Amino acid dipepetide frequency for Bacteroides intestinalis CAG:564

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.405AlaAla: 5.405 ± 0.104	1.06AlaCys: 1.06 ± 0.036	4.235AlaAsp: 4.235 ± 0.071	4.645AlaGlu: 4.645 ± 0.068	3.125AlaPhe: 3.125 ± 0.059	5.056AlaGly: 5.056 ± 0.068	1.208AlaHis: 1.208 ± 0.034	4.476AlaIle: 4.476 ± 0.066	3.807AlaLys: 3.807 ± 0.064	6.488AlaLeu: 6.488 ± 0.089	1.852AlaMet: 1.852 ± 0.041	3.236AlaAsn: 3.236 ± 0.063	2.379AlaPro: 2.379 ± 0.043	2.74AlaGln: 2.74 ± 0.047	2.999AlaArg: 2.999 ± 0.058	4.277AlaSer: 4.277 ± 0.072	3.978AlaThr: 3.978 ± 0.066	4.487AlaVal: 4.487 ± 0.074	0.987AlaTrp: 0.987 ± 0.033	3.033AlaTyr: 3.033 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.773CysAla: 0.773 ± 0.029	0.221CysCys: 0.221 ± 0.015	0.644CysAsp: 0.644 ± 0.023	0.706CysGlu: 0.706 ± 0.029	0.694CysPhe: 0.694 ± 0.03	1.003CysGly: 1.003 ± 0.031	0.288CysHis: 0.288 ± 0.018	0.963CysIle: 0.963 ± 0.031	0.634CysLys: 0.634 ± 0.023	1.168CysLeu: 1.168 ± 0.038	0.328CysMet: 0.328 ± 0.018	0.584CysAsn: 0.584 ± 0.024	0.525CysPro: 0.525 ± 0.027	0.378CysGln: 0.378 ± 0.017	0.624CysArg: 0.624 ± 0.022	0.809CysSer: 0.809 ± 0.027	0.714CysThr: 0.714 ± 0.025	0.657CysVal: 0.657 ± 0.025	0.163CysTrp: 0.163 ± 0.012	0.618CysTyr: 0.618 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	4.077AspAla: 4.077 ± 0.068	0.641AspCys: 0.641 ± 0.025	2.709AspAsp: 2.709 ± 0.051	3.828AspGlu: 3.828 ± 0.052	2.947AspPhe: 2.947 ± 0.066	4.46AspGly: 4.46 ± 0.076	0.878AspHis: 0.878 ± 0.028	3.982AspIle: 3.982 ± 0.066	4.042AspLys: 4.042 ± 0.058	4.442AspLeu: 4.442 ± 0.07	1.634AspMet: 1.634 ± 0.041	2.86AspAsn: 2.86 ± 0.063	1.99AspPro: 1.99 ± 0.05	1.302AspGln: 1.302 ± 0.039	2.455AspArg: 2.455 ± 0.051	3.132AspSer: 3.132 ± 0.059	2.789AspThr: 2.789 ± 0.05	3.398AspVal: 3.398 ± 0.067	1.013AspTrp: 1.013 ± 0.029	2.949AspTyr: 2.949 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	4.679GluAla: 4.679 ± 0.068	0.63GluCys: 0.63 ± 0.026	3.317GluAsp: 3.317 ± 0.062	4.934GluGlu: 4.934 ± 0.093	2.49GluPhe: 2.49 ± 0.054	4.258GluGly: 4.258 ± 0.069	1.193GluHis: 1.193 ± 0.036	4.53GluIle: 4.53 ± 0.08	5.032GluLys: 5.032 ± 0.072	5.927GluLeu: 5.927 ± 0.079	2.027GluMet: 2.027 ± 0.042	3.575GluAsn: 3.575 ± 0.065	1.734GluPro: 1.734 ± 0.039	2.568GluGln: 2.568 ± 0.054	3.022GluArg: 3.022 ± 0.059	3.075GluSer: 3.075 ± 0.05	3.404GluThr: 3.404 ± 0.054	4.296GluVal: 4.296 ± 0.067	0.914GluTrp: 0.914 ± 0.029	2.929GluTyr: 2.929 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.899PheAla: 2.899 ± 0.055	0.725PheCys: 0.725 ± 0.026	2.623PheAsp: 2.623 ± 0.046	2.371PheGlu: 2.371 ± 0.051	2.189PhePhe: 2.189 ± 0.056	3.15PheGly: 3.15 ± 0.069	0.875PheHis: 0.875 ± 0.027	3.24PheIle: 3.24 ± 0.066	2.38PheLys: 2.38 ± 0.047	4.027PheLeu: 4.027 ± 0.076	1.202PheMet: 1.202 ± 0.028	2.41PheAsn: 2.41 ± 0.048	1.757PhePro: 1.757 ± 0.048	1.388PheGln: 1.388 ± 0.036	2.292PheArg: 2.292 ± 0.045	3.537PheSer: 3.537 ± 0.052	2.885PheThr: 2.885 ± 0.056	2.769PheVal: 2.769 ± 0.055	0.664PheTrp: 0.664 ± 0.027	2.181PheTyr: 2.181 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.236GlyAla: 4.236 ± 0.072	0.887GlyCys: 0.887 ± 0.029	3.699GlyAsp: 3.699 ± 0.065	4.27GlyGlu: 4.27 ± 0.068	3.207GlyPhe: 3.207 ± 0.054	4.701GlyGly: 4.701 ± 0.087	1.243GlyHis: 1.243 ± 0.036	5.314GlyIle: 5.314 ± 0.064	5.287GlyLys: 5.287 ± 0.074	5.645GlyLeu: 5.645 ± 0.093	2.14GlyMet: 2.14 ± 0.037	3.767GlyAsn: 3.767 ± 0.072	1.339GlyPro: 1.339 ± 0.039	2.182GlyGln: 2.182 ± 0.049	2.943GlyArg: 2.943 ± 0.054	4.076GlySer: 4.076 ± 0.078	4.406GlyThr: 4.406 ± 0.063	4.635GlyVal: 4.635 ± 0.069	1.191GlyTrp: 1.191 ± 0.035	3.473GlyTyr: 3.473 ± 0.075	0.001GlyXaa: 0.001 ± 0.001
His	1.212HisAla: 1.212 ± 0.034	0.308HisCys: 0.308 ± 0.019	0.896HisAsp: 0.896 ± 0.032	1.034HisGlu: 1.034 ± 0.03	1.03HisPhe: 1.03 ± 0.03	1.195HisGly: 1.195 ± 0.037	0.464HisHis: 0.464 ± 0.023	1.359HisIle: 1.359 ± 0.037	0.988HisLys: 0.988 ± 0.033	1.756HisLeu: 1.756 ± 0.045	0.356HisMet: 0.356 ± 0.02	0.963HisAsn: 0.963 ± 0.031	1.077HisPro: 1.077 ± 0.027	0.614HisGln: 0.614 ± 0.023	0.892HisArg: 0.892 ± 0.028	1.149HisSer: 1.149 ± 0.031	1.161HisThr: 1.161 ± 0.033	1.008HisVal: 1.008 ± 0.031	0.294HisTrp: 0.294 ± 0.016	1.013HisTyr: 1.013 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.045IleAla: 5.045 ± 0.069	0.967IleCys: 0.967 ± 0.029	4.119IleAsp: 4.119 ± 0.061	4.167IleGlu: 4.167 ± 0.062	2.825IlePhe: 2.825 ± 0.053	4.663IleGly: 4.663 ± 0.073	1.358IleHis: 1.358 ± 0.037	4.386IleIle: 4.386 ± 0.078	3.755IleLys: 3.755 ± 0.074	5.961IleLeu: 5.961 ± 0.098	1.437IleMet: 1.437 ± 0.038	3.46IleAsn: 3.46 ± 0.058	3.171IlePro: 3.171 ± 0.055	2.127IleGln: 2.127 ± 0.048	3.467IleArg: 3.467 ± 0.053	4.675IleSer: 4.675 ± 0.07	4.133IleThr: 4.133 ± 0.073	4.094IleVal: 4.094 ± 0.067	0.877IleTrp: 0.877 ± 0.034	3.009IleTyr: 3.009 ± 0.053	0.001IleXaa: 0.001 ± 0.001
Lys	4.795LysAla: 4.795 ± 0.082	0.515LysCys: 0.515 ± 0.022	4.082LysAsp: 4.082 ± 0.059	5.598LysGlu: 5.598 ± 0.093	2.013LysPhe: 2.013 ± 0.043	4.528LysGly: 4.528 ± 0.062	1.213LysHis: 1.213 ± 0.032	3.944LysIle: 3.944 ± 0.067	4.762LysLys: 4.762 ± 0.08	5.283LysLeu: 5.283 ± 0.077	2.021LysMet: 2.021 ± 0.05	3.587LysAsn: 3.587 ± 0.06	2.116LysPro: 2.116 ± 0.051	2.573LysGln: 2.573 ± 0.045	2.883LysArg: 2.883 ± 0.048	3.317LysSer: 3.317 ± 0.054	3.282LysThr: 3.282 ± 0.05	4.242LysVal: 4.242 ± 0.076	0.845LysTrp: 0.845 ± 0.027	2.999LysTyr: 2.999 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	6.172LeuAla: 6.172 ± 0.09	1.41LeuCys: 1.41 ± 0.04	4.539LeuAsp: 4.539 ± 0.061	4.991LeuGlu: 4.991 ± 0.074	4.561LeuPhe: 4.561 ± 0.079	5.309LeuGly: 5.309 ± 0.074	1.723LeuHis: 1.723 ± 0.045	5.529LeuIle: 5.529 ± 0.101	6.248LeuLys: 6.248 ± 0.082	9.139LeuLeu: 9.139 ± 0.151	2.352LeuMet: 2.352 ± 0.048	4.771LeuAsn: 4.771 ± 0.072	4.148LeuPro: 4.148 ± 0.068	3.43LeuGln: 3.43 ± 0.051	4.068LeuArg: 4.068 ± 0.066	6.653LeuSer: 6.653 ± 0.086	5.325LeuThr: 5.325 ± 0.075	5.057LeuVal: 5.057 ± 0.071	1.258LeuTrp: 1.258 ± 0.035	3.931LeuTyr: 3.931 ± 0.067	0.002LeuXaa: 0.002 ± 0.001
Met	1.887MetAla: 1.887 ± 0.046	0.24MetCys: 0.24 ± 0.013	1.522MetAsp: 1.522 ± 0.04	1.752MetGlu: 1.752 ± 0.038	0.953MetPhe: 0.953 ± 0.029	1.811MetGly: 1.811 ± 0.041	0.491MetHis: 0.491 ± 0.022	1.622MetIle: 1.622 ± 0.039	2.653MetLys: 2.653 ± 0.048	2.543MetLeu: 2.543 ± 0.053	0.79MetMet: 0.79 ± 0.029	1.556MetAsn: 1.556 ± 0.042	1.186MetPro: 1.186 ± 0.031	1.088MetGln: 1.088 ± 0.031	1.282MetArg: 1.282 ± 0.035	1.512MetSer: 1.512 ± 0.038	1.449MetThr: 1.449 ± 0.033	1.504MetVal: 1.504 ± 0.039	0.313MetTrp: 0.313 ± 0.019	0.942MetTyr: 0.942 ± 0.03	0.001MetXaa: 0.001 ± 0.001
Asn	3.493AsnAla: 3.493 ± 0.067	0.534AsnCys: 0.534 ± 0.022	2.69AsnAsp: 2.69 ± 0.051	3.16AsnGlu: 3.16 ± 0.054	2.299AsnPhe: 2.299 ± 0.048	4.081AsnGly: 4.081 ± 0.083	1.038AsnHis: 1.038 ± 0.033	3.83AsnIle: 3.83 ± 0.072	3.169AsnLys: 3.169 ± 0.054	4.589AsnLeu: 4.589 ± 0.077	1.388AsnMet: 1.388 ± 0.032	2.769AsnAsn: 2.769 ± 0.061	2.609AsnPro: 2.609 ± 0.054	1.705AsnGln: 1.705 ± 0.047	2.476AsnArg: 2.476 ± 0.053	3.068AsnSer: 3.068 ± 0.065	2.903AsnThr: 2.903 ± 0.045	3.227AsnVal: 3.227 ± 0.065	0.796AsnTrp: 0.796 ± 0.028	2.657AsnTyr: 2.657 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.819ProAla: 2.819 ± 0.051	0.412ProCys: 0.412 ± 0.022	2.683ProAsp: 2.683 ± 0.051	3.381ProGlu: 3.381 ± 0.057	1.831ProPhe: 1.831 ± 0.034	2.592ProGly: 2.592 ± 0.059	0.743ProHis: 0.743 ± 0.027	2.326ProIle: 2.326 ± 0.047	1.94ProLys: 1.94 ± 0.044	3.442ProLeu: 3.442 ± 0.059	0.971ProMet: 0.971 ± 0.031	1.761ProAsn: 1.761 ± 0.039	0.838ProPro: 0.838 ± 0.03	1.528ProGln: 1.528 ± 0.039	1.344ProArg: 1.344 ± 0.036	2.219ProSer: 2.219 ± 0.05	1.965ProThr: 1.965 ± 0.042	3.065ProVal: 3.065 ± 0.065	0.551ProTrp: 0.551 ± 0.027	1.802ProTyr: 1.802 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.464GlnAla: 2.464 ± 0.052	0.285GlnCys: 0.285 ± 0.017	1.667GlnAsp: 1.667 ± 0.04	2.339GlnGlu: 2.339 ± 0.045	1.319GlnPhe: 1.319 ± 0.035	2.205GlnGly: 2.205 ± 0.049	0.655GlnHis: 0.655 ± 0.025	2.294GlnIle: 2.294 ± 0.049	2.539GlnLys: 2.539 ± 0.053	3.371GlnLeu: 3.371 ± 0.059	1.079GlnMet: 1.079 ± 0.032	1.821GlnAsn: 1.821 ± 0.041	1.368GlnPro: 1.368 ± 0.039	1.611GlnGln: 1.611 ± 0.047	1.699GlnArg: 1.699 ± 0.049	2.078GlnSer: 2.078 ± 0.051	2.128GlnThr: 2.128 ± 0.041	2.15GlnVal: 2.15 ± 0.042	0.556GlnTrp: 0.556 ± 0.022	1.607GlnTyr: 1.607 ± 0.047	0.0GlnXaa: 0.0 ± 0.0
Arg	2.804ArgAla: 2.804 ± 0.051	0.489ArgCys: 0.489 ± 0.021	2.16ArgAsp: 2.16 ± 0.045	2.995ArgGlu: 2.995 ± 0.059	2.262ArgPhe: 2.262 ± 0.048	2.497ArgGly: 2.497 ± 0.044	0.907ArgHis: 0.907 ± 0.029	3.525ArgIle: 3.525 ± 0.06	3.273ArgLys: 3.273 ± 0.063	4.428ArgLeu: 4.428 ± 0.072	1.544ArgMet: 1.544 ± 0.04	2.579ArgAsn: 2.579 ± 0.058	1.615ArgPro: 1.615 ± 0.05	1.727ArgGln: 1.727 ± 0.042	2.23ArgArg: 2.23 ± 0.053	2.484ArgSer: 2.484 ± 0.052	2.551ArgThr: 2.551 ± 0.051	2.528ArgVal: 2.528 ± 0.052	0.703ArgTrp: 0.703 ± 0.026	2.278ArgTyr: 2.278 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.225SerAla: 4.225 ± 0.054	0.844SerCys: 0.844 ± 0.026	3.36SerAsp: 3.36 ± 0.057	3.445SerGlu: 3.445 ± 0.06	3.357SerPhe: 3.357 ± 0.056	4.585SerGly: 4.585 ± 0.071	1.154SerHis: 1.154 ± 0.036	4.545SerIle: 4.545 ± 0.07	3.204SerLys: 3.204 ± 0.058	6.024SerLeu: 6.024 ± 0.084	1.45SerMet: 1.45 ± 0.038	2.926SerAsn: 2.926 ± 0.063	2.382SerPro: 2.382 ± 0.05	1.981SerGln: 1.981 ± 0.041	2.626SerArg: 2.626 ± 0.049	4.081SerSer: 4.081 ± 0.069	3.425SerThr: 3.425 ± 0.061	4.146SerVal: 4.146 ± 0.062	0.908SerTrp: 0.908 ± 0.028	3.021SerTyr: 3.021 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	4.025ThrAla: 4.025 ± 0.061	0.642ThrCys: 0.642 ± 0.024	3.551ThrAsp: 3.551 ± 0.057	3.446ThrGlu: 3.446 ± 0.057	2.806ThrPhe: 2.806 ± 0.055	4.447ThrGly: 4.447 ± 0.075	1.048ThrHis: 1.048 ± 0.034	3.768ThrIle: 3.768 ± 0.057	2.798ThrLys: 2.798 ± 0.051	5.597ThrLeu: 5.597 ± 0.067	1.182ThrMet: 1.182 ± 0.032	2.698ThrAsn: 2.698 ± 0.054	2.96ThrPro: 2.96 ± 0.055	1.86ThrGln: 1.86 ± 0.048	2.277ThrArg: 2.277 ± 0.052	3.38ThrSer: 3.38 ± 0.066	3.258ThrThr: 3.258 ± 0.062	4.025ThrVal: 4.025 ± 0.056	0.797ThrTrp: 0.797 ± 0.023	2.741ThrTyr: 2.741 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.371ValAla: 4.371 ± 0.074	0.935ValCys: 0.935 ± 0.029	3.497ValAsp: 3.497 ± 0.069	3.976ValGlu: 3.976 ± 0.064	2.774ValPhe: 2.774 ± 0.055	3.847ValGly: 3.847 ± 0.062	1.113ValHis: 1.113 ± 0.032	4.179ValIle: 4.179 ± 0.065	4.186ValLys: 4.186 ± 0.076	5.446ValLeu: 5.446 ± 0.077	1.606ValMet: 1.606 ± 0.035	3.378ValAsn: 3.378 ± 0.058	2.551ValPro: 2.551 ± 0.054	1.989ValGln: 1.989 ± 0.048	2.986ValArg: 2.986 ± 0.057	4.338ValSer: 4.338 ± 0.068	3.787ValThr: 3.787 ± 0.065	4.24ValVal: 4.24 ± 0.076	0.803ValTrp: 0.803 ± 0.031	2.797ValTyr: 2.797 ± 0.052	0.001ValXaa: 0.001 ± 0.001
Trp	0.913TrpAla: 0.913 ± 0.028	0.163TrpCys: 0.163 ± 0.012	0.872TrpAsp: 0.872 ± 0.03	0.923TrpGlu: 0.923 ± 0.03	0.659TrpPhe: 0.659 ± 0.027	1.109TrpGly: 1.109 ± 0.037	0.266TrpHis: 0.266 ± 0.014	0.925TrpIle: 0.925 ± 0.033	1.042TrpLys: 1.042 ± 0.032	1.209TrpLeu: 1.209 ± 0.035	0.516TrpMet: 0.516 ± 0.019	1.013TrpAsn: 1.013 ± 0.037	0.341TrpPro: 0.341 ± 0.018	0.632TrpGln: 0.632 ± 0.023	0.656TrpArg: 0.656 ± 0.03	0.813TrpSer: 0.813 ± 0.031	0.822TrpThr: 0.822 ± 0.032	0.794TrpVal: 0.794 ± 0.027	0.245TrpTrp: 0.245 ± 0.016	0.67TrpTyr: 0.67 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.182TyrAla: 3.182 ± 0.051	0.586TyrCys: 0.586 ± 0.025	2.661TyrAsp: 2.661 ± 0.049	2.573TyrGlu: 2.573 ± 0.051	2.227TyrPhe: 2.227 ± 0.046	3.146TyrGly: 3.146 ± 0.062	0.909TyrHis: 0.909 ± 0.03	2.956TyrIle: 2.956 ± 0.054	2.861TyrLys: 2.861 ± 0.058	4.132TyrLeu: 4.132 ± 0.059	1.219TyrMet: 1.219 ± 0.032	2.767TyrAsn: 2.767 ± 0.054	2.126TyrPro: 2.126 ± 0.046	1.812TyrGln: 1.812 ± 0.046	2.357TyrArg: 2.357 ± 0.045	3.015TyrSer: 3.015 ± 0.059	2.939TyrThr: 2.939 ± 0.058	2.477TyrVal: 2.477 ± 0.048	0.704TyrTrp: 0.704 ± 0.028	2.44TyrTyr: 2.44 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.002

Statistics based on 2827 proteins (1100216 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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