Amino acid dipepetide frequency for Marinitoga piezophila (strain DSM 14283 / JCM 11233 / KA3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.366AlaAla: 3.366 ± 0.098	0.25AlaCys: 0.25 ± 0.022	2.259AlaAsp: 2.259 ± 0.059	3.642AlaGlu: 3.642 ± 0.088	2.593AlaPhe: 2.593 ± 0.066	3.519AlaGly: 3.519 ± 0.089	0.779AlaHis: 0.779 ± 0.043	5.092AlaIle: 5.092 ± 0.097	4.628AlaLys: 4.628 ± 0.09	5.189AlaLeu: 5.189 ± 0.098	1.267AlaMet: 1.267 ± 0.051	2.401AlaAsn: 2.401 ± 0.065	1.239AlaPro: 1.239 ± 0.046	1.223AlaGln: 1.223 ± 0.046	1.875AlaArg: 1.875 ± 0.062	2.579AlaSer: 2.579 ± 0.065	2.458AlaThr: 2.458 ± 0.077	3.445AlaVal: 3.445 ± 0.081	0.377AlaTrp: 0.377 ± 0.023	2.198AlaTyr: 2.198 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	0.175CysAla: 0.175 ± 0.018	0.041CysCys: 0.041 ± 0.009	0.273CysAsp: 0.273 ± 0.02	0.371CysGlu: 0.371 ± 0.024	0.159CysPhe: 0.159 ± 0.014	0.549CysGly: 0.549 ± 0.038	0.096CysHis: 0.096 ± 0.011	0.368CysIle: 0.368 ± 0.024	0.37CysLys: 0.37 ± 0.023	0.24CysLeu: 0.24 ± 0.018	0.069CysMet: 0.069 ± 0.01	0.262CysAsn: 0.262 ± 0.021	0.333CysPro: 0.333 ± 0.025	0.098CysGln: 0.098 ± 0.012	0.171CysArg: 0.171 ± 0.015	0.3CysSer: 0.3 ± 0.022	0.235CysThr: 0.235 ± 0.022	0.272CysVal: 0.272 ± 0.022	0.044CysTrp: 0.044 ± 0.008	0.168CysTyr: 0.168 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	2.462AspAla: 2.462 ± 0.065	0.205AspCys: 0.205 ± 0.018	2.354AspAsp: 2.354 ± 0.063	4.767AspGlu: 4.767 ± 0.082	3.559AspPhe: 3.559 ± 0.079	3.056AspGly: 3.056 ± 0.089	0.586AspHis: 0.586 ± 0.028	6.154AspIle: 6.154 ± 0.099	4.707AspLys: 4.707 ± 0.079	5.068AspLeu: 5.068 ± 0.099	1.285AspMet: 1.285 ± 0.042	3.043AspAsn: 3.043 ± 0.079	1.852AspPro: 1.852 ± 0.048	0.735AspGln: 0.735 ± 0.034	1.39AspArg: 1.39 ± 0.047	2.638AspSer: 2.638 ± 0.075	2.294AspThr: 2.294 ± 0.06	3.219AspVal: 3.219 ± 0.072	0.501AspTrp: 0.501 ± 0.031	2.908AspTyr: 2.908 ± 0.07	0.0AspXaa: 0.0 ± 0.0
Glu	3.67GluAla: 3.67 ± 0.087	0.256GluCys: 0.256 ± 0.02	4.19GluAsp: 4.19 ± 0.085	7.703GluGlu: 7.703 ± 0.159	3.953GluPhe: 3.953 ± 0.075	3.718GluGly: 3.718 ± 0.076	1.033GluHis: 1.033 ± 0.045	9.558GluIle: 9.558 ± 0.162	10.676GluLys: 10.676 ± 0.17	7.424GluLeu: 7.424 ± 0.127	2.214GluMet: 2.214 ± 0.064	6.351GluAsn: 6.351 ± 0.117	1.685GluPro: 1.685 ± 0.052	1.432GluGln: 1.432 ± 0.05	2.638GluArg: 2.638 ± 0.066	3.369GluSer: 3.369 ± 0.083	3.108GluThr: 3.108 ± 0.067	4.546GluVal: 4.546 ± 0.087	0.513GluTrp: 0.513 ± 0.027	3.987GluTyr: 3.987 ± 0.08	0.0GluXaa: 0.0 ± 0.0
Phe	2.5PheAla: 2.5 ± 0.077	0.247PheCys: 0.247 ± 0.02	3.263PheAsp: 3.263 ± 0.069	4.694PheGlu: 4.694 ± 0.091	3.129PhePhe: 3.129 ± 0.08	3.358PheGly: 3.358 ± 0.076	0.697PheHis: 0.697 ± 0.035	4.896PheIle: 4.896 ± 0.104	4.728PheLys: 4.728 ± 0.092	5.213PheLeu: 5.213 ± 0.104	1.181PheMet: 1.181 ± 0.042	3.141PheAsn: 3.141 ± 0.073	1.575PhePro: 1.575 ± 0.055	1.046PheGln: 1.046 ± 0.04	1.404PheArg: 1.404 ± 0.043	4.165PheSer: 4.165 ± 0.093	2.268PheThr: 2.268 ± 0.062	3.184PheVal: 3.184 ± 0.072	0.492PheTrp: 0.492 ± 0.027	2.515PheTyr: 2.515 ± 0.073	0.0PheXaa: 0.0 ± 0.0
Gly	3.388GlyAla: 3.388 ± 0.079	0.406GlyCys: 0.406 ± 0.028	2.882GlyAsp: 2.882 ± 0.071	4.085GlyGlu: 4.085 ± 0.092	3.35GlyPhe: 3.35 ± 0.081	3.766GlyGly: 3.766 ± 0.095	0.881GlyHis: 0.881 ± 0.04	6.606GlyIle: 6.606 ± 0.123	5.954GlyLys: 5.954 ± 0.103	4.985GlyLeu: 4.985 ± 0.1	1.586GlyMet: 1.586 ± 0.061	3.151GlyAsn: 3.151 ± 0.079	1.347GlyPro: 1.347 ± 0.05	1.051GlyGln: 1.051 ± 0.038	1.942GlyArg: 1.942 ± 0.057	2.888GlySer: 2.888 ± 0.073	2.994GlyThr: 2.994 ± 0.064	3.917GlyVal: 3.917 ± 0.092	0.598GlyTrp: 0.598 ± 0.032	3.043GlyTyr: 3.043 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	0.663HisAla: 0.663 ± 0.033	0.101HisCys: 0.101 ± 0.012	0.674HisAsp: 0.674 ± 0.029	1.051HisGlu: 1.051 ± 0.044	0.799HisPhe: 0.799 ± 0.036	0.95HisGly: 0.95 ± 0.038	0.301HisHis: 0.301 ± 0.023	1.42HisIle: 1.42 ± 0.051	1.033HisLys: 1.033 ± 0.043	1.203HisLeu: 1.203 ± 0.04	0.31HisMet: 0.31 ± 0.022	0.775HisAsn: 0.775 ± 0.031	0.712HisPro: 0.712 ± 0.036	0.327HisGln: 0.327 ± 0.021	0.473HisArg: 0.473 ± 0.025	0.77HisSer: 0.77 ± 0.033	0.677HisThr: 0.677 ± 0.031	0.82HisVal: 0.82 ± 0.035	0.098HisTrp: 0.098 ± 0.011	0.647HisTyr: 0.647 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.491IleAla: 5.491 ± 0.092	0.431IleCys: 0.431 ± 0.026	5.935IleAsp: 5.935 ± 0.093	8.294IleGlu: 8.294 ± 0.124	5.669IlePhe: 5.669 ± 0.111	5.578IleGly: 5.578 ± 0.095	1.28IleHis: 1.28 ± 0.041	10.879IleIle: 10.879 ± 0.15	9.939IleLys: 9.939 ± 0.147	10.128IleLeu: 10.128 ± 0.145	2.246IleMet: 2.246 ± 0.059	6.307IleAsn: 6.307 ± 0.109	4.003IlePro: 4.003 ± 0.072	1.973IleGln: 1.973 ± 0.056	2.948IleArg: 2.948 ± 0.07	7.192IleSer: 7.192 ± 0.125	5.225IleThr: 5.225 ± 0.1	5.745IleVal: 5.745 ± 0.087	0.71IleTrp: 0.71 ± 0.038	4.69IleTyr: 4.69 ± 0.097	0.0IleXaa: 0.0 ± 0.0
Lys	4.275LysAla: 4.275 ± 0.088	0.409LysCys: 0.409 ± 0.028	5.762LysAsp: 5.762 ± 0.1	9.321LysGlu: 9.321 ± 0.136	4.133LysPhe: 4.133 ± 0.09	4.839LysGly: 4.839 ± 0.089	1.309LysHis: 1.309 ± 0.043	11.25LysIle: 11.25 ± 0.152	10.727LysLys: 10.727 ± 0.156	8.146LysLeu: 8.146 ± 0.129	2.388LysMet: 2.388 ± 0.057	7.694LysAsn: 7.694 ± 0.139	2.536LysPro: 2.536 ± 0.056	1.755LysGln: 1.755 ± 0.054	3.446LysArg: 3.446 ± 0.078	4.791LysSer: 4.791 ± 0.093	4.777LysThr: 4.777 ± 0.079	5.701LysVal: 5.701 ± 0.106	0.792LysTrp: 0.792 ± 0.039	5.292LysTyr: 5.292 ± 0.098	0.0LysXaa: 0.0 ± 0.0
Leu	4.582LeuAla: 4.582 ± 0.093	0.354LeuCys: 0.354 ± 0.021	4.712LeuAsp: 4.712 ± 0.084	7.364LeuGlu: 7.364 ± 0.108	4.956LeuPhe: 4.956 ± 0.113	5.368LeuGly: 5.368 ± 0.104	1.19LeuHis: 1.19 ± 0.047	8.517LeuIle: 8.517 ± 0.128	10.996LeuLys: 10.996 ± 0.133	8.432LeuLeu: 8.432 ± 0.129	2.248LeuMet: 2.248 ± 0.051	6.211LeuAsn: 6.211 ± 0.104	2.992LeuPro: 2.992 ± 0.07	1.79LeuGln: 1.79 ± 0.048	3.054LeuArg: 3.054 ± 0.077	6.242LeuSer: 6.242 ± 0.112	4.394LeuThr: 4.394 ± 0.09	4.506LeuVal: 4.506 ± 0.079	0.685LeuTrp: 0.685 ± 0.036	4.232LeuTyr: 4.232 ± 0.089	0.0LeuXaa: 0.0 ± 0.0
Met	1.442MetAla: 1.442 ± 0.052	0.107MetCys: 0.107 ± 0.014	1.293MetAsp: 1.293 ± 0.047	1.831MetGlu: 1.831 ± 0.047	1.093MetPhe: 1.093 ± 0.038	1.511MetGly: 1.511 ± 0.054	0.339MetHis: 0.339 ± 0.027	2.226MetIle: 2.226 ± 0.058	2.954MetLys: 2.954 ± 0.054	2.052MetLeu: 2.052 ± 0.053	0.63MetMet: 0.63 ± 0.035	1.387MetAsn: 1.387 ± 0.039	0.893MetPro: 0.893 ± 0.04	0.525MetGln: 0.525 ± 0.03	0.919MetArg: 0.919 ± 0.041	1.247MetSer: 1.247 ± 0.049	0.966MetThr: 0.966 ± 0.037	1.423MetVal: 1.423 ± 0.048	0.184MetTrp: 0.184 ± 0.016	0.896MetTyr: 0.896 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.926AsnAla: 2.926 ± 0.073	0.286AsnCys: 0.286 ± 0.023	2.867AsnAsp: 2.867 ± 0.06	4.804AsnGlu: 4.804 ± 0.083	3.184AsnPhe: 3.184 ± 0.075	3.523AsnGly: 3.523 ± 0.088	0.779AsnHis: 0.779 ± 0.034	7.398AsnIle: 7.398 ± 0.113	5.605AsnLys: 5.605 ± 0.114	5.892AsnLeu: 5.892 ± 0.096	1.369AsnMet: 1.369 ± 0.047	4.109AsnAsn: 4.109 ± 0.103	2.481AsnPro: 2.481 ± 0.077	1.119AsnGln: 1.119 ± 0.043	1.799AsnArg: 1.799 ± 0.055	3.44AsnSer: 3.44 ± 0.081	2.86AsnThr: 2.86 ± 0.066	3.525AsnVal: 3.525 ± 0.079	0.57AsnTrp: 0.57 ± 0.029	3.088AsnTyr: 3.088 ± 0.077	0.0AsnXaa: 0.0 ± 0.0
Pro	1.507ProAla: 1.507 ± 0.053	0.134ProCys: 0.134 ± 0.015	2.046ProAsp: 2.046 ± 0.057	3.616ProGlu: 3.616 ± 0.084	1.73ProPhe: 1.73 ± 0.052	2.037ProGly: 2.037 ± 0.06	0.566ProHis: 0.566 ± 0.028	2.812ProIle: 2.812 ± 0.073	2.313ProLys: 2.313 ± 0.06	2.768ProLeu: 2.768 ± 0.064	0.669ProMet: 0.669 ± 0.032	1.327ProAsn: 1.327 ± 0.046	0.889ProPro: 0.889 ± 0.041	0.871ProGln: 0.871 ± 0.038	0.862ProArg: 0.862 ± 0.035	1.581ProSer: 1.581 ± 0.055	1.559ProThr: 1.559 ± 0.055	2.332ProVal: 2.332 ± 0.06	0.288ProTrp: 0.288 ± 0.023	1.625ProTyr: 1.625 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	0.963GlnAla: 0.963 ± 0.042	0.086GlnCys: 0.086 ± 0.011	0.821GlnAsp: 0.821 ± 0.036	1.458GlnGlu: 1.458 ± 0.05	0.931GlnPhe: 0.931 ± 0.038	0.946GlnGly: 0.946 ± 0.038	0.313GlnHis: 0.313 ± 0.019	2.119GlnIle: 2.119 ± 0.056	2.316GlnLys: 2.316 ± 0.066	1.993GlnLeu: 1.993 ± 0.056	0.634GlnMet: 0.634 ± 0.032	1.377GlnAsn: 1.377 ± 0.051	0.564GlnPro: 0.564 ± 0.027	0.579GlnGln: 0.579 ± 0.034	0.742GlnArg: 0.742 ± 0.032	0.909GlnSer: 0.909 ± 0.037	0.929GlnThr: 0.929 ± 0.039	1.004GlnVal: 1.004 ± 0.036	0.191GlnTrp: 0.191 ± 0.017	0.925GlnTyr: 0.925 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	1.552ArgAla: 1.552 ± 0.049	0.197ArgCys: 0.197 ± 0.019	1.602ArgAsp: 1.602 ± 0.051	2.563ArgGlu: 2.563 ± 0.069	1.767ArgPhe: 1.767 ± 0.046	1.8ArgGly: 1.8 ± 0.052	0.421ArgHis: 0.421 ± 0.027	3.474ArgIle: 3.474 ± 0.072	3.418ArgLys: 3.418 ± 0.077	2.724ArgLeu: 2.724 ± 0.066	0.893ArgMet: 0.893 ± 0.037	1.985ArgAsn: 1.985 ± 0.058	0.864ArgPro: 0.864 ± 0.037	0.59ArgGln: 0.59 ± 0.035	1.33ArgArg: 1.33 ± 0.049	1.371ArgSer: 1.371 ± 0.045	1.365ArgThr: 1.365 ± 0.044	2.058ArgVal: 2.058 ± 0.061	0.259ArgTrp: 0.259 ± 0.02	1.54ArgTyr: 1.54 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	2.828SerAla: 2.828 ± 0.079	0.276SerCys: 0.276 ± 0.02	2.894SerAsp: 2.894 ± 0.075	4.184SerGlu: 4.184 ± 0.089	3.301SerPhe: 3.301 ± 0.067	3.902SerGly: 3.902 ± 0.069	0.827SerHis: 0.827 ± 0.038	5.745SerIle: 5.745 ± 0.113	5.235SerLys: 5.235 ± 0.09	5.552SerLeu: 5.552 ± 0.099	1.331SerMet: 1.331 ± 0.042	3.138SerAsn: 3.138 ± 0.075	1.891SerPro: 1.891 ± 0.055	1.38SerGln: 1.38 ± 0.043	1.805SerArg: 1.805 ± 0.053	3.291SerSer: 3.291 ± 0.083	2.645SerThr: 2.645 ± 0.066	3.338SerVal: 3.338 ± 0.072	0.45SerTrp: 0.45 ± 0.026	2.572SerTyr: 2.572 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	2.635ThrAla: 2.635 ± 0.072	0.215ThrCys: 0.215 ± 0.022	2.381ThrAsp: 2.381 ± 0.063	3.325ThrGlu: 3.325 ± 0.09	2.726ThrPhe: 2.726 ± 0.069	3.396ThrGly: 3.396 ± 0.068	0.776ThrHis: 0.776 ± 0.034	4.595ThrIle: 4.595 ± 0.084	3.499ThrLys: 3.499 ± 0.076	4.856ThrLeu: 4.856 ± 0.098	0.957ThrMet: 0.957 ± 0.036	2.27ThrAsn: 2.27 ± 0.067	1.944ThrPro: 1.944 ± 0.058	1.102ThrGln: 1.102 ± 0.044	1.4ThrArg: 1.4 ± 0.052	2.484ThrSer: 2.484 ± 0.063	2.585ThrThr: 2.585 ± 0.074	2.927ThrVal: 2.927 ± 0.064	0.373ThrTrp: 0.373 ± 0.027	2.034ThrTyr: 2.034 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	3.31ValAla: 3.31 ± 0.078	0.289ValCys: 0.289 ± 0.026	3.329ValAsp: 3.329 ± 0.074	4.928ValGlu: 4.928 ± 0.1	3.354ValPhe: 3.354 ± 0.077	3.525ValGly: 3.525 ± 0.091	0.792ValHis: 0.792 ± 0.036	5.724ValIle: 5.724 ± 0.098	5.333ValLys: 5.333 ± 0.08	5.688ValLeu: 5.688 ± 0.083	1.371ValMet: 1.371 ± 0.042	2.973ValAsn: 2.973 ± 0.075	1.872ValPro: 1.872 ± 0.054	1.07ValGln: 1.07 ± 0.041	1.9ValArg: 1.9 ± 0.055	3.798ValSer: 3.798 ± 0.067	2.496ValThr: 2.496 ± 0.067	3.95ValVal: 3.95 ± 0.088	0.424ValTrp: 0.424 ± 0.023	2.796ValTyr: 2.796 ± 0.07	0.0ValXaa: 0.0 ± 0.0
Trp	0.4TrpAla: 0.4 ± 0.025	0.057TrpCys: 0.057 ± 0.009	0.494TrpAsp: 0.494 ± 0.027	0.516TrpGlu: 0.516 ± 0.026	0.386TrpPhe: 0.386 ± 0.024	0.51TrpGly: 0.51 ± 0.027	0.155TrpHis: 0.155 ± 0.015	0.761TrpIle: 0.761 ± 0.031	0.843TrpLys: 0.843 ± 0.046	0.696TrpLeu: 0.696 ± 0.034	0.266TrpMet: 0.266 ± 0.019	0.57TrpAsn: 0.57 ± 0.029	0.228TrpPro: 0.228 ± 0.02	0.224TrpGln: 0.224 ± 0.017	0.259TrpArg: 0.259 ± 0.02	0.402TrpSer: 0.402 ± 0.026	0.354TrpThr: 0.354 ± 0.026	0.457TrpVal: 0.457 ± 0.026	0.139TrpTrp: 0.139 ± 0.015	0.381TrpTyr: 0.381 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.245TyrAla: 2.245 ± 0.066	0.247TyrCys: 0.247 ± 0.022	2.753TyrAsp: 2.753 ± 0.074	3.507TyrGlu: 3.507 ± 0.079	2.927TyrPhe: 2.927 ± 0.072	2.965TyrGly: 2.965 ± 0.069	0.684TyrHis: 0.684 ± 0.031	5.068TyrIle: 5.068 ± 0.096	4.07TyrLys: 4.07 ± 0.084	4.574TyrLeu: 4.574 ± 0.082	1.003TyrMet: 1.003 ± 0.04	3.157TyrAsn: 3.157 ± 0.074	1.634TyrPro: 1.634 ± 0.05	0.912TyrGln: 0.912 ± 0.039	1.415TyrArg: 1.415 ± 0.046	3.129TyrSer: 3.129 ± 0.079	2.287TyrThr: 2.287 ± 0.057	2.552TyrVal: 2.552 ± 0.066	0.409TyrTrp: 0.409 ± 0.026	2.803TyrTyr: 2.803 ± 0.082	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2044 proteins (684271 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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