Amino acid dipepetide frequency for Candidatus Phaeomarinobacter ectocarpi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.791AlaAla: 15.791 ± 0.18	0.98AlaCys: 0.98 ± 0.029	8.026AlaAsp: 8.026 ± 0.1	7.207AlaGlu: 7.207 ± 0.108	4.453AlaPhe: 4.453 ± 0.077	10.224AlaGly: 10.224 ± 0.132	2.394AlaHis: 2.394 ± 0.055	5.97AlaIle: 5.97 ± 0.081	4.384AlaLys: 4.384 ± 0.08	12.281AlaLeu: 12.281 ± 0.156	3.499AlaMet: 3.499 ± 0.059	3.175AlaAsn: 3.175 ± 0.069	5.585AlaPro: 5.585 ± 0.109	4.257AlaGln: 4.257 ± 0.064	7.778AlaArg: 7.778 ± 0.108	6.744AlaSer: 6.744 ± 0.087	6.229AlaThr: 6.229 ± 0.1	8.125AlaVal: 8.125 ± 0.11	1.389AlaTrp: 1.389 ± 0.036	2.625AlaTyr: 2.625 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.915CysAla: 0.915 ± 0.032	0.104CysCys: 0.104 ± 0.011	0.576CysAsp: 0.576 ± 0.025	0.411CysGlu: 0.411 ± 0.021	0.332CysPhe: 0.332 ± 0.019	0.828CysGly: 0.828 ± 0.031	0.207CysHis: 0.207 ± 0.016	0.377CysIle: 0.377 ± 0.019	0.219CysLys: 0.219 ± 0.015	0.661CysLeu: 0.661 ± 0.025	0.157CysMet: 0.157 ± 0.012	0.196CysAsn: 0.196 ± 0.015	0.415CysPro: 0.415 ± 0.022	0.214CysGln: 0.214 ± 0.016	0.448CysArg: 0.448 ± 0.022	0.415CysSer: 0.415 ± 0.024	0.446CysThr: 0.446 ± 0.022	0.618CysVal: 0.618 ± 0.023	0.088CysTrp: 0.088 ± 0.01	0.18CysTyr: 0.18 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.251AspAla: 8.251 ± 0.115	0.449AspCys: 0.449 ± 0.023	4.246AspAsp: 4.246 ± 0.077	4.229AspGlu: 4.229 ± 0.072	2.332AspPhe: 2.332 ± 0.051	5.835AspGly: 5.835 ± 0.117	1.385AspHis: 1.385 ± 0.039	3.666AspIle: 3.666 ± 0.068	2.222AspLys: 2.222 ± 0.056	6.17AspLeu: 6.17 ± 0.084	1.935AspMet: 1.935 ± 0.047	1.717AspAsn: 1.717 ± 0.06	3.5AspPro: 3.5 ± 0.054	1.885AspGln: 1.885 ± 0.046	3.885AspArg: 3.885 ± 0.064	2.306AspSer: 2.306 ± 0.058	3.544AspThr: 3.544 ± 0.064	5.255AspVal: 5.255 ± 0.095	0.978AspTrp: 0.978 ± 0.032	1.582AspTyr: 1.582 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.818GluAla: 7.818 ± 0.105	0.361GluCys: 0.361 ± 0.018	3.779GluAsp: 3.779 ± 0.074	3.821GluGlu: 3.821 ± 0.079	1.941GluPhe: 1.941 ± 0.05	4.738GluGly: 4.738 ± 0.074	1.261GluHis: 1.261 ± 0.034	3.421GluIle: 3.421 ± 0.062	2.401GluLys: 2.401 ± 0.057	5.455GluLeu: 5.455 ± 0.077	1.77GluMet: 1.77 ± 0.042	1.784GluAsn: 1.784 ± 0.058	2.755GluPro: 2.755 ± 0.066	2.182GluGln: 2.182 ± 0.049	4.34GluArg: 4.34 ± 0.077	2.492GluSer: 2.492 ± 0.053	4.05GluThr: 4.05 ± 0.062	3.99GluVal: 3.99 ± 0.077	0.732GluTrp: 0.732 ± 0.025	1.105GluTyr: 1.105 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.539PheAla: 4.539 ± 0.081	0.379PheCys: 0.379 ± 0.022	2.767PheAsp: 2.767 ± 0.058	2.546PheGlu: 2.546 ± 0.054	1.466PhePhe: 1.466 ± 0.047	3.565PheGly: 3.565 ± 0.056	0.743PheHis: 0.743 ± 0.027	1.654PheIle: 1.654 ± 0.047	1.195PheLys: 1.195 ± 0.035	3.149PheLeu: 3.149 ± 0.068	0.922PheMet: 0.922 ± 0.031	1.13PheAsn: 1.13 ± 0.035	1.387PhePro: 1.387 ± 0.042	0.948PheGln: 0.948 ± 0.027	1.816PheArg: 1.816 ± 0.039	2.19PheSer: 2.19 ± 0.056	2.114PheThr: 2.114 ± 0.049	2.844PheVal: 2.844 ± 0.058	0.535PheTrp: 0.535 ± 0.025	0.957PheTyr: 0.957 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	8.937GlyAla: 8.937 ± 0.115	0.745GlyCys: 0.745 ± 0.032	5.29GlyAsp: 5.29 ± 0.102	4.814GlyGlu: 4.814 ± 0.074	3.636GlyPhe: 3.636 ± 0.063	7.502GlyGly: 7.502 ± 0.142	1.922GlyHis: 1.922 ± 0.049	4.669GlyIle: 4.669 ± 0.067	3.328GlyLys: 3.328 ± 0.062	8.385GlyLeu: 8.385 ± 0.115	2.334GlyMet: 2.334 ± 0.053	2.435GlyAsn: 2.435 ± 0.064	3.522GlyPro: 3.522 ± 0.07	2.781GlyGln: 2.781 ± 0.063	5.143GlyArg: 5.143 ± 0.082	4.726GlySer: 4.726 ± 0.074	4.929GlyThr: 4.929 ± 0.11	6.236GlyVal: 6.236 ± 0.086	1.31GlyTrp: 1.31 ± 0.039	2.236GlyTyr: 2.236 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.264HisAla: 2.264 ± 0.058	0.232HisCys: 0.232 ± 0.016	1.221HisAsp: 1.221 ± 0.033	1.187HisGlu: 1.187 ± 0.041	0.874HisPhe: 0.874 ± 0.028	1.91HisGly: 1.91 ± 0.051	0.6HisHis: 0.6 ± 0.03	1.052HisIle: 1.052 ± 0.033	0.676HisLys: 0.676 ± 0.027	2.039HisLeu: 2.039 ± 0.049	0.644HisMet: 0.644 ± 0.027	0.519HisAsn: 0.519 ± 0.023	1.259HisPro: 1.259 ± 0.041	0.617HisGln: 0.617 ± 0.025	1.211HisArg: 1.211 ± 0.036	0.984HisSer: 0.984 ± 0.038	1.069HisThr: 1.069 ± 0.032	1.641HisVal: 1.641 ± 0.037	0.309HisTrp: 0.309 ± 0.019	0.554HisTyr: 0.554 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.902IleAla: 6.902 ± 0.081	0.513IleCys: 0.513 ± 0.024	3.718IleAsp: 3.718 ± 0.08	3.758IleGlu: 3.758 ± 0.063	1.681IlePhe: 1.681 ± 0.045	4.803IleGly: 4.803 ± 0.078	0.941IleHis: 0.941 ± 0.033	2.513IleIle: 2.513 ± 0.054	1.781IleLys: 1.781 ± 0.045	3.908IleLeu: 3.908 ± 0.076	1.166IleMet: 1.166 ± 0.035	1.607IleAsn: 1.607 ± 0.04	2.181IlePro: 2.181 ± 0.044	1.294IleGln: 1.294 ± 0.042	2.829IleArg: 2.829 ± 0.053	3.133IleSer: 3.133 ± 0.061	2.958IleThr: 2.958 ± 0.055	3.977IleVal: 3.977 ± 0.06	0.633IleTrp: 0.633 ± 0.028	1.133IleTyr: 1.133 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.503LysAla: 4.503 ± 0.076	0.204LysCys: 0.204 ± 0.015	2.174LysAsp: 2.174 ± 0.054	1.875LysGlu: 1.875 ± 0.045	0.949LysPhe: 0.949 ± 0.033	2.724LysGly: 2.724 ± 0.056	0.728LysHis: 0.728 ± 0.029	1.692LysIle: 1.692 ± 0.046	1.579LysLys: 1.579 ± 0.061	3.382LysLeu: 3.382 ± 0.066	0.922LysMet: 0.922 ± 0.031	0.973LysAsn: 0.973 ± 0.03	2.143LysPro: 2.143 ± 0.047	1.169LysGln: 1.169 ± 0.035	2.527LysArg: 2.527 ± 0.049	2.136LysSer: 2.136 ± 0.051	2.243LysThr: 2.243 ± 0.051	2.568LysVal: 2.568 ± 0.055	0.416LysTrp: 0.416 ± 0.019	0.742LysTyr: 0.742 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	12.086LeuAla: 12.086 ± 0.152	0.734LeuCys: 0.734 ± 0.031	6.223LeuAsp: 6.223 ± 0.102	5.914LeuGlu: 5.914 ± 0.092	3.321LeuPhe: 3.321 ± 0.081	7.799LeuGly: 7.799 ± 0.111	1.704LeuHis: 1.704 ± 0.04	4.756LeuIle: 4.756 ± 0.086	3.739LeuLys: 3.739 ± 0.08	8.085LeuLeu: 8.085 ± 0.123	2.557LeuMet: 2.557 ± 0.058	2.652LeuAsn: 2.652 ± 0.055	5.076LeuPro: 5.076 ± 0.078	2.522LeuGln: 2.522 ± 0.054	5.557LeuArg: 5.557 ± 0.078	5.986LeuSer: 5.986 ± 0.096	5.698LeuThr: 5.698 ± 0.077	7.158LeuVal: 7.158 ± 0.105	1.092LeuTrp: 1.092 ± 0.037	1.913LeuTyr: 1.913 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	3.428MetAla: 3.428 ± 0.063	0.185MetCys: 0.185 ± 0.014	1.581MetAsp: 1.581 ± 0.039	1.414MetGlu: 1.414 ± 0.052	0.801MetPhe: 0.801 ± 0.027	2.195MetGly: 2.195 ± 0.048	0.503MetHis: 0.503 ± 0.023	1.329MetIle: 1.329 ± 0.034	0.957MetLys: 0.957 ± 0.032	2.429MetLeu: 2.429 ± 0.044	0.769MetMet: 0.769 ± 0.028	0.771MetAsn: 0.771 ± 0.03	1.738MetPro: 1.738 ± 0.044	0.918MetGln: 0.918 ± 0.032	1.855MetArg: 1.855 ± 0.042	2.076MetSer: 2.076 ± 0.047	1.989MetThr: 1.989 ± 0.04	1.867MetVal: 1.867 ± 0.047	0.317MetTrp: 0.317 ± 0.02	0.376MetTyr: 0.376 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.41AsnAla: 3.41 ± 0.067	0.242AsnCys: 0.242 ± 0.014	1.601AsnAsp: 1.601 ± 0.039	1.589AsnGlu: 1.589 ± 0.044	0.952AsnPhe: 0.952 ± 0.033	2.54AsnGly: 2.54 ± 0.064	0.521AsnHis: 0.521 ± 0.025	1.483AsnIle: 1.483 ± 0.044	0.893AsnLys: 0.893 ± 0.033	2.572AsnLeu: 2.572 ± 0.049	0.778AsnMet: 0.778 ± 0.025	0.802AsnAsn: 0.802 ± 0.036	1.792AsnPro: 1.792 ± 0.039	0.876AsnGln: 0.876 ± 0.033	1.787AsnArg: 1.787 ± 0.044	1.305AsnSer: 1.305 ± 0.038	1.591AsnThr: 1.591 ± 0.06	2.138AsnVal: 2.138 ± 0.048	0.43AsnTrp: 0.43 ± 0.022	0.694AsnTyr: 0.694 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.8ProAla: 5.8 ± 0.095	0.322ProCys: 0.322 ± 0.019	4.119ProAsp: 4.119 ± 0.06	3.613ProGlu: 3.613 ± 0.065	1.926ProPhe: 1.926 ± 0.05	4.299ProGly: 4.299 ± 0.06	1.131ProHis: 1.131 ± 0.035	2.256ProIle: 2.256 ± 0.05	1.85ProLys: 1.85 ± 0.042	4.415ProLeu: 4.415 ± 0.074	1.219ProMet: 1.219 ± 0.035	1.448ProAsn: 1.448 ± 0.041	2.225ProPro: 2.225 ± 0.079	1.695ProGln: 1.695 ± 0.049	2.555ProArg: 2.555 ± 0.058	2.633ProSer: 2.633 ± 0.05	2.579ProThr: 2.579 ± 0.051	4.108ProVal: 4.108 ± 0.064	0.605ProTrp: 0.605 ± 0.028	1.165ProTyr: 1.165 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.2GlnAla: 4.2 ± 0.073	0.199GlnCys: 0.199 ± 0.014	1.684GlnAsp: 1.684 ± 0.049	1.587GlnGlu: 1.587 ± 0.04	1.123GlnPhe: 1.123 ± 0.037	2.305GlnGly: 2.305 ± 0.055	0.716GlnHis: 0.716 ± 0.029	1.848GlnIle: 1.848 ± 0.046	1.115GlnLys: 1.115 ± 0.036	3.007GlnLeu: 3.007 ± 0.063	1.043GlnMet: 1.043 ± 0.033	0.84GlnAsn: 0.84 ± 0.03	1.587GlnPro: 1.587 ± 0.039	1.184GlnGln: 1.184 ± 0.038	2.185GlnArg: 2.185 ± 0.056	1.859GlnSer: 1.859 ± 0.049	1.872GlnThr: 1.872 ± 0.043	2.411GlnVal: 2.411 ± 0.053	0.412GlnTrp: 0.412 ± 0.021	0.571GlnTyr: 0.571 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.886ArgAla: 6.886 ± 0.098	0.426ArgCys: 0.426 ± 0.023	4.131ArgAsp: 4.131 ± 0.07	3.815ArgGlu: 3.815 ± 0.069	2.489ArgPhe: 2.489 ± 0.056	4.163ArgGly: 4.163 ± 0.068	1.468ArgHis: 1.468 ± 0.041	3.441ArgIle: 3.441 ± 0.061	2.264ArgLys: 2.264 ± 0.048	6.467ArgLeu: 6.467 ± 0.097	1.845ArgMet: 1.845 ± 0.047	1.769ArgAsn: 1.769 ± 0.047	2.843ArgPro: 2.843 ± 0.053	2.143ArgGln: 2.143 ± 0.048	4.153ArgArg: 4.153 ± 0.078	3.243ArgSer: 3.243 ± 0.057	3.302ArgThr: 3.302 ± 0.059	4.5ArgVal: 4.5 ± 0.076	0.818ArgTrp: 0.818 ± 0.029	1.519ArgTyr: 1.519 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.278SerAla: 6.278 ± 0.095	0.382SerCys: 0.382 ± 0.021	3.691SerAsp: 3.691 ± 0.069	3.012SerGlu: 3.012 ± 0.046	2.208SerPhe: 2.208 ± 0.05	5.449SerGly: 5.449 ± 0.079	1.135SerHis: 1.135 ± 0.037	2.94SerIle: 2.94 ± 0.066	1.907SerLys: 1.907 ± 0.046	5.387SerLeu: 5.387 ± 0.08	1.579SerMet: 1.579 ± 0.043	1.628SerAsn: 1.628 ± 0.034	2.639SerPro: 2.639 ± 0.053	1.704SerGln: 1.704 ± 0.041	3.328SerArg: 3.328 ± 0.066	3.275SerSer: 3.275 ± 0.06	2.918SerThr: 2.918 ± 0.07	4.077SerVal: 4.077 ± 0.09	0.689SerTrp: 0.689 ± 0.025	1.304SerTyr: 1.304 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.36ThrAla: 6.36 ± 0.1	0.435ThrCys: 0.435 ± 0.024	3.589ThrAsp: 3.589 ± 0.106	2.839ThrGlu: 2.839 ± 0.055	2.115ThrPhe: 2.115 ± 0.057	5.498ThrGly: 5.498 ± 0.119	1.228ThrHis: 1.228 ± 0.045	2.893ThrIle: 2.893 ± 0.053	1.803ThrLys: 1.803 ± 0.049	5.844ThrLeu: 5.844 ± 0.078	1.352ThrMet: 1.352 ± 0.058	1.561ThrAsn: 1.561 ± 0.046	3.736ThrPro: 3.736 ± 0.06	1.939ThrGln: 1.939 ± 0.05	3.39ThrArg: 3.39 ± 0.059	3.375ThrSer: 3.375 ± 0.059	3.172ThrThr: 3.172 ± 0.105	4.124ThrVal: 4.124 ± 0.077	0.672ThrTrp: 0.672 ± 0.024	1.464ThrTyr: 1.464 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	9.013ValAla: 9.013 ± 0.123	0.555ValCys: 0.555 ± 0.025	4.657ValAsp: 4.657 ± 0.089	4.537ValGlu: 4.537 ± 0.068	2.826ValPhe: 2.826 ± 0.056	5.526ValGly: 5.526 ± 0.084	1.423ValHis: 1.423 ± 0.043	3.953ValIle: 3.953 ± 0.056	2.216ValLys: 2.216 ± 0.055	7.14ValLeu: 7.14 ± 0.105	2.082ValMet: 2.082 ± 0.049	2.003ValAsn: 2.003 ± 0.057	3.913ValPro: 3.913 ± 0.057	2.101ValGln: 2.101 ± 0.047	4.447ValArg: 4.447 ± 0.071	4.728ValSer: 4.728 ± 0.104	4.816ValThr: 4.816 ± 0.099	5.724ValVal: 5.724 ± 0.102	0.909ValTrp: 0.909 ± 0.03	1.482ValTyr: 1.482 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.256TrpAla: 1.256 ± 0.037	0.134TrpCys: 0.134 ± 0.012	0.725TrpAsp: 0.725 ± 0.031	0.611TrpGlu: 0.611 ± 0.023	0.502TrpPhe: 0.502 ± 0.024	0.943TrpGly: 0.943 ± 0.033	0.334TrpHis: 0.334 ± 0.018	0.627TrpIle: 0.627 ± 0.027	0.422TrpLys: 0.422 ± 0.022	1.54TrpLeu: 1.54 ± 0.042	0.39TrpMet: 0.39 ± 0.018	0.411TrpAsn: 0.411 ± 0.021	0.64TrpPro: 0.64 ± 0.029	0.587TrpGln: 0.587 ± 0.026	0.963TrpArg: 0.963 ± 0.03	0.765TrpSer: 0.765 ± 0.027	0.723TrpThr: 0.723 ± 0.027	0.903TrpVal: 0.903 ± 0.028	0.232TrpTrp: 0.232 ± 0.015	0.265TrpTyr: 0.265 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.481TyrAla: 2.481 ± 0.052	0.225TyrCys: 0.225 ± 0.017	1.574TyrAsp: 1.574 ± 0.041	1.42TyrGlu: 1.42 ± 0.038	0.921TyrPhe: 0.921 ± 0.032	2.035TyrGly: 2.035 ± 0.042	0.517TyrHis: 0.517 ± 0.025	0.889TyrIle: 0.889 ± 0.035	0.701TyrLys: 0.701 ± 0.025	2.256TyrLeu: 2.256 ± 0.051	0.531TyrMet: 0.531 ± 0.023	0.574TyrAsn: 0.574 ± 0.026	1.027TyrPro: 1.027 ± 0.035	0.73TyrGln: 0.73 ± 0.028	1.487TyrArg: 1.487 ± 0.041	1.157TyrSer: 1.157 ± 0.033	1.148TyrThr: 1.148 ± 0.041	1.787TyrVal: 1.787 ± 0.043	0.406TyrTrp: 0.406 ± 0.023	0.583TyrTyr: 0.583 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3295 proteins (1010352 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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