Amino acid dipepetide frequency for Microbacterium telephonicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.555AlaAla: 23.555 ± 0.258	0.678AlaCys: 0.678 ± 0.032	9.706AlaAsp: 9.706 ± 0.124	7.941AlaGlu: 7.941 ± 0.114	4.164AlaPhe: 4.164 ± 0.077	12.973AlaGly: 12.973 ± 0.129	2.757AlaHis: 2.757 ± 0.059	5.512AlaIle: 5.512 ± 0.073	2.48AlaLys: 2.48 ± 0.065	14.994AlaLeu: 14.994 ± 0.184	2.665AlaMet: 2.665 ± 0.056	2.052AlaAsn: 2.052 ± 0.055	7.388AlaPro: 7.388 ± 0.127	4.169AlaGln: 4.169 ± 0.085	9.965AlaArg: 9.965 ± 0.121	7.363AlaSer: 7.363 ± 0.093	7.806AlaThr: 7.806 ± 0.092	12.792AlaVal: 12.792 ± 0.13	2.037AlaTrp: 2.037 ± 0.05	2.591AlaTyr: 2.591 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.73CysAla: 0.73 ± 0.034	0.042CysCys: 0.042 ± 0.007	0.312CysAsp: 0.312 ± 0.018	0.238CysGlu: 0.238 ± 0.017	0.154CysPhe: 0.154 ± 0.012	0.521CysGly: 0.521 ± 0.026	0.12CysHis: 0.12 ± 0.012	0.163CysIle: 0.163 ± 0.013	0.051CysLys: 0.051 ± 0.008	0.41CysLeu: 0.41 ± 0.021	0.067CysMet: 0.067 ± 0.009	0.086CysAsn: 0.086 ± 0.009	0.284CysPro: 0.284 ± 0.017	0.106CysGln: 0.106 ± 0.01	0.3CysArg: 0.3 ± 0.019	0.255CysSer: 0.255 ± 0.015	0.329CysThr: 0.329 ± 0.02	0.396CysVal: 0.396 ± 0.019	0.061CysTrp: 0.061 ± 0.008	0.089CysTyr: 0.089 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	10.933AspAla: 10.933 ± 0.136	0.213AspCys: 0.213 ± 0.017	4.702AspAsp: 4.702 ± 0.093	4.375AspGlu: 4.375 ± 0.067	1.663AspPhe: 1.663 ± 0.043	6.628AspGly: 6.628 ± 0.095	1.208AspHis: 1.208 ± 0.035	2.407AspIle: 2.407 ± 0.052	0.967AspLys: 0.967 ± 0.037	6.426AspLeu: 6.426 ± 0.089	0.867AspMet: 0.867 ± 0.034	0.915AspAsn: 0.915 ± 0.062	4.47AspPro: 4.47 ± 0.079	1.456AspGln: 1.456 ± 0.039	4.562AspArg: 4.562 ± 0.078	2.234AspSer: 2.234 ± 0.053	3.148AspThr: 3.148 ± 0.065	5.95AspVal: 5.95 ± 0.09	0.95AspTrp: 0.95 ± 0.037	1.249AspTyr: 1.249 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	6.856GluAla: 6.856 ± 0.099	0.22GluCys: 0.22 ± 0.016	2.578GluAsp: 2.578 ± 0.06	2.569GluGlu: 2.569 ± 0.064	1.618GluPhe: 1.618 ± 0.044	3.836GluGly: 3.836 ± 0.069	1.27GluHis: 1.27 ± 0.038	2.654GluIle: 2.654 ± 0.066	1.326GluLys: 1.326 ± 0.047	6.01GluLeu: 6.01 ± 0.081	0.851GluMet: 0.851 ± 0.03	1.161GluAsn: 1.161 ± 0.037	2.94GluPro: 2.94 ± 0.065	1.998GluGln: 1.998 ± 0.045	4.956GluArg: 4.956 ± 0.085	2.517GluSer: 2.517 ± 0.059	2.988GluThr: 2.988 ± 0.063	4.704GluVal: 4.704 ± 0.071	0.837GluTrp: 0.837 ± 0.03	1.157GluTyr: 1.157 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.471PheAla: 4.471 ± 0.069	0.132PheCys: 0.132 ± 0.012	2.405PheAsp: 2.405 ± 0.053	1.59PheGlu: 1.59 ± 0.046	1.062PhePhe: 1.062 ± 0.04	3.306PheGly: 3.306 ± 0.063	0.559PheHis: 0.559 ± 0.026	1.088PheIle: 1.088 ± 0.04	0.422PheLys: 0.422 ± 0.021	2.793PheLeu: 2.793 ± 0.067	0.37PheMet: 0.37 ± 0.021	0.586PheAsn: 0.586 ± 0.024	1.447PhePro: 1.447 ± 0.039	0.783PheGln: 0.783 ± 0.03	1.816PheArg: 1.816 ± 0.045	1.615PheSer: 1.615 ± 0.046	2.159PheThr: 2.159 ± 0.048	2.86PheVal: 2.86 ± 0.059	0.495PheTrp: 0.495 ± 0.029	0.646PheTyr: 0.646 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	11.778GlyAla: 11.778 ± 0.134	0.534GlyCys: 0.534 ± 0.025	5.592GlyAsp: 5.592 ± 0.076	4.942GlyGlu: 4.942 ± 0.086	3.301GlyPhe: 3.301 ± 0.066	7.957GlyGly: 7.957 ± 0.119	1.762GlyHis: 1.762 ± 0.05	4.913GlyIle: 4.913 ± 0.067	2.009GlyLys: 2.009 ± 0.058	8.504GlyLeu: 8.504 ± 0.101	1.911GlyMet: 1.911 ± 0.047	1.591GlyAsn: 1.591 ± 0.045	3.712GlyPro: 3.712 ± 0.062	2.319GlyGln: 2.319 ± 0.059	6.511GlyArg: 6.511 ± 0.086	4.874GlySer: 4.874 ± 0.065	5.621GlyThr: 5.621 ± 0.08	8.332GlyVal: 8.332 ± 0.091	1.673GlyTrp: 1.673 ± 0.046	2.22GlyTyr: 2.22 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.529HisAla: 2.529 ± 0.057	0.108HisCys: 0.108 ± 0.011	1.335HisAsp: 1.335 ± 0.036	1.07HisGlu: 1.07 ± 0.032	0.53HisPhe: 0.53 ± 0.024	1.985HisGly: 1.985 ± 0.047	0.568HisHis: 0.568 ± 0.023	0.701HisIle: 0.701 ± 0.025	0.277HisLys: 0.277 ± 0.018	2.017HisLeu: 2.017 ± 0.046	0.292HisMet: 0.292 ± 0.015	0.341HisAsn: 0.341 ± 0.024	1.538HisPro: 1.538 ± 0.043	0.44HisGln: 0.44 ± 0.024	1.615HisArg: 1.615 ± 0.046	0.904HisSer: 0.904 ± 0.033	1.036HisThr: 1.036 ± 0.033	1.743HisVal: 1.743 ± 0.044	0.289HisTrp: 0.289 ± 0.02	0.404HisTyr: 0.404 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.934IleAla: 6.934 ± 0.097	0.201IleCys: 0.201 ± 0.016	3.381IleAsp: 3.381 ± 0.069	2.446IleGlu: 2.446 ± 0.059	1.042IlePhe: 1.042 ± 0.037	4.489IleGly: 4.489 ± 0.078	0.667IleHis: 0.667 ± 0.026	1.59IleIle: 1.59 ± 0.046	0.677IleLys: 0.677 ± 0.03	3.596IleLeu: 3.596 ± 0.069	0.56IleMet: 0.56 ± 0.023	0.805IleAsn: 0.805 ± 0.033	2.364IlePro: 2.364 ± 0.052	0.931IleGln: 0.931 ± 0.036	2.743IleArg: 2.743 ± 0.053	2.097IleSer: 2.097 ± 0.052	2.708IleThr: 2.708 ± 0.06	4.769IleVal: 4.769 ± 0.066	0.465IleTrp: 0.465 ± 0.022	0.675IleTyr: 0.675 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.34LysAla: 2.34 ± 0.064	0.055LysCys: 0.055 ± 0.008	1.041LysAsp: 1.041 ± 0.041	0.865LysGlu: 0.865 ± 0.036	0.425LysPhe: 0.425 ± 0.024	1.472LysGly: 1.472 ± 0.048	0.375LysHis: 0.375 ± 0.023	0.882LysIle: 0.882 ± 0.037	0.708LysLys: 0.708 ± 0.036	1.726LysLeu: 1.726 ± 0.042	0.305LysMet: 0.305 ± 0.02	0.438LysAsn: 0.438 ± 0.023	1.093LysPro: 1.093 ± 0.035	0.629LysGln: 0.629 ± 0.027	1.389LysArg: 1.389 ± 0.045	0.961LysSer: 0.961 ± 0.033	1.256LysThr: 1.256 ± 0.042	1.596LysVal: 1.596 ± 0.05	0.221LysTrp: 0.221 ± 0.013	0.402LysTyr: 0.402 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.011LeuAla: 15.011 ± 0.154	0.517LeuCys: 0.517 ± 0.025	6.689LeuAsp: 6.689 ± 0.101	4.852LeuGlu: 4.852 ± 0.068	2.79LeuPhe: 2.79 ± 0.064	9.048LeuGly: 9.048 ± 0.124	1.869LeuHis: 1.869 ± 0.046	4.082LeuIle: 4.082 ± 0.079	1.543LeuLys: 1.543 ± 0.046	9.968LeuLeu: 9.968 ± 0.143	1.487LeuMet: 1.487 ± 0.039	1.591LeuAsn: 1.591 ± 0.045	5.535LeuPro: 5.535 ± 0.077	2.581LeuGln: 2.581 ± 0.053	7.757LeuArg: 7.757 ± 0.112	5.502LeuSer: 5.502 ± 0.083	6.418LeuThr: 6.418 ± 0.079	9.505LeuVal: 9.505 ± 0.129	1.416LeuTrp: 1.416 ± 0.046	1.616LeuTyr: 1.616 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.048MetAla: 2.048 ± 0.05	0.106MetCys: 0.106 ± 0.01	0.803MetAsp: 0.803 ± 0.027	0.537MetGlu: 0.537 ± 0.023	0.474MetPhe: 0.474 ± 0.024	1.271MetGly: 1.271 ± 0.04	0.305MetHis: 0.305 ± 0.019	0.758MetIle: 0.758 ± 0.028	0.402MetLys: 0.402 ± 0.023	1.816MetLeu: 1.816 ± 0.048	0.302MetMet: 0.302 ± 0.021	0.444MetAsn: 0.444 ± 0.026	1.14MetPro: 1.14 ± 0.037	0.49MetGln: 0.49 ± 0.018	1.291MetArg: 1.291 ± 0.033	1.431MetSer: 1.431 ± 0.034	1.68MetThr: 1.68 ± 0.04	1.237MetVal: 1.237 ± 0.039	0.215MetTrp: 0.215 ± 0.014	0.28MetTyr: 0.28 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.34AsnAla: 2.34 ± 0.054	0.083AsnCys: 0.083 ± 0.01	1.059AsnAsp: 1.059 ± 0.039	0.865AsnGlu: 0.865 ± 0.031	0.56AsnPhe: 0.56 ± 0.024	1.672AsnGly: 1.672 ± 0.055	0.328AsnHis: 0.328 ± 0.019	0.779AsnIle: 0.779 ± 0.034	0.37AsnLys: 0.37 ± 0.022	1.778AsnLeu: 1.778 ± 0.041	0.28AsnMet: 0.28 ± 0.02	0.398AsnAsn: 0.398 ± 0.021	1.407AsnPro: 1.407 ± 0.038	0.512AsnGln: 0.512 ± 0.027	1.13AsnArg: 1.13 ± 0.031	0.86AsnSer: 0.86 ± 0.062	1.05AsnThr: 1.05 ± 0.038	1.562AsnVal: 1.562 ± 0.042	0.273AsnTrp: 0.273 ± 0.017	0.442AsnTyr: 0.442 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	8.061ProAla: 8.061 ± 0.117	0.164ProCys: 0.164 ± 0.014	4.173ProAsp: 4.173 ± 0.076	3.536ProGlu: 3.536 ± 0.065	1.726ProPhe: 1.726 ± 0.044	5.076ProGly: 5.076 ± 0.09	1.227ProHis: 1.227 ± 0.041	2.081ProIle: 2.081 ± 0.048	0.905ProLys: 0.905 ± 0.035	5.03ProLeu: 5.03 ± 0.074	0.86ProMet: 0.86 ± 0.031	0.917ProAsn: 0.917 ± 0.03	2.387ProPro: 2.387 ± 0.07	1.546ProGln: 1.546 ± 0.04	3.63ProArg: 3.63 ± 0.063	2.892ProSer: 2.892 ± 0.056	3.634ProThr: 3.634 ± 0.091	5.135ProVal: 5.135 ± 0.084	0.927ProTrp: 0.927 ± 0.033	1.03ProTyr: 1.03 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.417GlnAla: 3.417 ± 0.071	0.096GlnCys: 0.096 ± 0.011	1.305GlnAsp: 1.305 ± 0.041	1.203GlnGlu: 1.203 ± 0.037	0.816GlnPhe: 0.816 ± 0.028	1.981GlnGly: 1.981 ± 0.045	0.597GlnHis: 0.597 ± 0.026	1.33GlnIle: 1.33 ± 0.04	0.64GlnLys: 0.64 ± 0.033	3.104GlnLeu: 3.104 ± 0.062	0.465GlnMet: 0.465 ± 0.023	0.647GlnAsn: 0.647 ± 0.029	1.502GlnPro: 1.502 ± 0.041	1.149GlnGln: 1.149 ± 0.04	2.441GlnArg: 2.441 ± 0.055	1.469GlnSer: 1.469 ± 0.035	1.609GlnThr: 1.609 ± 0.037	2.303GlnVal: 2.303 ± 0.051	0.519GlnTrp: 0.519 ± 0.024	0.568GlnTyr: 0.568 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.716ArgAla: 9.716 ± 0.135	0.301ArgCys: 0.301 ± 0.02	4.593ArgAsp: 4.593 ± 0.074	4.245ArgGlu: 4.245 ± 0.077	2.442ArgPhe: 2.442 ± 0.052	5.952ArgGly: 5.952 ± 0.087	1.593ArgHis: 1.593 ± 0.039	3.553ArgIle: 3.553 ± 0.06	1.282ArgLys: 1.282 ± 0.041	7.343ArgLeu: 7.343 ± 0.098	1.771ArgMet: 1.771 ± 0.049	1.185ArgAsn: 1.185 ± 0.035	3.885ArgPro: 3.885 ± 0.076	1.855ArgGln: 1.855 ± 0.042	7.018ArgArg: 7.018 ± 0.106	3.686ArgSer: 3.686 ± 0.075	4.567ArgThr: 4.567 ± 0.073	6.353ArgVal: 6.353 ± 0.094	1.239ArgTrp: 1.239 ± 0.033	1.547ArgTyr: 1.547 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.949SerAla: 6.949 ± 0.092	0.255SerCys: 0.255 ± 0.015	3.256SerAsp: 3.256 ± 0.075	2.378SerGlu: 2.378 ± 0.05	1.777SerPhe: 1.777 ± 0.05	5.346SerGly: 5.346 ± 0.09	0.929SerHis: 0.929 ± 0.03	2.249SerIle: 2.249 ± 0.052	0.877SerLys: 0.877 ± 0.031	4.972SerLeu: 4.972 ± 0.078	1.021SerMet: 1.021 ± 0.035	0.956SerAsn: 0.956 ± 0.035	2.973SerPro: 2.973 ± 0.056	1.338SerGln: 1.338 ± 0.04	3.554SerArg: 3.554 ± 0.061	2.848SerSer: 2.848 ± 0.061	3.319SerThr: 3.319 ± 0.064	4.499SerVal: 4.499 ± 0.073	0.906SerTrp: 0.906 ± 0.031	1.111SerTyr: 1.111 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	8.5ThrAla: 8.5 ± 0.109	0.269ThrCys: 0.269 ± 0.016	3.881ThrAsp: 3.881 ± 0.067	2.849ThrGlu: 2.849 ± 0.06	1.804ThrPhe: 1.804 ± 0.051	5.91ThrGly: 5.91 ± 0.087	1.174ThrHis: 1.174 ± 0.033	2.83ThrIle: 2.83 ± 0.057	1.049ThrLys: 1.049 ± 0.035	6.103ThrLeu: 6.103 ± 0.083	0.942ThrMet: 0.942 ± 0.033	1.087ThrAsn: 1.087 ± 0.037	4.25ThrPro: 4.25 ± 0.091	1.534ThrGln: 1.534 ± 0.036	3.934ThrArg: 3.934 ± 0.064	3.291ThrSer: 3.291 ± 0.057	4.066ThrThr: 4.066 ± 0.074	6.175ThrVal: 6.175 ± 0.088	0.907ThrTrp: 0.907 ± 0.034	1.205ThrTyr: 1.205 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	13.147ValAla: 13.147 ± 0.135	0.536ValCys: 0.536 ± 0.021	6.257ValAsp: 6.257 ± 0.092	4.745ValGlu: 4.745 ± 0.067	3.016ValPhe: 3.016 ± 0.062	7.51ValGly: 7.51 ± 0.1	1.763ValHis: 1.763 ± 0.049	4.117ValIle: 4.117 ± 0.076	1.572ValLys: 1.572 ± 0.046	9.304ValLeu: 9.304 ± 0.108	1.408ValMet: 1.408 ± 0.042	1.671ValAsn: 1.671 ± 0.043	4.907ValPro: 4.907 ± 0.09	2.274ValGln: 2.274 ± 0.051	6.55ValArg: 6.55 ± 0.086	4.879ValSer: 4.879 ± 0.077	6.136ValThr: 6.136 ± 0.087	9.803ValVal: 9.803 ± 0.123	1.286ValTrp: 1.286 ± 0.039	1.633ValTyr: 1.633 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.699TrpAla: 1.699 ± 0.047	0.098TrpCys: 0.098 ± 0.01	0.873TrpAsp: 0.873 ± 0.035	0.71TrpGlu: 0.71 ± 0.027	0.56TrpPhe: 0.56 ± 0.024	1.163TrpGly: 1.163 ± 0.038	0.368TrpHis: 0.368 ± 0.02	0.731TrpIle: 0.731 ± 0.024	0.272TrpLys: 0.272 ± 0.016	1.819TrpLeu: 1.819 ± 0.054	0.353TrpMet: 0.353 ± 0.016	0.429TrpAsn: 0.429 ± 0.025	0.725TrpPro: 0.725 ± 0.029	0.557TrpGln: 0.557 ± 0.026	1.32TrpArg: 1.32 ± 0.037	0.895TrpSer: 0.895 ± 0.032	0.981TrpThr: 0.981 ± 0.031	1.208TrpVal: 1.208 ± 0.041	0.398TrpTrp: 0.398 ± 0.023	0.292TrpTyr: 0.292 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.574TyrAla: 2.574 ± 0.053	0.108TyrCys: 0.108 ± 0.012	1.384TyrAsp: 1.384 ± 0.045	1.088TyrGlu: 1.088 ± 0.033	0.682TyrPhe: 0.682 ± 0.028	1.959TyrGly: 1.959 ± 0.046	0.281TyrHis: 0.281 ± 0.018	0.718TyrIle: 0.718 ± 0.027	0.349TyrLys: 0.349 ± 0.02	2.064TyrLeu: 2.064 ± 0.046	0.25TyrMet: 0.25 ± 0.016	0.446TyrAsn: 0.446 ± 0.022	0.994TyrPro: 0.994 ± 0.032	0.496TyrGln: 0.496 ± 0.022	1.645TyrArg: 1.645 ± 0.039	0.939TyrSer: 0.939 ± 0.032	1.249TyrThr: 1.249 ± 0.043	1.596TyrVal: 1.596 ± 0.038	0.336TyrTrp: 0.336 ± 0.019	0.445TyrTyr: 0.445 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2897 proteins (950115 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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