Amino acid dipepetide frequency for Hubei picorna-like virus 18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.547AlaAla: 4.547 ± 0.693
0.7AlaCys: 0.7 ± 0.379
3.148AlaAsp: 3.148 ± 0.657
3.148AlaGlu: 3.148 ± 1.708
2.099AlaPhe: 2.099 ± 0.547
5.247AlaGly: 5.247 ± 0.11
2.798AlaHis: 2.798 ± 0.335
5.596AlaIle: 5.596 ± 0.671
3.847AlaLys: 3.847 ± 0.313
7.695AlaLeu: 7.695 ± 0.627
0.35AlaMet: 0.35 ± 0.19
4.197AlaAsn: 4.197 ± 0.503
4.897AlaPro: 4.897 ± 1.482
2.099AlaGln: 2.099 ± 0.547
2.798AlaArg: 2.798 ± 0.256
4.197AlaSer: 4.197 ± 1.27
4.547AlaThr: 4.547 ± 0.49
4.547AlaVal: 4.547 ± 2.263
1.749AlaTrp: 1.749 ± 0.949
1.049AlaTyr: 1.049 ± 0.022
0.0AlaXaa: 0.0 ± 0.0
Cys
0.35CysAla: 0.35 ± 0.19
0.0CysCys: 0.0 ± 0.0
0.7CysAsp: 0.7 ± 0.212
0.0CysGlu: 0.0 ± 0.0
0.35CysPhe: 0.35 ± 0.19
1.049CysGly: 1.049 ± 0.613
1.049CysHis: 1.049 ± 0.022
0.35CysIle: 0.35 ± 0.19
0.35CysLys: 0.35 ± 0.19
0.35CysLeu: 0.35 ± 0.19
0.0CysMet: 0.0 ± 0.0
0.35CysAsn: 0.35 ± 0.19
0.7CysPro: 0.7 ± 0.803
0.7CysGln: 0.7 ± 0.379
1.399CysArg: 1.399 ± 0.168
1.049CysSer: 1.049 ± 0.022
1.399CysThr: 1.399 ± 0.423
0.35CysVal: 0.35 ± 0.401
0.0CysTrp: 0.0 ± 0.0
1.399CysTyr: 1.399 ± 0.759
0.0CysXaa: 0.0 ± 0.0
Asp
2.798AspAla: 2.798 ± 0.256
0.7AspCys: 0.7 ± 0.212
3.148AspAsp: 3.148 ± 0.525
2.099AspGlu: 2.099 ± 0.044
4.197AspPhe: 4.197 ± 0.679
4.197AspGly: 4.197 ± 1.686
2.099AspHis: 2.099 ± 0.547
3.498AspIle: 3.498 ± 1.059
2.099AspLys: 2.099 ± 0.044
8.045AspLeu: 8.045 ± 1.999
0.7AspMet: 0.7 ± 0.379
1.749AspAsn: 1.749 ± 0.234
2.448AspPro: 2.448 ± 0.446
1.399AspGln: 1.399 ± 0.759
2.099AspArg: 2.099 ± 0.547
1.749AspSer: 1.749 ± 0.825
2.798AspThr: 2.798 ± 0.335
2.448AspVal: 2.448 ± 0.446
1.049AspTrp: 1.049 ± 0.569
1.749AspTyr: 1.749 ± 0.825
0.0AspXaa: 0.0 ± 0.0
Glu
2.798GluAla: 2.798 ± 0.335
1.749GluCys: 1.749 ± 0.234
2.099GluAsp: 2.099 ± 0.547
8.045GluGlu: 8.045 ± 0.816
2.798GluPhe: 2.798 ± 0.335
1.749GluGly: 1.749 ± 0.234
0.7GluHis: 0.7 ± 0.379
4.897GluIle: 4.897 ± 1.482
5.596GluLys: 5.596 ± 1.262
5.596GluLeu: 5.596 ± 2.444
3.148GluMet: 3.148 ± 0.525
2.099GluAsn: 2.099 ± 0.547
2.099GluPro: 2.099 ± 1.138
3.498GluGln: 3.498 ± 0.468
2.798GluArg: 2.798 ± 0.335
2.798GluSer: 2.798 ± 0.335
3.498GluThr: 3.498 ± 0.715
2.798GluVal: 2.798 ± 0.847
2.099GluTrp: 2.099 ± 0.547
3.498GluTyr: 3.498 ± 0.468
0.0GluXaa: 0.0 ± 0.0
Phe
2.798PheAla: 2.798 ± 0.847
0.35PheCys: 0.35 ± 0.401
2.448PheAsp: 2.448 ± 0.446
3.148PheGlu: 3.148 ± 0.066
1.399PhePhe: 1.399 ± 0.759
3.148PheGly: 3.148 ± 0.066
1.049PheHis: 1.049 ± 0.613
3.148PheIle: 3.148 ± 0.525
2.099PheLys: 2.099 ± 0.547
3.498PheLeu: 3.498 ± 1.306
0.35PheMet: 0.35 ± 0.401
3.148PheAsn: 3.148 ± 0.657
1.049PhePro: 1.049 ± 0.569
0.7PheGln: 0.7 ± 0.379
3.498PheArg: 3.498 ± 0.124
3.847PheSer: 3.847 ± 0.869
4.547PheThr: 4.547 ± 0.102
2.099PheVal: 2.099 ± 0.044
0.35PheTrp: 0.35 ± 0.19
3.148PheTyr: 3.148 ± 1.84
0.0PheXaa: 0.0 ± 0.0
Gly
2.798GlyAla: 2.798 ± 0.847
0.35GlyCys: 0.35 ± 0.19
3.148GlyAsp: 3.148 ± 1.248
5.247GlyGlu: 5.247 ± 0.11
1.399GlyPhe: 1.399 ± 0.423
1.049GlyGly: 1.049 ± 0.613
2.798GlyHis: 2.798 ± 1.518
2.798GlyIle: 2.798 ± 1.518
4.547GlyLys: 4.547 ± 1.284
4.197GlyLeu: 4.197 ± 0.679
1.749GlyMet: 1.749 ± 0.357
2.448GlyAsn: 2.448 ± 1.037
1.049GlyPro: 1.049 ± 0.569
3.148GlyGln: 3.148 ± 0.657
2.448GlyArg: 2.448 ± 0.737
5.247GlySer: 5.247 ± 0.11
2.798GlyThr: 2.798 ± 2.029
1.749GlyVal: 1.749 ± 0.825
0.0GlyTrp: 0.0 ± 0.0
3.498GlyTyr: 3.498 ± 0.715
0.0GlyXaa: 0.0 ± 0.0
His
1.749HisAla: 1.749 ± 0.949
0.35HisCys: 0.35 ± 0.19
1.399HisAsp: 1.399 ± 0.168
0.35HisGlu: 0.35 ± 0.19
0.7HisPhe: 0.7 ± 0.379
0.7HisGly: 0.7 ± 0.379
0.7HisHis: 0.7 ± 0.379
1.749HisIle: 1.749 ± 0.357
1.049HisLys: 1.049 ± 0.569
2.099HisLeu: 2.099 ± 0.635
1.399HisMet: 1.399 ± 0.759
1.049HisAsn: 1.049 ± 0.569
2.448HisPro: 2.448 ± 0.737
1.749HisGln: 1.749 ± 1.416
0.7HisArg: 0.7 ± 0.379
1.399HisSer: 1.399 ± 0.423
2.099HisThr: 2.099 ± 0.044
2.448HisVal: 2.448 ± 0.146
0.7HisTrp: 0.7 ± 0.379
1.049HisTyr: 1.049 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.596IleAla: 5.596 ± 1.694
0.0IleCys: 0.0 ± 0.0
1.399IleAsp: 1.399 ± 0.168
5.946IleGlu: 5.946 ± 0.269
3.498IlePhe: 3.498 ± 0.715
2.798IleGly: 2.798 ± 0.256
1.749IleHis: 1.749 ± 0.357
4.197IleIle: 4.197 ± 0.679
3.498IleLys: 3.498 ± 0.468
4.897IleLeu: 4.897 ± 2.073
2.798IleMet: 2.798 ± 0.45
4.197IleAsn: 4.197 ± 1.27
4.547IlePro: 4.547 ± 1.672
4.547IleGln: 4.547 ± 0.693
2.798IleArg: 2.798 ± 0.256
7.345IleSer: 7.345 ± 0.745
1.049IleThr: 1.049 ± 0.613
2.798IleVal: 2.798 ± 0.256
1.049IleTrp: 1.049 ± 0.569
3.847IleTyr: 3.847 ± 1.496
0.0IleXaa: 0.0 ± 0.0
Lys
4.897LysAla: 4.897 ± 1.474
0.0LysCys: 0.0 ± 0.0
2.798LysAsp: 2.798 ± 0.335
4.197LysGlu: 4.197 ± 1.094
2.448LysPhe: 2.448 ± 0.737
2.798LysGly: 2.798 ± 0.335
1.749LysHis: 1.749 ± 0.949
4.197LysIle: 4.197 ± 0.088
7.345LysLys: 7.345 ± 2.802
7.345LysLeu: 7.345 ± 0.437
0.7LysMet: 0.7 ± 0.379
1.749LysAsn: 1.749 ± 0.357
4.547LysPro: 4.547 ± 0.693
2.798LysGln: 2.798 ± 1.518
4.197LysArg: 4.197 ± 1.686
4.197LysSer: 4.197 ± 1.094
3.847LysThr: 3.847 ± 1.496
3.847LysVal: 3.847 ± 0.278
1.049LysTrp: 1.049 ± 0.022
2.099LysTyr: 2.099 ± 1.138
0.0LysXaa: 0.0 ± 0.0
Leu
6.646LeuAla: 6.646 ± 0.649
1.049LeuCys: 1.049 ± 0.022
5.247LeuAsp: 5.247 ± 0.11
5.596LeuGlu: 5.596 ± 2.444
3.847LeuPhe: 3.847 ± 0.313
3.498LeuGly: 3.498 ± 0.468
2.448LeuHis: 2.448 ± 1.328
5.247LeuIle: 5.247 ± 1.072
6.646LeuLys: 6.646 ± 1.24
5.247LeuLeu: 5.247 ± 1.293
1.049LeuMet: 1.049 ± 0.613
5.247LeuAsn: 5.247 ± 0.481
3.847LeuPro: 3.847 ± 0.278
3.498LeuGln: 3.498 ± 0.468
5.946LeuArg: 5.946 ± 0.322
8.395LeuSer: 8.395 ± 3.723
6.646LeuThr: 6.646 ± 0.058
5.247LeuVal: 5.247 ± 0.11
0.35LeuTrp: 0.35 ± 0.19
3.847LeuTyr: 3.847 ± 1.496
0.0LeuXaa: 0.0 ± 0.0
Met
2.099MetAla: 2.099 ± 0.547
0.7MetCys: 0.7 ± 0.803
1.399MetAsp: 1.399 ± 1.015
2.448MetGlu: 2.448 ± 1.328
0.7MetPhe: 0.7 ± 0.379
0.0MetGly: 0.0 ± 0.0
0.35MetHis: 0.35 ± 0.401
1.049MetIle: 1.049 ± 0.613
0.7MetLys: 0.7 ± 0.212
2.448MetLeu: 2.448 ± 0.146
0.7MetMet: 0.7 ± 0.379
2.099MetAsn: 2.099 ± 0.547
1.399MetPro: 1.399 ± 0.168
1.049MetGln: 1.049 ± 0.569
1.049MetArg: 1.049 ± 0.569
1.049MetSer: 1.049 ± 0.613
0.35MetThr: 0.35 ± 0.19
0.7MetVal: 0.7 ± 0.379
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.847AsnAla: 3.847 ± 0.278
1.399AsnCys: 1.399 ± 0.168
2.099AsnAsp: 2.099 ± 0.547
2.099AsnGlu: 2.099 ± 0.044
2.099AsnPhe: 2.099 ± 0.635
1.399AsnGly: 1.399 ± 0.168
0.7AsnHis: 0.7 ± 0.212
2.798AsnIle: 2.798 ± 1.438
2.798AsnLys: 2.798 ± 1.518
5.596AsnLeu: 5.596 ± 2.285
1.049AsnMet: 1.049 ± 0.569
3.498AsnAsn: 3.498 ± 0.468
1.749AsnPro: 1.749 ± 0.825
1.749AsnGln: 1.749 ± 0.357
4.547AsnArg: 4.547 ± 0.693
3.148AsnSer: 3.148 ± 0.525
3.498AsnThr: 3.498 ± 0.715
2.798AsnVal: 2.798 ± 0.335
0.7AsnTrp: 0.7 ± 0.379
0.7AsnTyr: 0.7 ± 0.212
0.0AsnXaa: 0.0 ± 0.0
Pro
3.498ProAla: 3.498 ± 0.715
0.7ProCys: 0.7 ± 0.212
2.099ProAsp: 2.099 ± 0.044
3.847ProGlu: 3.847 ± 0.905
4.197ProPhe: 4.197 ± 1.862
2.798ProGly: 2.798 ± 0.927
0.7ProHis: 0.7 ± 0.212
4.197ProIle: 4.197 ± 1.862
2.448ProLys: 2.448 ± 0.737
3.847ProLeu: 3.847 ± 0.278
0.7ProMet: 0.7 ± 0.617
1.399ProAsn: 1.399 ± 1.015
4.197ProPro: 4.197 ± 0.503
0.7ProGln: 0.7 ± 0.379
1.049ProArg: 1.049 ± 0.022
3.847ProSer: 3.847 ± 0.869
2.099ProThr: 2.099 ± 0.044
4.547ProVal: 4.547 ± 0.49
0.35ProTrp: 0.35 ± 0.401
1.749ProTyr: 1.749 ± 0.825
0.0ProXaa: 0.0 ± 0.0
Gln
4.197GlnAla: 4.197 ± 0.088
0.7GlnCys: 0.7 ± 0.212
2.448GlnAsp: 2.448 ± 0.737
4.547GlnGlu: 4.547 ± 0.102
1.749GlnPhe: 1.749 ± 0.234
2.448GlnGly: 2.448 ± 1.037
1.049GlnHis: 1.049 ± 0.569
2.448GlnIle: 2.448 ± 0.146
6.296GlnLys: 6.296 ± 2.233
4.197GlnLeu: 4.197 ± 1.094
0.7GlnMet: 0.7 ± 0.379
1.749GlnAsn: 1.749 ± 0.949
1.399GlnPro: 1.399 ± 1.015
3.847GlnGln: 3.847 ± 0.278
1.399GlnArg: 1.399 ± 0.168
3.148GlnSer: 3.148 ± 0.066
1.399GlnThr: 1.399 ± 0.423
1.399GlnVal: 1.399 ± 0.168
0.35GlnTrp: 0.35 ± 0.19
0.7GlnTyr: 0.7 ± 0.212
0.0GlnXaa: 0.0 ± 0.0
Arg
2.099ArgAla: 2.099 ± 0.044
0.7ArgCys: 0.7 ± 0.379
3.148ArgAsp: 3.148 ± 0.525
2.798ArgGlu: 2.798 ± 0.256
1.749ArgPhe: 1.749 ± 0.357
3.148ArgGly: 3.148 ± 1.116
1.749ArgHis: 1.749 ± 0.234
6.995ArgIle: 6.995 ± 0.344
3.847ArgLys: 3.847 ± 2.087
3.148ArgLeu: 3.148 ± 0.657
1.399ArgMet: 1.399 ± 0.168
2.448ArgAsn: 2.448 ± 0.146
1.049ArgPro: 1.049 ± 0.022
2.448ArgGln: 2.448 ± 0.146
2.099ArgArg: 2.099 ± 0.547
4.547ArgSer: 4.547 ± 1.672
2.099ArgThr: 2.099 ± 0.044
4.897ArgVal: 4.897 ± 0.891
0.35ArgTrp: 0.35 ± 0.19
0.7ArgTyr: 0.7 ± 0.212
0.0ArgXaa: 0.0 ± 0.0
Ser
3.498SerAla: 3.498 ± 0.715
1.049SerCys: 1.049 ± 0.022
3.498SerAsp: 3.498 ± 0.468
3.498SerGlu: 3.498 ± 0.468
4.547SerPhe: 4.547 ± 1.081
4.197SerGly: 4.197 ± 1.862
2.448SerHis: 2.448 ± 1.037
5.247SerIle: 5.247 ± 1.293
4.197SerLys: 4.197 ± 0.503
6.646SerLeu: 6.646 ± 1.831
0.35SerMet: 0.35 ± 0.401
2.448SerAsn: 2.448 ± 0.446
3.498SerPro: 3.498 ± 0.468
5.247SerGln: 5.247 ± 1.072
4.897SerArg: 4.897 ± 2.073
3.148SerSer: 3.148 ± 0.657
6.995SerThr: 6.995 ± 3.3
4.197SerVal: 4.197 ± 1.27
0.0SerTrp: 0.0 ± 0.0
2.798SerTyr: 2.798 ± 0.847
0.0SerXaa: 0.0 ± 0.0
Thr
4.197ThrAla: 4.197 ± 1.27
0.35ThrCys: 0.35 ± 0.19
2.099ThrAsp: 2.099 ± 0.547
2.798ThrGlu: 2.798 ± 0.256
2.798ThrPhe: 2.798 ± 2.029
3.148ThrGly: 3.148 ± 0.657
0.7ThrHis: 0.7 ± 0.212
4.197ThrIle: 4.197 ± 1.27
3.498ThrLys: 3.498 ± 1.897
5.596ThrLeu: 5.596 ± 0.512
1.399ThrMet: 1.399 ± 0.423
3.148ThrAsn: 3.148 ± 0.066
3.148ThrPro: 3.148 ± 1.116
2.099ThrGln: 2.099 ± 1.226
3.847ThrArg: 3.847 ± 0.313
6.296ThrSer: 6.296 ± 0.723
3.498ThrThr: 3.498 ± 2.241
2.798ThrVal: 2.798 ± 1.438
0.35ThrTrp: 0.35 ± 0.401
2.798ThrTyr: 2.798 ± 0.927
0.0ThrXaa: 0.0 ± 0.0
Val
5.596ValAla: 5.596 ± 0.08
0.35ValCys: 0.35 ± 0.19
5.596ValAsp: 5.596 ± 0.671
1.749ValGlu: 1.749 ± 1.416
2.798ValPhe: 2.798 ± 0.335
5.247ValGly: 5.247 ± 1.293
0.7ValHis: 0.7 ± 0.379
4.197ValIle: 4.197 ± 0.503
2.798ValLys: 2.798 ± 0.335
4.197ValLeu: 4.197 ± 0.088
0.35ValMet: 0.35 ± 0.401
2.448ValAsn: 2.448 ± 1.037
3.148ValPro: 3.148 ± 2.431
3.148ValGln: 3.148 ± 0.066
1.049ValArg: 1.049 ± 0.613
4.897ValSer: 4.897 ± 1.482
3.498ValThr: 3.498 ± 1.65
4.547ValVal: 4.547 ± 1.284
0.35ValTrp: 0.35 ± 0.19
1.749ValTyr: 1.749 ± 1.416
0.0ValXaa: 0.0 ± 0.0
Trp
0.35TrpAla: 0.35 ± 0.19
0.35TrpCys: 0.35 ± 0.19
1.049TrpAsp: 1.049 ± 0.569
0.0TrpGlu: 0.0 ± 0.0
0.35TrpPhe: 0.35 ± 0.19
1.399TrpGly: 1.399 ± 0.759
0.0TrpHis: 0.0 ± 0.0
0.7TrpIle: 0.7 ± 0.212
0.7TrpLys: 0.7 ± 0.379
2.099TrpLeu: 2.099 ± 0.044
0.7TrpMet: 0.7 ± 0.379
0.7TrpAsn: 0.7 ± 0.379
0.0TrpPro: 0.0 ± 0.0
0.7TrpGln: 0.7 ± 0.379
0.35TrpArg: 0.35 ± 0.19
0.35TrpSer: 0.35 ± 0.19
0.7TrpThr: 0.7 ± 0.212
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.7TrpTyr: 0.7 ± 0.379
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.897TyrAla: 4.897 ± 0.3
0.35TyrCys: 0.35 ± 0.19
2.099TyrAsp: 2.099 ± 1.138
2.798TyrGlu: 2.798 ± 0.335
2.099TyrPhe: 2.099 ± 0.044
2.448TyrGly: 2.448 ± 0.146
0.35TyrHis: 0.35 ± 0.19
1.399TyrIle: 1.399 ± 0.168
2.448TyrLys: 2.448 ± 1.037
2.798TyrLeu: 2.798 ± 0.335
0.35TyrMet: 0.35 ± 0.401
2.099TyrAsn: 2.099 ± 1.138
1.749TyrPro: 1.749 ± 0.825
1.049TyrGln: 1.049 ± 0.569
2.448TyrArg: 2.448 ± 1.628
1.749TyrSer: 1.749 ± 0.357
1.399TyrThr: 1.399 ± 0.168
4.197TyrVal: 4.197 ± 0.679
0.35TyrTrp: 0.35 ± 0.19
1.399TyrTyr: 1.399 ± 0.423
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2860 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski