931ValGlu: 3.931 ± 0.118
2.859ValPhe: 2.859 ± 0.106
3.799ValGly: 3.799 ± 0.117
0.709ValHis: 0.709 ± 0.05
6.671ValIle: 6.671 ± 0.135
5.937ValLys: 5.937 ± 0.147
6.05ValLeu: 6.05 ± 0.132
1.474ValMet: 1.474 ± 0.067
4.426ValAsn: 4.426 ± 0.109
1.855ValPro: 1.855 ± 0.079
0.906ValGln: 0.906 ± 0.054
2.07ValArg: 2.07 ± 0.068
4.447ValSer: 4.447 ± 0.122
3.787ValThr: 3.787 ± 0.116
4.638ValVal: 4.638 ± 0.121
0.31ValTrp: 0.31 ± 0.029
2.736ValTyr: 2.736 ± 0.092
0.0ValXaa: 0.0 ± 0.0
Trp
0.329TrpAla: 0.329 ± 0.034
0.074TrpCys: 0.074 ± 0.016
0.387TrpAsp: 0.387 ± 0.034
0.335TrpGlu: 0.335 ± 0.033
0.304TrpPhe: 0.304 ± 0.035
0.332TrpGly: 0.332 ± 0.029
0.098TrpHis: 0.098 ± 0.02
0.494TrpIle: 0.494 ± 0.034
0.448TrpLys: 0.448 ± 0.037
0.636TrpLeu: 0.636 ± 0.044
0.19TrpMet: 0.19 ± 0.024
0.442TrpAsn: 0.442 ± 0.038
0.169TrpPro: 0.169 ± 0.025
0.178TrpGln: 0.178 ± 0.024
0.123TrpArg: 0.123 ± 0.019
0.387TrpSer: 0.387 ± 0.034
0.372TrpThr: 0.372 ± 0.041
0.335TrpVal: 0.335 ± 0.038
0.08TrpTrp: 0.08 ± 0.017
0.372TrpTyr: 0.372 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.257TyrAla: 2.257 ± 0.107
0.544TyrCys: 0.544 ± 0.045
3.415TyrAsp: 3.415 ± 0.112
3.977TyrGlu: 3.977 ± 0.119
2.528TyrPhe: 2.528 ± 0.091
2.687TyrGly: 2.687 ± 0.105
0.752TyrHis: 0.752 ± 0.046
4.423TyrIle: 4.423 ± 0.135
4.926TyrLys: 4.926 ± 0.151
5.193TyrLeu: 5.193 ± 0.13
1.01TyrMet: 1.01 ± 0.052
3.959TyrAsn: 3.959 ± 0.128
1.336TyrPro: 1.336 ± 0.063
1.422TyrGln: 1.422 ± 0.076
1.456TyrArg: 1.456 ± 0.065
2.829TyrSer: 2.829 ± 0.101
2.337TyrThr: 2.337 ± 0.097
3.332TyrVal: 3.332 ± 0.11
0.258TyrTrp: 0.258 ± 0.03
3.154TyrTyr: 3.154 ± 0.107
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1169 proteins (325602 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski