Amino acid dipepetide frequency for Firmicutes bacterium CAG:475

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.277AlaAla: 5.277 ± 0.147
1.558AlaCys: 1.558 ± 0.073
4.84AlaAsp: 4.84 ± 0.109
4.459AlaGlu: 4.459 ± 0.114
3.577AlaPhe: 3.577 ± 0.11
4.8AlaGly: 4.8 ± 0.13
1.383AlaHis: 1.383 ± 0.064
6.386AlaIle: 6.386 ± 0.13
6.816AlaLys: 6.816 ± 0.138
8.126AlaLeu: 8.126 ± 0.155
2.27AlaMet: 2.27 ± 0.077
3.84AlaAsn: 3.84 ± 0.119
2.364AlaPro: 2.364 ± 0.077
2.915AlaGln: 2.915 ± 0.087
3.414AlaArg: 3.414 ± 0.104
4.911AlaSer: 4.911 ± 0.111
4.823AlaThr: 4.823 ± 0.144
6.5AlaVal: 6.5 ± 0.123
0.48AlaTrp: 0.48 ± 0.032
3.038AlaTyr: 3.038 ± 0.083
0.007AlaXaa: 0.007 ± 0.004
Cys
1.695CysAla: 1.695 ± 0.08
0.267CysCys: 0.267 ± 0.028
1.428CysAsp: 1.428 ± 0.07
1.144CysGlu: 1.144 ± 0.054
0.768CysPhe: 0.768 ± 0.052
1.733CysGly: 1.733 ± 0.072
0.336CysHis: 0.336 ± 0.031
1.085CysIle: 1.085 ± 0.057
1.175CysLys: 1.175 ± 0.063
1.104CysLeu: 1.104 ± 0.057
0.359CysMet: 0.359 ± 0.027
0.747CysAsn: 0.747 ± 0.047
0.688CysPro: 0.688 ± 0.051
0.376CysGln: 0.376 ± 0.029
0.593CysArg: 0.593 ± 0.043
0.974CysSer: 0.974 ± 0.045
0.79CysThr: 0.79 ± 0.051
1.532CysVal: 1.532 ± 0.067
0.118CysTrp: 0.118 ± 0.018
0.551CysTyr: 0.551 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
4.882AspAla: 4.882 ± 0.125
1.203AspCys: 1.203 ± 0.061
4.332AspAsp: 4.332 ± 0.126
5.644AspGlu: 5.644 ± 0.124
3.551AspPhe: 3.551 ± 0.114
5.44AspGly: 5.44 ± 0.142
0.695AspHis: 0.695 ± 0.042
4.291AspIle: 4.291 ± 0.097
5.261AspLys: 5.261 ± 0.095
4.473AspLeu: 4.473 ± 0.12
1.986AspMet: 1.986 ± 0.087
2.719AspAsn: 2.719 ± 0.076
1.286AspPro: 1.286 ± 0.061
0.998AspGln: 0.998 ± 0.049
2.052AspArg: 2.052 ± 0.066
3.09AspSer: 3.09 ± 0.087
3.201AspThr: 3.201 ± 0.095
5.722AspVal: 5.722 ± 0.131
0.489AspTrp: 0.489 ± 0.037
2.653AspTyr: 2.653 ± 0.087
0.0AspXaa: 0.0 ± 0.0
Glu
4.251GluAla: 4.251 ± 0.113
0.955GluCys: 0.955 ± 0.057
3.636GluAsp: 3.636 ± 0.102
4.972GluGlu: 4.972 ± 0.169
2.641GluPhe: 2.641 ± 0.081
3.996GluGly: 3.996 ± 0.099
1.104GluHis: 1.104 ± 0.05
5.161GluIle: 5.161 ± 0.124
6.313GluLys: 6.313 ± 0.152
5.32GluLeu: 5.32 ± 0.103
1.785GluMet: 1.785 ± 0.068
4.391GluAsn: 4.391 ± 0.117
1.471GluPro: 1.471 ± 0.067
2.679GluGln: 2.679 ± 0.103
3.003GluArg: 3.003 ± 0.102
3.438GluSer: 3.438 ± 0.087
3.059GluThr: 3.059 ± 0.104
4.232GluVal: 4.232 ± 0.112
0.556GluTrp: 0.556 ± 0.038
2.762GluTyr: 2.762 ± 0.099
0.0GluXaa: 0.0 ± 0.0
Phe
4.402PheAla: 4.402 ± 0.11
0.984PheCys: 0.984 ± 0.056
3.986PheAsp: 3.986 ± 0.108
3.409PheGlu: 3.409 ± 0.098
2.208PhePhe: 2.208 ± 0.103
3.459PheGly: 3.459 ± 0.096
0.549PheHis: 0.549 ± 0.035
2.494PheIle: 2.494 ± 0.086
2.946PheLys: 2.946 ± 0.081
3.246PheLeu: 3.246 ± 0.101
1.045PheMet: 1.045 ± 0.049
1.894PheAsn: 1.894 ± 0.073
1.185PhePro: 1.185 ± 0.055
0.768PheGln: 0.768 ± 0.044
1.409PheArg: 1.409 ± 0.058
3.081PheSer: 3.081 ± 0.097
2.407PheThr: 2.407 ± 0.079
4.076PheVal: 4.076 ± 0.119
0.296PheTrp: 0.296 ± 0.024
1.662PheTyr: 1.662 ± 0.072
0.0PheXaa: 0.0 ± 0.0
Gly
5.823GlyAla: 5.823 ± 0.145
1.097GlyCys: 1.097 ± 0.057
4.057GlyAsp: 4.057 ± 0.115
4.795GlyGlu: 4.795 ± 0.107
3.104GlyPhe: 3.104 ± 0.084
5.081GlyGly: 5.081 ± 0.137
1.088GlyHis: 1.088 ± 0.053
5.462GlyIle: 5.462 ± 0.136
6.02GlyLys: 6.02 ± 0.123
5.232GlyLeu: 5.232 ± 0.127
1.925GlyMet: 1.925 ± 0.069
3.033GlyAsn: 3.033 ± 0.101
0.903GlyPro: 0.903 ± 0.058
1.731GlyGln: 1.731 ± 0.075
2.551GlyArg: 2.551 ± 0.085
3.428GlySer: 3.428 ± 0.098
4.038GlyThr: 4.038 ± 0.141
6.013GlyVal: 6.013 ± 0.131
0.563GlyTrp: 0.563 ± 0.044
3.121GlyTyr: 3.121 ± 0.088
0.005GlyXaa: 0.005 ± 0.003
His
1.182HisAla: 1.182 ± 0.055
0.314HisCys: 0.314 ± 0.028
0.932HisAsp: 0.932 ± 0.049
0.818HisGlu: 0.818 ± 0.042
0.735HisPhe: 0.735 ± 0.043
1.187HisGly: 1.187 ± 0.056
0.303HisHis: 0.303 ± 0.032
1.199HisIle: 1.199 ± 0.049
0.922HisLys: 0.922 ± 0.052
1.218HisLeu: 1.218 ± 0.061
0.374HisMet: 0.374 ± 0.031
0.745HisAsn: 0.745 ± 0.039
0.709HisPro: 0.709 ± 0.047
0.35HisGln: 0.35 ± 0.03
0.657HisArg: 0.657 ± 0.043
0.924HisSer: 0.924 ± 0.048
0.849HisThr: 0.849 ± 0.05
1.14HisVal: 1.14 ± 0.061
0.078HisTrp: 0.078 ± 0.012
0.539HisTyr: 0.539 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
7.022IleAla: 7.022 ± 0.131
1.326IleCys: 1.326 ± 0.062
4.934IleAsp: 4.934 ± 0.129
4.722IleGlu: 4.722 ± 0.116
2.866IlePhe: 2.866 ± 0.091
4.837IleGly: 4.837 ± 0.104
0.872IleHis: 0.872 ± 0.046
4.36IleIle: 4.36 ± 0.124
4.58IleLys: 4.58 ± 0.114
5.611IleLeu: 5.611 ± 0.128
1.688IleMet: 1.688 ± 0.072
3.069IleAsn: 3.069 ± 0.09
2.319IlePro: 2.319 ± 0.084
1.374IleGln: 1.374 ± 0.055
2.379IleArg: 2.379 ± 0.074
4.525IleSer: 4.525 ± 0.102
3.674IleThr: 3.674 ± 0.095
6.62IleVal: 6.62 ± 0.146
0.407IleTrp: 0.407 ± 0.036
2.253IleTyr: 2.253 ± 0.081
0.0IleXaa: 0.0 ± 0.0
Lys
5.883LysAla: 5.883 ± 0.107
1.059LysCys: 1.059 ± 0.064
5.109LysAsp: 5.109 ± 0.113
5.303LysGlu: 5.303 ± 0.133
2.752LysPhe: 2.752 ± 0.095
4.473LysGly: 4.473 ± 0.111
1.237LysHis: 1.237 ± 0.053
5.419LysIle: 5.419 ± 0.136
6.474LysLys: 6.474 ± 0.144
5.892LysLeu: 5.892 ± 0.133
2.095LysMet: 2.095 ± 0.073
4.551LysAsn: 4.551 ± 0.103
2.161LysPro: 2.161 ± 0.078
2.672LysGln: 2.672 ± 0.085
3.471LysArg: 3.471 ± 0.099
4.577LysSer: 4.577 ± 0.114
4.57LysThr: 4.57 ± 0.116
5.23LysVal: 5.23 ± 0.11
0.679LysTrp: 0.679 ± 0.047
3.173LysTyr: 3.173 ± 0.086
0.0LysXaa: 0.0 ± 0.0
Leu
7.535LeuAla: 7.535 ± 0.159
1.901LeuCys: 1.901 ± 0.09
5.615LeuAsp: 5.615 ± 0.118
4.984LeuGlu: 4.984 ± 0.118
3.868LeuPhe: 3.868 ± 0.122
5.703LeuGly: 5.703 ± 0.145
1.286LeuHis: 1.286 ± 0.061
5.178LeuIle: 5.178 ± 0.126
6.455LeuLys: 6.455 ± 0.155
6.798LeuLeu: 6.798 ± 0.157
2.05LeuMet: 2.05 ± 0.081
3.424LeuAsn: 3.424 ± 0.095
3.052LeuPro: 3.052 ± 0.101
2.416LeuGln: 2.416 ± 0.089
3.298LeuArg: 3.298 ± 0.093
6.029LeuSer: 6.029 ± 0.126
4.776LeuThr: 4.776 ± 0.124
6.455LeuVal: 6.455 ± 0.121
0.52LeuTrp: 0.52 ± 0.045
2.802LeuTyr: 2.802 ± 0.086
0.0LeuXaa: 0.0 ± 0.0
Met
2.022MetAla: 2.022 ± 0.069
0.383MetCys: 0.383 ± 0.031
1.397MetAsp: 1.397 ± 0.058
1.168MetGlu: 1.168 ± 0.054
1.04MetPhe: 1.04 ± 0.047
1.591MetGly: 1.591 ± 0.067
0.395MetHis: 0.395 ± 0.031
1.636MetIle: 1.636 ± 0.074
2.024MetLys: 2.024 ± 0.066
2.65MetLeu: 2.65 ± 0.082
0.65MetMet: 0.65 ± 0.041
1.185MetAsn: 1.185 ± 0.051
1.161MetPro: 1.161 ± 0.06
1.102MetGln: 1.102 ± 0.052
1.383MetArg: 1.383 ± 0.062
1.865MetSer: 1.865 ± 0.059
1.397MetThr: 1.397 ± 0.056
1.518MetVal: 1.518 ± 0.07
0.184MetTrp: 0.184 ± 0.022
0.825MetTyr: 0.825 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
4.19AsnAla: 4.19 ± 0.117
0.747AsnCys: 0.747 ± 0.043
2.783AsnAsp: 2.783 ± 0.089
2.854AsnGlu: 2.854 ± 0.08
1.96AsnPhe: 1.96 ± 0.078
4.064AsnGly: 4.064 ± 0.133
0.676AsnHis: 0.676 ± 0.041
2.984AsnIle: 2.984 ± 0.094
3.116AsnLys: 3.116 ± 0.085
4.19AsnLeu: 4.19 ± 0.1
1.255AsnMet: 1.255 ± 0.054
2.059AsnAsn: 2.059 ± 0.077
2.045AsnPro: 2.045 ± 0.075
1.203AsnGln: 1.203 ± 0.06
1.771AsnArg: 1.771 ± 0.063
2.253AsnSer: 2.253 ± 0.078
2.447AsnThr: 2.447 ± 0.081
4.199AsnVal: 4.199 ± 0.121
0.426AsnTrp: 0.426 ± 0.036
1.83AsnTyr: 1.83 ± 0.084
0.0AsnXaa: 0.0 ± 0.0
Pro
2.036ProAla: 2.036 ± 0.071
0.553ProCys: 0.553 ± 0.04
1.979ProAsp: 1.979 ± 0.073
2.097ProGlu: 2.097 ± 0.077
1.558ProPhe: 1.558 ± 0.063
1.461ProGly: 1.461 ± 0.07
0.572ProHis: 0.572 ± 0.038
2.038ProIle: 2.038 ± 0.071
2.083ProLys: 2.083 ± 0.097
2.504ProLeu: 2.504 ± 0.08
0.792ProMet: 0.792 ± 0.041
1.168ProAsn: 1.168 ± 0.055
0.735ProPro: 0.735 ± 0.043
1.244ProGln: 1.244 ± 0.057
0.979ProArg: 0.979 ± 0.06
2.005ProSer: 2.005 ± 0.074
1.865ProThr: 1.865 ± 0.072
2.532ProVal: 2.532 ± 0.101
0.218ProTrp: 0.218 ± 0.022
1.367ProTyr: 1.367 ± 0.058
0.0ProXaa: 0.0 ± 0.0
Gln
2.005GlnAla: 2.005 ± 0.067
0.343GlnCys: 0.343 ± 0.032
1.523GlnAsp: 1.523 ± 0.065
1.811GlnGlu: 1.811 ± 0.099
0.96GlnPhe: 0.96 ± 0.051
1.747GlnGly: 1.747 ± 0.072
0.418GlnHis: 0.418 ± 0.033
2.381GlnIle: 2.381 ± 0.066
2.818GlnLys: 2.818 ± 0.093
2.135GlnLeu: 2.135 ± 0.09
0.688GlnMet: 0.688 ± 0.04
2.111GlnAsn: 2.111 ± 0.07
0.797GlnPro: 0.797 ± 0.057
0.839GlnGln: 0.839 ± 0.057
1.322GlnArg: 1.322 ± 0.062
1.915GlnSer: 1.915 ± 0.059
1.816GlnThr: 1.816 ± 0.066
1.622GlnVal: 1.622 ± 0.062
0.163GlnTrp: 0.163 ± 0.021
1.043GlnTyr: 1.043 ± 0.058
0.0GlnXaa: 0.0 ± 0.0
Arg
3.017ArgAla: 3.017 ± 0.091
0.577ArgCys: 0.577 ± 0.044
2.107ArgAsp: 2.107 ± 0.083
2.814ArgGlu: 2.814 ± 0.092
1.934ArgPhe: 1.934 ± 0.069
2.208ArgGly: 2.208 ± 0.076
0.634ArgHis: 0.634 ± 0.045
3.305ArgIle: 3.305 ± 0.093
3.095ArgLys: 3.095 ± 0.097
3.594ArgLeu: 3.594 ± 0.097
1.147ArgMet: 1.147 ± 0.05
1.967ArgAsn: 1.967 ± 0.071
1.05ArgPro: 1.05 ± 0.046
1.229ArgGln: 1.229 ± 0.053
1.868ArgArg: 1.868 ± 0.076
1.847ArgSer: 1.847 ± 0.084
1.932ArgThr: 1.932 ± 0.072
2.811ArgVal: 2.811 ± 0.082
0.234ArgTrp: 0.234 ± 0.025
1.665ArgTyr: 1.665 ± 0.071
0.002ArgXaa: 0.002 ± 0.002
Ser
5.228SerAla: 5.228 ± 0.109
0.889SerCys: 0.889 ± 0.055
3.901SerAsp: 3.901 ± 0.117
3.729SerGlu: 3.729 ± 0.101
2.863SerPhe: 2.863 ± 0.084
4.745SerGly: 4.745 ± 0.107
0.965SerHis: 0.965 ± 0.05
4.079SerIle: 4.079 ± 0.113
4.209SerLys: 4.209 ± 0.101
5.228SerLeu: 5.228 ± 0.124
1.416SerMet: 1.416 ± 0.063
2.388SerAsn: 2.388 ± 0.085
1.7SerPro: 1.7 ± 0.065
1.802SerGln: 1.802 ± 0.065
2.114SerArg: 2.114 ± 0.069
3.991SerSer: 3.991 ± 0.119
3.097SerThr: 3.097 ± 0.094
5.23SerVal: 5.23 ± 0.126
0.383SerTrp: 0.383 ± 0.028
2.173SerTyr: 2.173 ± 0.087
0.005SerXaa: 0.005 ± 0.004
Thr
4.577ThrAla: 4.577 ± 0.124
0.728ThrCys: 0.728 ± 0.042
3.197ThrAsp: 3.197 ± 0.104
2.866ThrGlu: 2.866 ± 0.09
2.7ThrPhe: 2.7 ± 0.092
3.733ThrGly: 3.733 ± 0.096
0.965ThrHis: 0.965 ± 0.052
4.145ThrIle: 4.145 ± 0.127
3.364ThrLys: 3.364 ± 0.101
5.674ThrLeu: 5.674 ± 0.154
1.187ThrMet: 1.187 ± 0.055
2.071ThrAsn: 2.071 ± 0.082
2.343ThrPro: 2.343 ± 0.083
1.584ThrGln: 1.584 ± 0.06
1.903ThrArg: 1.903 ± 0.07
3.39ThrSer: 3.39 ± 0.115
3.005ThrThr: 3.005 ± 0.117
4.514ThrVal: 4.514 ± 0.142
0.355ThrTrp: 0.355 ± 0.031
2.282ThrTyr: 2.282 ± 0.127
0.0ThrXaa: 0.0 ± 0.0
Val
7.003ValAla: 7.003 ± 0.142
1.773ValCys: 1.773 ± 0.081
4.994ValAsp: 4.994 ± 0.108
5.497ValGlu: 5.497 ± 0.117
4.012ValPhe: 4.012 ± 0.109
5.41ValGly: 5.41 ± 0.123
1.024ValHis: 1.024 ± 0.05
4.975ValIle: 4.975 ± 0.13
6.154ValLys: 6.154 ± 0.127
7.32ValLeu: 7.32 ± 0.158
1.752ValMet: 1.752 ± 0.067
3.428ValAsn: 3.428 ± 0.116
2.35ValPro: 2.35 ± 0.088
1.856ValGln: 1.856 ± 0.068
3.119ValArg: 3.119 ± 0.097
5.209ValSer: 5.209 ± 0.126
4.079ValThr: 4.079 ± 0.138
6.902ValVal: 6.902 ± 0.146
0.556ValTrp: 0.556 ± 0.036
2.984ValTyr: 2.984 ± 0.094
0.002ValXaa: 0.002 ± 0.002
Trp
0.525TrpAla: 0.525 ± 0.036
0.158TrpCys: 0.158 ± 0.019
0.404TrpAsp: 0.404 ± 0.03
0.355TrpGlu: 0.355 ± 0.03
0.409TrpPhe: 0.409 ± 0.034
0.598TrpGly: 0.598 ± 0.04
0.139TrpHis: 0.139 ± 0.02
0.478TrpIle: 0.478 ± 0.035
0.428TrpLys: 0.428 ± 0.032
0.75TrpLeu: 0.75 ± 0.045
0.158TrpMet: 0.158 ± 0.02
0.352TrpAsn: 0.352 ± 0.028
0.116TrpPro: 0.116 ± 0.016
0.324TrpGln: 0.324 ± 0.028
0.255TrpArg: 0.255 ± 0.031
0.381TrpSer: 0.381 ± 0.031
0.4TrpThr: 0.4 ± 0.031
0.388TrpVal: 0.388 ± 0.033
0.121TrpTrp: 0.121 ± 0.017
0.371TrpTyr: 0.371 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.23TyrAla: 3.23 ± 0.096
0.648TyrCys: 0.648 ± 0.046
2.816TyrAsp: 2.816 ± 0.087
2.282TyrGlu: 2.282 ± 0.071
2.0TyrPhe: 2.0 ± 0.081
2.797TyrGly: 2.797 ± 0.086
0.534TyrHis: 0.534 ± 0.042
2.381TyrIle: 2.381 ± 0.079
2.528TyrLys: 2.528 ± 0.083
3.081TyrLeu: 3.081 ± 0.08
0.953TyrMet: 0.953 ± 0.048
1.908TyrAsn: 1.908 ± 0.07
1.35TyrPro: 1.35 ± 0.066
0.993TyrGln: 0.993 ± 0.05
1.49TyrArg: 1.49 ± 0.064
2.298TyrSer: 2.298 ± 0.084
2.355TyrThr: 2.355 ± 0.11
3.164TyrVal: 3.164 ± 0.104
0.286TyrTrp: 0.286 ± 0.03
1.669TyrTyr: 1.669 ± 0.089
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.002XaaGlu: 0.002 ± 0.002
0.0XaaPhe: 0.0 ± 0.0
0.005XaaGly: 0.005 ± 0.004
0.0XaaHis: 0.0 ± 0.0
0.002XaaIle: 0.002 ± 0.003
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.002XaaAsn: 0.002 ± 0.002
0.0XaaPro: 0.0 ± 0.0
0.002XaaGln: 0.002 ± 0.002
0.005XaaArg: 0.005 ± 0.003
0.0XaaSer: 0.0 ± 0.0
0.002XaaThr: 0.002 ± 0.002
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.021XaaXaa: 0.021 ± 0.008
Statistics based on 1270 proteins (422948 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski