Amino acid dipepetide frequency for Syntrophaceticus schinkii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.29AlaAla: 8.29 ± 0.129	1.019AlaCys: 1.019 ± 0.035	3.982AlaAsp: 3.982 ± 0.071	5.287AlaGlu: 5.287 ± 0.095	2.928AlaPhe: 2.928 ± 0.061	7.316AlaGly: 7.316 ± 0.12	1.256AlaHis: 1.256 ± 0.041	4.963AlaIle: 4.963 ± 0.093	3.857AlaLys: 3.857 ± 0.066	8.643AlaLeu: 8.643 ± 0.12	1.979AlaMet: 1.979 ± 0.051	2.172AlaAsn: 2.172 ± 0.052	2.427AlaPro: 2.427 ± 0.066	2.46AlaGln: 2.46 ± 0.056	4.397AlaArg: 4.397 ± 0.07	3.983AlaSer: 3.983 ± 0.071	3.262AlaThr: 3.262 ± 0.062	7.32AlaVal: 7.32 ± 0.103	0.755AlaTrp: 0.755 ± 0.031	2.192AlaTyr: 2.192 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.005CysAla: 1.005 ± 0.036	0.395CysCys: 0.395 ± 0.024	0.711CysAsp: 0.711 ± 0.031	0.778CysGlu: 0.778 ± 0.036	0.667CysPhe: 0.667 ± 0.036	1.555CysGly: 1.555 ± 0.053	0.371CysHis: 0.371 ± 0.021	0.892CysIle: 0.892 ± 0.035	0.61CysLys: 0.61 ± 0.026	1.467CysLeu: 1.467 ± 0.048	0.316CysMet: 0.316 ± 0.02	0.454CysAsn: 0.454 ± 0.026	0.835CysPro: 0.835 ± 0.035	0.575CysGln: 0.575 ± 0.028	0.937CysArg: 0.937 ± 0.038	1.057CysSer: 1.057 ± 0.038	0.716CysThr: 0.716 ± 0.031	0.735CysVal: 0.735 ± 0.035	0.167CysTrp: 0.167 ± 0.015	0.604CysTyr: 0.604 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	3.891AspAla: 3.891 ± 0.084	0.705AspCys: 0.705 ± 0.032	2.525AspAsp: 2.525 ± 0.059	4.005AspGlu: 4.005 ± 0.072	2.226AspPhe: 2.226 ± 0.05	3.553AspGly: 3.553 ± 0.076	0.962AspHis: 0.962 ± 0.034	3.939AspIle: 3.939 ± 0.072	2.808AspLys: 2.808 ± 0.063	5.795AspLeu: 5.795 ± 0.098	1.234AspMet: 1.234 ± 0.045	1.862AspAsn: 1.862 ± 0.051	2.539AspPro: 2.539 ± 0.062	1.982AspGln: 1.982 ± 0.053	2.626AspArg: 2.626 ± 0.059	2.601AspSer: 2.601 ± 0.058	2.351AspThr: 2.351 ± 0.058	3.808AspVal: 3.808 ± 0.077	0.629AspTrp: 0.629 ± 0.03	2.2AspTyr: 2.2 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	5.273GluAla: 5.273 ± 0.094	0.736GluCys: 0.736 ± 0.029	3.428GluAsp: 3.428 ± 0.069	6.181GluGlu: 6.181 ± 0.099	2.242GluPhe: 2.242 ± 0.053	4.646GluGly: 4.646 ± 0.08	1.287GluHis: 1.287 ± 0.04	5.639GluIle: 5.639 ± 0.085	5.479GluLys: 5.479 ± 0.092	7.219GluLeu: 7.219 ± 0.109	2.207GluMet: 2.207 ± 0.053	2.721GluAsn: 2.721 ± 0.057	2.306GluPro: 2.306 ± 0.064	2.955GluGln: 2.955 ± 0.074	4.026GluArg: 4.026 ± 0.081	2.876GluSer: 2.876 ± 0.063	3.254GluThr: 3.254 ± 0.065	5.02GluVal: 5.02 ± 0.085	0.585GluTrp: 0.585 ± 0.027	2.115GluTyr: 2.115 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	2.887PheAla: 2.887 ± 0.057	0.764PheCys: 0.764 ± 0.037	2.089PheAsp: 2.089 ± 0.057	2.136PheGlu: 2.136 ± 0.05	1.939PhePhe: 1.939 ± 0.055	3.057PheGly: 3.057 ± 0.069	0.77PheHis: 0.77 ± 0.036	2.831PheIle: 2.831 ± 0.073	1.911PheLys: 1.911 ± 0.056	4.528PheLeu: 4.528 ± 0.094	0.999PheMet: 0.999 ± 0.04	1.519PheAsn: 1.519 ± 0.041	1.758PhePro: 1.758 ± 0.049	1.441PheGln: 1.441 ± 0.042	1.927PheArg: 1.927 ± 0.049	2.757PheSer: 2.757 ± 0.064	2.187PheThr: 2.187 ± 0.055	2.543PheVal: 2.543 ± 0.063	0.455PheTrp: 0.455 ± 0.026	1.53PheTyr: 1.53 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	5.688GlyAla: 5.688 ± 0.097	1.42GlyCys: 1.42 ± 0.048	3.758GlyAsp: 3.758 ± 0.075	5.283GlyGlu: 5.283 ± 0.085	3.27GlyPhe: 3.27 ± 0.068	5.64GlyGly: 5.64 ± 0.126	1.395GlyHis: 1.395 ± 0.039	6.013GlyIle: 6.013 ± 0.103	5.288GlyLys: 5.288 ± 0.088	7.394GlyLeu: 7.394 ± 0.103	2.316GlyMet: 2.316 ± 0.052	2.603GlyAsn: 2.603 ± 0.053	2.106GlyPro: 2.106 ± 0.061	2.344GlyGln: 2.344 ± 0.056	4.049GlyArg: 4.049 ± 0.073	4.385GlySer: 4.385 ± 0.078	4.074GlyThr: 4.074 ± 0.071	6.195GlyVal: 6.195 ± 0.1	0.939GlyTrp: 0.939 ± 0.04	2.821GlyTyr: 2.821 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.145HisAla: 1.145 ± 0.037	0.364HisCys: 0.364 ± 0.024	0.927HisAsp: 0.927 ± 0.033	0.995HisGlu: 0.995 ± 0.039	0.829HisPhe: 0.829 ± 0.03	1.327HisGly: 1.327 ± 0.043	0.482HisHis: 0.482 ± 0.023	1.215HisIle: 1.215 ± 0.041	0.838HisLys: 0.838 ± 0.033	2.154HisLeu: 2.154 ± 0.054	0.384HisMet: 0.384 ± 0.022	0.767HisAsn: 0.767 ± 0.029	1.121HisPro: 1.121 ± 0.037	0.818HisGln: 0.818 ± 0.032	1.058HisArg: 1.058 ± 0.04	1.052HisSer: 1.052 ± 0.035	0.944HisThr: 0.944 ± 0.034	1.063HisVal: 1.063 ± 0.03	0.234HisTrp: 0.234 ± 0.019	0.784HisTyr: 0.784 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.952IleAla: 5.952 ± 0.092	1.18IleCys: 1.18 ± 0.036	3.925IleAsp: 3.925 ± 0.074	4.309IleGlu: 4.309 ± 0.077	2.939IlePhe: 2.939 ± 0.07	4.933IleGly: 4.933 ± 0.1	1.247IleHis: 1.247 ± 0.039	5.541IleIle: 5.541 ± 0.093	4.28IleLys: 4.28 ± 0.075	6.954IleLeu: 6.954 ± 0.117	1.683IleMet: 1.683 ± 0.044	2.976IleAsn: 2.976 ± 0.07	3.48IlePro: 3.48 ± 0.063	2.033IleGln: 2.033 ± 0.048	3.344IleArg: 3.344 ± 0.071	4.421IleSer: 4.421 ± 0.067	3.986IleThr: 3.986 ± 0.068	4.509IleVal: 4.509 ± 0.09	0.691IleTrp: 0.691 ± 0.029	2.275IleTyr: 2.275 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.494LysAla: 4.494 ± 0.087	0.606LysCys: 0.606 ± 0.032	3.283LysAsp: 3.283 ± 0.072	5.089LysGlu: 5.089 ± 0.086	1.617LysPhe: 1.617 ± 0.05	4.256LysGly: 4.256 ± 0.08	1.078LysHis: 1.078 ± 0.038	4.284LysIle: 4.284 ± 0.074	4.548LysLys: 4.548 ± 0.088	5.04LysLeu: 5.04 ± 0.074	1.682LysMet: 1.682 ± 0.049	2.671LysAsn: 2.671 ± 0.062	2.39LysPro: 2.39 ± 0.062	2.11LysGln: 2.11 ± 0.049	3.228LysArg: 3.228 ± 0.059	2.892LysSer: 2.892 ± 0.061	3.08LysThr: 3.08 ± 0.066	4.056LysVal: 4.056 ± 0.077	0.59LysTrp: 0.59 ± 0.026	1.977LysTyr: 1.977 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	8.778LeuAla: 8.778 ± 0.102	1.402LeuCys: 1.402 ± 0.04	5.522LeuAsp: 5.522 ± 0.083	7.278LeuGlu: 7.278 ± 0.126	4.211LeuPhe: 4.211 ± 0.092	7.463LeuGly: 7.463 ± 0.12	1.795LeuHis: 1.795 ± 0.045	6.958LeuIle: 6.958 ± 0.109	6.213LeuLys: 6.213 ± 0.096	11.094LeuLeu: 11.094 ± 0.154	2.565LeuMet: 2.565 ± 0.063	3.666LeuAsn: 3.666 ± 0.068	4.747LeuPro: 4.747 ± 0.088	3.65LeuGln: 3.65 ± 0.073	5.272LeuArg: 5.272 ± 0.079	6.366LeuSer: 6.366 ± 0.106	5.248LeuThr: 5.248 ± 0.093	7.366LeuVal: 7.366 ± 0.116	0.97LeuTrp: 0.97 ± 0.042	3.066LeuTyr: 3.066 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.345MetAla: 2.345 ± 0.056	0.293MetCys: 0.293 ± 0.021	1.361MetAsp: 1.361 ± 0.04	1.744MetGlu: 1.744 ± 0.048	0.823MetPhe: 0.823 ± 0.036	2.106MetGly: 2.106 ± 0.056	0.434MetHis: 0.434 ± 0.024	1.798MetIle: 1.798 ± 0.047	1.707MetLys: 1.707 ± 0.052	2.569MetLeu: 2.569 ± 0.055	0.762MetMet: 0.762 ± 0.032	0.965MetAsn: 0.965 ± 0.031	1.137MetPro: 1.137 ± 0.042	0.929MetGln: 0.929 ± 0.033	1.483MetArg: 1.483 ± 0.043	1.481MetSer: 1.481 ± 0.038	1.199MetThr: 1.199 ± 0.042	1.968MetVal: 1.968 ± 0.045	0.201MetTrp: 0.201 ± 0.016	0.571MetTyr: 0.571 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.453AsnAla: 2.453 ± 0.064	0.577AsnCys: 0.577 ± 0.027	1.561AsnAsp: 1.561 ± 0.044	2.005AsnGlu: 2.005 ± 0.044	1.358AsnPhe: 1.358 ± 0.042	2.45AsnGly: 2.45 ± 0.063	0.672AsnHis: 0.672 ± 0.028	2.939AsnIle: 2.939 ± 0.063	2.258AsnLys: 2.258 ± 0.062	3.824AsnLeu: 3.824 ± 0.065	0.915AsnMet: 0.915 ± 0.029	1.687AsnAsn: 1.687 ± 0.052	2.12AsnPro: 2.12 ± 0.046	1.218AsnGln: 1.218 ± 0.037	1.99AsnArg: 1.99 ± 0.054	2.078AsnSer: 2.078 ± 0.049	1.829AsnThr: 1.829 ± 0.043	2.224AsnVal: 2.224 ± 0.049	0.481AsnTrp: 0.481 ± 0.022	1.471AsnTyr: 1.471 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	3.177ProAla: 3.177 ± 0.066	0.59ProCys: 0.59 ± 0.028	2.671ProAsp: 2.671 ± 0.058	3.821ProGlu: 3.821 ± 0.076	1.842ProPhe: 1.842 ± 0.043	3.763ProGly: 3.763 ± 0.075	0.898ProHis: 0.898 ± 0.035	2.189ProIle: 2.189 ± 0.052	1.788ProLys: 1.788 ± 0.055	4.294ProLeu: 4.294 ± 0.077	0.773ProMet: 0.773 ± 0.029	1.185ProAsn: 1.185 ± 0.039	1.654ProPro: 1.654 ± 0.05	1.657ProGln: 1.657 ± 0.049	2.11ProArg: 2.11 ± 0.055	2.149ProSer: 2.149 ± 0.063	1.827ProThr: 1.827 ± 0.051	3.739ProVal: 3.739 ± 0.071	0.474ProTrp: 0.474 ± 0.026	1.404ProTyr: 1.404 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.747GlnAla: 2.747 ± 0.057	0.393GlnCys: 0.393 ± 0.023	1.943GlnAsp: 1.943 ± 0.049	3.393GlnGlu: 3.393 ± 0.067	1.131GlnPhe: 1.131 ± 0.036	2.697GlnGly: 2.697 ± 0.062	0.627GlnHis: 0.627 ± 0.035	2.217GlnIle: 2.217 ± 0.05	2.319GlnLys: 2.319 ± 0.062	3.241GlnLeu: 3.241 ± 0.069	0.956GlnMet: 0.956 ± 0.032	1.278GlnAsn: 1.278 ± 0.043	1.242GlnPro: 1.242 ± 0.041	1.579GlnGln: 1.579 ± 0.052	1.933GlnArg: 1.933 ± 0.05	1.632GlnSer: 1.632 ± 0.045	1.537GlnThr: 1.537 ± 0.045	2.976GlnVal: 2.976 ± 0.059	0.301GlnTrp: 0.301 ± 0.021	1.034GlnTyr: 1.034 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.485ArgAla: 3.485 ± 0.076	0.878ArgCys: 0.878 ± 0.034	2.82ArgAsp: 2.82 ± 0.068	4.353ArgGlu: 4.353 ± 0.071	2.237ArgPhe: 2.237 ± 0.057	3.966ArgGly: 3.966 ± 0.069	1.0ArgHis: 1.0 ± 0.038	3.645ArgIle: 3.645 ± 0.067	3.318ArgLys: 3.318 ± 0.058	5.475ArgLeu: 5.475 ± 0.084	1.509ArgMet: 1.509 ± 0.046	1.841ArgAsn: 1.841 ± 0.047	1.926ArgPro: 1.926 ± 0.047	2.094ArgGln: 2.094 ± 0.052	3.355ArgArg: 3.355 ± 0.074	2.832ArgSer: 2.832 ± 0.07	2.346ArgThr: 2.346 ± 0.05	4.088ArgVal: 4.088 ± 0.076	0.614ArgTrp: 0.614 ± 0.027	1.936ArgTyr: 1.936 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.767SerAla: 3.767 ± 0.072	0.913SerCys: 0.913 ± 0.038	2.685SerAsp: 2.685 ± 0.059	3.21SerGlu: 3.21 ± 0.068	2.708SerPhe: 2.708 ± 0.064	4.877SerGly: 4.877 ± 0.082	1.009SerHis: 1.009 ± 0.034	3.788SerIle: 3.788 ± 0.072	2.918SerLys: 2.918 ± 0.064	6.149SerLeu: 6.149 ± 0.094	1.449SerMet: 1.449 ± 0.041	1.79SerAsn: 1.79 ± 0.054	2.507SerPro: 2.507 ± 0.061	1.914SerGln: 1.914 ± 0.047	3.163SerArg: 3.163 ± 0.068	3.413SerSer: 3.413 ± 0.076	2.658SerThr: 2.658 ± 0.064	3.808SerVal: 3.808 ± 0.073	0.661SerTrp: 0.661 ± 0.027	2.053SerTyr: 2.053 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.513ThrAla: 4.513 ± 0.087	0.708ThrCys: 0.708 ± 0.028	2.593ThrAsp: 2.593 ± 0.059	2.845ThrGlu: 2.845 ± 0.061	1.798ThrPhe: 1.798 ± 0.053	4.873ThrGly: 4.873 ± 0.09	0.892ThrHis: 0.892 ± 0.032	3.291ThrIle: 3.291 ± 0.069	2.461ThrLys: 2.461 ± 0.053	4.85ThrLeu: 4.85 ± 0.084	1.142ThrMet: 1.142 ± 0.04	1.644ThrAsn: 1.644 ± 0.049	2.563ThrPro: 2.563 ± 0.059	1.219ThrGln: 1.219 ± 0.043	2.466ThrArg: 2.466 ± 0.054	2.652ThrSer: 2.652 ± 0.055	2.709ThrThr: 2.709 ± 0.068	3.971ThrVal: 3.971 ± 0.077	0.507ThrTrp: 0.507 ± 0.027	1.452ThrTyr: 1.452 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	5.703ValAla: 5.703 ± 0.089	1.127ValCys: 1.127 ± 0.042	4.059ValAsp: 4.059 ± 0.075	4.811ValGlu: 4.811 ± 0.083	3.269ValPhe: 3.269 ± 0.065	5.036ValGly: 5.036 ± 0.092	1.268ValHis: 1.268 ± 0.038	5.839ValIle: 5.839 ± 0.089	4.258ValLys: 4.258 ± 0.072	7.921ValLeu: 7.921 ± 0.116	1.956ValMet: 1.956 ± 0.049	2.591ValAsn: 2.591 ± 0.058	3.135ValPro: 3.135 ± 0.064	2.329ValGln: 2.329 ± 0.058	3.588ValArg: 3.588 ± 0.069	4.375ValSer: 4.375 ± 0.08	3.905ValThr: 3.905 ± 0.089	6.144ValVal: 6.144 ± 0.087	0.608ValTrp: 0.608 ± 0.028	2.193ValTyr: 2.193 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.7TrpAla: 0.7 ± 0.029	0.142TrpCys: 0.142 ± 0.012	0.623TrpAsp: 0.623 ± 0.031	0.844TrpGlu: 0.844 ± 0.035	0.447TrpPhe: 0.447 ± 0.026	0.896TrpGly: 0.896 ± 0.035	0.216TrpHis: 0.216 ± 0.018	0.565TrpIle: 0.565 ± 0.024	0.58TrpLys: 0.58 ± 0.029	1.151TrpLeu: 1.151 ± 0.044	0.321TrpMet: 0.321 ± 0.021	0.403TrpAsn: 0.403 ± 0.023	0.388TrpPro: 0.388 ± 0.024	0.439TrpGln: 0.439 ± 0.024	0.586TrpArg: 0.586 ± 0.026	0.537TrpSer: 0.537 ± 0.024	0.423TrpThr: 0.423 ± 0.026	0.702TrpVal: 0.702 ± 0.032	0.161TrpTrp: 0.161 ± 0.015	0.31TrpTyr: 0.31 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.194TyrAla: 2.194 ± 0.053	0.634TyrCys: 0.634 ± 0.028	1.777TyrAsp: 1.777 ± 0.054	1.829TyrGlu: 1.829 ± 0.052	1.549TyrPhe: 1.549 ± 0.043	2.569TyrGly: 2.569 ± 0.054	0.84TyrHis: 0.84 ± 0.035	2.112TyrIle: 2.112 ± 0.05	1.534TyrLys: 1.534 ± 0.05	3.868TyrLeu: 3.868 ± 0.072	0.727TyrMet: 0.727 ± 0.031	1.316TyrAsn: 1.316 ± 0.043	1.623TyrPro: 1.623 ± 0.05	1.431TyrGln: 1.431 ± 0.043	2.179TyrArg: 2.179 ± 0.051	1.901TyrSer: 1.901 ± 0.052	1.614TyrThr: 1.614 ± 0.054	1.88TyrVal: 1.88 ± 0.051	0.41TyrTrp: 0.41 ± 0.022	1.443TyrTyr: 1.443 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3167 proteins (794821 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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