Amino acid dipepetide frequency for Eubacterium sp. CAG:76

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.386AlaAla: 6.386 ± 0.131
1.008AlaCys: 1.008 ± 0.04
5.113AlaAsp: 5.113 ± 0.099
4.319AlaGlu: 4.319 ± 0.087
2.68AlaPhe: 2.68 ± 0.066
6.082AlaGly: 6.082 ± 0.102
1.051AlaHis: 1.051 ± 0.042
5.446AlaIle: 5.446 ± 0.1
5.019AlaLys: 5.019 ± 0.1
6.093AlaLeu: 6.093 ± 0.097
2.315AlaMet: 2.315 ± 0.06
3.024AlaAsn: 3.024 ± 0.067
1.604AlaPro: 1.604 ± 0.053
1.931AlaGln: 1.931 ± 0.058
2.607AlaArg: 2.607 ± 0.065
4.132AlaSer: 4.132 ± 0.092
3.209AlaThr: 3.209 ± 0.077
6.32AlaVal: 6.32 ± 0.107
0.43AlaTrp: 0.43 ± 0.024
2.878AlaTyr: 2.878 ± 0.061
0.001AlaXaa: 0.001 ± 0.001
Cys
1.008CysAla: 1.008 ± 0.042
0.243CysCys: 0.243 ± 0.022
0.938CysAsp: 0.938 ± 0.037
0.915CysGlu: 0.915 ± 0.04
0.509CysPhe: 0.509 ± 0.024
1.431CysGly: 1.431 ± 0.054
0.268CysHis: 0.268 ± 0.017
1.386CysIle: 1.386 ± 0.048
0.874CysLys: 0.874 ± 0.036
0.955CysLeu: 0.955 ± 0.037
0.518CysMet: 0.518 ± 0.026
0.865CysAsn: 0.865 ± 0.036
0.515CysPro: 0.515 ± 0.029
0.361CysGln: 0.361 ± 0.022
0.577CysArg: 0.577 ± 0.026
0.912CysSer: 0.912 ± 0.036
0.731CysThr: 0.731 ± 0.031
1.173CysVal: 1.173 ± 0.05
0.088CysTrp: 0.088 ± 0.011
0.618CysTyr: 0.618 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.543AspAla: 3.543 ± 0.077
0.926AspCys: 0.926 ± 0.039
4.111AspAsp: 4.111 ± 0.086
5.281AspGlu: 5.281 ± 0.081
2.407AspPhe: 2.407 ± 0.059
4.196AspGly: 4.196 ± 0.089
0.6AspHis: 0.6 ± 0.032
6.613AspIle: 6.613 ± 0.09
5.604AspLys: 5.604 ± 0.085
3.696AspLeu: 3.696 ± 0.065
2.377AspMet: 2.377 ± 0.061
4.831AspAsn: 4.831 ± 0.095
1.28AspPro: 1.28 ± 0.047
0.77AspGln: 0.77 ± 0.034
2.27AspArg: 2.27 ± 0.06
3.516AspSer: 3.516 ± 0.064
3.928AspThr: 3.928 ± 0.073
4.486AspVal: 4.486 ± 0.078
0.491AspTrp: 0.491 ± 0.026
3.608AspTyr: 3.608 ± 0.08
0.0AspXaa: 0.0 ± 0.0
Glu
5.373GluAla: 5.373 ± 0.106
0.99GluCys: 0.99 ± 0.04
4.193GluAsp: 4.193 ± 0.077
5.394GluGlu: 5.394 ± 0.102
2.54GluPhe: 2.54 ± 0.056
3.713GluGly: 3.713 ± 0.079
1.249GluHis: 1.249 ± 0.036
4.935GluIle: 4.935 ± 0.09
5.2GluLys: 5.2 ± 0.103
6.705GluLeu: 6.705 ± 0.101
1.932GluMet: 1.932 ± 0.054
3.928GluAsn: 3.928 ± 0.08
1.512GluPro: 1.512 ± 0.046
2.586GluGln: 2.586 ± 0.071
2.674GluArg: 2.674 ± 0.063
3.436GluSer: 3.436 ± 0.072
2.962GluThr: 2.962 ± 0.067
4.294GluVal: 4.294 ± 0.085
0.581GluTrp: 0.581 ± 0.027
3.665GluTyr: 3.665 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
2.663PheAla: 2.663 ± 0.068
0.57PheCys: 0.57 ± 0.026
2.586PheAsp: 2.586 ± 0.064
2.411PheGlu: 2.411 ± 0.058
1.439PhePhe: 1.439 ± 0.051
2.642PheGly: 2.642 ± 0.063
0.524PheHis: 0.524 ± 0.026
3.378PheIle: 3.378 ± 0.08
2.697PheLys: 2.697 ± 0.067
2.804PheLeu: 2.804 ± 0.073
1.161PheMet: 1.161 ± 0.042
2.34PheAsn: 2.34 ± 0.064
1.082PhePro: 1.082 ± 0.035
0.708PheGln: 0.708 ± 0.03
1.281PheArg: 1.281 ± 0.045
2.419PheSer: 2.419 ± 0.062
2.265PheThr: 2.265 ± 0.061
2.72PheVal: 2.72 ± 0.067
0.258PheTrp: 0.258 ± 0.021
1.627PheTyr: 1.627 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
4.524GlyAla: 4.524 ± 0.085
1.228GlyCys: 1.228 ± 0.051
3.555GlyAsp: 3.555 ± 0.083
3.847GlyGlu: 3.847 ± 0.076
2.751GlyPhe: 2.751 ± 0.063
4.165GlyGly: 4.165 ± 0.084
1.172GlyHis: 1.172 ± 0.041
6.456GlyIle: 6.456 ± 0.103
4.867GlyLys: 4.867 ± 0.092
5.06GlyLeu: 5.06 ± 0.088
2.265GlyMet: 2.265 ± 0.056
3.513GlyAsn: 3.513 ± 0.071
1.036GlyPro: 1.036 ± 0.041
1.762GlyGln: 1.762 ± 0.049
2.858GlyArg: 2.858 ± 0.072
4.092GlySer: 4.092 ± 0.093
3.851GlyThr: 3.851 ± 0.086
5.019GlyVal: 5.019 ± 0.086
0.57GlyTrp: 0.57 ± 0.031
3.363GlyTyr: 3.363 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
0.761HisAla: 0.761 ± 0.037
0.257HisCys: 0.257 ± 0.021
0.688HisAsp: 0.688 ± 0.035
0.77HisGlu: 0.77 ± 0.031
0.83HisPhe: 0.83 ± 0.037
0.915HisGly: 0.915 ± 0.04
0.33HisHis: 0.33 ± 0.036
1.723HisIle: 1.723 ± 0.044
1.031HisLys: 1.031 ± 0.04
1.132HisLeu: 1.132 ± 0.042
0.539HisMet: 0.539 ± 0.027
1.123HisAsn: 1.123 ± 0.04
0.616HisPro: 0.616 ± 0.031
0.361HisGln: 0.361 ± 0.024
0.631HisArg: 0.631 ± 0.027
0.978HisSer: 0.978 ± 0.039
0.896HisThr: 0.896 ± 0.045
0.665HisVal: 0.665 ± 0.031
0.096HisTrp: 0.096 ± 0.01
0.673HisTyr: 0.673 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.485IleAla: 6.485 ± 0.096
1.399IleCys: 1.399 ± 0.052
5.624IleAsp: 5.624 ± 0.084
5.431IleGlu: 5.431 ± 0.099
3.042IlePhe: 3.042 ± 0.086
5.329IleGly: 5.329 ± 0.098
1.219IleHis: 1.219 ± 0.042
7.636IleIle: 7.636 ± 0.143
6.381IleLys: 6.381 ± 0.097
6.596IleLeu: 6.596 ± 0.111
2.492IleMet: 2.492 ± 0.062
5.105IleAsn: 5.105 ± 0.097
2.805IlePro: 2.805 ± 0.063
2.088IleGln: 2.088 ± 0.051
3.205IleArg: 3.205 ± 0.07
5.766IleSer: 5.766 ± 0.097
5.186IleThr: 5.186 ± 0.082
5.928IleVal: 5.928 ± 0.102
0.582IleTrp: 0.582 ± 0.03
3.492IleTyr: 3.492 ± 0.081
0.0IleXaa: 0.0 ± 0.0
Lys
5.728LysAla: 5.728 ± 0.084
0.989LysCys: 0.989 ± 0.046
5.242LysAsp: 5.242 ± 0.088
6.779LysGlu: 6.779 ± 0.113
2.08LysPhe: 2.08 ± 0.053
4.169LysGly: 4.169 ± 0.086
1.063LysHis: 1.063 ± 0.039
5.032LysIle: 5.032 ± 0.085
6.24LysLys: 6.24 ± 0.086
6.047LysLeu: 6.047 ± 0.086
2.157LysMet: 2.157 ± 0.056
4.479LysAsn: 4.479 ± 0.077
1.954LysPro: 1.954 ± 0.055
2.294LysGln: 2.294 ± 0.055
2.88LysArg: 2.88 ± 0.061
4.02LysSer: 4.02 ± 0.082
3.648LysThr: 3.648 ± 0.073
4.993LysVal: 4.993 ± 0.092
0.509LysTrp: 0.509 ± 0.027
3.438LysTyr: 3.438 ± 0.071
0.0LysXaa: 0.0 ± 0.0
Leu
5.766LeuAla: 5.766 ± 0.101
1.304LeuCys: 1.304 ± 0.045
5.062LeuAsp: 5.062 ± 0.084
4.936LeuGlu: 4.936 ± 0.091
2.975LeuPhe: 2.975 ± 0.073
5.169LeuGly: 5.169 ± 0.085
1.2LeuHis: 1.2 ± 0.042
6.666LeuIle: 6.666 ± 0.107
6.271LeuLys: 6.271 ± 0.093
6.751LeuLeu: 6.751 ± 0.113
2.543LeuMet: 2.543 ± 0.062
4.413LeuAsn: 4.413 ± 0.083
2.685LeuPro: 2.685 ± 0.069
1.954LeuGln: 1.954 ± 0.055
3.046LeuArg: 3.046 ± 0.065
6.154LeuSer: 6.154 ± 0.111
4.396LeuThr: 4.396 ± 0.076
5.354LeuVal: 5.354 ± 0.093
0.547LeuTrp: 0.547 ± 0.029
3.29LeuTyr: 3.29 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.412MetAla: 2.412 ± 0.057
0.432MetCys: 0.432 ± 0.023
1.907MetAsp: 1.907 ± 0.056
1.951MetGlu: 1.951 ± 0.044
1.189MetPhe: 1.189 ± 0.045
1.959MetGly: 1.959 ± 0.061
0.403MetHis: 0.403 ± 0.028
2.161MetIle: 2.161 ± 0.054
2.431MetLys: 2.431 ± 0.059
2.865MetLeu: 2.865 ± 0.064
0.868MetMet: 0.868 ± 0.04
1.851MetAsn: 1.851 ± 0.047
1.138MetPro: 1.138 ± 0.038
1.039MetGln: 1.039 ± 0.041
1.127MetArg: 1.127 ± 0.042
2.154MetSer: 2.154 ± 0.053
1.694MetThr: 1.694 ± 0.052
1.997MetVal: 1.997 ± 0.051
0.222MetTrp: 0.222 ± 0.017
1.284MetTyr: 1.284 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
3.851AsnAla: 3.851 ± 0.082
0.786AsnCys: 0.786 ± 0.039
3.362AsnAsp: 3.362 ± 0.078
3.765AsnGlu: 3.765 ± 0.078
1.616AsnPhe: 1.616 ± 0.048
3.921AsnGly: 3.921 ± 0.09
0.799AsnHis: 0.799 ± 0.033
5.794AsnIle: 5.794 ± 0.106
4.336AsnLys: 4.336 ± 0.085
3.923AsnLeu: 3.923 ± 0.068
1.974AsnMet: 1.974 ± 0.051
4.37AsnAsn: 4.37 ± 0.113
1.899AsnPro: 1.899 ± 0.055
1.401AsnGln: 1.401 ± 0.046
2.067AsnArg: 2.067 ± 0.055
3.7AsnSer: 3.7 ± 0.082
3.186AsnThr: 3.186 ± 0.072
4.352AsnVal: 4.352 ± 0.078
0.363AsnTrp: 0.363 ± 0.022
2.448AsnTyr: 2.448 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
2.085ProAla: 2.085 ± 0.054
0.403ProCys: 0.403 ± 0.021
2.282ProAsp: 2.282 ± 0.055
2.332ProGlu: 2.332 ± 0.062
1.19ProPhe: 1.19 ± 0.046
1.677ProGly: 1.677 ± 0.05
0.468ProHis: 0.468 ± 0.028
1.9ProIle: 1.9 ± 0.05
1.622ProLys: 1.622 ± 0.048
2.244ProLeu: 2.244 ± 0.06
0.722ProMet: 0.722 ± 0.035
1.015ProAsn: 1.015 ± 0.041
0.53ProPro: 0.53 ± 0.026
0.854ProGln: 0.854 ± 0.035
0.789ProArg: 0.789 ± 0.033
1.492ProSer: 1.492 ± 0.045
1.289ProThr: 1.289 ± 0.048
2.771ProVal: 2.771 ± 0.064
0.219ProTrp: 0.219 ± 0.017
1.407ProTyr: 1.407 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
2.009GlnAla: 2.009 ± 0.055
0.342GlnCys: 0.342 ± 0.023
1.357GlnAsp: 1.357 ± 0.038
1.757GlnGlu: 1.757 ± 0.054
1.095GlnPhe: 1.095 ± 0.037
1.466GlnGly: 1.466 ± 0.049
0.422GlnHis: 0.422 ± 0.023
2.424GlnIle: 2.424 ± 0.063
1.905GlnLys: 1.905 ± 0.05
2.68GlnLeu: 2.68 ± 0.071
1.046GlnMet: 1.046 ± 0.041
1.447GlnAsn: 1.447 ± 0.048
0.701GlnPro: 0.701 ± 0.033
0.969GlnGln: 0.969 ± 0.041
1.145GlnArg: 1.145 ± 0.036
1.578GlnSer: 1.578 ± 0.05
1.435GlnThr: 1.435 ± 0.049
1.586GlnVal: 1.586 ± 0.048
0.231GlnTrp: 0.231 ± 0.018
1.355GlnTyr: 1.355 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.277ArgAla: 2.277 ± 0.056
0.545ArgCys: 0.545 ± 0.029
1.93ArgAsp: 1.93 ± 0.053
2.651ArgGlu: 2.651 ± 0.065
1.551ArgPhe: 1.551 ± 0.05
2.0ArgGly: 2.0 ± 0.051
0.708ArgHis: 0.708 ± 0.031
3.482ArgIle: 3.482 ± 0.076
3.123ArgLys: 3.123 ± 0.067
3.444ArgLeu: 3.444 ± 0.061
1.307ArgMet: 1.307 ± 0.042
2.188ArgAsn: 2.188 ± 0.064
1.082ArgPro: 1.082 ± 0.042
1.503ArgGln: 1.503 ± 0.049
1.712ArgArg: 1.712 ± 0.059
1.857ArgSer: 1.857 ± 0.044
2.031ArgThr: 2.031 ± 0.053
2.401ArgVal: 2.401 ± 0.055
0.272ArgTrp: 0.272 ± 0.021
1.913ArgTyr: 1.913 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
4.267SerAla: 4.267 ± 0.089
0.804SerCys: 0.804 ± 0.035
4.461SerAsp: 4.461 ± 0.088
4.079SerGlu: 4.079 ± 0.081
2.539SerPhe: 2.539 ± 0.059
4.981SerGly: 4.981 ± 0.09
0.954SerHis: 0.954 ± 0.036
5.116SerIle: 5.116 ± 0.101
3.919SerLys: 3.919 ± 0.078
4.823SerLeu: 4.823 ± 0.092
1.754SerMet: 1.754 ± 0.052
3.181SerAsn: 3.181 ± 0.08
1.43SerPro: 1.43 ± 0.043
1.854SerGln: 1.854 ± 0.051
2.563SerArg: 2.563 ± 0.059
4.444SerSer: 4.444 ± 0.1
3.158SerThr: 3.158 ± 0.079
4.64SerVal: 4.64 ± 0.076
0.458SerTrp: 0.458 ± 0.028
2.855SerTyr: 2.855 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
4.223ThrAla: 4.223 ± 0.077
0.573ThrCys: 0.573 ± 0.024
3.927ThrAsp: 3.927 ± 0.075
3.302ThrGlu: 3.302 ± 0.09
2.358ThrPhe: 2.358 ± 0.066
4.575ThrGly: 4.575 ± 0.078
0.877ThrHis: 0.877 ± 0.035
4.425ThrIle: 4.425 ± 0.08
3.231ThrLys: 3.231 ± 0.07
4.579ThrLeu: 4.579 ± 0.086
1.342ThrMet: 1.342 ± 0.043
2.417ThrAsn: 2.417 ± 0.058
1.819ThrPro: 1.819 ± 0.053
1.528ThrGln: 1.528 ± 0.056
1.915ThrArg: 1.915 ± 0.051
3.332ThrSer: 3.332 ± 0.067
3.048ThrThr: 3.048 ± 0.086
4.162ThrVal: 4.162 ± 0.093
0.274ThrTrp: 0.274 ± 0.022
2.347ThrTyr: 2.347 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
4.921ValAla: 4.921 ± 0.091
1.285ValCys: 1.285 ± 0.045
4.483ValAsp: 4.483 ± 0.079
4.256ValGlu: 4.256 ± 0.087
2.74ValPhe: 2.74 ± 0.075
3.997ValGly: 3.997 ± 0.094
0.924ValHis: 0.924 ± 0.031
6.519ValIle: 6.519 ± 0.121
5.236ValLys: 5.236 ± 0.075
6.209ValLeu: 6.209 ± 0.098
2.113ValMet: 2.113 ± 0.05
4.188ValAsn: 4.188 ± 0.083
2.163ValPro: 2.163 ± 0.055
1.636ValGln: 1.636 ± 0.049
2.623ValArg: 2.623 ± 0.071
4.952ValSer: 4.952 ± 0.089
4.42ValThr: 4.42 ± 0.089
5.337ValVal: 5.337 ± 0.098
0.532ValTrp: 0.532 ± 0.03
3.15ValTyr: 3.15 ± 0.072
0.0ValXaa: 0.0 ± 0.0
Trp
0.424TrpAla: 0.424 ± 0.023
0.132TrpCys: 0.132 ± 0.013
0.47TrpAsp: 0.47 ± 0.024
0.457TrpGlu: 0.457 ± 0.025
0.328TrpPhe: 0.328 ± 0.023
0.497TrpGly: 0.497 ± 0.028
0.128TrpHis: 0.128 ± 0.015
0.55TrpIle: 0.55 ± 0.031
0.528TrpLys: 0.528 ± 0.027
0.668TrpLeu: 0.668 ± 0.034
0.216TrpMet: 0.216 ± 0.019
0.495TrpAsn: 0.495 ± 0.025
0.147TrpPro: 0.147 ± 0.016
0.253TrpGln: 0.253 ± 0.018
0.249TrpArg: 0.249 ± 0.021
0.392TrpSer: 0.392 ± 0.024
0.323TrpThr: 0.323 ± 0.019
0.45TrpVal: 0.45 ± 0.025
0.088TrpTrp: 0.088 ± 0.013
0.331TrpTyr: 0.331 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.939TyrAla: 2.939 ± 0.071
0.668TyrCys: 0.668 ± 0.033
3.242TyrAsp: 3.242 ± 0.062
3.231TyrGlu: 3.231 ± 0.065
1.716TyrPhe: 1.716 ± 0.045
3.071TyrGly: 3.071 ± 0.065
0.657TyrHis: 0.657 ± 0.028
4.147TyrIle: 4.147 ± 0.099
3.227TyrLys: 3.227 ± 0.084
3.208TyrLeu: 3.208 ± 0.064
1.443TyrMet: 1.443 ± 0.047
3.142TyrAsn: 3.142 ± 0.075
1.292TyrPro: 1.292 ± 0.042
1.097TyrGln: 1.097 ± 0.043
1.758TyrArg: 1.758 ± 0.054
2.954TyrSer: 2.954 ± 0.069
2.598TyrThr: 2.598 ± 0.066
3.038TyrVal: 3.038 ± 0.071
0.315TyrTrp: 0.315 ± 0.02
2.209TyrTyr: 2.209 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.001XaaXaa: 0.001 ± 0.001
Statistics based on 2278 proteins (740048 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski